                                                           The SAS System                        16:52 Thursday, January 5, 2023   1

                                                        The Mixed Procedure

                                                         Model Information

                                       Data Set                     WORK.TMP                 
                                       Dependent Variable           FEV1                     
                                       Covariance Structure         Unstructured             
                                       Subject Effect               USUBJID                  
                                       Estimation Method            REML                     
                                       Residual Variance Method     None                     
                                       Fixed Effects SE Method      Model-Based              
                                       Degrees of Freedom Method    Between-Within           


                                                      Class Level Information
 
                                        Class      Levels    Values

                                        AVISIT          4    VIS1 VIS2 VIS3 VIS4           
                                        USUBJID       200    PT1 PT10 PT100 PT101 PT102    
                                                             PT103 PT104 PT105 PT106 PT107 
                                                             PT108 PT109 PT11 PT110 PT111  
                                                             PT112 PT113 PT114 PT115 PT116 
                                                             PT117 PT118 PT119 PT12 PT120  
                                                             PT121 PT122 PT123 PT124 PT125 
                                                             PT126 PT127 PT128 PT129 PT13  
                                                             PT130 PT131 PT132 PT133 PT134 
                                                             PT135 PT136 PT137 PT138 PT139 
                                                             PT14 PT140 PT141 PT142 PT143  
                                                             PT144 PT145 PT146 PT147 PT148 
                                                             PT149 PT15 PT150 PT151 PT152  
                                                             PT153 PT154 PT155 PT156 PT157 
                                                             PT158 PT159 PT16 PT160 PT161  
                                                             PT162 PT163 PT164 PT165 PT166 
                                                             PT167 PT168 PT169 PT17 PT170  
                                                             PT171 PT172 PT173 PT174 PT175 
                                                             PT176 PT177 PT178 PT179 PT18  
                                                             PT180 PT181 PT182 PT183 PT184 
                                                             PT185 PT186 PT187 PT188 PT189 
                                                             PT19 PT190 PT191 PT192 PT193  
                                                             PT194 PT195 PT196 PT197 PT198 
                                                             PT199 PT2 PT20 PT200 PT21 PT22
                                                             PT23 PT24 PT25 PT26 PT27 PT28 
                                                             PT29 PT3 PT30 PT31 PT32 PT33  
                                                             PT34 PT35 PT36 PT37 PT38 PT39 
                                                             PT4 PT40 PT41 PT42 PT43 PT44  
                                                             PT45 PT46 PT47 PT48 PT49 PT5  
                                                             PT50 PT51 PT52 PT53 PT54 PT55 
                                                             PT56 PT57 PT58 PT59 PT6 PT60  
                                                             PT61 PT62 PT63 PT64 PT65 PT66 
                                                             PT67 PT68 PT69 PT7 PT70 PT71  
                                                             PT72 PT73 PT74 PT75 PT76 PT77 
                                                             PT78 PT79 PT8 PT80 PT81 PT82  
                                                             PT83 PT84 PT85 PT86 PT87 PT88 
                                                             PT89 PT9 PT90 PT91 PT92 PT93  
                                                             PT94 PT95 PT96 PT97 PT98 PT99 
                                        ARMCD           2    PBO TRT                       
                                                           The SAS System                        16:52 Thursday, January 5, 2023   2

                                                        The Mixed Procedure

                                                      Class Level Information
 
                                        Class      Levels    Values

                                        RACE            3    Asian Black or African        
                                                             American White                
                                        SEX             2    Female Male                   


                                                            Dimensions

                                                Covariance Parameters            10
                                                Columns in X                     14
                                                Columns in Z                      0
                                                Subjects                        200
                                                Max Obs per Subject               4


                                                      Number of Observations

                                            Number of Observations Read             800
                                            Number of Observations Used             537
                                            Number of Observations Not Used         263


                                                         Iteration History
 
                                    Iteration    Evaluations    -2 Res Log Like       Criterion

                                            0              1      3535.97413376                
                                            1              2      3386.46126144      0.00000927
                                            2              1      3386.44987722      0.00000001


                                                     Convergence criteria met.                    


                                                  Covariance Parameter Estimates
 
                                                  Cov Parm    Subject    Estimate

                                                  UN(1,1)     USUBJID     40.5509
                                                  UN(2,1)     USUBJID     14.3982
                                                  UN(2,2)     USUBJID     26.5692
                                                  UN(3,1)     USUBJID      4.9744
                                                  UN(3,2)     USUBJID      2.7851
                                                  UN(3,3)     USUBJID     14.8970
                                                  UN(4,1)     USUBJID     13.3731
                                                  UN(4,2)     USUBJID      7.4790
                                                  UN(4,3)     USUBJID      0.9017
                                                  UN(4,4)     USUBJID     95.5528


                                                           The SAS System                        16:52 Thursday, January 5, 2023   3

                                                        The Mixed Procedure

                                                          Fit Statistics

                                               -2 Res Log Likelihood          3386.4
                                               AIC (Smaller is Better)        3406.4
                                               AICC (Smaller is Better)       3406.9
                                               BIC (Smaller is Better)        3439.4


                                                  Null Model Likelihood Ratio Test
 
                                                    DF    Chi-Square      Pr > ChiSq

                                                     9        149.52          <.0001


                                                   Type 3 Tests of Fixed Effects
 
                                                          Num     Den
                                         Effect            DF      DF    F Value    Pr > F

                                         RACE               2     193      36.92    <.0001
                                         SEX                1     193       0.38    0.5405
                                         AVISIT*ARMCD       7     193      66.12    <.0001
                                                           The SAS System                        16:52 Thursday, January 5, 2023   4

 
  Obs USUBJID  AVISIT  ARMCD  RACE

    1  PT1      VIS1    TRT   Black or African American                                                                           
    2  PT1      VIS2    TRT   Black or African American                                                                           
    3  PT1      VIS3    TRT   Black or African American                                                                           
    4  PT1      VIS4    TRT   Black or African American                                                                           
    5  PT2      VIS1    PBO   Asian                                                                                               
    6  PT2      VIS2    PBO   Asian                                                                                               
    7  PT2      VIS3    PBO   Asian                                                                                               
    8  PT2      VIS4    PBO   Asian                                                                                               
    9  PT3      VIS1    PBO   Black or African American                                                                           
   10  PT3      VIS2    PBO   Black or African American                                                                           
   11  PT3      VIS3    PBO   Black or African American                                                                           
   12  PT3      VIS4    PBO   Black or African American                                                                           
   13  PT4      VIS1    TRT   Asian                                                                                               
   14  PT4      VIS2    TRT   Asian                                                                                               
   15  PT4      VIS3    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

    1 Female    25.271435093               .     0.676723117               1    -0.626453811    36.4086    0.90106    526     0.05
    2 Female    25.271435093    39.971049772    0.8006185545               2    0.1836433242    41.2059    0.76623    526     0.05
    3 Female    25.271435093               .    0.7087858627               3    -0.835628612    46.0568    0.70592    526     0.05
    4 Female    25.271435093    20.483789997     0.808899653               4    1.5952808021    52.0863    1.27509    526     0.05
    5 Male      45.024770977               .    0.4651847681               1    0.3295077718    30.7774    0.88653    526     0.05
    6 Male      45.024770977    31.455218862    0.2330974281               2    -0.820468384    35.6170    0.76366    526     0.05
    7 Male      45.024770977     36.87889346    0.3600763094               3    0.4874290524    41.1195    0.64540    526     0.05
    8 Male      45.024770977    48.808094647    0.5073794685               4    0.7383247051    45.8311    1.27598    526     0.05
    9 Female    43.500696824               .     0.682164203               1    0.5757813517    32.6341    0.85598    526     0.05
   10 Female    43.500696824    35.986991637    0.8917895503               2    -0.305388387    37.4737    0.74083    526     0.05
   11 Female    43.500696824               .     0.127628348               3    1.5117811685    42.9762    0.63127    526     0.05
   12 Female    43.500696824    37.164438717    0.2218987921               4    0.3898432364    47.6878    1.25995    526     0.05
   13 Female    31.603183398    33.892291438     0.688547962               1    -0.621240581    34.8780    0.86864    526     0.05
   14 Female    31.603183398    33.746374758    0.1009092692               2    -2.214699887    39.6754    0.71627    526     0.05
   15 Female    31.603183398               .    0.4129626682               3    1.1249309181    44.5263    0.62966    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

    1 34.6385    38.1787       .          .           .          .           .     
    2 39.7007    42.7112     -1.2349    -0.23957     7.7545    -0.24226    -0.23957
    3 44.6701    47.4436       .          .           .          .           .     
    4 49.5814    54.5912    -31.6025    -3.23322     0.9551    -3.26082    -3.23296
    5 29.0358    32.5189       .          .           .          .           .     
    6 34.1168    37.1172     -4.1618    -0.80740     6.1024    -0.81641    -0.80740
    7 39.8516    42.3874     -4.2406    -0.99548     8.7872    -1.11440    -1.09871
    8 43.3244    48.3377      2.9770     0.43232     4.1051     0.30718     0.30455
    9 30.9525    34.3156       .          .           .          .           .     
   10 36.0184    38.9290     -1.4867    -0.28843     6.9816    -0.29145    -0.28843
   11 41.7361    44.2164       .          .           .          .           .     
   12 45.2126    50.1629    -10.5233    -1.04531     2.7966    -1.08560    -1.07655
   13 33.1716    36.5845     -0.9857    -0.15480     5.3223    -0.15626    -0.15480
   14 38.2683    41.0825     -5.9290    -1.20440     4.6873    -1.16152    -1.15025
   15 43.2893    45.7632       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023   5

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   16  PT4      VIS4    TRT   Asian                                                                                               
   17  PT5      VIS1    PBO   Black or African American                                                                           
   18  PT5      VIS2    PBO   Black or African American                                                                           
   19  PT5      VIS3    PBO   Black or African American                                                                           
   20  PT5      VIS4    PBO   Black or African American                                                                           
   21  PT6      VIS1    PBO   Black or African American                                                                           
   22  PT6      VIS2    PBO   Black or African American                                                                           
   23  PT6      VIS3    PBO   Black or African American                                                                           
   24  PT6      VIS4    PBO   Black or African American                                                                           
   25  PT7      VIS1    PBO   Asian                                                                                               
   26  PT7      VIS2    PBO   Asian                                                                                               
   27  PT7      VIS3    PBO   Asian                                                                                               
   28  PT7      VIS4    PBO   Asian                                                                                               
   29  PT8      VIS1    PBO   Black or African American                                                                           
   30  PT8      VIS2    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   16 Female    31.603183398    54.450547528    0.4699957233               4    -0.044933609    50.5558    1.26066    526     0.05
   17 Male      43.646909655    32.313859554    0.4105151853               1    -0.016190263    32.3079    0.85058    526     0.05
   18 Male      43.646909655               .    0.4219881134               2    0.9438362107    37.1475    0.72572    526     0.05
   19 Male      43.646909655    46.793614059    0.2431708679               3    0.8212211951    42.6501    0.61298    526     0.05
   20 Male      43.646909655    41.711537613    0.8613270029               4    0.5939013212    47.3616    1.25303    526     0.05
   21 Male      21.594722051               .    0.4629824586               1    0.9189773716    32.3079    0.85058    526     0.05
   22 Male      21.594722051               .    0.3614019269               2    0.7821363007    37.1475    0.72572    526     0.05
   23 Male      21.594722051    39.024226214    0.8723322587               3    0.0745649834    42.6501    0.61298    526     0.05
   24 Male      21.594722051               .    0.6659855017               4    -1.989351696    47.3616    1.25303    526     0.05
   25 Female    25.481653915    31.930501636    0.6156341093               1    0.6198257479    31.1035    0.85562    526     0.05
   26 Female    25.481653915    32.909471719     0.411862788               2     -0.05612874    35.9432    0.73638    526     0.05
   27 Female    25.481653915               .    0.6588349115               3    -0.155795507    41.4457    0.61338    526     0.05
   28 Female    25.481653915     48.28031161    0.5352462916               4    -1.470752384    46.1572    1.25796    526     0.05
   29 Male      47.812250568    32.230211213    0.2811737429               1    -0.478150055    32.3079    0.85058    526     0.05
   30 Male      47.812250568    35.910799302     0.487646204               2    0.4179415602    37.1475    0.72572    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   16 48.0792    53.0323      3.8948     0.51737     4.2514     0.40179     0.39844
   17 30.6370    33.9789      0.0060     0.00094     5.0744     0.00094     0.00094
   18 35.7219    38.5732       .          .           .          .           .     
   19 41.4459    43.8543      4.1435     1.09604    11.3312     1.08735     1.07355
   20 44.9001    49.8232     -5.6501    -0.56971     3.4856    -0.58282    -0.57801
   21 30.6370    33.9789       .          .           .          .           .     
   22 35.7219    38.5732       .          .           .          .           .     
   23 41.4459    43.8543     -3.6259    -0.93942    10.1108    -0.95150    -0.93942
   24 44.9001    49.8232       .          .           .          .           .     
   25 29.4227    32.7844      0.8270     0.12987     5.0142     0.13106     0.12987
   26 34.4965    37.3898     -3.0337    -0.71831     4.6570    -0.59465    -0.58855
   27 40.2407    42.6507       .          .           .          .           .     
   28 43.6860    48.6285      2.1231     0.23863     3.6736     0.21901     0.21719
   29 30.6370    33.9789     -0.0777    -0.01220     5.0613    -0.01231    -0.01220
   30 35.7219    38.5732     -1.2367    -0.26104     5.2820    -0.24235    -0.23993
                                                           The SAS System                        16:52 Thursday, January 5, 2023   6

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   31  PT8      VIS3    PBO   Black or African American                                                                           
   32  PT8      VIS4    PBO   Black or African American                                                                           
   33  PT9      VIS1    TRT   White                                                                                               
   34  PT9      VIS2    TRT   White                                                                                               
   35  PT9      VIS3    TRT   White                                                                                               
   36  PT9      VIS4    TRT   White                                                                                               
   37  PT10     VIS1    PBO   Black or African American                                                                           
   38  PT10     VIS2    PBO   Black or African American                                                                           
   39  PT10     VIS3    PBO   Black or African American                                                                           
   40  PT10     VIS4    PBO   Black or African American                                                                           
   41  PT11     VIS1    TRT   Asian                                                                                               
   42  PT11     VIS2    TRT   Asian                                                                                               
   43  PT11     VIS3    TRT   Asian                                                                                               
   44  PT11     VIS4    TRT   Asian                                                                                               
   45  PT12     VIS1    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   31 Male      47.812250568    45.548975957    0.7344057359               3    1.3586795515    42.6501    0.61298    526     0.05
   32 Male      47.812250568    53.028768228    0.1047901036               4    -0.102787727    47.3616    1.25303    526     0.05
   33 Male      50.871292507    47.168980221    0.2501699567               1    0.3876716116    40.1955    0.89869    526     0.05
   34 Male      50.871292507    46.642867011    0.6454668986               2    -0.053805041    44.9928    0.77940    526     0.05
   35 Male      50.871292507               .    0.3960832989               3    -1.377059557    49.8437    0.70210    526     0.05
   36 Male      50.871292507    58.097132232    0.3893004561               4    -0.414994563    55.8732    1.28130    526     0.05
   37 Female    57.726129497               .    0.7950359188               1    -0.394289954    32.6341    0.85598    526     0.05
   38 Female    57.726129497               .    0.8233237326               2    -0.059313397    37.4737    0.74083    526     0.05
   39 Female    57.726129497    44.976131984    0.5939396525               3     1.100025372    42.9762    0.63127    526     0.05
   40 Female    57.726129497               .    0.2072253076               4    0.7631757485    47.6878    1.25995    526     0.05
   41 Female    50.985018211    44.327547822    0.7257546244               1    -0.164523596    34.8780    0.86864    526     0.05
   42 Female    50.985018211    38.978127123    0.4433590559               2     -0.25336168    39.6754    0.71627    526     0.05
   43 Female    50.985018211    43.728623823      0.84181918               3    0.6969633754    44.5263    0.62966    526     0.05
   44 Female    50.985018211    46.433934978    0.7185945798               4    0.5566631987    50.5558    1.26066    526     0.05
   45 Male      34.712714863    40.345759238    0.3077449974               1    -0.688755695    30.7774    0.88653    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   31 41.4459    43.8543      2.8989     0.78599    10.7154     0.76073     0.75107
   32 44.9001    49.8232      5.6671     0.63275     4.3830     0.58457     0.57975
   33 38.4300    41.9609      6.9735     1.09510     7.4072     1.10617     1.09510
   34 43.4617    46.5239      1.6501    -0.17831     6.4538     0.32385     0.32012
   35 48.4644    51.2230       .          .           .          .           .     
   36 53.3561    58.3903      2.2239     0.00307     4.0653     0.22949     0.22751
   37 30.9525    34.3156       .          .           .          .           .     
   38 36.0184    38.9290       .          .           .          .           .     
   39 41.7361    44.2164      1.9999     0.51815    11.6528     0.52522     0.51815
   40 45.2126    50.1629       .          .           .          .           .     
   41 33.1716    36.5845      9.4495     1.48392     6.9610     1.49792     1.48392
   42 38.2683    41.0825     -0.6972    -0.87484     5.0169    -0.13659    -0.13527
   43 43.2893    45.7632     -0.7977    -0.46760     9.8552    -0.20947    -0.20667
   44 48.0792    53.0323     -4.1218    -0.71700     3.2675    -0.42522    -0.42167
   45 29.0358    32.5189      9.5684     1.50259     6.3357     1.51736     1.50259
                                                           The SAS System                        16:52 Thursday, January 5, 2023   7

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   46  PT12     VIS2    PBO   Asian                                                                                               
   47  PT12     VIS3    PBO   Asian                                                                                               
   48  PT12     VIS4    PBO   Asian                                                                                               
   49  PT13     VIS1    TRT   White                                                                                               
   50  PT13     VIS2    TRT   White                                                                                               
   51  PT13     VIS3    TRT   White                                                                                               
   52  PT13     VIS4    TRT   White                                                                                               
   53  PT14     VIS1    PBO   Black or African American                                                                           
   54  PT14     VIS2    PBO   Black or African American                                                                           
   55  PT14     VIS3    PBO   Black or African American                                                                           
   56  PT14     VIS4    PBO   Black or African American                                                                           
   57  PT15     VIS1    PBO   Asian                                                                                               
   58  PT15     VIS2    PBO   Asian                                                                                               
   59  PT15     VIS3    PBO   Asian                                                                                               
   60  PT15     VIS4    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   46 Male      34.712714863    42.765678991    0.3569797387               2    -0.707495157    35.6170    0.76366    526     0.05
   47 Male      34.712714863    40.111548968    0.1481561258               3    0.3645819621    41.1195    0.64540    526     0.05
   48 Male      34.712714863               .    0.1347651631               4    0.7685329245    45.8311    1.27598    526     0.05
   49 Male      47.263577712               .    0.1440430546               1    -0.112346212    40.1955    0.89869    526     0.05
   50 Male      47.263577712               .    0.6004342375               2    0.8811077265    44.9928    0.77940    526     0.05
   51 Male      47.263577712    53.317914347     0.871576231               3    0.3981058804    49.8437    0.70210    526     0.05
   52 Male      47.263577712    56.076412729    0.7618422952               4    -0.612026393    55.8732    1.28130    526     0.05
   53 Male      42.000955239               .    0.3520225892               1    0.3411196914    32.3079    0.85058    526     0.05
   54 Male      42.000955239               .    0.2704203608               2    -1.129363096    37.1475    0.72572    526     0.05
   55 Male      42.000955239    41.908371762    0.6859968951               3    1.4330237017    42.6501    0.61298    526     0.05
   56 Male      42.000955239               .    0.4993928164               4    1.9803998985    47.3616    1.25303    526     0.05
   57 Male      14.342696762               .    0.6838175774               1    -0.367221476    30.7774    0.88653    526     0.05
   58 Male      14.342696762               .    0.1642688354               2    -1.044134626    35.6170    0.76366    526     0.05
   59 Male      14.342696762    34.656625058    0.4484243879               3    0.5697196274    41.1195    0.64540    526     0.05
   60 Male      14.342696762    39.077914763    0.2892643627               4    -0.135054604    45.8311    1.27598    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   46 34.1168    37.1172      7.1487     0.80983     6.1397     1.40235     1.38687
   47 39.8516    42.3874     -1.0080    -0.62540     8.9606    -0.26489    -0.26116
   48 43.3244    48.3377       .          .           .          .           .     
   49 38.4300    41.9609       .          .           .          .           .     
   50 43.4617    46.5239       .          .           .          .           .     
   51 48.4644    51.2230      3.4742     0.90013    13.8141     0.91540     0.90013
   52 53.3561    58.3903      0.2032    -0.00073     5.4080     0.02097     0.02079
   53 30.6370    33.9789       .          .           .          .           .     
   54 35.7219    38.5732       .          .           .          .           .     
   55 41.4459    43.8543     -0.7417    -0.19217    10.8580    -0.19464    -0.19217
   56 44.9001    49.8232       .          .           .          .           .     
   57 29.0358    32.5189       .          .           .          .           .     
   58 34.1168    37.1172       .          .           .          .           .     
   59 39.8516    42.3874     -6.4629    -1.67447     8.9792    -1.69839    -1.67447
   60 43.3244    48.3377     -6.7532    -0.65102     3.7842    -0.69682    -0.69085
                                                           The SAS System                        16:52 Thursday, January 5, 2023   8

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   61  PT16     VIS1    PBO   Asian                                                                                               
   62  PT16     VIS2    PBO   Asian                                                                                               
   63  PT16     VIS3    PBO   Asian                                                                                               
   64  PT16     VIS4    PBO   Asian                                                                                               
   65  PT17     VIS1    PBO   White                                                                                               
   66  PT17     VIS2    PBO   White                                                                                               
   67  PT17     VIS3    PBO   White                                                                                               
   68  PT17     VIS4    PBO   White                                                                                               
   69  PT18     VIS1    TRT   Asian                                                                                               
   70  PT18     VIS2    TRT   Asian                                                                                               
   71  PT18     VIS3    TRT   Asian                                                                                               
   72  PT18     VIS4    TRT   Asian                                                                                               
   73  PT19     VIS1    TRT   Asian                                                                                               
   74  PT19     VIS2    TRT   Asian                                                                                               
   75  PT19     VIS3    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   61 Female    47.072849856               .    0.7332542388               1    2.4016177605    31.1035    0.85562    526     0.05
   62 Female    47.072849856    35.896120271    0.3069474535               2    -0.039240003    35.9432    0.73638    526     0.05
   63 Female    47.072849856               .    0.8887870654               3    0.6897393625    41.4457    0.61338    526     0.05
   64 Female    47.072849856    47.672635935    0.7054989949               4    0.0280021588    46.1572    1.25796    526     0.05
   65 Female    17.175155287    22.654403763    0.8838225977               1    -0.743273209    36.7471    0.93146    526     0.05
   66 Female    17.175155287               .    0.2751582714               2    0.1887922995    41.5867    0.81945    526     0.05
   67 Female    17.175155287               .    0.8589657465               3    -1.804958629    47.0893    0.71124    526     0.05
   68 Female    17.175155287    40.853755873    0.2195663569               4    1.4655548616    51.8008    1.30442    526     0.05
   69 Male      55.162419118    32.600479538    0.5802855765               1    0.1532533382    34.5519    0.89709    526     0.05
   70 Male      55.162419118    33.643287918    0.8571446015               2    2.1726116704    39.3492    0.76415    526     0.05
   71 Male      55.162419118               .    0.6506826855               3    0.4755095289    44.2001    0.69465    526     0.05
   72 Male      55.162419118    40.922778459    0.5044269785               4    -0.709946431    50.2296    1.28428    526     0.05
   73 Male      32.751436889    32.148306778    0.3983489959               1    0.6107263535    34.5519    0.89709    526     0.05
   74 Male      32.751436889    46.436038998    0.3686440308               2    -0.934097632    39.3492    0.76415    526     0.05
   75 Male      32.751436889    41.349734123     0.138601082               3      -1.2536334    44.2001    0.69465    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   61 29.4227    32.7844       .          .           .          .           .     
   62 34.4965    37.3898     -0.0470    -0.00912     6.9640    -0.00922    -0.00912
   63 40.2407    42.6507       .          .           .          .           .     
   64 43.6860    48.6285      1.5154     0.15813     3.8863     0.15633     0.15503
   65 34.9173    38.5769    -14.0927    -2.21306     3.5576    -2.23712    -2.21306
   66 39.9769    43.1965       .          .           .          .           .     
   67 45.6921    48.4865       .          .           .          .           .     
   68 49.2383    54.3633    -10.9471    -0.65985     3.4967    -1.13000    -1.11989
   69 32.7896    36.3142     -1.9514    -0.30644     5.1195    -0.30953    -0.30644
   70 37.8480    40.8504     -5.7059    -1.08223     4.7641    -1.11934    -1.10697
   71 42.8355    45.5648       .          .           .          .           .     
   72 47.7067    52.7526     -9.3069    -0.84223     2.8717    -0.96042    -0.95210
   73 32.7896    36.3142     -2.4036    -0.37745     5.0484    -0.38125    -0.37745
   74 37.8480    40.8504      7.0868     1.71415     7.5605     1.39023     1.37487
   75 42.8355    45.5648     -2.8504    -0.77717     9.4724    -0.75077    -0.73851
                                                           The SAS System                        16:52 Thursday, January 5, 2023   9

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   76  PT19     VIS4    TRT   Asian                                                                                               
   77  PT20     VIS1    TRT   White                                                                                               
   78  PT20     VIS2    TRT   White                                                                                               
   79  PT20     VIS3    TRT   White                                                                                               
   80  PT20     VIS4    TRT   White                                                                                               
   81  PT21     VIS1    TRT   White                                                                                               
   82  PT21     VIS2    TRT   White                                                                                               
   83  PT21     VIS3    TRT   White                                                                                               
   84  PT21     VIS4    TRT   White                                                                                               
   85  PT22     VIS1    TRT   White                                                                                               
   86  PT22     VIS2    TRT   White                                                                                               
   87  PT22     VIS3    TRT   White                                                                                               
   88  PT22     VIS4    TRT   White                                                                                               
   89  PT23     VIS1    PBO   Black or African American                                                                           
   90  PT23     VIS2    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   76 Male      32.751436889    66.303816636    0.5951580312               4    0.2914462355    50.2296    1.28428    526     0.05
   77 Female    37.372227859               .    0.8691578334               1    -0.443291873    40.5216    0.89674    526     0.05
   78 Female    37.372227859    47.953584861    0.6239684077               2    0.0011053516    45.3189    0.76375    526     0.05
   79 Female    37.372227859    53.973639192    0.5082335932               3    0.0743413242    50.1699    0.67350    526     0.05
   80 Female    37.372227859               .    0.2200785685               4    -0.589520946    56.1994    1.27606    526     0.05
   81 Male      54.846752762               .    0.7963583043               1    -0.568668733    40.1955    0.89869    526     0.05
   82 Male      54.846752762    56.645435878    0.5115533423               2    -0.135178615    44.9928    0.77940    526     0.05
   83 Male      54.846752762    49.708716212    0.1069183309               3    1.1780869966    49.8437    0.70210    526     0.05
   84 Male      54.846752762    60.404967756    0.1153558124               4      -1.5235668    55.8732    1.28130    526     0.05
   85 Male      51.574745598    45.985250447    0.2156095212               1    0.5939461876    40.1955    0.89869    526     0.05
   86 Male      51.574745598    51.909105323    0.3440254038               2    0.3329503712    44.9928    0.77940    526     0.05
   87 Male      51.574745598    41.507874578    0.7605254902               3    1.0630998373    49.8437    0.70210    526     0.05
   88 Male      51.574745598    53.427273335    0.5018757138               4    -0.304183924    55.8732    1.28130    526     0.05
   89 Female    29.925606083    23.868591882    0.7428581007               1    0.3700188099    32.6341    0.85598    526     0.05
   90 Female    29.925606083    35.985632123    0.1485119857               2    0.2670987908    37.4737    0.74083    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   76 47.7067    52.7526     16.0742     1.64578     5.6084     1.65878     1.64440
   77 38.7600    42.2832       .          .           .          .           .     
   78 43.8186    46.8193      2.6346     0.51113     9.3032     0.51684     0.51113
   79 48.8468    51.4929      3.8038     0.92305    12.8078     1.00087     0.98552
   80 53.6926    58.7062       .          .           .          .           .     
   81 38.4300    41.9609       .          .           .          .           .     
   82 43.4617    46.5239     11.6526     2.26066    10.9894     2.28695     2.26066
   83 48.4644    51.2230     -0.1350    -0.35494    11.4534    -0.03557    -0.03498
   84 53.3561    58.3903      4.5318     0.13061     4.5627     0.46764     0.46360
   85 38.4300    41.9609      5.7898     0.90921     7.2213     0.91840     0.90921
   86 43.4617    46.5239      6.9163     1.04931     7.6814     1.35740     1.34179
   87 48.4644    51.2230     -8.3358    -2.45850     9.0575    -2.19638    -2.15973
   88 53.3561    58.3903     -2.4459    -0.58154     3.7601    -0.25240    -0.25022
   89 30.9525    34.3156     -8.7655    -1.37650     3.7482    -1.38910    -1.37650
   90 36.0184    38.9290     -1.4881     0.35064     5.9391    -0.29172    -0.28869
                                                           The SAS System                        16:52 Thursday, January 5, 2023  10

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   91  PT23     VIS3    PBO   Black or African American                                                                           
   92  PT23     VIS4    PBO   Black or African American                                                                           
   93  PT24     VIS1    TRT   White                                                                                               
   94  PT24     VIS2    TRT   White                                                                                               
   95  PT24     VIS3    TRT   White                                                                                               
   96  PT24     VIS4    TRT   White                                                                                               
   97  PT25     VIS1    TRT   White                                                                                               
   98  PT25     VIS2    TRT   White                                                                                               
   99  PT25     VIS3    TRT   White                                                                                               
  100  PT25     VIS4    TRT   White                                                                                               
  101  PT26     VIS1    TRT   White                                                                                               
  102  PT26     VIS2    TRT   White                                                                                               
  103  PT26     VIS3    TRT   White                                                                                               
  104  PT26     VIS4    TRT   White                                                                                               
  105  PT27     VIS1    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   91 Female    29.925606083    43.606263938    0.8423641091               3    -0.542520031    42.9762    0.63127    526     0.05
   92 Female    29.925606083               .    0.7465428408               4     1.207867806    47.6878    1.25995    526     0.05
   93 Female    39.073571252    29.597732758    0.1630506719               1    1.1604026157    40.5216    0.89674    526     0.05
   94 Female    39.073571252    35.506880204    0.5807426253               2    0.7002136495    45.3189    0.76375    526     0.05
   95 Female    39.073571252     55.42944438    0.6718239045               3    1.5868334545    50.1699    0.67350    526     0.05
   96 Female    39.073571252    52.105298162    0.5110765226               4    0.5584864256    56.1994    1.27606    526     0.05
   97 Female    49.125423343    31.696436889    0.6760932039               1    -1.276592208    40.5216    0.89674    526     0.05
   98 Female    49.125423343     32.16159321    0.6999570159               2    -0.573265414    45.3189    0.76375    526     0.05
   99 Female    49.125423343    51.047349622    0.1765124191               3    -1.224612615    50.1699    0.67350    526     0.05
  100 Female    49.125423343    55.859865519    0.4182606921               4    -0.473400636    56.1994    1.27606    526     0.05
  101 Female    53.224143056    49.117058066    0.3355723225               1    -0.620366677    40.5216    0.89674    526     0.05
  102 Female    53.224143056    49.255437211    0.5938029325               2    0.0421158731    45.3189    0.76375    526     0.05
  103 Female    53.224143056    51.722113705    0.8794193018               3    -0.910921649    50.1699    0.67350    526     0.05
  104 Female    53.224143056    69.991277128    0.5945696304               4    0.1580287724    56.1994    1.27606    526     0.05
  105 Female    45.795904443    22.071687171    0.5170953548               1    -0.654584644    36.4086    0.90106    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   91 41.7361    44.2164      0.6300     0.43149    10.4341     0.16546     0.16323
   92 45.2126    50.1629       .          .           .          .           .     
   93 38.7600    42.2832    -10.9239    -1.71544     4.6479    -1.73271    -1.71544
   94 43.8186    46.8193     -9.8121    -1.28091     5.3966    -1.92482    -1.90358
   95 48.8468    51.4929      5.2596     1.82365    13.4128     1.38393     1.36270
   96 53.6926    58.7062     -4.0941     0.07173     4.4353    -0.42244    -0.41883
   97 38.7600    42.2832     -8.8252    -1.38587     4.9775    -1.39982    -1.38587
   98 43.8186    46.8193    -13.1573    -2.16396     4.5135    -2.58107    -2.55258
   99 48.8468    51.4929      0.8775     0.64558    12.2347     0.23089     0.22735
  100 53.6926    58.7062     -0.3395     0.41940     4.7830    -0.03503    -0.03473
  101 38.7600    42.2832      8.5955     1.34980     7.7132     1.36338     1.34980
  102 43.8186    46.8193      3.9365     0.19096     6.8684     0.77222     0.76370
  103 48.8468    51.4929      1.5522     0.12080    11.7100     0.40844     0.40217
  104 53.6926    58.7062     13.7919     1.14137     5.5049     1.42310     1.41092
  105 34.6385    38.1787    -14.3369    -2.25141     3.4661    -2.27429    -2.25141
                                                           The SAS System                        16:52 Thursday, January 5, 2023  11

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  106  PT27     VIS2    TRT   Black or African American                                                                           
  107  PT27     VIS3    TRT   Black or African American                                                                           
  108  PT27     VIS4    TRT   Black or African American                                                                           
  109  PT28     VIS1    TRT   Black or African American                                                                           
  110  PT28     VIS2    TRT   Black or African American                                                                           
  111  PT28     VIS3    TRT   Black or African American                                                                           
  112  PT28     VIS4    TRT   Black or African American                                                                           
  113  PT29     VIS1    TRT   Black or African American                                                                           
  114  PT29     VIS2    TRT   Black or African American                                                                           
  115  PT29     VIS3    TRT   Black or African American                                                                           
  116  PT29     VIS4    TRT   Black or African American                                                                           
  117  PT30     VIS1    TRT   Asian                                                                                               
  118  PT30     VIS2    TRT   Asian                                                                                               
  119  PT30     VIS3    TRT   Asian                                                                                               
  120  PT30     VIS4    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  106 Female    45.795904443               .    0.8220030367               2    1.7672872694    41.2059    0.76623    526     0.05
  107 Female    45.795904443    46.083927828    0.6099635461               3     0.716707476    46.0568    0.70592    526     0.05
  108 Female    45.795904443    52.422880333    0.7914409064               4    0.9101742295    52.0863    1.27509    526     0.05
  109 Male      44.137340321    37.694659801    0.3008941928               1    0.3841853578    36.0824    0.89390    526     0.05
  110 Male      44.137340321    44.593999244    0.2720552646               2    1.6821760805    40.8798    0.77131    526     0.05
  111 Male      44.137340321    52.088974364    0.5875808358               3    -0.635736454    45.7307    0.72203    526     0.05
  112 Male      44.137340321    58.229606251    0.4067557083               4     -0.46164473    51.7602    1.27393    526     0.05
  113 Male      31.228939603    37.228241585    0.7042168356               1    1.4322822385    36.0824    0.89390    526     0.05
  114 Male      31.228939603     34.39862752    0.4037889943               2    -0.650696353    40.8798    0.77131    526     0.05
  115 Male      31.228939603               .    0.7359776508               3    -0.207380744    45.7307    0.72203    526     0.05
  116 Male      31.228939603    36.340121328    0.8245529087               4    -0.392807929    51.7602    1.27393    526     0.05
  117 Female    39.906338663    45.441815913    0.8872209387               1    -0.319992869    34.8780    0.86864    526     0.05
  118 Female    39.906338663    41.548470143    0.5703583788               2    -0.279113303    39.6754    0.71627    526     0.05
  119 Female    39.906338663    43.921722801    0.1075712413               3    0.4941883313    44.5263    0.62966    526     0.05
  120 Female    39.906338663    61.832428688    0.3566336554               4    -0.177330482    50.5558    1.26066    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  106 39.7007    42.7112       .          .           .          .           .     
  107 44.6701    47.4436      0.0271     0.47246    11.4759     0.00714     0.00702
  108 49.5814    54.5912      0.3365     0.54029     4.9647     0.03473     0.03443
  109 34.3264    37.8385      1.6122     0.25318     5.9194     0.25571     0.25318
  110 39.3645    42.3950      3.7142     0.67826     6.7377     0.72878     0.72058
  111 44.3123    47.1491      6.3583     1.59309    12.1861     1.67697     1.64737
  112 49.2576    54.2628      6.4694     0.61984     4.6853     0.66752     0.66183
  113 34.3264    37.8385      1.1458     0.17994     5.8462     0.18173     0.17994
  114 39.3645    42.3950     -6.4811    -1.48699     4.5724    -1.27168    -1.25736
  115 44.3123    47.1491       .          .           .          .           .     
  116 49.2576    54.2628    -15.4201    -1.56595     2.2424    -1.59105    -1.57748
  117 33.1716    36.5845     10.5638     1.65890     7.1360     1.67455     1.65890
  118 38.2683    41.0825      1.8731    -0.40536     5.4864     0.36695     0.36339
  119 43.2893    45.7632     -0.6046    -0.48001     9.8428    -0.15876    -0.15664
  120 48.0792    53.0323     11.2766     0.83156     4.8161     1.16332     1.15361
                                                           The SAS System                        16:52 Thursday, January 5, 2023  12

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  121  PT31     VIS1    PBO   Asian                                                                                               
  122  PT31     VIS2    PBO   Asian                                                                                               
  123  PT31     VIS3    PBO   Asian                                                                                               
  124  PT31     VIS4    PBO   Asian                                                                                               
  125  PT32     VIS1    TRT   Black or African American                                                                           
  126  PT32     VIS2    TRT   Black or African American                                                                           
  127  PT32     VIS3    TRT   Black or African American                                                                           
  128  PT32     VIS4    TRT   Black or African American                                                                           
  129  PT33     VIS1    TRT   Black or African American                                                                           
  130  PT33     VIS2    TRT   Black or African American                                                                           
  131  PT33     VIS3    TRT   Black or African American                                                                           
  132  PT33     VIS4    TRT   Black or African American                                                                           
  133  PT34     VIS1    PBO   Asian                                                                                               
  134  PT34     VIS2    PBO   Asian                                                                                               
  135  PT34     VIS3    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  121 Female     51.85189773    27.256556394    0.5475653866               1    -0.505957462    31.1035    0.85562    526     0.05
  122 Female     51.85189773               .    0.5119340481               2    1.3430388252    35.9432    0.73638    526     0.05
  123 Female     51.85189773     45.65133289    0.1717694897               3    -0.214579409    41.4457    0.61338    526     0.05
  124 Female     51.85189773               .     0.646600459               4     -0.17955653    46.1572    1.25796    526     0.05
  125 Male      38.091867548    33.193337655    0.6679776397               1    -0.100190741    36.0824    0.89390    526     0.05
  126 Male      38.091867548               .    0.7401852433               2    0.7126663071    40.8798    0.77131    526     0.05
  127 Male      38.091867548               .    0.8552627319               3    -0.073564404    45.7307    0.72203    526     0.05
  128 Male      38.091867548    41.668264343    0.2493169101               4    -0.037634171    51.7602    1.27393    526     0.05
  129 Male      20.183215828    27.127529337    0.3229138259               1    -0.681660479    36.0824    0.89390    526     0.05
  130 Male      20.183215828    31.748579276    0.7194106311               2    -0.324270272    40.8798    0.77131    526     0.05
  131 Male      20.183215828               .    0.1267580917               3    0.0601604404    45.7307    0.72203    526     0.05
  132 Male      20.183215828    41.600002284    0.6375345126               4    -0.588894486    51.7602    1.27393    526     0.05
  133 Female    49.270799769    39.452503413    0.7502136976               1    0.5314961926    31.1035    0.85562    526     0.05
  134 Female    49.270799769    32.618233958    0.6305289911               2    -1.518394082    35.9432    0.73638    526     0.05
  135 Female    49.270799769     34.62445244    0.8555797381               3    0.3065578608    41.4457    0.61338    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  121 29.4227    32.7844     -3.8470    -0.60411     4.2803    -0.60964    -0.60411
  122 34.4965    37.3898       .          .           .          .           .     
  123 40.2407    42.6507      4.2056     1.23752    11.1931     1.10366     1.08964
  124 43.6860    48.6285       .          .           .          .           .     
  125 34.3264    37.8385     -2.8891    -0.45369     5.2126    -0.45823    -0.45369
  126 39.3645    42.3950       .          .           .          .           .     
  127 44.3123    47.1491       .          .           .          .           .     
  128 49.2576    54.2628    -10.0919    -0.95729     3.2180    -1.04129    -1.03241
  129 34.3264    37.8385     -8.9549    -1.40624     4.2600    -1.42031    -1.40624
  130 39.3645    42.3950     -9.1312    -1.28484     4.7746    -1.79166    -1.77148
  131 44.3123    47.1491       .          .           .          .           .     
  132 49.2576    54.2628    -10.1602    -0.67686     3.1315    -1.04833    -1.03939
  133 29.4227    32.7844      8.3490     1.31109     6.1955     1.32309     1.31109
  134 34.4965    37.3898     -3.3249    -1.35775     4.0176    -0.65173    -0.64505
  135 40.2407    42.6507     -6.8212    -2.00000     7.6592    -1.79006    -1.76731
                                                           The SAS System                        16:52 Thursday, January 5, 2023  13

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  136  PT34     VIS4    PBO   Asian                                                                                               
  137  PT35     VIS1    TRT   Black or African American                                                                           
  138  PT35     VIS2    TRT   Black or African American                                                                           
  139  PT35     VIS3    TRT   Black or African American                                                                           
  140  PT35     VIS4    TRT   Black or African American                                                                           
  141  PT36     VIS1    TRT   Asian                                                                                               
  142  PT36     VIS2    TRT   Asian                                                                                               
  143  PT36     VIS3    TRT   Asian                                                                                               
  144  PT36     VIS4    TRT   Asian                                                                                               
  145  PT37     VIS1    PBO   White                                                                                               
  146  PT37     VIS2    PBO   White                                                                                               
  147  PT37     VIS3    PBO   White                                                                                               
  148  PT37     VIS4    PBO   White                                                                                               
  149  PT38     VIS1    PBO   Asian                                                                                               
  150  PT38     VIS2    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  136 Female    49.270799769    45.905148261    0.7998752542               4    -1.536449824    46.1572    1.25796    526     0.05
  137 Female    55.987010244    36.177803217    0.6578969581               1    -0.300976127    36.4086    0.90106    526     0.05
  138 Female    55.987010244    39.797955816    0.2480327131               2    -0.528279904    41.2059    0.76623    526     0.05
  139 Female    55.987010244               .    0.1780354483               3    -0.652094781    46.0568    0.70592    526     0.05
  140 Female    55.987010244    50.082717241    0.7462079927               4    -0.056896778    52.0863    1.27509    526     0.05
  141 Female    22.720081408               .    0.5174221084               1    -1.914359426    34.8780    0.86864    526     0.05
  142 Female    22.720081408     44.64315775    0.6548325414               2     1.176583312    39.6754    0.71627    526     0.05
  143 Female    22.720081408               .    0.2730636714               3    -1.664972436    44.5263    0.62966    526     0.05
  144 Female    22.720081408    39.735287881    0.6039542973               4    -0.463530401    50.5558    1.26066    526     0.05
  145 Female    28.610500458    34.061642527     0.217606302               1    -1.115920105    36.7471    0.93146    526     0.05
  146 Female    28.610500458    40.185923507    0.8672563674               2    -0.750819001    41.5867    0.81945    526     0.05
  147 Female    28.610500458    41.175841555    0.8920883574               3    2.0871665456    47.0893    0.71124    526     0.05
  148 Female    28.610500458    57.766693925    0.4971514463               4    0.0173956197    51.8008    1.30442    526     0.05
  149 Female    59.302696135    38.184602643    0.8357181149               1     -1.28630053    31.1035    0.85562    526     0.05
  150 Female    59.302696135               .    0.3977041127               2    -1.640605534    35.9432    0.73638    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  136 43.6860    48.6285     -0.2521    -0.27980     3.3896    -0.02601    -0.02579
  137 34.6385    38.1787     -0.2308    -0.03624     5.6812    -0.03661    -0.03624
  138 39.7007    42.7112     -1.4080    -0.28626     5.8186    -0.27622    -0.27315
  139 44.6701    47.4436       .          .           .          .           .     
  140 49.5814    54.5912     -2.0036    -0.18458     3.6439    -0.20674    -0.20497
  141 33.1716    36.5845       .          .           .          .           .     
  142 38.2683    41.0825      4.9678     0.96377     8.6609     0.97321     0.96377
  143 43.2893    45.7632       .          .           .          .           .     
  144 48.0792    53.0323    -10.8205    -1.26400     2.8105    -1.11627    -1.10694
  145 34.9173    38.5769     -2.6854    -0.42171     5.3489    -0.42630    -0.42171
  146 39.9769    43.1965     -1.4008    -0.09656     6.0645    -0.27526    -0.27176
  147 45.6921    48.4865     -5.9134    -1.47421     9.4513    -1.55880    -1.53211
  148 49.2383    54.3633      5.9659     0.68961     4.7380     0.61582     0.61031
  149 29.4227    32.7844      7.0811     1.11199     5.9964     1.12216     1.11199
  150 34.4965    37.3898       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  14

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  151  PT38     VIS3    PBO   Asian                                                                                               
  152  PT38     VIS4    PBO   Asian                                                                                               
  153  PT39     VIS1    PBO   Asian                                                                                               
  154  PT39     VIS2    PBO   Asian                                                                                               
  155  PT39     VIS3    PBO   Asian                                                                                               
  156  PT39     VIS4    PBO   Asian                                                                                               
  157  PT40     VIS1    PBO   Black or African American                                                                           
  158  PT40     VIS2    PBO   Black or African American                                                                           
  159  PT40     VIS3    PBO   Black or African American                                                                           
  160  PT40     VIS4    PBO   Black or African American                                                                           
  161  PT41     VIS1    PBO   Black or African American                                                                           
  162  PT41     VIS2    PBO   Black or African American                                                                           
  163  PT41     VIS3    PBO   Black or African American                                                                           
  164  PT41     VIS4    PBO   Black or African American                                                                           
  165  PT42     VIS1    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  151 Female    59.302696135    47.198925604    0.7616459567               3    0.4501871013    41.4457    0.61338    526     0.05
  152 Female    59.302696135               .    0.5472343583               4    -0.018559833    46.1572    1.25796    526     0.05
  153 Female    30.074932572    37.327851507    0.7365369637               1    -0.318068375    31.1035    0.85562    526     0.05
  154 Female    30.074932572               .    0.3816173961               2    -0.929362147    35.9432    0.73638    526     0.05
  155 Female    30.074932572    43.160483725    0.2668221382               3     -1.48746031    41.4457    0.61338    526     0.05
  156 Female    30.074932572    41.403488821    0.7278244995               4    -1.075192297    46.1572    1.25796    526     0.05
  157 Male      47.973963444    30.157325274    0.6464410005               1    1.0000288037    32.3079    0.85058    526     0.05
  158 Male      47.973963444    35.843527162    0.4456088113               2    -0.621266695    37.1475    0.72572    526     0.05
  159 Male      47.973963444    40.952495072    0.7771471895               3    -1.384426847    42.6501    0.61298    526     0.05
  160 Male      47.973963444               .    0.5815550713               4    1.8692906224    47.3616    1.25303    526     0.05
  161 Male      40.206803961               .    0.6925284123               1    0.4251003774    32.3079    0.85058    526     0.05
  162 Male      40.206803961    41.379278113    0.5759216009               2    -0.238647101    37.1475    0.72572    526     0.05
  163 Male      40.206803961    50.173155965    0.7812472718               3    1.0584830487    42.6501    0.61298    526     0.05
  164 Male      40.206803961    45.352257596     0.751120807               4    0.8864226514    47.3616    1.25303    526     0.05
  165 Male      31.498258171    39.064908638    0.4043386811               1    -0.619243048    32.3079    0.85058    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  151 40.2407    42.6507      5.7532     1.29229    11.2479     1.50979     1.49060
  152 43.6860    48.6285       .          .           .          .           .     
  153 29.4227    32.7844      6.2243     0.97745     5.8618     0.98639     0.97745
  154 34.4965    37.3898       .          .           .          .           .     
  155 40.2407    42.6507      1.7148     0.25167    10.2073     0.45000     0.44429
  156 43.6860    48.6285     -4.7538    -0.70795     3.2571    -0.49039    -0.48631
  157 30.6370    33.9789     -2.1506    -0.33772     4.7358    -0.34077    -0.33772
  158 35.7219    38.5732     -1.3040    -0.11667     5.4263    -0.25553    -0.25298
  159 41.4459    43.8543     -1.6976    -0.37317     9.5563    -0.44548    -0.43983
  160 44.9001    49.8232       .          .           .          .           .     
  161 30.6370    33.9789       .          .           .          .           .     
  162 35.7219    38.5732      4.2317     0.82097     8.0277     0.82923     0.82097
  163 41.4459    43.8543      7.5231     1.85246    11.9936     1.97421     1.94915
  164 44.9001    49.8232     -2.0094    -0.33699     3.4484    -0.20727    -0.20556
  165 30.6370    33.9789      6.7570     1.06109     6.1346     1.07069     1.06109
                                                           The SAS System                        16:52 Thursday, January 5, 2023  15

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  166  PT42     VIS2    PBO   Black or African American                                                                           
  167  PT42     VIS3    PBO   Black or African American                                                                           
  168  PT42     VIS4    PBO   Black or African American                                                                           
  169  PT43     VIS1    TRT   Black or African American                                                                           
  170  PT43     VIS2    TRT   Black or African American                                                                           
  171  PT43     VIS3    TRT   Black or African American                                                                           
  172  PT43     VIS4    TRT   Black or African American                                                                           
  173  PT44     VIS1    TRT   Black or African American                                                                           
  174  PT44     VIS2    TRT   Black or African American                                                                           
  175  PT44     VIS3    TRT   Black or African American                                                                           
  176  PT44     VIS4    TRT   Black or African American                                                                           
  177  PT45     VIS1    PBO   Asian                                                                                               
  178  PT45     VIS2    PBO   Asian                                                                                               
  179  PT45     VIS3    PBO   Asian                                                                                               
  180  PT45     VIS4    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  166 Male      31.498258171               .    0.4938465619               2    2.2061024645    37.1475    0.72572    526     0.05
  167 Male      31.498258171               .    0.8947019717               3     -0.25502703    42.6501    0.61298    526     0.05
  168 Male      31.498258171    42.119598119    0.2392715601               4     -1.42449465    47.3616    1.25303    526     0.05
  169 Female    43.793881966    29.810419719    0.7674246397               1    -0.144399602    36.4086    0.90106    526     0.05
  170 Female    43.793881966     42.57054682    0.4166522989               2    0.2075383392    41.2059    0.76623    526     0.05
  171 Female    43.793881966    47.816515276    0.8752449073               3    2.3079783991    46.0568    0.70592    526     0.05
  172 Female    43.793881966    68.060238315    0.2505651735               4    0.1058023679    52.0863    1.27509    526     0.05
  173 Male      43.887601096    35.620712052    0.6993773358               1    0.4569988054    36.0824    0.89390    526     0.05
  174 Male      43.887601096               .     0.346775688               2    -0.077152935    40.8798    0.77131    526     0.05
  175 Male      43.887601096               .    0.4032471212               3    -0.334000842    45.7307    0.72203    526     0.05
  176 Male      43.887601096               .    0.7006126745               4    -0.034726028    51.7602    1.27393    526     0.05
  177 Female      30.0524415    33.891339091    0.6633613404               1    0.7876396056    31.1035    0.85562    526     0.05
  178 Female      30.0524415    36.428078825    0.8364744268               2    2.0752450087    35.9432    0.73638    526     0.05
  179 Female      30.0524415    37.575188622    0.7362218501               3    1.0273924388    41.4457    0.61338    526     0.05
  180 Female      30.0524415    58.468734346    0.7632615706               4    1.2079083984    46.1572    1.25796    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  166 35.7219    38.5732       .          .           .          .           .     
  167 41.4459    43.8543       .          .           .          .           .     
  168 44.9001    49.8232     -5.2420    -0.78250     3.0624    -0.54072    -0.53626
  169 34.6385    38.1787     -6.5982    -1.03615     4.6813    -1.04668    -1.03615
  170 39.7007    42.7112      1.3646     0.80036     6.9052     0.26772     0.26474
  171 44.6701    47.4436      1.7597     0.63419    11.3004     0.46374     0.45591
  172 49.5814    54.5912     15.9739     1.87112     5.9584     1.64822     1.63414
  173 34.3264    37.8385     -0.4617    -0.07250     5.5937    -0.07323    -0.07250
  174 39.3645    42.3950       .          .           .          .           .     
  175 44.3123    47.1491       .          .           .          .           .     
  176 49.2576    54.2628       .          .           .          .           .     
  177 29.4227    32.7844      2.7878     0.43779     5.3222     0.44180     0.43779
  178 34.4965    37.3898      0.4849    -0.10901     5.2663     0.09505     0.09408
  179 40.2407    42.6507     -3.8705    -1.11001     8.5492    -1.01571    -1.00281
  180 43.6860    48.6285     12.3115     1.17584     4.8452     1.27003     1.25947
                                                           The SAS System                        16:52 Thursday, January 5, 2023  16

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  181  PT46     VIS1    PBO   Asian                                                                                               
  182  PT46     VIS2    PBO   Asian                                                                                               
  183  PT46     VIS3    PBO   Asian                                                                                               
  184  PT46     VIS4    PBO   Asian                                                                                               
  185  PT47     VIS1    TRT   Asian                                                                                               
  186  PT47     VIS2    TRT   Asian                                                                                               
  187  PT47     VIS3    TRT   Asian                                                                                               
  188  PT47     VIS4    TRT   Asian                                                                                               
  189  PT48     VIS1    PBO   Black or African American                                                                           
  190  PT48     VIS2    PBO   Black or African American                                                                           
  191  PT48     VIS3    PBO   Black or African American                                                                           
  192  PT48     VIS4    PBO   Black or African American                                                                           
  193  PT49     VIS1    PBO   White                                                                                               
  194  PT49     VIS2    PBO   White                                                                                               
  195  PT49     VIS3    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  181 Male      43.459024826    19.545158439      0.23403813               1    -1.231323422    30.7774    0.88653    526     0.05
  182 Male      43.459024826    31.135414577    0.4279678235               2    0.9838955701    35.6170    0.76366    526     0.05
  183 Male      43.459024826     40.89955126    0.2570021925               3    0.2199248037    41.1195    0.64540    526     0.05
  184 Male      43.459024826               .    0.3075204995               4    -1.467250029    45.8311    1.27598    526     0.05
  185 Male      31.832628377    22.188086021    0.8763330135               1    0.5210227426    34.5519    0.89709    526     0.05
  186 Male      31.832628377    41.058565358    0.7493145617               2    -0.158754605    39.3492    0.76415    526     0.05
  187 Male      31.832628377     37.32451604    0.3780766716               3     1.464587312    44.2001    0.69465    526     0.05
  188 Male      31.832628377               .    0.8506764222               4       -0.766082    50.2296    1.28428    526     0.05
  189 Male      46.596643994               .    0.2307095151               1    -0.430211754    32.3079    0.85058    526     0.05
  190 Male      46.596643994    43.124316646    0.2254473282               2    -0.926109497    37.1475    0.72572    526     0.05
  191 Male      46.596643994    41.993490944    0.7032506058               3    -0.177103961    42.6501    0.61298    526     0.05
  192 Male      46.596643994               .    0.8088403223               4    0.4020117795    47.3616    1.25303    526     0.05
  193 Female    50.272027416    44.030804534     0.345411309               1    -0.731748173    36.7471    0.93146    526     0.05
  194 Female    50.272027416    38.664171218    0.3488653988               2     0.830373168    41.5867    0.81945    526     0.05
  195 Female    50.272027416     53.45993169    0.8876201514               3    -1.208082786    47.0893    0.71124    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  181 29.0358    32.5189    -11.2322    -1.76386     3.0693    -1.78121    -1.76386
  182 34.1168    37.1172     -4.4816    -0.10652     5.2234    -0.87915    -0.86944
  183 39.8516    42.3874     -0.2200     0.31306     9.8991    -0.05781    -0.05700
  184 43.3244    48.3377       .          .           .          .           .     
  185 32.7896    36.3142    -12.3638    -1.94156     3.4843    -1.96112    -1.94156
  186 37.8480    40.8504      1.7094     1.31673     7.1630     0.33533     0.33162
  187 42.8355    45.5648     -6.8756    -1.49694     8.7527    -1.81097    -1.78140
  188 47.7067    52.7526       .          .           .          .           .     
  189 30.6370    33.9789       .          .           .          .           .     
  190 35.7219    38.5732      5.9768     1.15952     8.3663     1.17118     1.15952
  191 41.4459    43.8543     -0.6566    -0.33574     9.8054    -0.17230    -0.17012
  192 44.9001    49.8232       .          .           .          .           .     
  193 34.9173    38.5769      7.2837     1.14381     6.9144     1.15624     1.14381
  194 39.9769    43.1965     -2.9226    -1.18924     4.9718    -0.57429    -0.56699
  195 45.6921    48.4865      6.3707     1.52084    12.4464     1.67933     1.65057
                                                           The SAS System                        16:52 Thursday, January 5, 2023  17

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  196  PT49     VIS4    PBO   White                                                                                               
  197  PT50     VIS1    TRT   Asian                                                                                               
  198  PT50     VIS2    TRT   Asian                                                                                               
  199  PT50     VIS3    TRT   Asian                                                                                               
  200  PT50     VIS4    TRT   Asian                                                                                               
  201  PT51     VIS1    TRT   Black or African American                                                                           
  202  PT51     VIS2    TRT   Black or African American                                                                           
  203  PT51     VIS3    TRT   Black or African American                                                                           
  204  PT51     VIS4    TRT   Black or African American                                                                           
  205  PT52     VIS1    TRT   Black or African American                                                                           
  206  PT52     VIS2    TRT   Black or African American                                                                           
  207  PT52     VIS3    TRT   Black or African American                                                                           
  208  PT52     VIS4    TRT   Black or African American                                                                           
  209  PT53     VIS1    PBO   White                                                                                               
  210  PT53     VIS2    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  196 Female    50.272027416               .    0.1055433841               4    -1.047984413    51.8008    1.30442    526     0.05
  197 Female    26.037342838     29.81948312    0.3194564622               1    1.4411577068    34.8780    0.86864    526     0.05
  198 Female    26.037342838    30.438587317    0.7384353718               2    -1.015847465    39.6754    0.71627    526     0.05
  199 Female    26.037342838    40.180949072    0.2949357742               3    0.4119747123    44.5263    0.62966    526     0.05
  200 Female    26.037342838               .    0.4666187696               4    -0.381076051    50.5558    1.26066    526     0.05
  201 Female    25.582965315    26.785779162     0.570873859               1    0.4094018397    36.4086    0.90106    526     0.05
  202 Female    25.582965315     34.55115461    0.8140734229               2    1.6888732862    41.2059    0.76623    526     0.05
  203 Female    25.582965315               .    0.1990359258               3    1.5865884334    46.0568    0.70592    526     0.05
  204 Female    25.582965315    40.064211927    0.5106472129               4    -0.330907801    52.0863    1.27509    526     0.05
  205 Female    52.970446576               .    0.6309121765               1    -2.285235535    36.4086    0.90106    526     0.05
  206 Female    52.970446576    43.093286904    0.7124336001               2    2.4976615898    41.2059    0.76623    526     0.05
  207 Female    52.970446576               .    0.1741009394               3    0.6670661668    46.0568    0.70592    526     0.05
  208 Female    52.970446576    45.715674129    0.1541156266               4     0.541327336    52.0863    1.27509    526     0.05
  209 Male      37.896001364    40.749922948    0.5448786659               1    -0.013399523    36.4209    0.93528    526     0.05
  210 Male      37.896001364    44.746345225    0.6210547257               2     0.510108423    41.2606    0.81589    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  196 49.2383    54.3633       .          .           .          .           .     
  197 33.1716    36.5845     -5.0585    -0.79437     4.6827    -0.80187    -0.79437
  198 38.2683    41.0825     -9.2368    -1.60630     4.2854    -1.80953    -1.79197
  199 43.2893    45.7632     -4.3453    -0.89350     9.4293    -1.14112    -1.12583
  200 48.0792    53.0323       .          .           .          .           .     
  201 34.6385    38.1787     -9.6228    -1.51113     4.2063    -1.52649    -1.51113
  202 39.7007    42.7112     -6.6548    -0.69903     5.4058    -1.30555    -1.29105
  203 44.6701    47.4436       .          .           .          .           .     
  204 49.5814    54.5912    -12.0221    -0.88539     2.9431    -1.24047    -1.22987
  205 34.6385    38.1787       .          .           .          .           .     
  206 39.7007    42.7112      1.8874     0.36616     8.3603     0.37027     0.36616
  207 44.6701    47.4436       .          .           .          .           .     
  208 49.5814    54.5912     -6.3707    -0.71398     3.4743    -0.65734    -0.65172
  209 34.5836    38.2583      4.3290     0.67981     6.3992     0.68726     0.67981
  210 39.6578    42.8634      3.4858     0.42069     6.5364     0.68489     0.67625
                                                           The SAS System                        16:52 Thursday, January 5, 2023  18

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  211  PT53     VIS3    PBO   White                                                                                               
  212  PT53     VIS4    PBO   White                                                                                               
  213  PT54     VIS1    TRT   White                                                                                               
  214  PT54     VIS2    TRT   White                                                                                               
  215  PT54     VIS3    TRT   White                                                                                               
  216  PT54     VIS4    TRT   White                                                                                               
  217  PT55     VIS1    TRT   Asian                                                                                               
  218  PT55     VIS2    TRT   Asian                                                                                               
  219  PT55     VIS3    TRT   Asian                                                                                               
  220  PT55     VIS4    TRT   Asian                                                                                               
  221  PT56     VIS1    PBO   Black or African American                                                                           
  222  PT56     VIS2    PBO   Black or African American                                                                           
  223  PT56     VIS3    PBO   Black or African American                                                                           
  224  PT56     VIS4    PBO   Black or African American                                                                           
  225  PT57     VIS1    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  211 Male      37.896001364               .    0.3367701508               3    -0.164375832    46.7631    0.70671    526     0.05
  212 Male      37.896001364               .    0.6564039065               4    0.4206946433    51.4747    1.30402    526     0.05
  213 Female    41.543149552               .    0.4021359652               1    -0.400246744    40.5216    0.89674    526     0.05
  214 Female    41.543149552               .     0.308769553               2    -1.370207878    45.3189    0.76375    526     0.05
  215 Female    41.543149552               .    0.8521271899               3    0.9878382675    50.1699    0.67350    526     0.05
  216 Female    41.543149552               .    0.4447119582               4    1.5197450255    56.1994    1.27606    526     0.05
  217 Male      50.709326063    40.146740063    0.3616516676               1    -0.308740569    34.5519    0.89709    526     0.05
  218 Male      50.709326063    48.758590233    0.5279265106               2    -1.253289756    39.3492    0.76415    526     0.05
  219 Male      50.709326063    46.434617632    0.6007532934               3    0.6422413057    44.2001    0.69465    526     0.05
  220 Male      50.709326063               .    0.2363375895               4    -0.044709137    50.2296    1.28428    526     0.05
  221 Male      39.562896292    29.339898377    0.1874530435               1    -1.733218407    32.3079    0.85058    526     0.05
  222 Male      39.562896292               .    0.1858230261               2    0.0021318597    37.1475    0.72572    526     0.05
  223 Male      39.562896292               .    0.1741934184               3    -0.630300334    42.6501    0.61298    526     0.05
  224 Male      39.562896292     47.93164615    0.5276604237               4     -0.34096858    47.3616    1.25303    526     0.05
  225 Male      39.364331875               .    0.8171113716               1    -1.156572363    36.0824    0.89390    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  211 45.3748    48.1514       .          .           .          .           .     
  212 48.9129    54.0364       .          .           .          .           .     
  213 38.7600    42.2832       .          .           .          .           .     
  214 43.8186    46.8193       .          .           .          .           .     
  215 48.8468    51.4929       .          .           .          .           .     
  216 53.6926    58.7062       .          .           .          .           .     
  217 32.7896    36.3142      5.5949     0.87860     6.3045     0.88745     0.87860
  218 37.8480    40.8504      9.4094     1.60246     7.4488     1.84585     1.82546
  219 42.8355    45.5648      2.2345     0.31688    10.5665     0.58854     0.57893
  220 47.7067    52.7526       .          .           .          .           .     
  221 30.6370    33.9789     -2.9680    -0.46608     4.6074    -0.47030    -0.46608
  222 35.7219    38.5732       .          .           .          .           .     
  223 41.4459    43.8543       .          .           .          .           .     
  224 44.9001    49.8232      0.5700     0.16223     4.0072     0.05880     0.05831
  225 34.3264    37.8385       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  19

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  226  PT57     VIS2    TRT   Black or African American                                                                           
  227  PT57     VIS3    TRT   Black or African American                                                                           
  228  PT57     VIS4    TRT   Black or African American                                                                           
  229  PT58     VIS1    TRT   White                                                                                               
  230  PT58     VIS2    TRT   White                                                                                               
  231  PT58     VIS3    TRT   White                                                                                               
  232  PT58     VIS4    TRT   White                                                                                               
  233  PT59     VIS1    TRT   White                                                                                               
  234  PT59     VIS2    TRT   White                                                                                               
  235  PT59     VIS3    TRT   White                                                                                               
  236  PT59     VIS4    TRT   White                                                                                               
  237  PT60     VIS1    TRT   Black or African American                                                                           
  238  PT60     VIS2    TRT   Black or African American                                                                           
  239  PT60     VIS3    TRT   Black or African American                                                                           
  240  PT60     VIS4    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  226 Male      39.364331875    41.116315332    0.6680208152               2    1.8031419079    40.8798    0.77131    526     0.05
  227 Male      39.364331875    47.058887596    0.8251633376               3    -0.331132036    45.7307    0.72203    526     0.05
  228 Male      39.364331875    52.245990919    0.4493508866               4    -1.605513412    51.7602    1.27393    526     0.05
  229 Female    56.770273206               .    0.4742551142               1    0.1971934387    40.5216    0.89674    526     0.05
  230 Female    56.770273206    54.142358224    0.5784956098               2    0.2631756464    45.3189    0.76375    526     0.05
  231 Female    56.770273206    50.446179579    0.3453983054               3      -0.9858267    50.1699    0.67350    526     0.05
  232 Female    56.770273206               .    0.5576006792               4    -2.888920672    56.1994    1.27606    526     0.05
  233 Female    47.800421972    37.536574647    0.4833625233               1    -0.640481703    40.5216    0.89674    526     0.05
  234 Female    47.800421972               .    0.6572935842               2    0.5705076359    45.3189    0.76375    526     0.05
  235 Female    47.800421972    49.458402751      0.68822388               3    -0.059723276    50.1699    0.67350    526     0.05
  236 Female    47.800421972     59.12866327    0.5132509131               4    -0.098178744    56.1994    1.27606    526     0.05
  237 Female    33.464257733    40.312676503    0.8882970853               1    0.5608207286    36.4086    0.90106    526     0.05
  238 Female    33.464257733    39.660494163    0.8343834065               2    -1.186458639    41.2059    0.76623    526     0.05
  239 Female    33.464257733    50.897259494    0.4779903404               3    1.0967770443    46.0568    0.70592    526     0.05
  240 Female    33.464257733     56.13116468    0.4045013223               4    -0.005344028    52.0863    1.27509    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  226 39.3645    42.3950      0.2366     0.04589     7.9767     0.04642     0.04589
  227 44.3123    47.1491      1.3282     0.34106    11.1860     0.35031     0.34412
  228 49.2576    54.2628      0.4858     0.04228     4.1718     0.05013     0.04970
  229 38.7600    42.2832       .          .           .          .           .     
  230 43.8186    46.8193      8.8234     1.71178    10.5038     1.73088     1.71178
  231 48.8468    51.4929      0.2763    -0.16971    11.7150     0.07270     0.07159
  232 53.6926    58.7062       .          .           .          .           .     
  233 38.7600    42.2832     -2.9850    -0.46876     5.8946    -0.47348    -0.46876
  234 43.8186    46.8193       .          .           .          .           .     
  235 48.8468    51.4929     -0.7115    -0.09135    11.8667    -0.18721    -0.18433
  236 53.6926    58.7062      2.9293     0.40816     5.1409     0.30226     0.29967
  237 34.6385    38.1787      3.9041     0.61309     6.3305     0.61932     0.61309
  238 39.7007    42.7112     -1.5454    -0.63288     5.4719    -0.30319    -0.29982
  239 44.6701    47.4436      4.8404     1.19275    11.8590     1.27562     1.25410
  240 49.5814    54.5912      4.0448     0.35744     4.4448     0.41735     0.41379
                                                           The SAS System                        16:52 Thursday, January 5, 2023  20

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  241  PT61     VIS1    TRT   Asian                                                                                               
  242  PT61     VIS2    TRT   Asian                                                                                               
  243  PT61     VIS3    TRT   Asian                                                                                               
  244  PT61     VIS4    TRT   Asian                                                                                               
  245  PT62     VIS1    PBO   Asian                                                                                               
  246  PT62     VIS2    PBO   Asian                                                                                               
  247  PT62     VIS3    PBO   Asian                                                                                               
  248  PT62     VIS4    PBO   Asian                                                                                               
  249  PT63     VIS1    PBO   White                                                                                               
  250  PT63     VIS2    PBO   White                                                                                               
  251  PT63     VIS3    PBO   White                                                                                               
  252  PT63     VIS4    PBO   White                                                                                               
  253  PT64     VIS1    PBO   Black or African American                                                                           
  254  PT64     VIS2    PBO   Black or African American                                                                           
  255  PT64     VIS3    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  241 Male      40.936610464    32.829811967    0.8510482939               1    0.7073106674    34.5519    0.89709    526     0.05
  242 Male      40.936610464    46.538372511    0.8555816347               2    1.0341077347    39.3492    0.76415    526     0.05
  243 Male      40.936610464               .    0.8254597241               3    0.2234804149    44.2001    0.69465    526     0.05
  244 Male      40.936610464    51.812645697    0.7275021588               4    -0.878707613    50.2296    1.28428    526     0.05
  245 Female    37.139052323               .    0.6010648532               1     1.162964556    31.1035    0.85562    526     0.05
  246 Female    37.139052323    29.919390341    0.6405149708               2    -2.000164945    35.9432    0.73638    526     0.05
  247 Female    37.139052323               .    0.8496878035               3     -0.54479074    41.4457    0.61338    526     0.05
  248 Female    37.139052323               .    0.5276217207               4    -0.255670709    46.1572    1.25796    526     0.05
  249 Female     42.97010526               .    0.3694320207               1    -0.166121037    36.7471    0.93146    526     0.05
  250 Female     42.97010526    51.056564567    0.7325366184               2    1.0204639088    41.5867    0.81945    526     0.05
  251 Female     42.97010526    50.500586325    0.1986116573               3    0.1362218931    47.0893    0.71124    526     0.05
  252 Female     42.97010526    64.113878971    0.8673026577               4    0.4071676034    51.8008    1.30442    526     0.05
  253 Female    31.091887032    32.218432885    0.1259935936               1    -0.069654813    32.6341    0.85598    526     0.05
  254 Female    31.091887032    29.647321565    0.3077513471               2    -0.247664342    37.4737    0.74083    526     0.05
  255 Female    31.091887032               .    0.8011442011               3    0.6955508066    42.9762    0.63127    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  241 32.7896    36.3142     -1.7221    -0.27043     5.1555    -0.27315    -0.27043
  242 37.8480    40.8504      7.1892     1.68401     7.5303     1.41031     1.39473
  243 42.8355    45.5648       .          .           .          .           .     
  244 47.7067    52.7526      1.5830     0.12155     3.8355     0.16336     0.16194
  245 29.4227    32.7844       .          .           .          .           .     
  246 34.4965    37.3898     -6.0238    -1.16863     5.8045    -1.18074    -1.16863
  247 40.2407    42.6507       .          .           .          .           .     
  248 43.6860    48.6285       .          .           .          .           .     
  249 34.9173    38.5769       .          .           .          .           .     
  250 39.9769    43.1965      9.4698     1.83718     9.9052     1.86085     1.83718
  251 45.6921    48.4865      3.4113     0.63288    11.8139     0.89924     0.88384
  252 49.2383    54.3633     12.3131     0.99598     5.1080     1.27100     1.25963
  253 30.9525    34.3156     -0.4156    -0.06527     5.0595    -0.06587    -0.06527
  254 36.0184    38.9290     -7.8264    -1.65771     3.9307    -1.53428    -1.51835
  255 41.7361    44.2164       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  21

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  256  PT64     VIS4    PBO   Black or African American                                                                           
  257  PT65     VIS1    TRT   Asian                                                                                               
  258  PT65     VIS2    TRT   Asian                                                                                               
  259  PT65     VIS3    TRT   Asian                                                                                               
  260  PT65     VIS4    TRT   Asian                                                                                               
  261  PT66     VIS1    TRT   Asian                                                                                               
  262  PT66     VIS2    TRT   Asian                                                                                               
  263  PT66     VIS3    TRT   Asian                                                                                               
  264  PT66     VIS4    TRT   Asian                                                                                               
  265  PT67     VIS1    TRT   White                                                                                               
  266  PT67     VIS2    TRT   White                                                                                               
  267  PT67     VIS3    TRT   White                                                                                               
  268  PT67     VIS4    TRT   White                                                                                               
  269  PT68     VIS1    TRT   White                                                                                               
  270  PT68     VIS2    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  256 Female    31.091887032    45.099187294    0.7764995754               4    1.1462283572    47.6878    1.25995    526     0.05
  257 Female    29.588498795    39.756591574    0.1134831225               1    -2.403096215    34.8780    0.86864    526     0.05
  258 Female    29.588498795    37.288937461    0.2469126964               2    0.5727395552    39.6754    0.71627    526     0.05
  259 Female    29.588498795    44.801446093    0.1926737046               3    0.3747244068    44.5263    0.62966    526     0.05
  260 Female    29.588498795    65.959197101    0.4827316964               4    -0.425267722    50.5558    1.26066    526     0.05
  261 Male       30.76419069    33.434393783    0.8597799066               1    0.9510128076    34.5519    0.89709    526     0.05
  262 Male       30.76419069    33.570422159    0.7605901524               2    -0.389237182    39.3492    0.76415    526     0.05
  263 Male       30.76419069    39.915432525     0.749246968               3    -0.284330662    44.2001    0.69465    526     0.05
  264 Male       30.76419069    49.570977059    0.8325895442               4    0.8574097781    50.2296    1.28428    526     0.05
  265 Female    25.601290344    38.916343315    0.6601322159               1    1.7196272991    40.5216    0.89674    526     0.05
  266 Female    25.601290344     36.69010922    0.1664308568               2    0.2700549009    45.3189    0.76375    526     0.05
  267 Female    25.601290344    45.666649734    0.1944609081               3     -0.42218401    50.1699    0.67350    526     0.05
  268 Female    25.601290344    52.074314233    0.7349197242               4    -1.189113295    56.1994    1.27606    526     0.05
  269 Female    21.938934396    42.214112374    0.8968350682               1    -0.331032979    40.5216    0.89674    526     0.05
  270 Female    21.938934396    45.029008433    0.6528285215               2    -0.939829327    45.3189    0.76375    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  256 45.2126    50.1629     -2.5886    -0.15472     3.3748    -0.26704    -0.26482
  257 33.1716    36.5845      4.8786     0.76611     6.2432     0.77334     0.76611
  258 38.2683    41.0825     -2.3864    -0.88914     5.0026    -0.46751    -0.46298
  259 43.2893    45.7632      0.2752    -0.03385    10.2889     0.07226     0.07129
  260 48.0792    53.0323     15.4034     1.50232     5.4869     1.58905     1.57578
  261 32.7896    36.3142     -1.1175    -0.17548     5.2504    -0.17725    -0.17548
  262 37.8480    40.8504     -5.7788    -1.16188     4.6844    -1.13363    -1.12111
  263 42.8355    45.5648     -4.2847    -1.03145     9.2182    -1.12855    -1.11012
  264 47.7067    52.7526     -0.6587     0.01653     3.9792    -0.06797    -0.06738
  265 38.7600    42.2832     -1.6053    -0.25208     6.1113    -0.25462    -0.25208
  266 43.8186    46.8193     -8.6288    -1.73976     4.9377    -1.69271    -1.67403
  267 48.8468    51.4929     -4.5032    -1.03982    10.5493    -1.18492    -1.16674
  268 53.6926    58.7062     -4.1251    -0.29492     4.0687    -0.42564    -0.42200
  269 38.7600    42.2832      1.6925     0.26578     6.6291     0.26846     0.26578
  270 43.8186    46.8193     -0.2899    -0.19233     6.4851    -0.05688    -0.05625
                                                           The SAS System                        16:52 Thursday, January 5, 2023  22

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  271  PT68     VIS3    TRT   White                                                                                               
  272  PT68     VIS4    TRT   White                                                                                               
  273  PT69     VIS1    PBO   Black or African American                                                                           
  274  PT69     VIS2    PBO   Black or African American                                                                           
  275  PT69     VIS3    PBO   Black or African American                                                                           
  276  PT69     VIS4    PBO   Black or African American                                                                           
  277  PT70     VIS1    PBO   Black or African American                                                                           
  278  PT70     VIS2    PBO   Black or African American                                                                           
  279  PT70     VIS3    PBO   Black or African American                                                                           
  280  PT70     VIS4    PBO   Black or African American                                                                           
  281  PT71     VIS1    TRT   Asian                                                                                               
  282  PT71     VIS2    TRT   Asian                                                                                               
  283  PT71     VIS3    TRT   Asian                                                                                               
  284  PT71     VIS4    TRT   Asian                                                                                               
  285  PT72     VIS1    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  271 Female    21.938934396               .    0.2178713454               3    -0.258932583    50.1699    0.67350    526     0.05
  272 Female    21.938934396               .    0.3542782543               4    0.3943791682    56.1994    1.27606    526     0.05
  273 Male      51.741896784    30.983375056    0.2247831132               1    -0.851857092    32.3079    0.85058    526     0.05
  274 Male      51.741896784    44.729319186    0.8962028382               2    2.6491668811    37.1475    0.72572    526     0.05
  275 Male      51.741896784    40.687109013    0.6985818183               3    0.1560116757    42.6501    0.61298    526     0.05
  276 Male      51.741896784    34.715298508    0.4144314721               4    1.1302072675    47.3616    1.25303    526     0.05
  277 Male      43.348050968    27.307524806    0.5411130585               1     -2.28912398    32.3079    0.85058    526     0.05
  278 Male      43.348050968    37.315845238    0.1235280413               2    0.7410011572    37.1475    0.72572    526     0.05
  279 Male      43.348050968               .    0.3690416019               3     -1.31624516    42.6501    0.61298    526     0.05
  280 Male      43.348050968    44.829998571    0.7867033411               4    0.9198036776    47.3616    1.25303    526     0.05
  281 Male      41.143654822    32.930420054    0.2016705088               1    0.3981301555    34.5519    0.89709    526     0.05
  282 Male      41.143654822     44.91911419    0.7331955833               2    -0.407528579    39.3492    0.76415    526     0.05
  283 Male      41.143654822    45.686356781     0.178305514               3    1.3242586302    44.2001    0.69465    526     0.05
  284 Male      41.143654822    65.987998659     0.115322772               4    -0.701231669    50.2296    1.28428    526     0.05
  285 Female    37.102864171    46.601299546    0.3208179358               1    -0.580614304    34.8780    0.86864    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  271 48.8468    51.4929       .          .           .          .           .     
  272 53.6926    58.7062       .          .           .          .           .     
  273 30.6370    33.9789     -1.3245    -0.20800     4.8655    -0.20988    -0.20800
  274 35.7219    38.5732      7.5818     1.73829     7.2813     1.48569     1.47089
  275 41.4459    43.8543     -1.9630    -0.57848     9.3510    -0.51512    -0.50859
  276 44.9001    49.8232    -12.6463    -1.40327     2.3470    -1.30449    -1.29373
  277 30.6370    33.9789     -5.0004    -0.78524     4.2883    -0.79234    -0.78524
  278 35.7219    38.5732      0.1683     0.41962     5.9626     0.03298     0.03265
  279 41.4459    43.8543       .          .           .          .           .     
  280 44.9001    49.8232     -2.5316    -0.11858     3.3908    -0.26114    -0.25899
  281 32.7896    36.3142     -1.6215    -0.25463     5.1713    -0.25719    -0.25463
  282 37.8480    40.8504      5.5699     1.32673     7.1730     1.09266     1.08058
  283 42.8355    45.5648      1.4862     0.36925    10.6189     0.39146     0.38506
  284 47.7067    52.7526     15.7584     1.63722     5.5999     1.62619     1.61209
  285 33.1716    36.5845     11.7233     1.84098     7.3181     1.85835     1.84098
                                                           The SAS System                        16:52 Thursday, January 5, 2023  23

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  286  PT72     VIS2    TRT   Asian                                                                                               
  287  PT72     VIS3    TRT   Asian                                                                                               
  288  PT72     VIS4    TRT   Asian                                                                                               
  289  PT73     VIS1    PBO   White                                                                                               
  290  PT73     VIS2    PBO   White                                                                                               
  291  PT73     VIS3    PBO   White                                                                                               
  292  PT73     VIS4    PBO   White                                                                                               
  293  PT74     VIS1    PBO   White                                                                                               
  294  PT74     VIS2    PBO   White                                                                                               
  295  PT74     VIS3    PBO   White                                                                                               
  296  PT74     VIS4    PBO   White                                                                                               
  297  PT75     VIS1    PBO   White                                                                                               
  298  PT75     VIS2    PBO   White                                                                                               
  299  PT75     VIS3    PBO   White                                                                                               
  300  PT75     VIS4    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  286 Female    37.102864171    40.897859799    0.4289215248               2    -1.001072181    39.6754    0.71627    526     0.05
  287 Female    37.102864171    46.667083188    0.1533614621               3    -0.668178607    44.5263    0.62966    526     0.05
  288 Female    37.102864171               .    0.7372252515               4    0.9451849534    50.5558    1.26066    526     0.05
  289 Male      43.464318216               .    0.5050601944               1    0.4337021495    36.4209    0.93528    526     0.05
  290 Male      43.464318216               .    0.5148990551               2    1.0051592177    41.2606    0.81589    526     0.05
  291 Male      43.464318216    43.832698078    0.6643679611               3    -0.390118664    46.7631    0.70671    526     0.05
  292 Male      43.464318216     44.11603782    0.7652952664               4    0.3763702918    51.4747    1.30402    526     0.05
  293 Female     35.51143796    38.296117048    0.1487171441               1    0.2441649245    36.7471    0.93146    526     0.05
  294 Female     35.51143796               .    0.3694686206               2    -1.426257342    41.5867    0.81945    526     0.05
  295 Female     35.51143796    51.385702012    0.7417927701               3    1.7784292875    47.0893    0.71124    526     0.05
  296 Female     35.51143796    56.209792538    0.3268020285               4    0.1344476609    51.8008    1.30442    526     0.05
  297 Male      31.247727014               .    0.7519017152               1    0.7655989992    36.4209    0.93528    526     0.05
  298 Male      31.247727014    43.458191936    0.2720664909               2    0.9551366769    41.2606    0.81589    526     0.05
  299 Male      31.247727014    38.387411892    0.5441222714               3    -0.050565701    46.7631    0.70671    526     0.05
  300 Male      31.247727014    56.428178863    0.1124221612               4     -0.30581542    51.4747    1.30402    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  286 38.2683    41.0825      1.2225    -0.63470     5.2570     0.23949     0.23717
  287 43.2893    45.7632      2.1408     0.22322    10.5460     0.56219     0.55466
  288 48.0792    53.0323       .          .           .          .           .     
  289 34.5836    38.2583       .          .           .          .           .     
  290 39.6578    42.8634       .          .           .          .           .     
  291 45.3748    48.1514     -2.9304    -0.75924    11.3566    -0.77230    -0.75924
  292 48.9129    54.0364     -7.3586    -0.73486     4.2429    -0.75958    -0.75279
  293 34.9173    38.5769      1.5490     0.24325     6.0139     0.24590     0.24325
  294 39.9769    43.1965       .          .           .          .           .     
  295 45.6921    48.4865      4.2964     1.08641    12.3520     1.13256     1.11316
  296 49.2383    54.3633      4.4090     0.43065     4.8188     0.45511     0.45104
  297 34.5836    38.2583       .          .           .          .           .     
  298 39.6578    42.8634      2.1976     0.42635     8.4311     0.43179     0.42635
  299 45.3748    48.1514     -8.3757    -2.25192     8.8527    -2.20738    -2.17006
  300 48.9129    54.0364      4.9535     0.45561     4.5436     0.51132     0.50675
                                                           The SAS System                        16:52 Thursday, January 5, 2023  24

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  301  PT76     VIS1    TRT   White                                                                                               
  302  PT76     VIS2    TRT   White                                                                                               
  303  PT76     VIS3    TRT   White                                                                                               
  304  PT76     VIS4    TRT   White                                                                                               
  305  PT77     VIS1    TRT   Asian                                                                                               
  306  PT77     VIS2    TRT   Asian                                                                                               
  307  PT77     VIS3    TRT   Asian                                                                                               
  308  PT77     VIS4    TRT   Asian                                                                                               
  309  PT78     VIS1    TRT   White                                                                                               
  310  PT78     VIS2    TRT   White                                                                                               
  311  PT78     VIS3    TRT   White                                                                                               
  312  PT78     VIS4    TRT   White                                                                                               
  313  PT79     VIS1    PBO   Asian                                                                                               
  314  PT79     VIS2    PBO   Asian                                                                                               
  315  PT79     VIS3    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  301 Male      35.618713533    39.050495386     0.142150653               1    0.8936737024    40.1955    0.89869    526     0.05
  302 Male      35.618713533               .    0.5789258255               2    -1.047298149    44.9928    0.77940    526     0.05
  303 Male      35.618713533               .    0.6666325172               3    1.9713373862    49.8437    0.70210    526     0.05
  304 Male      35.618713533    54.092000431    0.6227525279               4    -0.383632106    55.8732    1.28130    526     0.05
  305 Male      33.275382105     31.40520682    0.5619311748               1    1.6541453023    34.5519    0.89709    526     0.05
  306 Male      33.275382105    46.133296488    0.6426284265               2     1.512212694    39.3492    0.76415    526     0.05
  307 Male      33.275382105      45.2984459    0.2679823095               3    0.0829657336    44.2001    0.69465    526     0.05
  308 Male      33.275382105    28.069356213    0.2895840839               4    0.5672209149    50.2296    1.28428    526     0.05
  309 Female    37.024704112               .    0.4654002141               1     -1.02454848    40.5216    0.89674    526     0.05
  310 Female    37.024704112    42.502827117    0.3721210616               2     0.323006503    45.3189    0.76375    526     0.05
  311 Female    37.024704112    46.453678626    0.4207421489               3    1.0436124584    50.1699    0.67350    526     0.05
  312 Female    37.024704112    64.973663495     0.445353776               4    0.0990784869    56.1994    1.27606    526     0.05
  313 Female    41.272469434               .    0.8642984485               1    -0.454136909    31.1035    0.85562    526     0.05
  314 Female    41.272469434               .    0.2778232574               2    -0.655781852    35.9432    0.73638    526     0.05
  315 Female    41.272469434               .    0.3922486344               3    -0.035922423    41.4457    0.61338    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  301 38.4300    41.9609     -1.1450    -0.17980     6.1323    -0.18162    -0.17980
  302 43.4617    46.5239       .          .           .          .           .     
  303 48.4644    51.2230       .          .           .          .           .     
  304 53.3561    58.3903     -1.7812    -0.14702     4.3170    -0.18380    -0.18222
  305 32.7896    36.3142     -3.1467    -0.49414     4.9318    -0.49912    -0.49414
  306 37.8480    40.8504      6.7841     1.70576     7.5521     1.33084     1.31614
  307 42.8355    45.5648      1.0983     0.29394    10.5435     0.28928     0.28456
  308 47.7067    52.7526    -22.1603    -2.31585     1.6468    -2.28683    -2.26701
  309 38.7600    42.2832       .          .           .          .           .     
  310 43.8186    46.8193     -2.8161    -0.54634     8.2457    -0.55244    -0.54634
  311 48.8468    51.4929     -3.7162    -0.89516    10.9896    -0.97783    -0.96283
  312 53.6926    58.7062      8.7743     0.99253     5.4487     0.90536     0.89762
  313 29.4227    32.7844       .          .           .          .           .     
  314 34.4965    37.3898       .          .           .          .           .     
  315 40.2407    42.6507       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  25

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  316  PT79     VIS4    PBO   Asian                                                                                               
  317  PT80     VIS1    TRT   Asian                                                                                               
  318  PT80     VIS2    TRT   Asian                                                                                               
  319  PT80     VIS3    TRT   Asian                                                                                               
  320  PT80     VIS4    TRT   Asian                                                                                               
  321  PT81     VIS1    PBO   White                                                                                               
  322  PT81     VIS2    PBO   White                                                                                               
  323  PT81     VIS3    PBO   White                                                                                               
  324  PT81     VIS4    PBO   White                                                                                               
  325  PT82     VIS1    PBO   Black or African American                                                                           
  326  PT82     VIS2    PBO   Black or African American                                                                           
  327  PT82     VIS3    PBO   Black or African American                                                                           
  328  PT82     VIS4    PBO   Black or African American                                                                           
  329  PT83     VIS1    TRT   White                                                                                               
  330  PT83     VIS2    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  316 Female    41.272469434    43.978466825     0.805980291               4    1.0691614607    46.1572    1.25796    526     0.05
  317 Male      50.338269315    35.334664216     0.521613168               1     -0.48397493    34.5519    0.89709    526     0.05
  318 Male      50.338269315    39.343782448    0.5685701761               2    -0.121010111    39.3492    0.76415    526     0.05
  319 Male      50.338269315    41.276330727    0.3061297096               3    -1.294140004    44.2001    0.69465    526     0.05
  320 Male      50.338269315               .    0.7950951956               4     0.494312836    50.2296    1.28428    526     0.05
  321 Male      34.293489863               .    0.3503223652               1    1.3079015201    36.4209    0.93528    526     0.05
  322 Male      34.293489863     39.83058385    0.6382881265               2    1.4970410094    41.2606    0.81589    526     0.05
  323 Male      34.293489863    43.496732633    0.5952901594               3    0.8147027309    46.7631    0.70671    526     0.05
  324 Male      34.293489863    44.061139901    0.4228193168               4     -1.86978879    51.4747    1.30402    526     0.05
  325 Female    46.100432418    41.437421986    0.4235201139               1    0.4820295041    32.6341    0.85598    526     0.05
  326 Female    46.100432418               .    0.8698687866               2    0.4561356033    37.4737    0.74083    526     0.05
  327 Female    46.100432418    46.169542792    0.3519980954               3    -0.353400286    42.9762    0.63127    526     0.05
  328 Female    46.100432418    54.240243738    0.1126966383               4    0.1704894709    47.6878    1.25995    526     0.05
  329 Male      45.249850446    36.618313005    0.2285174802               1    -0.864035954    40.1955    0.89869    526     0.05
  330 Male      45.249850446    42.092722715    0.2834050415               2     0.679230774    44.9928    0.77940    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  316 43.6860    48.6285     -2.1788    -0.22289     4.4990    -0.22476    -0.22289
  317 32.7896    36.3142      0.7828     0.12293     5.5488     0.12416     0.12293
  318 37.8480    40.8504     -0.0054    -0.06117     5.7851    -0.00106    -0.00105
  319 42.8355    45.5648     -2.9238    -0.79673     9.4529    -0.77010    -0.75753
  320 47.7067    52.7526       .          .           .          .           .     
  321 34.5836    38.2583       .          .           .          .           .     
  322 39.6578    42.8634     -1.4300    -0.27742     7.7273    -0.28097    -0.27742
  323 45.3748    48.1514     -3.2664    -0.81548    10.2891    -0.86084    -0.84629
  324 48.9129    54.0364     -7.4135    -0.72267     3.3654    -0.76525    -0.75841
  325 30.9525    34.3156      8.8034     1.38245     6.5072     1.39511     1.38245
  326 36.0184    38.9290       .          .           .          .           .     
  327 41.7361    44.2164      3.1933     0.55913    10.8700     0.83865     0.82735
  328 45.2126    50.1629      6.5525     0.39377     4.4735     0.67596     0.67032
  329 38.4300    41.9609     -3.5771    -0.56174     5.7504    -0.56742    -0.56174
  330 43.4617    46.5239     -2.9001    -0.35188     6.2802    -0.56917    -0.56262
                                                           The SAS System                        16:52 Thursday, January 5, 2023  26

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  331  PT83     VIS3    TRT   White                                                                                               
  332  PT83     VIS4    TRT   White                                                                                               
  333  PT84     VIS1    PBO   Asian                                                                                               
  334  PT84     VIS2    PBO   Asian                                                                                               
  335  PT84     VIS3    PBO   Asian                                                                                               
  336  PT84     VIS4    PBO   Asian                                                                                               
  337  PT85     VIS1    PBO   Asian                                                                                               
  338  PT85     VIS2    PBO   Asian                                                                                               
  339  PT85     VIS3    PBO   Asian                                                                                               
  340  PT85     VIS4    PBO   Asian                                                                                               
  341  PT86     VIS1    TRT   Black or African American                                                                           
  342  PT86     VIS2    TRT   Black or African American                                                                           
  343  PT86     VIS3    TRT   Black or African American                                                                           
  344  PT86     VIS4    TRT   Black or African American                                                                           
  345  PT87     VIS1    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  331 Male      45.249850446    50.695561404    0.4115918091               3    -0.327101015    49.8437    0.70210    526     0.05
  332 Male      45.249850446    51.725633857    0.7792745316               4    -1.569082185    55.8732    1.28130    526     0.05
  333 Female    31.986982608               .    0.6893110707               1    -0.367450756    31.1035    0.85562    526     0.05
  334 Female    31.986982608               .    0.6398778101               2    1.3644349291    35.9432    0.73638    526     0.05
  335 Female    31.986982608               .    0.1860170372               3    -0.334281365    41.4457    0.61338    526     0.05
  336 Female    31.986982608    53.899474237    0.1475270119               4    0.7327500422    46.1572    1.25796    526     0.05
  337 Female     40.07873121               .    0.8689283516               1    0.9465856402    31.1035    0.85562    526     0.05
  338 Female     40.07873121               .     0.683759198               2    0.0043987043    35.9432    0.73638    526     0.05
  339 Female     40.07873121    39.944202407    0.4924431762               3    -0.352322306    41.4457    0.61338    526     0.05
  340 Female     40.07873121    56.424817938     0.804766986               4    -0.529695509    46.1572    1.25796    526     0.05
  341 Female    29.145562986     41.86385048    0.5633828919               1    0.7395892256    36.4086    0.90106    526     0.05
  342 Female    29.145562986    34.564195555    0.6554693775               2    -1.063457415    41.2059    0.76623    526     0.05
  343 Female    29.145562986    38.689267709    0.8288327355               3    0.2462108435    46.0568    0.70592    526     0.05
  344 Female    29.145562986    62.887430874      0.77028496               4    -0.289499367    52.0863    1.27509    526     0.05
  345 Male      39.322245197    28.853427926    0.5115104964               1    -2.264889356    36.4209    0.93528    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  331 48.4644    51.2230      0.8518     0.36255    11.8785     0.22445     0.22070
  332 53.3561    58.3903     -4.1476    -0.28103     4.0606    -0.42799    -0.42430
  333 29.4227    32.7844       .          .           .          .           .     
  334 34.4965    37.3898       .          .           .          .           .     
  335 40.2407    42.6507       .          .           .          .           .     
  336 43.6860    48.6285      7.7422     0.79204     5.5140     0.79868     0.79204
  337 29.4227    32.7844       .          .           .          .           .     
  338 34.4965    37.3898       .          .           .          .           .     
  339 40.2407    42.6507     -1.5015    -0.38902    10.3491    -0.39403    -0.38902
  340 43.6860    48.6285     10.2676     1.05998     5.5265     1.05919     1.05038
  341 34.6385    38.1787      5.4553     0.85668     6.5741     0.86538     0.85668
  342 39.7007    42.7112     -6.6417    -1.85198     4.2528    -1.30300    -1.28852
  343 44.6701    47.4436     -7.3676    -2.02191     8.6443    -1.94161    -1.90886
  344 49.5814    54.5912     10.8011     1.01077     5.0981     1.11448     1.10496
  345 34.5836    38.2583     -7.5675    -1.18837     4.5310    -1.20140    -1.18837
                                                           The SAS System                        16:52 Thursday, January 5, 2023  27

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  346  PT87     VIS2    PBO   White                                                                                               
  347  PT87     VIS3    PBO   White                                                                                               
  348  PT87     VIS4    PBO   White                                                                                               
  349  PT88     VIS1    PBO   Black or African American                                                                           
  350  PT88     VIS2    PBO   Black or African American                                                                           
  351  PT88     VIS3    PBO   Black or African American                                                                           
  352  PT88     VIS4    PBO   Black or African American                                                                           
  353  PT89     VIS1    PBO   Black or African American                                                                           
  354  PT89     VIS2    PBO   Black or African American                                                                           
  355  PT89     VIS3    PBO   Black or African American                                                                           
  356  PT89     VIS4    PBO   Black or African American                                                                           
  357  PT90     VIS1    PBO   Asian                                                                                               
  358  PT90     VIS2    PBO   Asian                                                                                               
  359  PT90     VIS3    PBO   Asian                                                                                               
  360  PT90     VIS4    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  346 Male      39.322245197               .    0.6012658233               2    -1.408850456    41.2606    0.81589    526     0.05
  347 Male      39.322245197    49.294954744    0.7361562224               3    0.9160193288    46.7631    0.70671    526     0.05
  348 Male      39.322245197               .    0.8550508689               4    -0.191278951    51.4747    1.30402    526     0.05
  349 Female    45.559909336    28.740293981    0.1354517993               1    0.8032832161    32.6341    0.85598    526     0.05
  350 Female    45.559909336               .     0.702786405               2    1.8874744633    37.4737    0.74083    526     0.05
  351 Female    45.559909336    43.599938722    0.6477792295               3    1.4738811811    42.9762    0.63127    526     0.05
  352 Female    45.559909336    57.386164796    0.5979018016               4    0.6772684923    47.6878    1.25995    526     0.05
  353 Male      32.132592138    35.368243291    0.8947968001               1    0.3799626866    32.3079    0.85058    526     0.05
  354 Male      32.132592138    43.061099952    0.6085221883               2    -0.192798426    37.1475    0.72572    526     0.05
  355 Male      32.132592138    31.275512104    0.6247394318               3    1.5778917949    42.6501    0.61298    526     0.05
  356 Male      32.132592138    54.132452405    0.6819577958               4    0.5962341093    47.3616    1.25303    526     0.05
  357 Male      36.371783478     25.97049929    0.5681483218               1    -1.173576941    30.7774    0.88653    526     0.05
  358 Male      36.371783478               .    0.5602181038               2    -0.155642535    35.6170    0.76366    526     0.05
  359 Male      36.371783478               .     0.127765804               3     -1.91890982    41.1195    0.64540    526     0.05
  360 Male      36.371783478               .    0.7296180442               4    -0.195258846    45.8311    1.27598    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  346 39.6578    42.8634       .          .           .          .           .     
  347 45.3748    48.1514      2.5318     0.91544    12.1053     0.66725     0.65597
  348 48.9129    54.0364       .          .           .          .           .     
  349 30.9525    34.3156     -3.8938    -0.61146     4.5133    -0.61706    -0.61146
  350 36.0184    38.9290       .          .           .          .           .     
  351 41.7361    44.2164      0.6237     0.29138    10.6023     0.16380     0.16159
  352 45.2126    50.1629      9.6984     1.15658     5.2364     1.00050     0.99215
  353 30.6370    33.9789      3.0603     0.48058     5.5541     0.48493     0.48058
  354 35.7219    38.5732      5.9136     1.04205     6.5851     1.15880     1.14725
  355 41.4459    43.8543    -11.3746    -3.17465     6.7548    -2.98492    -2.94703
  356 44.9001    49.8232      6.7708     0.46365     4.2139     0.69842     0.69266
  357 29.0358    32.5189     -4.8069    -0.75485     4.0783    -0.76227    -0.75485
  358 34.1168    37.1172       .          .           .          .           .     
  359 39.8516    42.3874       .          .           .          .           .     
  360 43.3244    48.3377       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  28

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  361  PT91     VIS1    TRT   White                                                                                               
  362  PT91     VIS2    TRT   White                                                                                               
  363  PT91     VIS3    TRT   White                                                                                               
  364  PT91     VIS4    TRT   White                                                                                               
  365  PT92     VIS1    TRT   White                                                                                               
  366  PT92     VIS2    TRT   White                                                                                               
  367  PT92     VIS3    TRT   White                                                                                               
  368  PT92     VIS4    TRT   White                                                                                               
  369  PT93     VIS1    PBO   Black or African American                                                                           
  370  PT93     VIS2    PBO   Black or African American                                                                           
  371  PT93     VIS3    PBO   Black or African American                                                                           
  372  PT93     VIS4    PBO   Black or African American                                                                           
  373  PT94     VIS1    PBO   Asian                                                                                               
  374  PT94     VIS2    PBO   Asian                                                                                               
  375  PT94     VIS3    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  361 Female    41.351740137               .    0.2447623642               1     -2.59232767    40.5216    0.89674    526     0.05
  362 Female    41.351740137               .    0.2346616827               2    1.3140021672    45.3189    0.76375    526     0.05
  363 Female    41.351740137    51.174932756    0.4843534712               3    -0.635543001    50.1699    0.67350    526     0.05
  364 Female    41.351740137    48.440432784    0.2940355126               4    -0.429978839    56.1994    1.27606    526     0.05
  365 Female    25.673679634    43.331284857    0.3740770869               1    -0.169318332    40.5216    0.89674    526     0.05
  366 Female    25.673679634               .    0.6738519104               2     0.612218174    45.3189    0.76375    526     0.05
  367 Female    25.673679634    55.935463619    0.7966738462               3    0.6783401772    50.1699    0.67350    526     0.05
  368 Female    25.673679634    54.153120872    0.3032056639               4    0.5679519725    56.1994    1.27606    526     0.05
  369 Male      45.771560037               .    0.7340774624               1    -0.572542604    32.3079    0.85058    526     0.05
  370 Male      45.771560037    40.602519889    0.5571871808               2    -1.363291256    37.1475    0.72572    526     0.05
  371 Male      45.771560037     44.44714803    0.5243652239               3    -0.388722244    42.6501    0.61298    526     0.05
  372 Male      45.771560037    40.541610414    0.7276369119               4    0.2779141325    47.3616    1.25303    526     0.05
  373 Female    40.311140504    33.955631719    0.8415934522               1    -0.823081122    31.1035    0.85562    526     0.05
  374 Female    40.311140504               .    0.5973482806               2    -0.068840934    35.9432    0.73638    526     0.05
  375 Female    40.311140504    43.678023003    0.6166743089               3    -1.167662326    41.4457    0.61338    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  361 38.7600    42.2832       .          .           .          .           .     
  362 43.8186    46.8193       .          .           .          .           .     
  363 48.8468    51.4929      1.0051     0.26040    13.2589     0.26446     0.26040
  364 53.6926    58.7062     -7.7589    -0.80020     4.6399    -0.80059    -0.79374
  365 38.7600    42.2832      2.8097     0.44122     6.8046     0.44566     0.44122
  366 43.8186    46.8193       .          .           .          .           .     
  367 48.8468    51.4929      5.7656     1.43419    13.3923     1.51708     1.49381
  368 53.6926    58.7062     -2.0462    -0.28209     4.4506    -0.21114    -0.20933
  369 30.6370    33.9789       .          .           .          .           .     
  370 35.7219    38.5732      3.4550     0.67028     7.8770     0.67702     0.67028
  371 41.4459    43.8543      1.7971     0.37547    10.5166     0.47159     0.46560
  372 44.9001    49.8232     -6.8200    -0.80731     2.9781    -0.70350    -0.69769
  373 29.4227    32.7844      2.8521     0.44789     5.3323     0.45198     0.44789
  374 34.4965    37.3898       .          .           .          .           .     
  375 40.2407    42.6507      2.2323     0.49803    10.4537     0.58582     0.57837
                                                           The SAS System                        16:52 Thursday, January 5, 2023  29

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  376  PT94     VIS4    PBO   Asian                                                                                               
  377  PT95     VIS1    PBO   Asian                                                                                               
  378  PT95     VIS2    PBO   Asian                                                                                               
  379  PT95     VIS3    PBO   Asian                                                                                               
  380  PT95     VIS4    PBO   Asian                                                                                               
  381  PT96     VIS1    PBO   Black or African American                                                                           
  382  PT96     VIS2    PBO   Black or African American                                                                           
  383  PT96     VIS3    PBO   Black or African American                                                                           
  384  PT96     VIS4    PBO   Black or African American                                                                           
  385  PT97     VIS1    TRT   White                                                                                               
  386  PT97     VIS2    TRT   White                                                                                               
  387  PT97     VIS3    TRT   White                                                                                               
  388  PT97     VIS4    TRT   White                                                                                               
  389  PT98     VIS1    PBO   Asian                                                                                               
  390  PT98     VIS2    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  376 Female    40.311140504    42.760231025    0.4475151697               4    -0.008309014    46.1572    1.25796    526     0.05
  377 Female    37.514556575               .    0.4457196789               1    0.1288554016    31.1035    0.85562    526     0.05
  378 Female    37.514556575    42.826783537     0.880089429               2    -0.145875628    35.9432    0.73638    526     0.05
  379 Female    37.514556575    39.592179866    0.3462071322               3    -0.163910957    41.4457    0.61338    526     0.05
  380 Female    37.514556575               .    0.4657343598               4    1.7635520028    46.1572    1.25796    526     0.05
  381 Female    40.292593413    33.492156579    0.6652918475               1    0.7625865124    32.6341    0.85598    526     0.05
  382 Female    40.292593413    35.392663722    0.7488246793               2    1.1114310807    37.4737    0.74083    526     0.05
  383 Female    40.292593413               .    0.3453712786               3    -0.923206953    42.9762    0.63127    526     0.05
  384 Female    40.292593413    42.362662552    0.6424444387               4    0.1643418384    47.6878    1.25995    526     0.05
  385 Male      37.236485427    48.543682645    0.7274394294               1    1.1548251871    40.1955    0.89869    526     0.05
  386 Male      37.236485427    43.943663442    0.7881291825               2    -0.056521425    44.9928    0.77940    526     0.05
  387 Male      37.236485427               .    0.5946187686               3    -2.129360648    49.8437    0.70210    526     0.05
  388 Male      37.236485427     47.91203977     0.250822502               4    0.3448457621    55.8732    1.28130    526     0.05
  389 Male       39.73143883    20.729276526    0.8239519622               1    -1.904955446    30.7774    0.88653    526     0.05
  390 Male       39.73143883     28.00599427     0.125677423               2    -0.811170153    35.6170    0.76366    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  376 43.6860    48.6285     -3.3970    -0.44424     3.5208    -0.35043    -0.34752
  377 29.4227    32.7844       .          .           .          .           .     
  378 34.4965    37.3898      6.8836     1.33545     8.3086     1.34929     1.33545
  379 40.2407    42.6507     -1.8535    -0.67381     9.1853    -0.48641    -0.48022
  380 43.6860    48.6285       .          .           .          .           .     
  381 30.9525    34.3156      0.8581     0.13475     5.2595     0.13599     0.13475
  382 36.0184    38.9290     -2.0810    -0.51503     5.0734    -0.40796    -0.40373
  383 41.7361    44.2164       .          .           .          .           .     
  384 45.2126    50.1629     -5.3251    -0.55669     2.9728    -0.54935    -0.54476
  385 38.4300    41.9609      8.3482     1.31097     7.6231     1.32423     1.31097
  386 43.4617    46.5239     -1.0491    -0.86639     5.7657    -0.20590    -0.20353
  387 48.4644    51.2230       .          .           .          .           .     
  388 53.3561    58.3903     -7.9612    -1.07083     2.9914    -0.82152    -0.81443
  389 29.0358    32.5189    -10.0481    -1.57791     3.2552    -1.59343    -1.57791
  390 34.1168    37.1172     -7.6110    -0.87287     4.4570    -1.49304    -1.47656
                                                           The SAS System                        16:52 Thursday, January 5, 2023  30

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  391  PT98     VIS3    PBO   Asian                                                                                               
  392  PT98     VIS4    PBO   Asian                                                                                               
  393  PT99     VIS1    PBO   Black or African American                                                                           
  394  PT99     VIS2    PBO   Black or African American                                                                           
  395  PT99     VIS3    PBO   Black or African American                                                                           
  396  PT99     VIS4    PBO   Black or African American                                                                           
  397  PT100    VIS1    PBO   Black or African American                                                                           
  398  PT100    VIS2    PBO   Black or African American                                                                           
  399  PT100    VIS3    PBO   Black or African American                                                                           
  400  PT100    VIS4    PBO   Black or African American                                                                           
  401  PT101    VIS1    TRT   White                                                                                               
  402  PT101    VIS2    TRT   White                                                                                               
  403  PT101    VIS3    TRT   White                                                                                               
  404  PT101    VIS4    TRT   White                                                                                               
  405  PT102    VIS1    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  391 Male       39.73143883    40.192554077    0.7301524745               3    1.3240043213    41.1195    0.64540    526     0.05
  392 Male       39.73143883    37.793604182    0.7835199976               4    0.6156368493    45.8311    1.27598    526     0.05
  393 Male      47.692307897               .    0.7420612512               1    1.0916689555    32.3079    0.85058    526     0.05
  394 Male      47.692307897    36.751772198    0.2343967596               2    0.3066048615    37.1475    0.72572    526     0.05
  395 Male      47.692307897               .    0.3629419899               3    -0.110158762    42.6501    0.61298    526     0.05
  396 Male      47.692307897               .    0.2594918536               4    -0.924312773    47.3616    1.25303    526     0.05
  397 Female    51.841876524    34.598222892    0.3620150704               1    1.5929137537    32.6341    0.85598    526     0.05
  398 Female    51.841876524    39.320343052    0.4044874851               2    0.0450105981    37.4737    0.74083    526     0.05
  399 Female    51.841876524    40.657018747    0.5042462299               3    -0.715128401    42.9762    0.63127    526     0.05
  400 Female    51.841876524               .    0.2008041842               4    0.8652230997    47.6878    1.25995    526     0.05
  401 Male      38.980275498               .    0.1603843566               1    1.0744409583    40.1955    0.89869    526     0.05
  402 Male      38.980275498    43.032546813     0.479507393               2    1.8956547742    44.9928    0.77940    526     0.05
  403 Male      38.980275498    54.657154397    0.3116716364               3    -0.602997304    49.8437    0.70210    526     0.05
  404 Male      38.980275498               .    0.2845968585               4    -0.390867821    55.8732    1.28130    526     0.05
  405 Female    52.179964825    35.557415061    0.5769595092               1    -0.416222032    31.1035    0.85562    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  391 39.8516    42.3874     -0.9270     0.13187     9.7179    -0.24360    -0.24017
  392 43.3244    48.3377     -8.0375    -0.43869     3.2088    -0.82934    -0.82224
  393 30.6370    33.9789       .          .           .          .           .     
  394 35.7219    38.5732     -0.3958    -0.07678     7.1300    -0.07755    -0.07678
  395 41.4459    43.8543       .          .           .          .           .     
  396 44.9001    49.8232       .          .           .          .           .     
  397 30.9525    34.3156      1.9642     0.30844     5.4332     0.31127     0.30844
  398 36.0184    38.9290      1.8466     0.24810     5.8365     0.36201     0.35826
  399 41.7361    44.2164     -2.3192    -0.69294     9.3097    -0.60909    -0.60089
  400 45.2126    50.1629       .          .           .          .           .     
  401 38.4300    41.9609       .          .           .          .           .     
  402 43.4617    46.5239     -1.9602    -0.38029     8.3485    -0.38472    -0.38029
  403 48.4644    51.2230      4.8134     1.31328    13.1216     1.26827     1.24711
  404 53.3561    58.3903       .          .           .          .           .     
  405 29.4227    32.7844      4.4539     0.69942     5.5838     0.70582     0.69942
                                                           The SAS System                        16:52 Thursday, January 5, 2023  31

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  406  PT102    VIS2    PBO   Asian                                                                                               
  407  PT102    VIS3    PBO   Asian                                                                                               
  408  PT102    VIS4    PBO   Asian                                                                                               
  409  PT103    VIS1    PBO   Asian                                                                                               
  410  PT103    VIS2    PBO   Asian                                                                                               
  411  PT103    VIS3    PBO   Asian                                                                                               
  412  PT103    VIS4    PBO   Asian                                                                                               
  413  PT104    VIS1    PBO   Black or African American                                                                           
  414  PT104    VIS2    PBO   Black or African American                                                                           
  415  PT104    VIS3    PBO   Black or African American                                                                           
  416  PT104    VIS4    PBO   Black or African American                                                                           
  417  PT105    VIS1    TRT   Black or African American                                                                           
  418  PT105    VIS2    TRT   Black or African American                                                                           
  419  PT105    VIS3    TRT   Black or African American                                                                           
  420  PT105    VIS4    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  406 Female    52.179964825    43.702152586    0.2271404631               2    -0.375657423    35.9432    0.73638    526     0.05
  407 Female    52.179964825    42.521568696    0.7840438703               3    -0.366630946    41.4457    0.61338    526     0.05
  408 Female    52.179964825    54.893365921    0.2899630366               4    -0.295677453    46.1572    1.25796    526     0.05
  409 Female    26.992628636    32.034600291    0.7376893589               1    1.4418204102    31.1035    0.85562    526     0.05
  410 Female    26.992628636    29.451072583    0.1627884734               2    -0.697538292    35.9432    0.73638    526     0.05
  411 Female    26.992628636    45.351381398     0.533516906               3    -0.388167506    41.4457    0.61338    526     0.05
  412 Female    26.992628636               .    0.6735556956               4    0.6525364522    46.1572    1.25796    526     0.05
  413 Female    27.043193829    38.737840062    0.1326234689               1    1.1247724465    32.6341    0.85598    526     0.05
  414 Female    27.043193829               .    0.1204803582               2    -0.772110803    37.4737    0.74083    526     0.05
  415 Female    27.043193829     41.42283465     0.692493145               3    -0.508086216    42.9762    0.63127    526     0.05
  416 Female    27.043193829    47.323847899    0.7161192531               4    0.5236205905    47.6878    1.25995    526     0.05
  417 Female    38.587493423               .    0.5309425518               1    1.0177542265    36.4086    0.90106    526     0.05
  418 Female    38.587493423    47.553095462    0.4105091531               2    -0.251164588    41.2059    0.76623    526     0.05
  419 Female    38.587493423    49.065089714    0.4755341625               3    -1.429993447    46.0568    0.70592    526     0.05
  420 Female    38.587493423               .    0.1979891878               4    1.7091210321    52.0863    1.27509    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  406 34.4965    37.3898      7.7590     1.33363     6.7090     1.52088     1.50528
  407 40.2407    42.6507      1.0759     0.06259     9.7218     0.28234     0.27875
  408 43.6860    48.6285      8.7361     0.68188     4.3513     0.90120     0.89371
  409 29.4227    32.7844      0.9311     0.14621     5.0306     0.14755     0.14621
  410 34.4965    37.3898     -6.4921    -1.47289     3.9024    -1.27254    -1.25949
  411 40.2407    42.6507      3.9057     1.09065    10.7498     1.02495     1.01192
  412 43.6860    48.6285       .          .           .          .           .     
  413 30.9525    34.3156      6.1038     0.95851     6.0832     0.96729     0.95851
  414 36.0184    38.9290       .          .           .          .           .     
  415 41.7361    44.2164     -1.5534    -0.60907     9.7018    -0.40796    -0.40247
  416 45.2126    50.1629     -0.3639    -0.26149     3.8183    -0.03754    -0.03723
  417 34.6385    38.1787       .          .           .          .           .     
  418 39.7007    42.7112      6.3472     1.23138     9.2255     1.24521     1.23138
  419 44.6701    47.4436      3.0083     0.61306    11.5344     0.79278     0.77941
  420 49.5814    54.5912       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  32

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  421  PT106    VIS1    TRT   Asian                                                                                               
  422  PT106    VIS2    TRT   Asian                                                                                               
  423  PT106    VIS3    TRT   Asian                                                                                               
  424  PT106    VIS4    TRT   Asian                                                                                               
  425  PT107    VIS1    PBO   White                                                                                               
  426  PT107    VIS2    PBO   White                                                                                               
  427  PT107    VIS3    PBO   White                                                                                               
  428  PT107    VIS4    PBO   White                                                                                               
  429  PT108    VIS1    TRT   White                                                                                               
  430  PT108    VIS2    TRT   White                                                                                               
  431  PT108    VIS3    TRT   White                                                                                               
  432  PT108    VIS4    TRT   White                                                                                               
  433  PT109    VIS1    PBO   Black or African American                                                                           
  434  PT109    VIS2    PBO   Black or African American                                                                           
  435  PT109    VIS3    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  421 Female    44.310465081    29.225909995    0.7715113647               1    1.4350695723    34.8780    0.86864    526     0.05
  422 Female    44.310465081    40.081749147    0.3138964275               2    -0.710371146    39.6754    0.71627    526     0.05
  423 Female    44.310465081     45.68141624    0.2560808755               3    -0.065067574    44.5263    0.62966    526     0.05
  424 Female    44.310465081    41.474030249     0.301040126               4    -1.759468735    50.5558    1.26066    526     0.05
  425 Female    41.464612305               .    0.4113063261               1    0.5697229718    36.7471    0.93146    526     0.05
  426 Female    41.464612305               .    0.7748796843               2    1.6123467982    41.5867    0.81945    526     0.05
  427 Female    41.464612305    42.519702198     0.884477945               3    -1.637280647    47.0893    0.71124    526     0.05
  428 Female    41.464612305    69.360987138    0.3450557554               4    -0.779568513    51.8008    1.30442    526     0.05
  429 Male      50.997042806    42.397601226    0.3163334224               1    -0.641176934    40.1955    0.89869    526     0.05
  430 Male      50.997042806    43.723762652    0.5983500777               2    -0.681131394    44.9928    0.77940    526     0.05
  431 Male      50.997042806    49.476013002     0.599081441               3    -2.033285596    49.8437    0.70210    526     0.05
  432 Male      50.997042806    51.941884446     0.144632175               4    0.5009635592    55.8732    1.28130    526     0.05
  433 Female    42.262212224               .    0.6963737682               1     -1.53179814    32.6341    0.85598    526     0.05
  434 Female    42.262212224    40.591001862    0.3486706894               2    -0.024997639    37.4737    0.74083    526     0.05
  435 Female    42.262212224    39.978332399    0.1340131456               3     0.592984721    42.9762    0.63127    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  421 33.1716    36.5845     -5.6521    -0.88759     4.5895    -0.89596    -0.88759
  422 38.2683    41.0825      0.4064     0.52098     6.4127     0.07961     0.07884
  423 43.2893    45.7632      1.1551     0.45950    10.7823     0.30335     0.29928
  424 48.0792    53.0323     -9.0818    -0.77884     3.2057    -0.93689    -0.92907
  425 34.9173    38.5769       .          .           .          .           .     
  426 39.9769    43.1965       .          .           .          .           .     
  427 45.6921    48.4865     -4.5696    -1.18393    11.0164    -1.20456    -1.18393
  428 49.2383    54.3633     17.5602     1.82523     6.8343     1.81263     1.79642
  429 38.4300    41.9609      2.2021     0.34582     6.6580     0.34931     0.34582
  430 43.4617    46.5239     -1.2690    -0.44276     6.1893    -0.24906    -0.24620
  431 48.4644    51.2230     -0.3677    -0.14323    11.3727    -0.09688    -0.09527
  432 53.3561    58.3903     -3.9313    -0.46500     3.8767    -0.40568    -0.40218
  433 30.9525    34.3156       .          .           .          .           .     
  434 36.0184    38.9290      3.1173     0.60477     7.8748     0.61111     0.60477
  435 41.7361    44.2164     -2.9979    -0.86995     9.3476    -0.78733    -0.77673
                                                           The SAS System                        16:52 Thursday, January 5, 2023  33

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  436  PT109    VIS4    PBO   Black or African American                                                                           
  437  PT110    VIS1    TRT   Asian                                                                                               
  438  PT110    VIS2    TRT   Asian                                                                                               
  439  PT110    VIS3    TRT   Asian                                                                                               
  440  PT110    VIS4    TRT   Asian                                                                                               
  441  PT111    VIS1    PBO   White                                                                                               
  442  PT111    VIS2    PBO   White                                                                                               
  443  PT111    VIS3    PBO   White                                                                                               
  444  PT111    VIS4    PBO   White                                                                                               
  445  PT112    VIS1    PBO   Black or African American                                                                           
  446  PT112    VIS2    PBO   Black or African American                                                                           
  447  PT112    VIS3    PBO   Black or African American                                                                           
  448  PT112    VIS4    PBO   Black or African American                                                                           
  449  PT113    VIS1    PBO   Asian                                                                                               
  450  PT113    VIS2    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  436 Female    42.262212224    31.690491427    0.5538420347               4    -0.198195421    47.6878    1.25995    526     0.05
  437 Male      34.166269966               .    0.1131166263               1    0.8920083925    34.5519    0.89709    526     0.05
  438 Male      34.166269966    37.205173236    0.8006922355               2    -0.025715071    39.3492    0.76415    526     0.05
  439 Male      34.166269966    46.287395636    0.5219868351               3    -0.647660451    44.2001    0.69465    526     0.05
  440 Male      34.166269966               .    0.1875650849               4     0.646359415    50.2296    1.28428    526     0.05
  441 Female    37.007722535               .     0.745803226               1     -0.43383274    36.7471    0.93146    526     0.05
  442 Female    37.007722535               .     0.747261795               2     1.772611185    41.5867    0.81945    526     0.05
  443 Female    37.007722535               .     0.108807501               3    -0.018259711    47.0893    0.71124    526     0.05
  444 Female    37.007722535    41.587204769    0.6467258405               4    0.8528149936    51.8008    1.30442    526     0.05
  445 Female    40.256688303    32.173647252    0.4522457954               1    0.2051629032    32.6341    0.85598    526     0.05
  446 Female    40.256688303               .    0.8224680828               2    -3.008048599    37.4737    0.74083    526     0.05
  447 Female    40.256688303    40.693753874    0.4152390437               3    -1.366111931    42.9762    0.63127    526     0.05
  448 Female    40.256688303               .    0.1034034293               4     -0.42410226    47.6878    1.25995    526     0.05
  449 Male      41.880398355    32.287706643    0.8707039833               1    0.2368036637    30.7774    0.88653    526     0.05
  450 Male      41.880398355    41.762051891     0.873548194               2     -2.34272312    35.6170    0.76366    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  436 45.2126    50.1629    -15.9973    -1.74287     2.0665    -1.65030    -1.63653
  437 32.7896    36.3142       .          .           .          .           .     
  438 37.8480    40.8504     -2.1440    -0.41595     7.2179    -0.42060    -0.41595
  439 42.8355    45.5648      2.0873     0.60497    11.0914     0.54976     0.54079
  440 47.7067    52.7526       .          .           .          .           .     
  441 34.9173    38.5769       .          .           .          .           .     
  442 39.9769    43.1965       .          .           .          .           .     
  443 45.6921    48.4865       .          .           .          .           .     
  444 49.2383    54.3633    -10.2136    -1.04486     4.2544    -1.05429    -1.04486
  445 30.9525    34.3156     -0.4604    -0.07230     5.0524    -0.07296    -0.07230
  446 36.0184    38.9290       .          .           .          .           .     
  447 41.7361    44.2164     -2.2825    -0.58892     9.7220    -0.59944    -0.59137
  448 45.2126    50.1629       .          .           .          .           .     
  449 29.0358    32.5189      1.5104     0.23718     5.0703     0.23951     0.23718
  450 34.1168    37.1172      6.1451     1.21083     6.5407     1.20547     1.19216
                                                           The SAS System                        16:52 Thursday, January 5, 2023  34

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  451  PT113    VIS3    PBO   Asian                                                                                               
  452  PT113    VIS4    PBO   Asian                                                                                               
  453  PT114    VIS1    PBO   Black or African American                                                                           
  454  PT114    VIS2    PBO   Black or African American                                                                           
  455  PT114    VIS3    PBO   Black or African American                                                                           
  456  PT114    VIS4    PBO   Black or African American                                                                           
  457  PT115    VIS1    PBO   Asian                                                                                               
  458  PT115    VIS2    PBO   Asian                                                                                               
  459  PT115    VIS3    PBO   Asian                                                                                               
  460  PT115    VIS4    PBO   Asian                                                                                               
  461  PT116    VIS1    TRT   Black or African American                                                                           
  462  PT116    VIS2    TRT   Black or African American                                                                           
  463  PT116    VIS3    TRT   Black or African American                                                                           
  464  PT116    VIS4    TRT   Black or African American                                                                           
  465  PT117    VIS1    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  451 Male      41.880398355    40.067675009    0.6994347693               3    0.9616966334    41.1195    0.64540    526     0.05
  452 Male      41.880398355               .    0.4200331116               4    -0.604425734    45.8311    1.27598    526     0.05
  453 Male      40.209544417    29.142127866    0.4336852638               1    -0.752877279    32.3079    0.85058    526     0.05
  454 Male      40.209544417    39.509887552    0.7580932161               2    -1.555611593    37.1475    0.72572    526     0.05
  455 Male      40.209544417    43.323491235    0.5038879933               3    -1.453893738    42.6501    0.61298    526     0.05
  456 Male      40.209544417    47.167558567    0.6570055664               4    0.0563318361    47.3616    1.25303    526     0.05
  457 Female    41.063220567    40.930200746    0.8499996375               1    0.5093694067    31.1035    0.85562    526     0.05
  458 Female    41.063220567    42.194059566    0.3047771621               2     -2.09788296    35.9432    0.73638    526     0.05
  459 Female    41.063220567    41.210574158     0.524643443               3    -1.004361979    41.4457    0.61338    526     0.05
  460 Female    41.063220567               .    0.1735217895               4    0.5357717223    46.1572    1.25796    526     0.05
  461 Male      29.829308889    38.543302397    0.5250079878               1    -0.453037085    36.0824    0.89390    526     0.05
  462 Male      29.829308889               .    0.8395318298               2    2.1653685018    40.8798    0.77131    526     0.05
  463 Male      29.829308889    43.963239237    0.2743303731               3    1.2457466727    45.7307    0.72203    526     0.05
  464 Male      29.829308889    42.676516472     0.788868906               4    0.5954980341    51.7602    1.27393    526     0.05
  465 Male      49.233903488    22.795835641    0.5529133879               1    0.0048844495    32.3079    0.85058    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  451 39.8516    42.3874     -1.0519    -0.39844     9.1876    -0.27642    -0.27253
  452 43.3244    48.3377       .          .           .          .           .     
  453 30.6370    33.9789     -3.1658    -0.49714     4.5764    -0.50164    -0.49714
  454 35.7219    38.5732      2.3623     0.75265     6.2957     0.46291     0.45830
  455 41.4459    43.8543      0.6734     0.23751    10.1670     0.17672     0.17447
  456 44.9001    49.8232     -0.1941     0.04839     3.7987    -0.02002    -0.01985
  457 29.4227    32.7844      9.8267     1.54315     6.4275     1.55727     1.54315
  458 34.4965    37.3898      6.2509     0.59622     5.9715     1.22527     1.21270
  459 40.2407    42.6507     -0.2351    -0.41652     9.2427    -0.06170    -0.06092
  460 43.6860    48.6285       .          .           .          .           .     
  461 34.3264    37.8385      2.4609     0.38645     6.0527     0.39031     0.38645
  462 39.3645    42.3950       .          .           .          .           .     
  463 44.3123    47.1491     -1.7674    -0.54747    10.3802    -0.46616    -0.45793
  464 49.2576    54.2628     -9.0837    -1.04792     3.3520    -0.93726    -0.92926
  465 30.6370    33.9789     -9.5121    -1.49374     3.5798    -1.50725    -1.49374
                                                           The SAS System                        16:52 Thursday, January 5, 2023  35

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  466  PT117    VIS2    PBO   Black or African American                                                                           
  467  PT117    VIS3    PBO   Black or African American                                                                           
  468  PT117    VIS4    PBO   Black or African American                                                                           
  469  PT118    VIS1    PBO   Asian                                                                                               
  470  PT118    VIS2    PBO   Asian                                                                                               
  471  PT118    VIS3    PBO   Asian                                                                                               
  472  PT118    VIS4    PBO   Asian                                                                                               
  473  PT119    VIS1    TRT   White                                                                                               
  474  PT119    VIS2    TRT   White                                                                                               
  475  PT119    VIS3    TRT   White                                                                                               
  476  PT119    VIS4    TRT   White                                                                                               
  477  PT120    VIS1    PBO   Asian                                                                                               
  478  PT120    VIS2    PBO   Asian                                                                                               
  479  PT120    VIS3    PBO   Asian                                                                                               
  480  PT120    VIS4    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  466 Male      49.233903488               .     0.417984846               2    0.2793607821    37.1475    0.72572    526     0.05
  467 Male      49.233903488               .    0.5836962275               3    -0.705906125    42.6501    0.61298    526     0.05
  468 Male      49.233903488               .    0.4011023493               4     0.628017153    47.3616    1.25303    526     0.05
  469 Female    35.315541583    31.435589536    0.7507812683               1    1.4802139601    31.1035    0.85562    526     0.05
  470 Female    35.315541583    38.850636263    0.3338311851               2    1.0834299101    35.9432    0.73638    526     0.05
  471 Female    35.315541583    48.242880925    0.3559457714               3    -0.813244257    41.4457    0.61338    526     0.05
  472 Female    35.315541583               .    0.4335960688               4    -1.618876849    46.1572    1.25796    526     0.05
  473 Male      48.695792095    44.713024438    0.7207092866               1    -0.109655699    40.1955    0.89869    526     0.05
  474 Male      48.695792095    51.853703176     0.612409672               2    0.4408893709    44.9928    0.77940    526     0.05
  475 Male      48.695792095               .    0.3084177544               3    1.3509939798    49.8437    0.70210    526     0.05
  476 Male      48.695792095               .    0.3501463152               4    -1.318609485    55.8732    1.28130    526     0.05
  477 Female    53.248494323    30.567569062    0.6879124193               1    0.3643845926    31.1035    0.85562    526     0.05
  478 Female    53.248494323               .    0.7205283258               2    0.2334998351    35.9432    0.73638    526     0.05
  479 Female    53.248494323               .    0.5784484079               3    1.1939552613    41.4457    0.61338    526     0.05
  480 Female    53.248494323               .    0.1932855669               4    -0.027909972    46.1572    1.25796    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  466 35.7219    38.5732       .          .           .          .           .     
  467 41.4459    43.8543       .          .           .          .           .     
  468 44.9001    49.8232       .          .           .          .           .     
  469 29.4227    32.7844      0.3321     0.05215     4.9365     0.05263     0.05215
  470 34.4965    37.3898      2.9075     0.60222     5.9775     0.56991     0.56406
  471 40.2407    42.6507      6.7972     1.75545    11.4147     1.78375     1.76108
  472 43.6860    48.6285       .          .           .          .           .     
  473 38.4300    41.9609      4.5176     0.70942     7.0216     0.71659     0.70942
  474 43.4617    46.5239      6.8609     1.13487     7.7669     1.34653     1.33104
  475 48.4644    51.2230       .          .           .          .           .     
  476 53.3561    58.3903       .          .           .          .           .     
  477 29.4227    32.7844     -0.5359    -0.08416     4.8002    -0.08493    -0.08416
  478 34.4965    37.3898       .          .           .          .           .     
  479 40.2407    42.6507       .          .           .          .           .     
  480 43.6860    48.6285       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  36

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  481  PT121    VIS1    TRT   Black or African American                                                                           
  482  PT121    VIS2    TRT   Black or African American                                                                           
  483  PT121    VIS3    TRT   Black or African American                                                                           
  484  PT121    VIS4    TRT   Black or African American                                                                           
  485  PT122    VIS1    PBO   Asian                                                                                               
  486  PT122    VIS2    PBO   Asian                                                                                               
  487  PT122    VIS3    PBO   Asian                                                                                               
  488  PT122    VIS4    PBO   Asian                                                                                               
  489  PT123    VIS1    PBO   White                                                                                               
  490  PT123    VIS2    PBO   White                                                                                               
  491  PT123    VIS3    PBO   White                                                                                               
  492  PT123    VIS4    PBO   White                                                                                               
  493  PT124    VIS1    TRT   Asian                                                                                               
  494  PT124    VIS2    TRT   Asian                                                                                               
  495  PT124    VIS3    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  481 Male      30.335696305               .    0.2935519826               1    -0.357298855    36.0824    0.89390    526     0.05
  482 Male      30.335696305               .    0.3114775918               2    -1.146814136    40.8798    0.77131    526     0.05
  483 Male      30.335696305               .    0.3281765494               3    -0.517420484    45.7307    0.72203    526     0.05
  484 Male      30.335696305    59.904725735    0.5270576445               4    -0.362123773    51.7602    1.27393    526     0.05
  485 Female    39.726788231               .    0.4175154943               1    2.3505543258    31.1035    0.85562    526     0.05
  486 Female    39.726788231               .    0.6153126735               2    2.4465313757    35.9432    0.73638    526     0.05
  487 Female    39.726788231    49.761503667    0.2149523126               3    -0.166703279    41.4457    0.61338    526     0.05
  488 Female    39.726788231               .    0.7930123126               4    -1.043667439    46.1572    1.25796    526     0.05
  489 Female     38.45244607    47.219851148    0.4661159409               1    -1.972934934    36.7471    0.93146    526     0.05
  490 Female     38.45244607    40.345250047    0.8196187196               2    0.5146716334    41.5867    0.81945    526     0.05
  491 Female     38.45244607    48.297927833    0.7237418193               3    -1.090573584    47.0893    0.71124    526     0.05
  492 Female     38.45244607               .    0.7524373984               4    2.2846593255    51.8008    1.30442    526     0.05
  493 Female    60.239006639               .    0.8975972332               1    -0.885617573    34.8780    0.86864    526     0.05
  494 Female    60.239006639    44.396339557    0.5718397625               2    0.1111064297    39.6754    0.71627    526     0.05
  495 Female    60.239006639     41.71421115    0.4732433211               3    3.8102766807    44.5263    0.62966    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  481 34.3264    37.8385       .          .           .          .           .     
  482 39.3645    42.3950       .          .           .          .           .     
  483 44.3123    47.1491       .          .           .          .           .     
  484 49.2576    54.2628      8.1445     0.83319     6.1283     0.84036     0.83319
  485 29.4227    32.7844       .          .           .          .           .     
  486 34.4965    37.3898       .          .           .          .           .     
  487 40.2407    42.6507      8.3158     2.15454    12.8927     2.18228     2.15454
  488 43.6860    48.6285       .          .           .          .           .     
  489 34.9173    38.5769     10.4728     1.64460     7.4152     1.66248     1.64460
  490 39.9769    43.1965     -1.2415    -1.07077     5.0903    -0.24395    -0.24085
  491 45.6921    48.4865      1.2087     0.04226    10.9678     0.31861     0.31315
  492 49.2383    54.3633       .          .           .          .           .     
  493 33.1716    36.5845       .          .           .          .           .     
  494 38.2683    41.0825      4.7210     0.91589     8.6131     0.92486     0.91589
  495 43.2893    45.7632     -2.8121    -0.86532     9.6975    -0.73847    -0.72858
                                                           The SAS System                        16:52 Thursday, January 5, 2023  37

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  496  PT124    VIS4    TRT   Asian                                                                                               
  497  PT125    VIS1    PBO   White                                                                                               
  498  PT125    VIS2    PBO   White                                                                                               
  499  PT125    VIS3    PBO   White                                                                                               
  500  PT125    VIS4    PBO   White                                                                                               
  501  PT126    VIS1    TRT   Asian                                                                                               
  502  PT126    VIS2    TRT   Asian                                                                                               
  503  PT126    VIS3    TRT   Asian                                                                                               
  504  PT126    VIS4    TRT   Asian                                                                                               
  505  PT127    VIS1    TRT   Black or African American                                                                           
  506  PT127    VIS2    TRT   Black or African American                                                                           
  507  PT127    VIS3    TRT   Black or African American                                                                           
  508  PT127    VIS4    TRT   Black or African American                                                                           
  509  PT128    VIS1    TRT   Asian                                                                                               
  510  PT128    VIS2    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  496 Female    60.239006639    47.375349609    0.3647900168               4    -1.108909998    50.5558    1.26066    526     0.05
  497 Male      42.331105096    42.037970091    0.6653043864               1    0.3075666244    36.4209    0.93528    526     0.05
  498 Male      42.331105096      37.5610027    0.7059032962               2    -1.106894472    41.2606    0.81589    526     0.05
  499 Male      42.331105096    45.117927565    0.7193866694               3    0.3476536488    46.7631    0.70671    526     0.05
  500 Male      42.331105096               .     0.797009776               4    -0.873264535    51.4747    1.30402    526     0.05
  501 Male      35.582185154    34.625295643    0.2674810445               1    0.0773031227    34.5519    0.89709    526     0.05
  502 Male      35.582185154    45.282062635     0.712990582               2    -0.296868642    39.3492    0.76415    526     0.05
  503 Male      35.582185154               .    0.7732924491               3     -1.18324224    44.2001    0.69465    526     0.05
  504 Male      35.582185154    63.577605472    0.8473010343               4    0.0112926884    50.2296    1.28428    526     0.05
  505 Female    43.567679828    35.808780258    0.6406591097               1    0.9916010361    36.4086    0.90106    526     0.05
  506 Female    43.567679828               .    0.7871668009               2    1.5939674539    41.2059    0.76623    526     0.05
  507 Female    43.567679828               .    0.1606003361               3    -1.372711271    46.0568    0.70592    526     0.05
  508 Female    43.567679828    52.673135042    0.6083979685               4    -0.249610933    52.0863    1.27509    526     0.05
  509 Female    46.259935036    35.887340129     0.416309863               1    1.1594245269    34.8780    0.86864    526     0.05
  510 Female    46.259935036    38.732221712    0.6981816463               2    -1.114222348    39.6754    0.71627    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  496 48.0792    53.0323     -3.1804    -0.46372     3.5771    -0.32810    -0.32536
  497 34.5836    38.2583      5.6170     0.88208     6.6015     0.89175     0.88208
  498 39.6578    42.8634     -3.6996    -1.22923     4.8864    -0.72690    -0.71773
  499 45.3748    48.1514     -1.6452    -0.54695    10.3054    -0.43358    -0.42625
  500 48.9129    54.0364       .          .           .          .           .     
  501 32.7896    36.3142      0.0734     0.01153     5.4374     0.01165     0.01153
  502 37.8480    40.8504      5.9329     1.27517     7.1215     1.16386     1.15100
  503 42.8355    45.5648       .          .           .          .           .     
  504 47.7067    52.7526     13.3480     1.31940     5.0333     1.37745     1.36551
  505 34.6385    38.1787     -0.5998    -0.09419     5.6233    -0.09515    -0.09419
  506 39.7007    42.7112       .          .           .          .           .     
  507 44.6701    47.4436       .          .           .          .           .     
  508 49.5814    54.5912      0.5868     0.08218     4.2804     0.06055     0.06003
  509 33.1716    36.5845      1.0093     0.15850     5.6356     0.15999     0.15850
  510 38.2683    41.0825     -0.9431    -0.28097     5.6107    -0.18477    -0.18297
                                                           The SAS System                        16:52 Thursday, January 5, 2023  38

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  511  PT128    VIS3    TRT   Asian                                                                                               
  512  PT128    VIS4    TRT   Asian                                                                                               
  513  PT129    VIS1    TRT   White                                                                                               
  514  PT129    VIS2    TRT   White                                                                                               
  515  PT129    VIS3    TRT   White                                                                                               
  516  PT129    VIS4    TRT   White                                                                                               
  517  PT130    VIS1    PBO   White                                                                                               
  518  PT130    VIS2    PBO   White                                                                                               
  519  PT130    VIS3    PBO   White                                                                                               
  520  PT130    VIS4    PBO   White                                                                                               
  521  PT131    VIS1    PBO   Asian                                                                                               
  522  PT131    VIS2    PBO   Asian                                                                                               
  523  PT131    VIS3    PBO   Asian                                                                                               
  524  PT131    VIS4    PBO   Asian                                                                                               
  525  PT132    VIS1    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  511 Female    46.259935036    46.703612948     0.691590769               3    -2.528500689    44.5263    0.62966    526     0.05
  512 Female    46.259935036    53.653978531    0.3973725559               4    -0.935902559    50.5558    1.26066    526     0.05
  513 Male       29.29119059    36.715434003    0.3712506013               1    -0.967239458    40.1955    0.89869    526     0.05
  514 Male       29.29119059               .    0.6382426787               2    0.0474885923    44.9928    0.77940    526     0.05
  515 Male       29.29119059               .     0.358328329               3    -0.403736793    49.8437    0.70210    526     0.05
  516 Male       29.29119059               .    0.6472893724               4    0.2314961282    55.8732    1.28130    526     0.05
  517 Male      51.717294784               .    0.2712290714               1    -0.422372408    36.4209    0.93528    526     0.05
  518 Male      51.717294784    41.543170228    0.2971716022               2    0.3741183947    41.2606    0.81589    526     0.05
  519 Male      51.717294784    51.679090849    0.1986576321               3    -0.366005775    46.7631    0.70671    526     0.05
  520 Male      51.717294784               .    0.7283097483               4    1.1901014465    51.4747    1.30402    526     0.05
  521 Female    35.719789663    27.401304422    0.7091390382               1    -0.737327525    31.1035    0.85562    526     0.05
  522 Female    35.719789663    30.335168668    0.2569599641               2    0.2906666454    35.9432    0.73638    526     0.05
  523 Female    35.719789663    37.730920936    0.8180239145               3    -0.884849568    41.4457    0.61338    526     0.05
  524 Female    35.719789663    29.116682507    0.5763214841               4    0.2080064789    46.1572    1.25796    526     0.05
  525 Male      50.537229891               .    0.4544683563               1    -0.047730172    30.7774    0.88653    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  511 43.2893    45.7632      2.1773     0.56059    10.8834     0.57178     0.56412
  512 48.0792    53.0323      3.0982     0.32123     4.3058     0.31962     0.31695
  513 38.4300    41.9609     -3.4800    -0.54649     5.7657    -0.55201    -0.54649
  514 43.4617    46.5239       .          .           .          .           .     
  515 48.4644    51.2230       .          .           .          .           .     
  516 53.3561    58.3903       .          .           .          .           .     
  517 34.5836    38.2583       .          .           .          .           .     
  518 39.6578    42.8634      0.2826     0.05482     8.0595     0.05552     0.05482
  519 45.3748    48.1514      4.9160     1.27859    12.3832     1.29558     1.27368
  520 48.9129    54.0364       .          .           .          .           .     
  521 29.4227    32.7844     -3.7022    -0.58138     4.3030    -0.58670    -0.58138
  522 34.4965    37.3898     -5.6080    -0.92688     4.4484    -1.09925    -1.08797
  523 40.2407    42.6507     -3.7148    -0.81008     8.8491    -0.97485    -0.96246
  524 43.6860    48.6285    -17.0406    -1.62292     2.0465    -1.75788    -1.74326
  525 29.0358    32.5189       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  39

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  526  PT132    VIS2    PBO   Asian                                                                                               
  527  PT132    VIS3    PBO   Asian                                                                                               
  528  PT132    VIS4    PBO   Asian                                                                                               
  529  PT133    VIS1    PBO   White                                                                                               
  530  PT133    VIS2    PBO   White                                                                                               
  531  PT133    VIS3    PBO   White                                                                                               
  532  PT133    VIS4    PBO   White                                                                                               
  533  PT134    VIS1    PBO   Black or African American                                                                           
  534  PT134    VIS2    PBO   Black or African American                                                                           
  535  PT134    VIS3    PBO   Black or African American                                                                           
  536  PT134    VIS4    PBO   Black or African American                                                                           
  537  PT135    VIS1    PBO   Black or African American                                                                           
  538  PT135    VIS2    PBO   Black or African American                                                                           
  539  PT135    VIS3    PBO   Black or African American                                                                           
  540  PT135    VIS4    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  526 Male      50.537229891    32.088295356    0.3391362362               2    -1.684520646    35.6170    0.76366    526     0.05
  527 Male      50.537229891    41.660670405     0.342613125               3    -0.144226557    41.1195    0.64540    526     0.05
  528 Male      50.537229891    53.908153331    0.5589785654               4    1.1802136655    45.8311    1.27598    526     0.05
  529 Male      44.399431431               .    0.8447586689               1    0.6813999232    36.4209    0.93528    526     0.05
  530 Male      44.399431431    35.069371205    0.7476395493               2    0.1432476309    41.2606    0.81589    526     0.05
  531 Male      44.399431431    47.176146957    0.4483368471               3    -1.192316444    46.7631    0.70671    526     0.05
  532 Male      44.399431431     56.49347176      0.38481462               4    1.1692286528    51.4747    1.30402    526     0.05
  533 Male       41.73307334               .    0.5133077858               1    0.0792017089    32.3079    0.85058    526     0.05
  534 Male       41.73307334    38.880060226    0.6218274815               2    -0.451773753    37.1475    0.72572    526     0.05
  535 Male       41.73307334    47.540701181    0.6483730331               3    1.6420282128    42.6501    0.61298    526     0.05
  536 Male       41.73307334     43.53704952    0.7585478347               4    -0.769592322    47.3616    1.25303    526     0.05
  537 Male      40.666683598     31.82054002    0.1951798543               1    0.3033609608    32.3079    0.85058    526     0.05
  538 Male      40.666683598    39.628156371    0.8322863601               2    1.2817374212    37.1475    0.72572    526     0.05
  539 Male      40.666683598    44.955431666    0.3027852708               3    0.6022227952    42.6501    0.61298    526     0.05
  540 Male      40.666683598    21.115430799    0.4248988645               4    -0.307022265    47.3616    1.25303    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  526 34.1168    37.1172     -3.5287    -0.68458     6.2253    -0.69222    -0.68458
  527 39.8516    42.3874      0.5411     0.23838    10.0211     0.14221     0.14020
  528 43.3244    48.3377      8.0771     0.93754     4.6103     0.83342     0.82629
  529 34.5836    38.2583       .          .           .          .           .     
  530 39.6578    42.8634     -6.1912    -1.20112     6.8036    -1.21645    -1.20112
  531 45.3748    48.1514      0.4130     0.27789    11.3825     0.10885     0.10701
  532 48.9129    54.0364      5.0188     0.69858     4.7866     0.51806     0.51343
  533 30.6370    33.9789       .          .           .          .           .     
  534 35.7219    38.5732      1.7325     0.33611     7.5429     0.33950     0.33611
  535 41.4459    43.8543      4.8906     1.23219    11.3734     1.28340     1.26711
  536 44.9001    49.8232     -3.8246    -0.45002     3.3354    -0.39451    -0.39126
  537 30.6370    33.9789     -0.4874    -0.07653     4.9970    -0.07723    -0.07653
  538 35.7219    38.5732      2.4806     0.57288     6.1159     0.48609     0.48125
  539 41.4459    43.8543      2.3054     0.59340    10.5229     0.60497     0.59729
  540 44.9001    49.8232    -26.2462    -2.75950     0.9908    -2.70734    -2.68500
                                                           The SAS System                        16:52 Thursday, January 5, 2023  40

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  541  PT136    VIS1    TRT   White                                                                                               
  542  PT136    VIS2    TRT   White                                                                                               
  543  PT136    VIS3    TRT   White                                                                                               
  544  PT136    VIS4    TRT   White                                                                                               
  545  PT137    VIS1    TRT   Asian                                                                                               
  546  PT137    VIS2    TRT   Asian                                                                                               
  547  PT137    VIS3    TRT   Asian                                                                                               
  548  PT137    VIS4    TRT   Asian                                                                                               
  549  PT138    VIS1    TRT   Asian                                                                                               
  550  PT138    VIS2    TRT   Asian                                                                                               
  551  PT138    VIS3    TRT   Asian                                                                                               
  552  PT138    VIS4    TRT   Asian                                                                                               
  553  PT139    VIS1    TRT   Asian                                                                                               
  554  PT139    VIS2    TRT   Asian                                                                                               
  555  PT139    VIS3    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  541 Female    39.064786002    34.746713872    0.3102627149               1    -0.418418103    40.5216    0.89674    526     0.05
  542 Female    39.064786002               .    0.3560140539               2      0.35513553    45.3189    0.76375    526     0.05
  543 Female    39.064786002               .    0.2930808876               3    0.5134811146    50.1699    0.67350    526     0.05
  544 Female    39.064786002     56.69248543    0.5299581571               4    0.0186074003    56.1994    1.27606    526     0.05
  545 Female    31.377644674    22.731261449    0.6743837861               1    1.3184489723    34.8780    0.86864    526     0.05
  546 Female    31.377644674     32.50075458    0.5303139884               2       -0.065832    39.6754    0.71627    526     0.05
  547 Female    31.377644674    42.372055198    0.1138375578               3    -0.700296078    44.5263    0.62966    526     0.05
  548 Female    31.377644674    42.898473522     0.598362161               4    0.5373261315    50.5558    1.26066    526     0.05
  549 Male       46.14103795     55.62581723    0.5823351327               1    -2.201782322    34.5519    0.89709    526     0.05
  550 Male       46.14103795    45.389983114     0.711383274               2    0.3919737438    39.3492    0.76415    526     0.05
  551 Male       46.14103795    52.667429601    0.7994683793               3    0.4969609524    44.2001    0.69465    526     0.05
  552 Male       46.14103795               .    0.4547656061               4    -0.224874715    50.2296    1.28428    526     0.05
  553 Female    40.203936196               .    0.5047212752               1    -1.117143165    34.8780    0.86864    526     0.05
  554 Female    40.203936196               .    0.8126725445               2    -0.394994603    39.6754    0.71627    526     0.05
  555 Female    40.203936196    34.189306444    0.4020954825               3    1.5498303422    44.5263    0.62966    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  541 38.7600    42.2832     -5.7749    -0.90687     5.4565    -0.91600    -0.90687
  542 43.8186    46.8193       .          .           .          .           .     
  543 48.8468    51.4929       .          .           .          .           .     
  544 53.6926    58.7062      0.4931     0.25114     4.7381     0.05088     0.05045
  545 33.1716    36.5845    -12.1468    -1.90748     3.5696    -1.92548    -1.90748
  546 38.2683    41.0825     -7.1746    -0.61779     5.2739    -1.40554    -1.39190
  547 43.2893    45.7632     -2.1542    -0.14001    10.1828    -0.56572    -0.55814
  548 48.0792    53.0323     -7.6573    -0.34848     3.6361    -0.78994    -0.78335
  549 32.7896    36.3142     21.0739     3.30937     8.7353     3.34271     3.30937
  550 37.8480    40.8504      6.0408    -0.31126     5.5350     1.18503     1.17193
  551 42.8355    45.5648      8.4673     1.57699    11.8266     2.23021     2.19379
  552 47.7067    52.7526       .          .           .          .           .     
  553 33.1716    36.5845       .          .           .          .           .     
  554 38.2683    41.0825       .          .           .          .           .     
  555 43.2893    45.7632    -10.3370    -2.67821     8.8581    -2.71457    -2.67821
                                                           The SAS System                        16:52 Thursday, January 5, 2023  41

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  556  PT139    VIS4    TRT   Asian                                                                                               
  557  PT140    VIS1    PBO   Black or African American                                                                           
  558  PT140    VIS2    PBO   Black or African American                                                                           
  559  PT140    VIS3    PBO   Black or African American                                                                           
  560  PT140    VIS4    PBO   Black or African American                                                                           
  561  PT141    VIS1    TRT   White                                                                                               
  562  PT141    VIS2    TRT   White                                                                                               
  563  PT141    VIS3    TRT   White                                                                                               
  564  PT141    VIS4    TRT   White                                                                                               
  565  PT142    VIS1    TRT   Black or African American                                                                           
  566  PT142    VIS2    TRT   Black or African American                                                                           
  567  PT142    VIS3    TRT   Black or African American                                                                           
  568  PT142    VIS4    TRT   Black or African American                                                                           
  569  PT143    VIS1    TRT   Black or African American                                                                           
  570  PT143    VIS2    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  556 Female    40.203936196    45.597401628    0.3062421832               4     -0.74351448    50.5558    1.26066    526     0.05
  557 Female    37.649560312    28.891981993    0.2355892679               1    -2.331712118    32.6341    0.85598    526     0.05
  558 Female    37.649560312    38.461474229    0.1691324634               2    0.8122454422    37.4737    0.74083    526     0.05
  559 Female    37.649560312               .    0.6456327958               3    -0.501310657    42.9762    0.63127    526     0.05
  560 Female    37.649560312    49.903566961    0.3869567472               4    -0.510886566    47.6878    1.25995    526     0.05
  561 Male      29.861173465               .    0.1520241268               1    -1.215364041    40.1955    0.89869    526     0.05
  562 Male      29.861173465    44.141668419    0.1543199213               2    -0.022558628    44.9928    0.77940    526     0.05
  563 Male      29.861173465               .    0.5521960208               3    0.7012393004    49.8437    0.70210    526     0.05
  564 Male      29.861173465    55.242779968    0.6456647232               4    -0.587482026    55.8732    1.28130    526     0.05
  565 Male      50.859323663               .    0.2535311041               1    -0.606727941    36.0824    0.89390    526     0.05
  566 Male      50.859323663               .    0.3125065207               2     1.096640215    40.8798    0.77131    526     0.05
  567 Male      50.859323663               .    0.8555654401               3    -0.247509677    45.7307    0.72203    526     0.05
  568 Male      50.859323663               .    0.5157021796               4    -0.159901713    51.7602    1.27393    526     0.05
  569 Female    22.859362148    27.380009675    0.6928430172               1    -0.625778251    36.4086    0.90106    526     0.05
  570 Female    22.859362148    33.632505256    0.2772447322               2    0.9004346356    41.2059    0.76623    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  556 48.0792    53.0323     -4.9584    -0.44336     4.4542    -0.51152    -0.50725
  557 30.9525    34.3156     -3.7421    -0.58764     4.5371    -0.59302    -0.58764
  558 36.0184    38.9290      0.9878     0.50008     6.0885     0.19364     0.19163
  559 41.7361    44.2164       .          .           .          .           .     
  560 45.2126    50.1629      2.2158     0.33111     3.8606     0.22858     0.22668
  561 38.4300    41.9609       .          .           .          .           .     
  562 43.4617    46.5239     -0.8511    -0.16512     8.5637    -0.16704    -0.16512
  563 48.4644    51.2230       .          .           .          .           .     
  564 53.3561    58.3903     -0.6304    -0.04043     4.4293    -0.06505    -0.06449
  565 34.3264    37.8385       .          .           .          .           .     
  566 39.3645    42.3950       .          .           .          .           .     
  567 44.3123    47.1491       .          .           .          .           .     
  568 49.2576    54.2628       .          .           .          .           .     
  569 34.6385    38.1787     -9.0286    -1.41781     4.2997    -1.43222    -1.41781
  570 39.7007    42.7112     -7.5734    -0.94290     5.1619    -1.48578    -1.46927
                                                           The SAS System                        16:52 Thursday, January 5, 2023  42

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  571  PT143    VIS3    TRT   Black or African American                                                                           
  572  PT143    VIS4    TRT   Black or African American                                                                           
  573  PT144    VIS1    PBO   Asian                                                                                               
  574  PT144    VIS2    PBO   Asian                                                                                               
  575  PT144    VIS3    PBO   Asian                                                                                               
  576  PT144    VIS4    PBO   Asian                                                                                               
  577  PT145    VIS1    PBO   Black or African American                                                                           
  578  PT145    VIS2    PBO   Black or African American                                                                           
  579  PT145    VIS3    PBO   Black or African American                                                                           
  580  PT145    VIS4    PBO   Black or African American                                                                           
  581  PT146    VIS1    TRT   Asian                                                                                               
  582  PT146    VIS2    TRT   Asian                                                                                               
  583  PT146    VIS3    TRT   Asian                                                                                               
  584  PT146    VIS4    TRT   Asian                                                                                               
  585  PT147    VIS1    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  571 Female    22.859362148               .    0.6116739746               3    -0.994193629    46.0568    0.70592    526     0.05
  572 Female    22.859362148    39.344095119    0.6010438742               4    0.8492503859    52.0863    1.27509    526     0.05
  573 Female    43.960853015    26.985752843     0.532622125               1     0.805702289    31.1035    0.85562    526     0.05
  574 Female    43.960853015    24.041749967    0.2927148407               2    -0.467600936    35.9432    0.73638    526     0.05
  575 Female    43.960853015    42.166482121    0.2998025049               3    0.8484203137    41.4457    0.61338    526     0.05
  576 Female    43.960853015    44.753801826    0.4741948145               4    0.9867698636    46.1572    1.25796    526     0.05
  577 Male      56.023147312    31.554694982    0.7675967027               1    0.5756202885    32.3079    0.85058    526     0.05
  578 Male      56.023147312    44.426957648    0.2871362656               2    2.0248420454    37.1475    0.72572    526     0.05
  579 Male      56.023147312    44.103434093    0.7201091271               3    -1.962353191    42.6501    0.61298    526     0.05
  580 Male      56.023147312               .    0.5172903882               4    -1.164920931    47.3616    1.25303    526     0.05
  581 Female    39.594341681               .    0.3673772749               1    -1.376519214    34.8780    0.86864    526     0.05
  582 Female    39.594341681    37.874454282    0.7227710366               2    0.1676799345    39.6754    0.71627    526     0.05
  583 Female    39.594341681    48.318283028    0.2901094802               3    1.5846290792    44.5263    0.62966    526     0.05
  584 Female    39.594341681     50.21519948    0.3693820415               4     1.677888953    50.5558    1.26066    526     0.05
  585 Female    49.956502045    41.946151662    0.4396032711               1    0.4882966984    31.1035    0.85562    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  571 44.6701    47.4436       .          .           .          .           .     
  572 49.5814    54.5912    -12.7422    -0.96645     2.8621    -1.31477    -1.30354
  573 29.4227    32.7844     -4.1178    -0.64664     4.2377    -0.65255    -0.64664
  574 34.4965    37.3898    -11.9014    -2.25366     3.1217    -2.33285    -2.30892
  575 40.2407    42.6507      0.7208     0.45625    10.1155     0.18915     0.18675
  576 43.6860    48.6285     -1.4034     0.14572     3.8151    -0.14478    -0.14357
  577 30.6370    33.9789     -0.7532    -0.11828     4.9552    -0.11935    -0.11828
  578 35.7219    38.5732      7.2794     1.62923     7.1722     1.42644     1.41223
  579 41.4459    43.8543      1.4534     0.31468    10.2441     0.38139     0.37655
  580 44.9001    49.8232       .          .           .          .           .     
  581 33.1716    36.5845       .          .           .          .           .     
  582 38.2683    41.0825     -1.8009    -0.34938     7.3478    -0.35281    -0.34938
  583 43.2893    45.7632      3.7920     1.04163    11.6044     0.99581     0.98247
  584 48.0792    53.0323     -0.3406     0.01389     4.0548    -0.03514    -0.03484
  585 29.4227    32.7844     10.8426     1.70269     6.5871     1.71827     1.70269
                                                           The SAS System                        16:52 Thursday, January 5, 2023  43

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  586  PT147    VIS2    PBO   Asian                                                                                               
  587  PT147    VIS3    PBO   Asian                                                                                               
  588  PT147    VIS4    PBO   Asian                                                                                               
  589  PT148    VIS1    TRT   Black or African American                                                                           
  590  PT148    VIS2    TRT   Black or African American                                                                           
  591  PT148    VIS3    TRT   Black or African American                                                                           
  592  PT148    VIS4    TRT   Black or African American                                                                           
  593  PT149    VIS1    PBO   Asian                                                                                               
  594  PT149    VIS2    PBO   Asian                                                                                               
  595  PT149    VIS3    PBO   Asian                                                                                               
  596  PT149    VIS4    PBO   Asian                                                                                               
  597  PT150    VIS1    PBO   White                                                                                               
  598  PT150    VIS2    PBO   White                                                                                               
  599  PT150    VIS3    PBO   White                                                                                               
  600  PT150    VIS4    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  586 Female    49.956502045     39.62690071    0.6584950881               2    0.8786732626    35.9432    0.73638    526     0.05
  587 Female    49.956502045    46.697634075    0.6242975602               3    -0.144874874    41.4457    0.61338    526     0.05
  588 Female    49.956502045               .     0.677617274               4    0.4689717601    46.1572    1.25796    526     0.05
  589 Male       43.28537313               .    0.2312604148               1    0.3762354771    36.0824    0.89390    526     0.05
  590 Male       43.28537313    43.752547605    0.1405221678               2    -0.761040275    40.8798    0.77131    526     0.05
  591 Male       43.28537313     47.38873166    0.5583120586               3    -0.293294934    45.7307    0.72203    526     0.05
  592 Male       43.28537313               .    0.1913288863               4    -0.134841264    51.7602    1.27393    526     0.05
  593 Female    42.405682283    32.434119624    0.1126122644               1    1.3938458162    31.1035    0.85562    526     0.05
  594 Female    42.405682283    43.071625346     0.721795881               2     -1.03698869    35.9432    0.73638    526     0.05
  595 Female    42.405682283    42.995513212     0.313322608               3    -2.114335148    41.4457    0.61338    526     0.05
  596 Female    42.405682283    53.827587537    0.6441660281               4    0.7682782182    46.1572    1.25796    526     0.05
  597 Male      41.611736369               .    0.2776039908               1    -0.816160621    36.4209    0.93528    526     0.05
  598 Male      41.611736369               .    0.8793941246               2    -0.436106923    41.2606    0.81589    526     0.05
  599 Male      41.611736369    50.648022218     0.643029568               3    0.9047050313    46.7631    0.70671    526     0.05
  600 Male      41.611736369    63.440509706    0.7253027093               4    -0.763086265    51.4747    1.30402    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  586 34.4965    37.3898      3.6837    -0.03585     5.3395     0.72207     0.71466
  587 40.2407    42.6507      5.2519     1.04144    10.7006     1.37824     1.36072
  588 43.6860    48.6285       .          .           .          .           .     
  589 34.3264    37.8385       .          .           .          .           .     
  590 39.3645    42.3950      2.8728     0.55733     8.4882     0.56368     0.55733
  591 44.3123    47.1491      1.6580     0.35506    11.2000     0.43730     0.42958
  592 49.2576    54.2628       .          .           .          .           .     
  593 29.4227    32.7844      1.3306     0.20895     5.0933     0.21087     0.20895
  594 34.4965    37.3898      7.1285     1.43691     6.8122     1.39728     1.38295
  595 40.2407    42.6507      1.5498     0.28371     9.9429     0.40671     0.40154
  596 43.6860    48.6285      7.6703     0.67708     4.3465     0.79126     0.78468
  597 34.5836    38.2583       .          .           .          .           .     
  598 39.6578    42.8634       .          .           .          .           .     
  599 45.3748    48.1514      3.8849     1.00654    13.1224     1.02385     1.00654
  600 48.9129    54.0364     11.9658     1.20040     6.1781     1.23515     1.22411
                                                           The SAS System                        16:52 Thursday, January 5, 2023  44

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  601  PT151    VIS1    PBO   Asian                                                                                               
  602  PT151    VIS2    PBO   Asian                                                                                               
  603  PT151    VIS3    PBO   Asian                                                                                               
  604  PT151    VIS4    PBO   Asian                                                                                               
  605  PT152    VIS1    TRT   Asian                                                                                               
  606  PT152    VIS2    TRT   Asian                                                                                               
  607  PT152    VIS3    TRT   Asian                                                                                               
  608  PT152    VIS4    TRT   Asian                                                                                               
  609  PT153    VIS1    PBO   Black or African American                                                                           
  610  PT153    VIS2    PBO   Black or African American                                                                           
  611  PT153    VIS3    PBO   Black or African American                                                                           
  612  PT153    VIS4    PBO   Black or African American                                                                           
  613  PT154    VIS1    PBO   Black or African American                                                                           
  614  PT154    VIS2    PBO   Black or African American                                                                           
  615  PT154    VIS3    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  601 Female    50.605325775    34.489490276      0.65941045               1     -0.34106698    31.1035    0.85562    526     0.05
  602 Female    50.605325775    40.080562048     0.108325576               2    1.5024245342    35.9432    0.73638    526     0.05
  603 Female    50.605325775               .    0.5031256646               3    0.5283077123    41.4457    0.61338    526     0.05
  604 Female    50.605325775    47.465530183    0.6848473679               4    0.5421913555    46.1572    1.25796    526     0.05
  605 Female    41.799866574               .    0.3638224179               1    -0.136673356    34.8780    0.86864    526     0.05
  606 Female    41.799866574    37.116968426    0.7563993162               2    -1.136733853    39.6754    0.71627    526     0.05
  607 Female    41.799866574               .    0.8078649396               3    -1.496627154    44.5263    0.62966    526     0.05
  608 Female    41.799866574    36.251199442    0.7847775655               4    -0.223385644    50.5558    1.26066    526     0.05
  609 Male      37.316621041    29.201705264    0.4625955278               1    2.0017192278    32.3079    0.85058    526     0.05
  610 Male      37.316621041    31.537725138     0.476304342               2    0.2217038162    37.1475    0.72572    526     0.05
  611 Male      37.316621041    42.356827013    0.5121918378               3    0.1643729092    42.6501    0.61298    526     0.05
  612 Male      37.316621041    64.783524587    0.2310740603               4    0.3326236089    47.3616    1.25303    526     0.05
  613 Female    43.013754766    32.727572301    0.8071348075               1    -0.385207999    32.6341    0.85598    526     0.05
  614 Female    43.013754766    37.500220927    0.2605141932               2    -1.398754027    37.4737    0.74083    526     0.05
  615 Female    43.013754766               .    0.6076489605               3    2.6757407959    42.9762    0.63127    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  601 29.4227    32.7844      3.3860     0.53172     5.4161     0.53659     0.53172
  602 34.4965    37.3898      4.1374     0.63365     6.0090     0.81099     0.80267
  603 40.2407    42.6507       .          .           .          .           .     
  604 43.6860    48.6285      1.3083    -0.01909     3.4159     0.13496     0.13384
  605 33.1716    36.5845       .          .           .          .           .     
  606 38.2683    41.0825     -2.5584    -0.49634     7.2008    -0.50120    -0.49634
  607 43.2893    45.7632       .          .           .          .           .     
  608 48.0792    53.0323    -14.3046    -1.40526     2.6692    -1.47569    -1.46337
  609 30.6370    33.9789     -3.1062    -0.48779     4.5857    -0.49220    -0.48779
  610 35.7219    38.5732     -5.6098    -0.97296     4.5701    -1.09928    -1.08833
  611 41.4459    43.8543     -0.2933     0.07998    10.0094    -0.07696    -0.07598
  612 44.9001    49.8232     17.4219     1.99858     5.7489     1.79710     1.78227
  613 30.9525    34.3156      0.0935     0.01469     5.1394     0.01482     0.01469
  614 36.0184    38.9290      0.0265    -0.00144     5.5870     0.00520     0.00515
  615 41.7361    44.2164       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  45

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  616  PT154    VIS4    PBO   Black or African American                                                                           
  617  PT155    VIS1    TRT   Asian                                                                                               
  618  PT155    VIS2    TRT   Asian                                                                                               
  619  PT155    VIS3    TRT   Asian                                                                                               
  620  PT155    VIS4    TRT   Asian                                                                                               
  621  PT156    VIS1    PBO   White                                                                                               
  622  PT156    VIS2    PBO   White                                                                                               
  623  PT156    VIS3    PBO   White                                                                                               
  624  PT156    VIS4    PBO   White                                                                                               
  625  PT157    VIS1    TRT   Black or African American                                                                           
  626  PT157    VIS2    TRT   Black or African American                                                                           
  627  PT157    VIS3    TRT   Black or African American                                                                           
  628  PT157    VIS4    TRT   Black or African American                                                                           
  629  PT158    VIS1    TRT   Black or African American                                                                           
  630  PT158    VIS2    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  616 Female    43.013754766    57.038614852    0.1353991063               4    -0.423686089    47.6878    1.25995    526     0.05
  617 Male      45.220753959    36.324751219    0.3968402132               1    -0.298601512    34.5519    0.89709    526     0.05
  618 Male      45.220753959               .    0.5830664467               2    -1.792341727    39.3492    0.76415    526     0.05
  619 Male      45.220753959    41.467253135     0.862100105               3    -0.248008225    44.2001    0.69465    526     0.05
  620 Male      45.220753959    59.014108955    0.2718862941               4    -0.247303918    50.2296    1.28428    526     0.05
  621 Male      38.321849667    30.149703335    0.2434353588               1    -0.255510379    36.4209    0.93528    526     0.05
  622 Male      38.321849667    34.917399892    0.7935770174               2      -1.7869381    41.2606    0.81589    526     0.05
  623 Male      38.321849667    52.138999315    0.4720119247               3     1.784662816    46.7631    0.70671    526     0.05
  624 Male      38.321849667    58.738392884     0.281557945               4    1.7635863477    51.4747    1.30402    526     0.05
  625 Male       44.79605932    35.831845084    0.8253052091               1    0.6896002219    36.0824    0.89390    526     0.05
  626 Male       44.79605932               .    0.8776743021               2    -1.100740644    40.8798    0.77131    526     0.05
  627 Male       44.79605932               .    0.8666040316               3    0.7145093569    45.7307    0.72203    526     0.05
  628 Male       44.79605932    56.414090905    0.5381546557               4    -0.246470317    51.7602    1.27393    526     0.05
  629 Male        54.6073631               .    0.8877710968               1    -0.319786166    36.0824    0.89390    526     0.05
  630 Male        54.6073631    43.555932987    0.3788180798               2     1.362644293    40.8798    0.77131    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  616 45.2126    50.1629      9.3508     0.97819     4.5077     0.96464     0.95660
  617 32.7896    36.3142      1.7729     0.27841     5.7043     0.28121     0.27841
  618 37.8480    40.8504       .          .           .          .           .     
  619 42.8355    45.5648     -2.7329    -0.78056     9.7919    -0.71982    -0.70806
  620 47.7067    52.7526      8.7845     0.84310     5.1283     0.90652     0.89866
  621 34.5836    38.2583     -6.2712    -0.98481     4.7346    -0.99561    -0.98481
  622 39.6578    42.8634     -6.3432    -0.88867     5.2270    -1.24631    -1.23060
  623 45.3748    48.1514      5.3759     1.68036    12.5327     1.41679     1.39284
  624 48.9129    54.0364      7.2637     1.07523     5.1017     0.74979     0.74308
  625 34.3264    37.8385     -0.2506    -0.03935     5.6269    -0.03974    -0.03935
  626 39.3645    42.3950       .          .           .          .           .     
  627 44.3123    47.1491       .          .           .          .           .     
  628 49.2576    54.2628      4.6539     0.49614     4.6714     0.48019     0.47610
  629 34.3264    37.8385       .          .           .          .           .     
  630 39.3645    42.3950      2.6762     0.51919     8.4500     0.52510     0.51919
                                                           The SAS System                        16:52 Thursday, January 5, 2023  46

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  631  PT158    VIS3    TRT   Black or African American                                                                           
  632  PT158    VIS4    TRT   Black or African American                                                                           
  633  PT159    VIS1    TRT   Asian                                                                                               
  634  PT159    VIS2    TRT   Asian                                                                                               
  635  PT159    VIS3    TRT   Asian                                                                                               
  636  PT159    VIS4    TRT   Asian                                                                                               
  637  PT160    VIS1    TRT   Asian                                                                                               
  638  PT160    VIS2    TRT   Asian                                                                                               
  639  PT160    VIS3    TRT   Asian                                                                                               
  640  PT160    VIS4    TRT   Asian                                                                                               
  641  PT161    VIS1    PBO   Black or African American                                                                           
  642  PT161    VIS2    PBO   Black or African American                                                                           
  643  PT161    VIS3    PBO   Black or African American                                                                           
  644  PT161    VIS4    PBO   Black or African American                                                                           
  645  PT162    VIS1    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  631 Male        54.6073631    44.263200721    0.4008822316               3     -1.22788259    45.7307    0.72203    526     0.05
  632 Male        54.6073631    59.255791204    0.4362320513               4    -0.511219233    51.7602    1.27393    526     0.05
  633 Female    46.641110281    28.473144181    0.3260905223               1    -0.731194999    34.8780    0.86864    526     0.05
  634 Female    46.641110281    47.475807851    0.1532159889               2    0.0197520069    39.6754    0.71627    526     0.05
  635 Female    46.641110281               .    0.1638473235               3    -1.572863915    44.5263    0.62966    526     0.05
  636 Female    46.641110281               .    0.4462351073               4     -0.70333327    50.5558    1.26066    526     0.05
  637 Male      44.732231797               .    0.8906649049               1    0.7159320889    34.5519    0.89709    526     0.05
  638 Male      44.732231797    46.474830978    0.1903943321               2    0.4652149064    39.3492    0.76415    526     0.05
  639 Male      44.732231797    51.226770331    0.2763174089               3    -0.973902306    44.2001    0.69465    526     0.05
  640 Male      44.732231797    45.827765924    0.2762516337               4    0.5592177305    50.2296    1.28428    526     0.05
  641 Female    24.037995496               .    0.6185155679               1    -2.432639745    32.6341    0.85598    526     0.05
  642 Female    24.037995496    39.067827202    0.5074244408               2    -0.340484927    37.4737    0.74083    526     0.05
  643 Female    24.037995496               .    0.6819647532               3    0.7130331949    42.9762    0.63127    526     0.05
  644 Female    24.037995496               .    0.3527575683               4    -0.659037386    47.6878    1.25995    526     0.05
  645 Male      47.695167544    29.995422255    0.7768467894               1    -0.036402623    30.7774    0.88653    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  631 44.3123    47.1491     -1.4675    -0.45739    10.3875    -0.38704    -0.38021
  632 49.2576    54.2628      7.4956     0.69893     4.8284     0.77340     0.76681
  633 33.1716    36.5845     -6.4049    -1.00580     4.4713    -1.01529    -1.00580
  634 38.2683    41.0825      7.8004     2.17492     8.0666     1.52814     1.51332
  635 43.2893    45.7632       .          .           .          .           .     
  636 48.0792    53.0323       .          .           .          .           .     
  637 32.7896    36.3142       .          .           .          .           .     
  638 37.8480    40.8504      7.1256     1.38240     9.0163     1.39784     1.38240
  639 42.8355    45.5648      7.0266     1.64319    12.1296     1.85075     1.82053
  640 47.7067    52.7526     -4.4019    -0.66809     3.3488    -0.45425    -0.45031
  641 30.9525    34.3156       .          .           .          .           .     
  642 36.0184    38.9290      1.5941     0.30927     7.5793     0.31251     0.30927
  643 41.7361    44.2164       .          .           .          .           .     
  644 45.2126    50.1629       .          .           .          .           .     
  645 29.0358    32.5189     -0.7819    -0.12279     4.7104    -0.12400    -0.12279
                                                           The SAS System                        16:52 Thursday, January 5, 2023  47

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  646  PT162    VIS2    PBO   Asian                                                                                               
  647  PT162    VIS3    PBO   Asian                                                                                               
  648  PT162    VIS4    PBO   Asian                                                                                               
  649  PT163    VIS1    PBO   White                                                                                               
  650  PT163    VIS2    PBO   White                                                                                               
  651  PT163    VIS3    PBO   White                                                                                               
  652  PT163    VIS4    PBO   White                                                                                               
  653  PT164    VIS1    PBO   Black or African American                                                                           
  654  PT164    VIS2    PBO   Black or African American                                                                           
  655  PT164    VIS3    PBO   Black or African American                                                                           
  656  PT164    VIS4    PBO   Black or African American                                                                           
  657  PT165    VIS1    TRT   White                                                                                               
  658  PT165    VIS2    TRT   White                                                                                               
  659  PT165    VIS3    TRT   White                                                                                               
  660  PT165    VIS4    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  646 Male      47.695167544               .    0.5049247766               2    -1.593286302    35.6170    0.76366    526     0.05
  647 Male      47.695167544               .     0.646068969               3    0.8477927972    41.1195    0.64540    526     0.05
  648 Male      47.695167544    54.177955868     0.855536741               4    -1.850388849    45.8311    1.27598    526     0.05
  649 Male      56.247513589               .    0.1115278088               1    -0.323650632    36.4209    0.93528    526     0.05
  650 Male      56.247513589    44.557432809    0.5168663993               2    -0.255248113    41.2606    0.81589    526     0.05
  651 Male      56.247513589               .    0.7597116996               3    0.0609212273    46.7631    0.70671    526     0.05
  652 Male      56.247513589    62.595793691    0.3624407209               4    -0.823491629    51.4747    1.30402    526     0.05
  653 Female    38.186502186               .    0.6462093361               1    1.8297304848    32.6341    0.85598    526     0.05
  654 Female    38.186502186    35.483960044     0.594192197               2    -1.429916216    37.4737    0.74083    526     0.05
  655 Female    38.186502186    44.077675008    0.6214686664               3     0.254137143    42.9762    0.63127    526     0.05
  656 Female    38.186502186    46.578370494    0.8649803828               4    -2.939773695    47.6878    1.25995    526     0.05
  657 Female    39.434505983    47.679791279    0.2868099846               1    0.0024158089    40.5216    0.89674    526     0.05
  658 Female    39.434505983               .    0.3637476992               2    0.5096655713    45.3189    0.76375    526     0.05
  659 Female    39.434505983               .    0.7704558508               3    -1.084720001    50.1699    0.67350    526     0.05
  660 Female    39.434505983               .    0.2160246981               4    0.7048329769    56.1994    1.27606    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  646 34.1168    37.1172       .          .           .          .           .     
  647 39.8516    42.3874       .          .           .          .           .     
  648 43.3244    48.3377      8.3469     0.90132     4.6388     0.86126     0.85389
  649 34.5836    38.2583       .          .           .          .           .     
  650 39.6578    42.8634      3.2969     0.63960     8.6443     0.64777     0.63960
  651 45.3748    48.1514       .          .           .          .           .     
  652 48.9129    54.0364     11.1211     1.05444     5.1778     1.14796     1.13770
  653 30.9525    34.3156       .          .           .          .           .     
  654 36.0184    38.9290     -1.9897    -0.38602     6.8840    -0.39007    -0.38602
  655 41.7361    44.2164      1.1014     0.34279    10.5604     0.28927     0.28537
  656 45.2126    50.1629     -1.1094    -0.05792     3.7515    -0.11445    -0.11349
  657 38.7600    42.2832      7.1582     1.12409     7.4875     1.13541     1.12409
  658 43.8186    46.8193       .          .           .          .           .     
  659 48.8468    51.4929       .          .           .          .           .     
  660 53.6926    58.7062       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  48

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  661  PT166    VIS1    TRT   Asian                                                                                               
  662  PT166    VIS2    TRT   Asian                                                                                               
  663  PT166    VIS3    TRT   Asian                                                                                               
  664  PT166    VIS4    TRT   Asian                                                                                               
  665  PT167    VIS1    PBO   Black or African American                                                                           
  666  PT167    VIS2    PBO   Black or African American                                                                           
  667  PT167    VIS3    PBO   Black or African American                                                                           
  668  PT167    VIS4    PBO   Black or African American                                                                           
  669  PT168    VIS1    PBO   Black or African American                                                                           
  670  PT168    VIS2    PBO   Black or African American                                                                           
  671  PT168    VIS3    PBO   Black or African American                                                                           
  672  PT168    VIS4    PBO   Black or African American                                                                           
  673  PT169    VIS1    PBO   White                                                                                               
  674  PT169    VIS2    PBO   White                                                                                               
  675  PT169    VIS3    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  661 Male      38.420370308    22.154387355    0.8382195136               1      0.33097635    34.5519    0.89709    526     0.05
  662 Male      38.420370308               .    0.1695157314               2     0.976327473    39.3492    0.76415    526     0.05
  663 Male      38.420370308               .    0.6488529904               3     -0.84333988    44.2001    0.69465    526     0.05
  664 Male      38.420370308               .    0.8741210921               4    -0.970579905    50.2296    1.28428    526     0.05
  665 Male      51.713270467    34.277652797    0.6092352802               1    -1.771531349    32.3079    0.85058    526     0.05
  666 Male      51.713270467    36.900588497     0.436412215               2    -0.322470342    37.1475    0.72572    526     0.05
  667 Male      51.713270467               .    0.7441117814               3    -1.338800742    42.6501    0.61298    526     0.05
  668 Male      51.713270467    40.542854177    0.3083100043               4    0.6881560281    47.3616    1.25303    526     0.05
  669 Female    41.247113228    29.094939852    0.6256946541               1    0.0712806523    32.6341    0.85598    526     0.05
  670 Female    41.247113228      37.2176805    0.5660386879               2    2.1897523593    37.4737    0.74083    526     0.05
  671 Female    41.247113228    43.084912398    0.6145658007               3    -1.157707599    42.9762    0.63127    526     0.05
  672 Female    41.247113228               .    0.1201660458               4    1.1816880641    47.6878    1.25995    526     0.05
  673 Female    33.617744016    27.121739597     0.151484956               1    -0.527368362    36.7471    0.93146    526     0.05
  674 Female    33.617744016    34.119161664    0.8846772501               2    -1.456628011    41.5867    0.81945    526     0.05
  675 Female    33.617744016               .    0.8515245084               3    0.5729673705    47.0893    0.71124    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  661 32.7896    36.3142    -12.3975    -1.94685     3.4790    -1.96646    -1.94685
  662 37.8480    40.8504       .          .           .          .           .     
  663 42.8355    45.5648       .          .           .          .           .     
  664 47.7067    52.7526       .          .           .          .           .     
  665 30.6370    33.9789      1.9697     0.30932     5.3828     0.31212     0.30932
  666 35.7219    38.5732     -0.2470    -0.20430     5.3387    -0.04839    -0.04791
  667 41.4459    43.8543       .          .           .          .           .     
  668 44.9001    49.8232     -6.8188    -0.77114     2.7382    -0.70337    -0.69757
  669 30.9525    34.3156     -3.5391    -0.55577     4.5690    -0.56086    -0.55577
  670 36.0184    38.9290     -0.2560     0.21601     5.8044    -0.05019    -0.04967
  671 41.7361    44.2164      0.1087     0.13126    10.1339     0.02854     0.02816
  672 45.2126    50.1629       .          .           .          .           .     
  673 34.9173    38.5769     -9.6254    -1.51153     4.2591    -1.52796    -1.51153
  674 39.9769    43.1965     -7.4676    -0.87431     5.2868    -1.46740    -1.44874
  675 45.6921    48.4865       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  49

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  676  PT169    VIS4    PBO   White                                                                                               
  677  PT170    VIS1    TRT   White                                                                                               
  678  PT170    VIS2    TRT   White                                                                                               
  679  PT170    VIS3    TRT   White                                                                                               
  680  PT170    VIS4    TRT   White                                                                                               
  681  PT171    VIS1    PBO   Asian                                                                                               
  682  PT171    VIS2    PBO   Asian                                                                                               
  683  PT171    VIS3    PBO   Asian                                                                                               
  684  PT171    VIS4    PBO   Asian                                                                                               
  685  PT172    VIS1    TRT   Asian                                                                                               
  686  PT172    VIS2    TRT   Asian                                                                                               
  687  PT172    VIS3    TRT   Asian                                                                                               
  688  PT172    VIS4    TRT   Asian                                                                                               
  689  PT173    VIS1    TRT   White                                                                                               
  690  PT173    VIS2    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  676 Female    33.617744016               .    0.2576674003               4    -1.433377705    51.8008    1.30442    526     0.05
  677 Female    37.149436684               .     0.653136472               1    -1.055185019    40.5216    0.89674    526     0.05
  678 Female    37.149436684    40.802298142    0.3638632571               2    -0.733111877    45.3189    0.76375    526     0.05
  679 Female    37.149436684    45.892688168    0.6420440694               3    0.2109072643    50.1699    0.67350    526     0.05
  680 Female    37.149436684    43.691525577    0.1581865866               4    -0.998920727    56.1994    1.27606    526     0.05
  681 Female    46.106061083               .    0.8848686654               1    1.0778503232    31.1035    0.85562    526     0.05
  682 Female    46.106061083    29.228689037    0.2008532796               2    -1.198974383    35.9432    0.73638    526     0.05
  683 Female    46.106061083               .    0.4033392947               3    0.2166370352    41.4457    0.61338    526     0.05
  684 Female    46.106061083     55.68361847     0.782635471               4    0.1430870298    46.1572    1.25796    526     0.05
  685 Female    47.137504476     31.90698384    0.7636364322               1    -1.065750091    34.8780    0.86864    526     0.05
  686 Female    47.137504476    37.310607623    0.6366974687               2    -0.428623411    39.6754    0.71627    526     0.05
  687 Female    47.137504476    40.755459096    0.6623279421               3    -0.656179477    44.5263    0.62966    526     0.05
  688 Female    47.137504476               .    0.8076594321               4    0.9593943269    50.5558    1.26066    526     0.05
  689 Female    36.429200449    42.194736599     0.469551916               1    1.5560526361    40.5216    0.89674    526     0.05
  690 Female    36.429200449    44.872277155    0.6602340568               2    -1.040796434    45.3189    0.76375    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  676 49.2383    54.3633       .          .           .          .           .     
  677 38.7600    42.2832       .          .           .          .           .     
  678 43.8186    46.8193     -4.5166    -0.87625     7.9158    -0.88603    -0.87625
  679 48.8468    51.4929     -4.2772    -0.99531    10.8894    -1.12544    -1.10817
  680 53.6926    58.7062    -12.5078    -1.15921     3.2969    -1.29060    -1.27956
  681 29.4227    32.7844       .          .           .          .           .     
  682 34.4965    37.3898     -6.7145    -1.30263     5.6705    -1.31613    -1.30263
  683 40.2407    42.6507       .          .           .          .           .     
  684 43.6860    48.6285      9.5264     1.18099     4.9092     0.98273     0.97455
  685 33.1716    36.5845     -2.9710    -0.46656     5.0106    -0.47096    -0.46656
  686 38.2683    41.0825     -2.3648    -0.28277     5.6089    -0.46327    -0.45877
  687 43.2893    45.7632     -3.7708    -0.88625     9.4365    -0.99025    -0.97698
  688 48.0792    53.0323       .          .           .          .           .     
  689 38.7600    42.2832      1.6731     0.26274     6.6261     0.26539     0.26274
  690 43.8186    46.8193     -0.4467    -0.22468     6.4528    -0.08762    -0.08665
                                                           The SAS System                        16:52 Thursday, January 5, 2023  50

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  691  PT173    VIS3    TRT   White                                                                                               
  692  PT173    VIS4    TRT   White                                                                                               
  693  PT174    VIS1    TRT   Black or African American                                                                           
  694  PT174    VIS2    TRT   Black or African American                                                                           
  695  PT174    VIS3    TRT   Black or African American                                                                           
  696  PT174    VIS4    TRT   Black or African American                                                                           
  697  PT175    VIS1    PBO   Black or African American                                                                           
  698  PT175    VIS2    PBO   Black or African American                                                                           
  699  PT175    VIS3    PBO   Black or African American                                                                           
  700  PT175    VIS4    PBO   Black or African American                                                                           
  701  PT176    VIS1    TRT   Black or African American                                                                           
  702  PT176    VIS2    TRT   Black or African American                                                                           
  703  PT176    VIS3    TRT   Black or African American                                                                           
  704  PT176    VIS4    TRT   Black or African American                                                                           
  705  PT177    VIS1    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  691 Female    36.429200449     47.55198474    0.4548119729               3    0.9305724085    50.1699    0.67350    526     0.05
  692 Female    36.429200449               .    0.8281013902               4    -0.075445931    56.1994    1.27606    526     0.05
  693 Female    45.105409543    50.628943087    0.1947195886               1    -1.967195349    36.4086    0.90106    526     0.05
  694 Female    45.105409543    45.475511103    0.1446256643               2    -0.755903643    41.2059    0.76623    526     0.05
  695 Female    45.105409543    48.621679848    0.6657861808               3    0.4611491605    46.0568    0.70592    526     0.05
  696 Female    45.105409543               .    0.7947959404               4     0.145106631    52.0863    1.27509    526     0.05
  697 Female    24.259885343    29.664926185    0.1039308261               1    -2.442311321    32.6341    0.85598    526     0.05
  698 Female    24.259885343     34.57406021    0.7065688981               2    0.5803186855    37.4737    0.74083    526     0.05
  699 Female    24.259885343               .    0.7255845582               3    0.6550519985    42.9762    0.63127    526     0.05
  700 Female    24.259885343    38.116757394     0.495015345               4    -0.304508837    47.6878    1.25995    526     0.05
  701 Male      34.428275123    33.772041634    0.5921728868               1    -0.707568233    36.0824    0.89390    526     0.05
  702 Male      34.428275123    34.261479368    0.3848576339               2    1.9715720145    40.8798    0.77131    526     0.05
  703 Male      34.428275123               .     0.472361481               3    -0.089998681    45.7307    0.72203    526     0.05
  704 Male      34.428275123    58.810371486    0.3391542539               4    -0.014017252    51.7602    1.27393    526     0.05
  705 Male      33.608440326               .    0.1570201496               1    -1.123456937    32.3079    0.85058    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  691 48.8468    51.4929     -2.6179    -0.73507    10.8541    -0.68884    -0.67827
  692 53.6926    58.7062       .          .           .          .           .     
  693 34.6385    38.1787     14.2204     2.23311     7.9506     2.25581     2.23311
  694 39.7007    42.7112      4.2696    -0.16829     5.9365     0.83763     0.82832
  695 44.6701    47.4436      2.5648     0.22723    10.8935     0.67593     0.66452
  696 49.5814    54.5912       .          .           .          .           .     
  697 30.9525    34.3156     -2.9691    -0.46626     4.6585    -0.47053    -0.46626
  698 36.0184    38.9290     -2.8996    -0.39839     5.1900    -0.56844    -0.56254
  699 41.7361    44.2164       .          .           .          .           .     
  700 45.2126    50.1629     -9.5710    -0.87704     2.6524    -0.98736    -0.97912
  701 34.3264    37.8385     -2.3104    -0.36281     5.3034    -0.36644    -0.36281
  702 39.3645    42.3950     -6.6183    -1.25167     4.8077    -1.29859    -1.28397
  703 44.3123    47.1491       .          .           .          .           .     
  704 49.2576    54.2628      7.0502     0.89729     4.7057     0.72744     0.72124
  705 30.6370    33.9789       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  51

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  706  PT177    VIS2    PBO   Black or African American                                                                           
  707  PT177    VIS3    PBO   Black or African American                                                                           
  708  PT177    VIS4    PBO   Black or African American                                                                           
  709  PT178    VIS1    PBO   Black or African American                                                                           
  710  PT178    VIS2    PBO   Black or African American                                                                           
  711  PT178    VIS3    PBO   Black or African American                                                                           
  712  PT178    VIS4    PBO   Black or African American                                                                           
  713  PT179    VIS1    TRT   White                                                                                               
  714  PT179    VIS2    TRT   White                                                                                               
  715  PT179    VIS3    TRT   White                                                                                               
  716  PT179    VIS4    TRT   White                                                                                               
  717  PT180    VIS1    PBO   Asian                                                                                               
  718  PT180    VIS2    PBO   Asian                                                                                               
  719  PT180    VIS3    PBO   Asian                                                                                               
  720  PT180    VIS4    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  706 Male      33.608440326               .    0.6779579315               2    -1.344130123    37.1475    0.72572    526     0.05
  707 Male      33.608440326    39.881193305    0.2114915131               3    -1.523155771    42.6501    0.61298    526     0.05
  708 Male      33.608440326               .    0.7238571499               4     -0.42196821    47.3616    1.25303    526     0.05
  709 Male      42.991675558    31.627076856    0.7839299222               1    1.3609244641    32.3079    0.85058    526     0.05
  710 Male      42.991675558               .     0.375554511               2    1.7537948453    37.1475    0.72572    526     0.05
  711 Male      42.991675558               .     0.387442893               3    1.5683647344    42.6501    0.61298    526     0.05
  712 Male      42.991675558    48.220491988    0.8508342981               4    1.2967555699    47.3616    1.25303    526     0.05
  713 Male      33.437948069    42.588288304     0.609642745               1    -0.237596251    40.1955    0.89869    526     0.05
  714 Male      33.437948069               .    0.3708735675               2    -1.224150136    44.9928    0.77940    526     0.05
  715 Male      33.437948069    49.332622184    0.5090173379               3     -0.32781268    49.8437    0.70210    526     0.05
  716 Male      33.437948069    53.743311488    0.4497337842               4    -2.412450276    55.8732    1.28130    526     0.05
  717 Male      31.509103384    29.718574136    0.6455284989               1    -0.313792873    30.7774    0.88653    526     0.05
  718 Male      31.509103384    30.456514813    0.8264439745               2    1.6598787046    35.6170    0.76366    526     0.05
  719 Male      31.509103384    38.298000505    0.2432058582               3    0.1309531006    41.1195    0.64540    526     0.05
  720 Male      31.509103384               .    0.3114751875               4    1.0958886827    45.8311    1.27598    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  706 35.7219    38.5732       .          .           .          .           .     
  707 41.4459    43.8543     -2.7689    -0.71739    10.3328    -0.72661    -0.71739
  708 44.9001    49.8232       .          .           .          .           .     
  709 30.6370    33.9789     -0.6808    -0.10691     4.9666    -0.10788    -0.10691
  710 35.7219    38.5732       .          .           .          .           .     
  711 41.4459    43.8543       .          .           .          .           .     
  712 44.9001    49.8232      0.8589     0.11348     3.9584     0.08859     0.08786
  713 38.4300    41.9609      2.3928     0.37576     6.6879     0.37956     0.37576
  714 43.4617    46.5239       .          .           .          .           .     
  715 48.4644    51.2230     -0.5111    -0.21288    11.6695    -0.13467    -0.13242
  716 53.3561    58.3903     -2.1299    -0.31018     4.3981    -0.21979    -0.21789
  717 29.0358    32.5189     -1.0588    -0.16627     4.6669    -0.16790    -0.16627
  718 34.1168    37.1172     -5.1605    -1.03290     4.2970    -1.01232    -1.00115
  719 39.8516    42.3874     -2.8215    -0.65312     8.9329    -0.74147    -0.73103
  720 43.3244    48.3377       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  52

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  721  PT181    VIS1    PBO   Asian                                                                                               
  722  PT181    VIS2    PBO   Asian                                                                                               
  723  PT181    VIS3    PBO   Asian                                                                                               
  724  PT181    VIS4    PBO   Asian                                                                                               
  725  PT182    VIS1    TRT   Black or African American                                                                           
  726  PT182    VIS2    TRT   Black or African American                                                                           
  727  PT182    VIS3    TRT   Black or African American                                                                           
  728  PT182    VIS4    TRT   Black or African American                                                                           
  729  PT183    VIS1    TRT   Black or African American                                                                           
  730  PT183    VIS2    TRT   Black or African American                                                                           
  731  PT183    VIS3    TRT   Black or African American                                                                           
  732  PT183    VIS4    TRT   Black or African American                                                                           
  733  PT184    VIS1    TRT   White                                                                                               
  734  PT184    VIS2    TRT   White                                                                                               
  735  PT184    VIS3    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  721 Female    34.933346602    36.810396399     0.382819267               1    0.4893409569    31.1035    0.85562    526     0.05
  722 Female    34.933346602               .    0.1242745982               2    -0.778910295    35.9432    0.73638    526     0.05
  723 Female    34.933346602    42.350448494    0.1279429894               3    1.7435593529    41.4457    0.61338    526     0.05
  724 Female    34.933346602    39.398604824    0.1728286337               4    -0.078387285    46.1572    1.25796    526     0.05
  725 Female    48.424776669               .    0.5908450671               1    -0.975553793    36.4086    0.90106    526     0.05
  726 Female    48.424776669               .    0.1157625053               2    0.0706598247    41.2059    0.76623    526     0.05
  727 Female    48.424776669    49.736287916    0.4398419563               3    -1.518599529    46.0568    0.70592    526     0.05
  728 Female    48.424776669    41.580817213     0.164195691               4    0.8637790328    52.0863    1.27509    526     0.05
  729 Female     30.20877967    43.589010424    0.5056998502               1    0.5015683854    36.4086    0.90106    526     0.05
  730 Female     30.20877967    40.167615484    0.5280545501               2     -0.35478133    41.2059    0.76623    526     0.05
  731 Female     30.20877967               .    0.6938342603               3    -0.488428888    46.0568    0.70592    526     0.05
  732 Female     30.20877967               .    0.6117273418               4    0.9362939473    52.0863    1.27509    526     0.05
  733 Female    59.123126961               .    0.5974531716               1    -1.062408386    40.5216    0.89674    526     0.05
  734 Female    59.123126961    41.082056345    0.7869781205               2    -0.983820872    45.3189    0.76375    526     0.05
  735 Female    59.123126961               .    0.8619020602               3     0.424247877    50.1699    0.67350    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  721 29.4227    32.7844      5.7069     0.89619     5.7806     0.90439     0.89619
  722 34.4965    37.3898       .          .           .          .           .     
  723 40.2407    42.6507      0.9048     0.05415    10.0098     0.23743     0.23441
  724 43.6860    48.6285     -6.7586    -0.90416     3.0609    -0.69721    -0.69141
  725 34.6385    38.1787       .          .           .          .           .     
  726 39.7007    42.7112       .          .           .          .           .     
  727 44.6701    47.4436      3.6794     0.95331    12.8862     0.96966     0.95331
  728 49.5814    54.5912    -10.5055    -1.09782     3.9469    -1.08398    -1.07472
  729 34.6385    38.1787      7.1804     1.12759     6.8451     1.13905     1.12759
  730 39.7007    42.7112     -1.0383    -0.77454     5.3303    -0.20370    -0.20143
  731 44.6701    47.4436       .          .           .          .           .     
  732 49.5814    54.5912       .          .           .          .           .     
  733 38.7600    42.2832       .          .           .          .           .     
  734 43.8186    46.8193     -4.2369    -0.82197     7.9701    -0.83115    -0.82197
  735 48.8468    51.4929       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  53

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  736  PT184    VIS4    TRT   White                                                                                               
  737  PT185    VIS1    PBO   Black or African American                                                                           
  738  PT185    VIS2    PBO   Black or African American                                                                           
  739  PT185    VIS3    PBO   Black or African American                                                                           
  740  PT185    VIS4    PBO   Black or African American                                                                           
  741  PT186    VIS1    PBO   White                                                                                               
  742  PT186    VIS2    PBO   White                                                                                               
  743  PT186    VIS3    PBO   White                                                                                               
  744  PT186    VIS4    PBO   White                                                                                               
  745  PT187    VIS1    PBO   Black or African American                                                                           
  746  PT187    VIS2    PBO   Black or African American                                                                           
  747  PT187    VIS3    PBO   Black or African American                                                                           
  748  PT187    VIS4    PBO   Black or African American                                                                           
  749  PT188    VIS1    PBO   Black or African American                                                                           
  750  PT188    VIS2    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  736 Female    59.123126961    69.374086153    0.5978893928               4    -0.451313481    56.1994    1.27606    526     0.05
  737 Female     49.86060304               .    0.6995229786               1    0.9250847967    32.6341    0.85598    526     0.05
  738 Female     49.86060304    41.276245306    0.1918663196               2     -0.19862081    37.4737    0.74083    526     0.05
  739 Female     49.86060304    44.761382808    0.4125529574               3    1.1948510169    42.9762    0.63127    526     0.05
  740 Female     49.86060304    39.698154918    0.8342022549               4    0.4955447052    47.6878    1.25995    526     0.05
  741 Male      50.025948006    38.442958786    0.4535602255               1    -2.245152574    36.4209    0.93528    526     0.05
  742 Male      50.025948006    48.205857775    0.1531047627               2     -1.33537136    41.2606    0.81589    526     0.05
  743 Male      50.025948006               .    0.8644552255               3    1.2827752062    46.7631    0.70671    526     0.05
  744 Male      50.025948006     35.50734863     0.854869622               4    0.6907959042    51.4747    1.30402    526     0.05
  745 Female    37.655450451     32.08152787    0.6450459264               1    -0.967062668    32.6341    0.85598    526     0.05
  746 Female    37.655450451               .    0.1440276315               2    -1.345793685    37.4737    0.74083    526     0.05
  747 Female    37.655450451               .    0.6756925162               3    1.0336653893    42.9762    0.63127    526     0.05
  748 Female    37.655450451               .    0.3623819601               4     -0.81177646    47.6878    1.25995    526     0.05
  749 Female       53.650774     44.69256059    0.6978408502               1    1.8017254786    32.6341    0.85598    526     0.05
  750 Female       53.650774               .      0.85261639               2    1.7715419604    37.4737    0.74083    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  736 53.6926    58.7062     13.1747     1.48625     5.9802     1.35942     1.34778
  737 30.9525    34.3156       .          .           .          .           .     
  738 36.0184    38.9290      3.8025     0.73771     8.0078     0.74545     0.73771
  739 41.7361    44.2164      1.7851     0.36281    10.5804     0.46883     0.46251
  740 45.2126    50.1629     -7.9896    -0.93839     2.8710    -0.82422    -0.81734
  741 34.5836    38.2583      2.0220     0.31753     6.0369     0.32101     0.31753
  742 39.6578    42.8634      6.9453     1.34437     7.4600     1.36461     1.34741
  743 45.3748    48.1514       .          .           .          .           .     
  744 48.9129    54.0364    -15.9673    -1.82887     1.9344    -1.64820    -1.63347
  745 30.9525    34.3156     -0.5525    -0.08677     5.0380    -0.08756    -0.08677
  746 36.0184    38.9290       .          .           .          .           .     
  747 41.7361    44.2164       .          .           .          .           .     
  748 45.2126    50.1629       .          .           .          .           .     
  749 30.9525    34.3156     12.0585     1.89362     7.0183     1.91096     1.89362
  750 36.0184    38.9290       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  54

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  751  PT188    VIS3    PBO   Black or African American                                                                           
  752  PT188    VIS4    PBO   Black or African American                                                                           
  753  PT189    VIS1    TRT   Asian                                                                                               
  754  PT189    VIS2    TRT   Asian                                                                                               
  755  PT189    VIS3    TRT   Asian                                                                                               
  756  PT189    VIS4    TRT   Asian                                                                                               
  757  PT190    VIS1    TRT   Black or African American                                                                           
  758  PT190    VIS2    TRT   Black or African American                                                                           
  759  PT190    VIS3    TRT   Black or African American                                                                           
  760  PT190    VIS4    TRT   Black or African American                                                                           
  761  PT191    VIS1    TRT   White                                                                                               
  762  PT191    VIS2    TRT   White                                                                                               
  763  PT191    VIS3    TRT   White                                                                                               
  764  PT191    VIS4    TRT   White                                                                                               
  765  PT192    VIS1    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  751 Female       53.650774    42.186893965    0.2744149249               3     -1.45469137    42.9762    0.63127    526     0.05
  752 Female       53.650774               .    0.6938024225               4    -0.845654313    47.6878    1.25995    526     0.05
  753 Female    48.000041599    37.017405812    0.8021209063               1    -1.250479659    34.8780    0.86864    526     0.05
  754 Female    48.000041599    38.269197329    0.4642523983               2    0.6672880679    39.6754    0.71627    526     0.05
  755 Female    48.000041599     49.28805689    0.1197868071               3    -1.290769688    44.5263    0.62966    526     0.05
  756 Female    48.000041599               .     0.315147469               4    -2.035003538    50.5558    1.26066    526     0.05
  757 Female    45.597075649    40.459533114    0.7232831979               1    2.0213469945    36.4086    0.90106    526     0.05
  758 Female    45.597075649    45.103365199    0.6709012946               2    1.0059734876    41.2059    0.76623    526     0.05
  759 Female    45.597075649    45.582497323    0.8904658424               3    0.8171236012    46.0568    0.70592    526     0.05
  760 Female    45.597075649    62.969894641    0.1136214962               4    -0.663988284    52.0863    1.27509    526     0.05
  761 Male      18.792378606    30.782524511    0.3532672957               1    -0.011281231    40.1955    0.89869    526     0.05
  762 Male      18.792378606               .    0.3032777878               2    0.6196772562    44.9928    0.77940    526     0.05
  763 Male      18.792378606               .    0.4673183646               3    -1.281238742    49.8437    0.70210    526     0.05
  764 Male      18.792378606    44.696667272    0.5270021191               4    -0.124261326    55.8732    1.28130    526     0.05
  765 Female    37.433381846    32.724907349    0.6150583168               1    0.1757416545    40.5216    0.89674    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  751 41.7361    44.2164     -0.7893    -0.60018     9.7107    -0.20730    -0.20451
  752 45.2126    50.1629       .          .           .          .           .     
  753 33.1716    36.5845      2.1394     0.33596     5.8131     0.33913     0.33596
  754 38.2683    41.0825     -1.4062    -0.46755     5.4242    -0.27547    -0.27280
  755 43.2893    45.7632      4.7618     1.21964    11.5424     1.25048     1.23372
  756 48.0792    53.0323       .          .           .          .           .     
  757 34.6385    38.1787      4.0510     0.63615     6.3536     0.64261     0.63615
  758 39.7007    42.7112      3.8975     0.53088     6.6357     0.76462     0.75612
  759 44.6701    47.4436     -0.4743    -0.28835    10.3779    -0.12501    -0.12290
  760 49.5814    54.5912     10.8836     0.96246     5.0498     1.12299     1.11340
  761 38.4300    41.9609     -9.4129    -1.47817     4.8340    -1.49311    -1.47817
  762 43.4617    46.5239       .          .           .          .           .     
  763 48.4644    51.2230       .          .           .          .           .     
  764 53.3561    58.3903    -11.1765    -0.84555     3.6185    -1.15332    -1.14337
  765 38.7600    42.2832     -7.7967    -1.22436     5.1390    -1.23669    -1.22436
                                                           The SAS System                        16:52 Thursday, January 5, 2023  55

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  766  PT192    VIS2    TRT   White                                                                                               
  767  PT192    VIS3    TRT   White                                                                                               
  768  PT192    VIS4    TRT   White                                                                                               
  769  PT193    VIS1    PBO   Asian                                                                                               
  770  PT193    VIS2    PBO   Asian                                                                                               
  771  PT193    VIS3    PBO   Asian                                                                                               
  772  PT193    VIS4    PBO   Asian                                                                                               
  773  PT194    VIS1    PBO   Black or African American                                                                           
  774  PT194    VIS2    PBO   Black or African American                                                                           
  775  PT194    VIS3    PBO   Black or African American                                                                           
  776  PT194    VIS4    PBO   Black or African American                                                                           
  777  PT195    VIS1    TRT   White                                                                                               
  778  PT195    VIS2    TRT   White                                                                                               
  779  PT195    VIS3    TRT   White                                                                                               
  780  PT195    VIS4    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  766 Female    37.433381846    45.787023997     0.838085144               2    1.6927737945    45.3189    0.76375    526     0.05
  767 Female    37.433381846     48.74885768    0.3369401917               3    0.6421327172    50.1699    0.67350    526     0.05
  768 Female    37.433381846    84.084487078     0.749780922               4    1.2822330323    56.1994    1.27606    526     0.05
  769 Male      21.971170914               .    0.6550263461               1    0.1405469735    30.7774    0.88653    526     0.05
  770 Male      21.971170914    30.194945315    0.2527406447               2    -1.112502683    35.6170    0.76366    526     0.05
  771 Male      21.971170914    36.785734378    0.4521300426               3    -0.339676972    41.1195    0.64540    526     0.05
  772 Male      21.971170914    61.035875425    0.7878315348               4    -1.664764639    45.8311    1.27598    526     0.05
  773 Male      34.462375838    20.367493986     0.753653493               1    0.9288517617    32.3079    0.85058    526     0.05
  774 Male      34.462375838    35.224795499    0.3500484597               2    1.4168268347    37.1475    0.72572    526     0.05
  775 Male      34.462375838    37.428470912    0.8900163852               3    -0.062720778    42.6501    0.61298    526     0.05
  776 Male      34.462375838    30.205007008    0.4135350725               4    -0.980902336    47.3616    1.25303    526     0.05
  777 Female    35.881101046               .    0.1928156102               1    1.0871502512    40.5216    0.89674    526     0.05
  778 Female    35.881101046    49.128616211    0.1140906462               2    0.1393270266    45.3189    0.76375    526     0.05
  779 Female    35.881101046    47.312339949    0.3702260323               3    -0.386272098    50.1699    0.67350    526     0.05
  780 Female    35.881101046               .    0.7603676483               4    1.1235854232    56.1994    1.27606    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  766 43.8186    46.8193      0.4681     0.69868     7.3762     0.09182     0.09081
  767 48.8468    51.4929     -1.4210    -0.16385    11.4253    -0.37391    -0.36817
  768 53.6926    58.7062     27.8851     3.15003     7.5136     2.87729     2.85267
  769 29.0358    32.5189       .          .           .          .           .     
  770 34.1168    37.1172     -5.4221    -1.05190     5.8579    -1.06364    -1.05190
  771 39.8516    42.3874     -4.3338    -0.98529     8.7974    -1.13888    -1.12284
  772 43.3244    48.3377     15.2048     1.73392     5.4067     1.56888     1.55546
  773 30.6370    33.9789    -11.9404    -1.87508     3.1984    -1.89203    -1.87508
  774 35.7219    38.5732     -1.9227     0.50017     6.0432    -0.37677    -0.37302
  775 41.4459    43.8543     -5.2216    -1.02478     8.9047    -1.37026    -1.35286
  776 44.9001    49.8232    -17.1566    -1.44339     2.3069    -1.76973    -1.75513
  777 38.7600    42.2832       .          .           .          .           .     
  778 43.8186    46.8193      3.8097     0.73909     9.5311     0.74734     0.73909
  779 48.8468    51.4929     -2.8575    -0.85221    11.0325    -0.75189    -0.74036
  780 53.6926    58.7062       .          .           .          .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  56

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  781  PT196    VIS1    PBO   Asian                                                                                               
  782  PT196    VIS2    PBO   Asian                                                                                               
  783  PT196    VIS3    PBO   Asian                                                                                               
  784  PT196    VIS4    PBO   Asian                                                                                               
  785  PT197    VIS1    PBO   Black or African American                                                                           
  786  PT197    VIS2    PBO   Black or African American                                                                           
  787  PT197    VIS3    PBO   Black or African American                                                                           
  788  PT197    VIS4    PBO   Black or African American                                                                           
  789  PT198    VIS1    TRT   Black or African American                                                                           
  790  PT198    VIS2    TRT   Black or African American                                                                           
  791  PT198    VIS3    TRT   Black or African American                                                                           
  792  PT198    VIS4    TRT   Black or African American                                                                           
  793  PT199    VIS1    TRT   White                                                                                               
  794  PT199    VIS2    TRT   White                                                                                               
  795  PT199    VIS3    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  781 Male      29.393058415     19.28388473     0.730110155               1    -0.759845657    30.7774    0.88653    526     0.05
  782 Male      29.393058415    30.006815822     0.400501891               2    1.1489591032    35.6170    0.76366    526     0.05
  783 Male      29.393058415               .    0.6526549218               3    -0.842476259    41.1195    0.64540    526     0.05
  784 Male      29.393058415    49.217682043    0.5862825496               4    0.3914133404    45.8311    1.27598    526     0.05
  785 Male       35.69673346               .    0.5380673863               1    0.8913772423    32.3079    0.85058    526     0.05
  786 Male       35.69673346               .    0.7863398317               2    -1.335258713    37.1475    0.72572    526     0.05
  787 Male       35.69673346               .     0.385387123               3    0.3981234778    42.6501    0.61298    526     0.05
  788 Male       35.69673346    40.133533747    0.3443687845               4    -0.111586803    47.3616    1.25303    526     0.05
  789 Male      29.474841317    42.345344243    0.5827735232               1    0.6757439166    36.0824    0.89390    526     0.05
  790 Male      29.474841317    52.325750041    0.3612457639               2    -0.788597935    40.8798    0.77131    526     0.05
  791 Male      29.474841317               .    0.5828885486               3    -0.086986334    45.7307    0.72203    526     0.05
  792 Male      29.474841317      69.2625362    0.2989890486               4    1.3822840078    51.7602    1.27393    526     0.05
  793 Male      41.054005919               .    0.6913230626               1    0.1684901638    40.1955    0.89869    526     0.05
  794 Male      41.054005919               .     0.112059233               2    0.8231909483    44.9928    0.77940    526     0.05
  795 Male      41.054005919               .    0.5964899974               3    -0.220894598    49.8437    0.70210    526     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper       Resid       Resid       Dep        Resid       Resid

  781 29.0358    32.5189    -11.4935    -1.80489    3.02827    -1.82264    -1.80489
  782 34.1168    37.1172     -5.6102    -0.33014    4.99978    -1.10054    -1.08840
  783 39.8516    42.3874       .          .          .           .           .     
  784 43.3244    48.3377      3.3866     0.77362    4.18851     0.34944     0.34645
  785 30.6370    33.9789       .          .          .           .           .     
  786 35.7219    38.5732       .          .          .           .           .     
  787 41.4459    43.8543       .          .          .           .           .     
  788 44.9001    49.8232     -7.2281    -0.73944    4.10569    -0.74559    -0.73944
  789 34.3264    37.8385      6.2629     0.98351    6.64975     0.99334     0.98351
  790 39.3645    42.3950     11.4460     1.99092    8.05032     2.24585     2.22057
  791 44.3123    47.1491       .          .          .           .           .     
  792 49.2576    54.2628     17.5024     1.49689    5.30527     1.80590     1.79050
  793 38.4300    41.9609       .          .          .           .           .     
  794 43.4617    46.5239       .          .          .           .           .     
  795 48.4644    51.2230       .          .          .           .           .     
                                                           The SAS System                        16:52 Thursday, January 5, 2023  57

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  796  PT199    VIS4    TRT   White                                                                                               
  797  PT200    VIS1    PBO   Black or African American                                                                           
  798  PT200    VIS2    PBO   Black or African American                                                                           
  799  PT200    VIS3    PBO   Black or African American                                                                           
  800  PT200    VIS4    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF

  796 Male      41.054005919               .    0.7897474121               4    -1.029391655    55.8732    1.28130    526
  797 Male      51.191006818    35.703411791    0.4894285582               1    -0.010925691    32.3079    0.85058    526
  798 Male      51.191006818    41.644542707    0.4903211238               2    -1.224991155    37.1475    0.72572    526
  799 Male      51.191006818               .    0.1676835185               3    -2.596111388    42.6501    0.61298    526
  800 Male      51.191006818    54.250812574    0.4189190561               4     1.169122592    47.3616    1.25303    526

                                                 Scaled     Scaled    Student    Pearson
  Obs Alpha     Lower      Upper      Resid      Resid       Dep       Resid      Resid

  796  0.05    53.3561    58.3903     .          .          .          .          .     
  797  0.05    30.6370    33.9789    3.39551    0.53322    5.60673    0.53804    0.53322
  798  0.05    35.7219    38.5732    4.49700    0.71055    6.25356    0.88121    0.87243
  799  0.05    41.4459    43.8543     .          .          .          .          .     
  800  0.05    44.9001    49.8232    6.88918    0.56152    4.07087    0.71063    0.70477

