                                                           The SAS System                          11:46 Friday, January 6, 2023   1

                                                        The Mixed Procedure

                                                         Model Information

                                       Data Set                     WORK.TMP                 
                                       Dependent Variable           FEV1                     
                                       Covariance Structure         Unstructured             
                                       Subject Effect               USUBJID                  
                                       Group Effect                 ARMCD                    
                                       Estimation Method            REML                     
                                       Residual Variance Method     None                     
                                       Fixed Effects SE Method      Model-Based              
                                       Degrees of Freedom Method    Between-Within           


                                                      Class Level Information
 
                                        Class      Levels    Values

                                        AVISIT          4    VIS1 VIS2 VIS3 VIS4           
                                        USUBJID       200    PT1 PT10 PT100 PT101 PT102    
                                                             PT103 PT104 PT105 PT106 PT107 
                                                             PT108 PT109 PT11 PT110 PT111  
                                                             PT112 PT113 PT114 PT115 PT116 
                                                             PT117 PT118 PT119 PT12 PT120  
                                                             PT121 PT122 PT123 PT124 PT125 
                                                             PT126 PT127 PT128 PT129 PT13  
                                                             PT130 PT131 PT132 PT133 PT134 
                                                             PT135 PT136 PT137 PT138 PT139 
                                                             PT14 PT140 PT141 PT142 PT143  
                                                             PT144 PT145 PT146 PT147 PT148 
                                                             PT149 PT15 PT150 PT151 PT152  
                                                             PT153 PT154 PT155 PT156 PT157 
                                                             PT158 PT159 PT16 PT160 PT161  
                                                             PT162 PT163 PT164 PT165 PT166 
                                                             PT167 PT168 PT169 PT17 PT170  
                                                             PT171 PT172 PT173 PT174 PT175 
                                                             PT176 PT177 PT178 PT179 PT18  
                                                             PT180 PT181 PT182 PT183 PT184 
                                                             PT185 PT186 PT187 PT188 PT189 
                                                             PT19 PT190 PT191 PT192 PT193  
                                                             PT194 PT195 PT196 PT197 PT198 
                                                             PT199 PT2 PT20 PT200 PT21 PT22
                                                             PT23 PT24 PT25 PT26 PT27 PT28 
                                                             PT29 PT3 PT30 PT31 PT32 PT33  
                                                             PT34 PT35 PT36 PT37 PT38 PT39 
                                                             PT4 PT40 PT41 PT42 PT43 PT44  
                                                             PT45 PT46 PT47 PT48 PT49 PT5  
                                                             PT50 PT51 PT52 PT53 PT54 PT55 
                                                             PT56 PT57 PT58 PT59 PT6 PT60  
                                                             PT61 PT62 PT63 PT64 PT65 PT66 
                                                             PT67 PT68 PT69 PT7 PT70 PT71  
                                                             PT72 PT73 PT74 PT75 PT76 PT77 
                                                             PT78 PT79 PT8 PT80 PT81 PT82  
                                                             PT83 PT84 PT85 PT86 PT87 PT88 
                                                             PT89 PT9 PT90 PT91 PT92 PT93  
                                                             PT94 PT95 PT96 PT97 PT98 PT99 
                                        ARMCD           2    PBO TRT                       
                                                           The SAS System                          11:46 Friday, January 6, 2023   2

                                                        The Mixed Procedure

                                                      Class Level Information
 
                                        Class      Levels    Values

                                        RACE            3    Asian Black or African        
                                                             American White                
                                        SEX             2    Female Male                   


                                                            Dimensions

                                                Covariance Parameters            20
                                                Columns in X                      3
                                                Columns in Z                      0
                                                Subjects                        200
                                                Max Obs per Subject               4


                                                      Number of Observations

                                            Number of Observations Read             800
                                            Number of Observations Used             537
                                            Number of Observations Not Used         263


                                                         Iteration History
 
                                    Iteration    Evaluations    -2 Res Log Like       Criterion

                                            0              1      3891.08088197                
                                            1              2      3667.82891297      0.00275821
                                            2              1      3663.41921624      0.00045881
                                            3              1      3662.71404497      0.00003709
                                            4              1      3662.66115436      0.00000041
                                            5              1      3662.66059721      0.00000000


                                                     Convergence criteria met.                    


                                                   Covariance Parameter Estimates
 
                                            Cov Parm    Subject    Group        Estimate

                                            UN(1,1)     USUBJID    ARMCD PBO      110.73
                                            UN(2,1)     USUBJID    ARMCD PBO     49.1944
                                            UN(2,2)     USUBJID    ARMCD PBO     40.0749
                                            UN(3,1)     USUBJID    ARMCD PBO     -6.9791
                                            UN(3,2)     USUBJID    ARMCD PBO     -2.7015
                                            UN(3,3)     USUBJID    ARMCD PBO     23.4985
                                            UN(4,1)     USUBJID    ARMCD PBO    -47.0069
                                            UN(4,2)     USUBJID    ARMCD PBO    -22.4250
                                            UN(4,3)     USUBJID    ARMCD PBO     17.7001
                                            UN(4,4)     USUBJID    ARMCD PBO      131.95
                                            UN(1,1)     USUBJID    ARMCD TRT      106.77
                                            UN(2,1)     USUBJID    ARMCD TRT     42.6121
                                                           The SAS System                          11:46 Friday, January 6, 2023   3

                                                        The Mixed Procedure

                                                   Covariance Parameter Estimates
 
                                            Cov Parm    Subject    Group        Estimate

                                            UN(2,2)     USUBJID    ARMCD TRT     40.6660
                                            UN(3,1)     USUBJID    ARMCD TRT      2.7452
                                            UN(3,2)     USUBJID    ARMCD TRT      4.5650
                                            UN(3,3)     USUBJID    ARMCD TRT     25.9531
                                            UN(4,1)     USUBJID    ARMCD TRT    -46.3357
                                            UN(4,2)     USUBJID    ARMCD TRT     -4.7493
                                            UN(4,3)     USUBJID    ARMCD TRT     20.5110
                                            UN(4,4)     USUBJID    ARMCD TRT      172.93


                                                          Fit Statistics

                                               -2 Res Log Likelihood          3662.7
                                               AIC (Smaller is Better)        3702.7
                                               AICC (Smaller is Better)       3704.3
                                               BIC (Smaller is Better)        3768.6


                                                  Null Model Likelihood Ratio Test
 
                                                    DF    Chi-Square      Pr > ChiSq

                                                    19        228.42          <.0001


                                                   Type 3 Tests of Fixed Effects
 
                                                         Num     Den
                                           Effect         DF      DF    F Value    Pr > F

                                           ARMCD           1     195      30.09    <.0001
                                                           The SAS System                          11:46 Friday, January 6, 2023   4

 
  Obs USUBJID  AVISIT  ARMCD  RACE

    1  PT1      VIS1    TRT   Black or African American                                                                           
    2  PT1      VIS2    TRT   Black or African American                                                                           
    3  PT1      VIS3    TRT   Black or African American                                                                           
    4  PT1      VIS4    TRT   Black or African American                                                                           
    5  PT2      VIS1    PBO   Asian                                                                                               
    6  PT2      VIS2    PBO   Asian                                                                                               
    7  PT2      VIS3    PBO   Asian                                                                                               
    8  PT2      VIS4    PBO   Asian                                                                                               
    9  PT3      VIS1    PBO   Black or African American                                                                           
   10  PT3      VIS2    PBO   Black or African American                                                                           
   11  PT3      VIS3    PBO   Black or African American                                                                           
   12  PT3      VIS4    PBO   Black or African American                                                                           
   13  PT4      VIS1    TRT   Asian                                                                                               
   14  PT4      VIS2    TRT   Asian                                                                                               
   15  PT4      VIS3    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

    1 Female    25.271435093               .     0.676723117               1    -0.626453811    44.6795    0.49709    535     0.05
    2 Female    25.271435093    39.971049772    0.8006185545               2    0.1836433242    44.6795    0.49709    535     0.05
    3 Female    25.271435093               .    0.7087858627               3    -0.835628612    44.6795    0.49709    535     0.05
    4 Female    25.271435093    20.483789997     0.808899653               4    1.5952808021    44.6795    0.49709    535     0.05
    5 Male      45.024770977               .    0.4651847681               1    0.3295077718    41.1517    0.40805    535     0.05
    6 Male      45.024770977    31.455218862    0.2330974281               2    -0.820468384    41.1517    0.40805    535     0.05
    7 Male      45.024770977     36.87889346    0.3600763094               3    0.4874290524    41.1517    0.40805    535     0.05
    8 Male      45.024770977    48.808094647    0.5073794685               4    0.7383247051    41.1517    0.40805    535     0.05
    9 Female    43.500696824               .     0.682164203               1    0.5757813517    41.1517    0.40805    535     0.05
   10 Female    43.500696824    35.986991637    0.8917895503               2    -0.305388387    41.1517    0.40805    535     0.05
   11 Female    43.500696824               .     0.127628348               3    1.5117811685    41.1517    0.40805    535     0.05
   12 Female    43.500696824    37.164438717    0.2218987921               4    0.3898432364    41.1517    0.40805    535     0.05
   13 Female    31.603183398    33.892291438     0.688547962               1    -0.621240581    44.6795    0.49709    535     0.05
   14 Female    31.603183398    33.746374758    0.1009092692               2    -2.214699887    44.6795    0.49709    535     0.05
   15 Female    31.603183398               .    0.4129626682               3    1.1249309181    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

    1 43.7030    45.6560       .          .           .          .           .     
    2 43.7030    45.6560     -4.7084    -0.73835     6.2680    -0.74060    -0.73835
    3 43.7030    45.6560       .          .           .          .           .     
    4 43.7030    45.6560    -24.1957    -1.88475     1.9157    -1.84123    -1.83991
    5 40.3502    41.9533       .          .           .          .           .     
    6 40.3502    41.9533     -9.6965    -1.53172     4.9689    -1.53491    -1.53172
    7 40.3502    41.9533     -4.2728    -1.02026     8.0766    -0.88459    -0.88145
    8 40.3502    41.9533      7.6564     0.54335     3.7819     0.66695     0.66653
    9 40.3502    41.9533       .          .           .          .           .     
   10 40.3502    41.9533     -5.1648    -0.81586     5.6847    -0.81756    -0.81586
   11 40.3502    41.9533       .          .           .          .           .     
   12 40.3502    41.9533     -3.9873    -0.62939     5.2440    -0.34733    -0.34712
   13 43.7030    45.6560    -10.7872    -1.04397     3.2801    -1.04518    -1.04397
   14 43.7030    45.6560    -10.9331    -1.36261     4.1569    -1.71969    -1.71446
   15 43.7030    45.6560       .          .           .          .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023   5

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   16  PT4      VIS4    TRT   Asian                                                                                               
   17  PT5      VIS1    PBO   Black or African American                                                                           
   18  PT5      VIS2    PBO   Black or African American                                                                           
   19  PT5      VIS3    PBO   Black or African American                                                                           
   20  PT5      VIS4    PBO   Black or African American                                                                           
   21  PT6      VIS1    PBO   Black or African American                                                                           
   22  PT6      VIS2    PBO   Black or African American                                                                           
   23  PT6      VIS3    PBO   Black or African American                                                                           
   24  PT6      VIS4    PBO   Black or African American                                                                           
   25  PT7      VIS1    PBO   Asian                                                                                               
   26  PT7      VIS2    PBO   Asian                                                                                               
   27  PT7      VIS3    PBO   Asian                                                                                               
   28  PT7      VIS4    PBO   Asian                                                                                               
   29  PT8      VIS1    PBO   Black or African American                                                                           
   30  PT8      VIS2    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   16 Female    31.603183398    54.450547528    0.4699957233               4    -0.044933609    44.6795    0.49709    535     0.05
   17 Male      43.646909655    32.313859554    0.4105151853               1    -0.016190263    41.1517    0.40805    535     0.05
   18 Male      43.646909655               .    0.4219881134               2    0.9438362107    41.1517    0.40805    535     0.05
   19 Male      43.646909655    46.793614059    0.2431708679               3    0.8212211951    41.1517    0.40805    535     0.05
   20 Male      43.646909655    41.711537613    0.8613270029               4    0.5939013212    41.1517    0.40805    535     0.05
   21 Male      21.594722051               .    0.4629824586               1    0.9189773716    41.1517    0.40805    535     0.05
   22 Male      21.594722051               .    0.3614019269               2    0.7821363007    41.1517    0.40805    535     0.05
   23 Male      21.594722051    39.024226214    0.8723322587               3    0.0745649834    41.1517    0.40805    535     0.05
   24 Male      21.594722051               .    0.6659855017               4    -1.989351696    41.1517    0.40805    535     0.05
   25 Female    25.481653915    31.930501636    0.6156341093               1    0.6198257479    41.1517    0.40805    535     0.05
   26 Female    25.481653915    32.909471719     0.411862788               2     -0.05612874    41.1517    0.40805    535     0.05
   27 Female    25.481653915               .    0.6588349115               3    -0.155795507    41.1517    0.40805    535     0.05
   28 Female    25.481653915     48.28031161    0.5352462916               4    -1.470752384    41.1517    0.40805    535     0.05
   29 Male      47.812250568    32.230211213    0.2811737429               1    -0.478150055    41.1517    0.40805    535     0.05
   30 Male      47.812250568    35.910799302     0.487646204               2    0.4179415602    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   16 43.7030    45.6560      9.7711     0.74281     4.7705     0.74355     0.74302
   17 40.3502    41.9533     -8.8379    -0.83989     3.0709    -0.84052    -0.83989
   18 40.3502    41.9533       .          .           .          .           .     
   19 40.3502    41.9533      5.6419     1.05891    10.1689     1.16801     1.16387
   20 40.3502    41.9533      0.5598    -0.63606     2.3915     0.04876     0.04873
   21 40.3502    41.9533       .          .           .          .           .     
   22 40.3502    41.9533       .          .           .          .           .     
   23 40.3502    41.9533     -2.1275    -0.43889     8.0503    -0.44045    -0.43889
   24 40.3502    41.9533       .          .           .          .           .     
   25 40.3502    41.9533     -9.2212    -0.87632     3.0344    -0.87698    -0.87632
   26 40.3502    41.9533     -8.2423    -0.97121     4.3866    -1.30471    -1.30200
   27 40.3502    41.9533       .          .           .          .           .     
   28 40.3502    41.9533      7.1286     0.27073     5.9962     0.62097     0.62058
   29 40.3502    41.9533     -8.9215    -0.84784     3.0629    -0.84847    -0.84784
   30 40.3502    41.9533     -5.2409    -0.29924     5.0585    -0.82962    -0.82789
                                                           The SAS System                          11:46 Friday, January 6, 2023   6

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   31  PT8      VIS3    PBO   Black or African American                                                                           
   32  PT8      VIS4    PBO   Black or African American                                                                           
   33  PT9      VIS1    TRT   White                                                                                               
   34  PT9      VIS2    TRT   White                                                                                               
   35  PT9      VIS3    TRT   White                                                                                               
   36  PT9      VIS4    TRT   White                                                                                               
   37  PT10     VIS1    PBO   Black or African American                                                                           
   38  PT10     VIS2    PBO   Black or African American                                                                           
   39  PT10     VIS3    PBO   Black or African American                                                                           
   40  PT10     VIS4    PBO   Black or African American                                                                           
   41  PT11     VIS1    TRT   Asian                                                                                               
   42  PT11     VIS2    TRT   Asian                                                                                               
   43  PT11     VIS3    TRT   Asian                                                                                               
   44  PT11     VIS4    TRT   Asian                                                                                               
   45  PT12     VIS1    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   31 Male      47.812250568    45.548975957    0.7344057359               3    1.3586795515    41.1517    0.40805    535     0.05
   32 Male      47.812250568    53.028768228    0.1047901036               4    -0.102787727    41.1517    0.40805    535     0.05
   33 Male      50.871292507    47.168980221    0.2501699567               1    0.3876716116    44.6795    0.49709    535     0.05
   34 Male      50.871292507    46.642867011    0.6454668986               2    -0.053805041    44.6795    0.49709    535     0.05
   35 Male      50.871292507               .    0.3960832989               3    -1.377059557    44.6795    0.49709    535     0.05
   36 Male      50.871292507    58.097132232    0.3893004561               4    -0.414994563    44.6795    0.49709    535     0.05
   37 Female    57.726129497               .    0.7950359188               1    -0.394289954    41.1517    0.40805    535     0.05
   38 Female    57.726129497               .    0.8233237326               2    -0.059313397    41.1517    0.40805    535     0.05
   39 Female    57.726129497    44.976131984    0.5939396525               3     1.100025372    41.1517    0.40805    535     0.05
   40 Female    57.726129497               .    0.2072253076               4    0.7631757485    41.1517    0.40805    535     0.05
   41 Female    50.985018211    44.327547822    0.7257546244               1    -0.164523596    44.6795    0.49709    535     0.05
   42 Female    50.985018211    38.978127123    0.4433590559               2     -0.25336168    44.6795    0.49709    535     0.05
   43 Female    50.985018211    43.728623823      0.84181918               3    0.6969633754    44.6795    0.49709    535     0.05
   44 Female    50.985018211    46.433934978    0.7185945798               4    0.5566631987    44.6795    0.49709    535     0.05
   45 Male      34.712714863    40.345759238    0.3077449974               1    -0.688755695    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   31 40.3502    41.9533      4.3972     0.80460     9.8119     0.91034     0.90711
   32 40.3502    41.9533     11.8770     0.54412     3.7898     1.03461     1.03396
   33 43.7030    45.6560      2.4895     0.24093     4.5650     0.24121     0.24093
   34 43.7030    45.6560      1.9634     0.19938     5.7189     0.30883     0.30789
   35 43.7030    45.6560       .          .           .          .           .     
   36 43.7030    45.6560     13.4177     1.15785     5.1856     1.02105     1.02032
   37 40.3502    41.9533       .          .           .          .           .     
   38 40.3502    41.9533       .          .           .          .           .     
   39 40.3502    41.9533      3.8244     0.78894     9.2782     0.79175     0.78894
   40 40.3502    41.9533       .          .           .          .           .     
   41 43.7030    45.6560     -0.3519    -0.03406     4.2900    -0.03410    -0.03406
   42 43.7030    45.6560     -5.7014    -1.14326     4.3763    -0.89678    -0.89405
   43 43.7030    45.6560     -0.9509    -0.02509     7.8351    -0.18754    -0.18665
   44 43.7030    45.6560      1.7545     0.43313     1.9928     0.13351     0.13341
   45 40.3502    41.9533     -0.8060    -0.07659     3.8342    -0.07665    -0.07659
                                                           The SAS System                          11:46 Friday, January 6, 2023   7

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   46  PT12     VIS2    PBO   Asian                                                                                               
   47  PT12     VIS3    PBO   Asian                                                                                               
   48  PT12     VIS4    PBO   Asian                                                                                               
   49  PT13     VIS1    TRT   White                                                                                               
   50  PT13     VIS2    TRT   White                                                                                               
   51  PT13     VIS3    TRT   White                                                                                               
   52  PT13     VIS4    TRT   White                                                                                               
   53  PT14     VIS1    PBO   Black or African American                                                                           
   54  PT14     VIS2    PBO   Black or African American                                                                           
   55  PT14     VIS3    PBO   Black or African American                                                                           
   56  PT14     VIS4    PBO   Black or African American                                                                           
   57  PT15     VIS1    PBO   Asian                                                                                               
   58  PT15     VIS2    PBO   Asian                                                                                               
   59  PT15     VIS3    PBO   Asian                                                                                               
   60  PT15     VIS4    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   46 Male      34.712714863    42.765678991    0.3569797387               2    -0.707495157    41.1517    0.40805    535     0.05
   47 Male      34.712714863    40.111548968    0.1481561258               3    0.3645819621    41.1517    0.40805    535     0.05
   48 Male      34.712714863               .    0.1347651631               4    0.7685329245    41.1517    0.40805    535     0.05
   49 Male      47.263577712               .    0.1440430546               1    -0.112346212    44.6795    0.49709    535     0.05
   50 Male      47.263577712               .    0.6004342375               2    0.8811077265    44.6795    0.49709    535     0.05
   51 Male      47.263577712    53.317914347     0.871576231               3    0.3981058804    44.6795    0.49709    535     0.05
   52 Male      47.263577712    56.076412729    0.7618422952               4    -0.612026393    44.6795    0.49709    535     0.05
   53 Male      42.000955239               .    0.3520225892               1    0.3411196914    41.1517    0.40805    535     0.05
   54 Male      42.000955239               .    0.2704203608               2    -1.129363096    41.1517    0.40805    535     0.05
   55 Male      42.000955239    41.908371762    0.6859968951               3    1.4330237017    41.1517    0.40805    535     0.05
   56 Male      42.000955239               .    0.4993928164               4    1.9803998985    41.1517    0.40805    535     0.05
   57 Male      14.342696762               .    0.6838175774               1    -0.367221476    41.1517    0.40805    535     0.05
   58 Male      14.342696762               .    0.1642688354               2    -1.044134626    41.1517    0.40805    535     0.05
   59 Male      14.342696762    34.656625058    0.4484243879               3    0.5697196274    41.1517    0.40805    535     0.05
   60 Male      14.342696762    39.077914763    0.2892643627               4    -0.135054604    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   46 40.3502    41.9533      1.6139     0.46201     5.8198     0.25548     0.25495
   47 40.3502    41.9533     -1.0402    -0.23624     8.7711    -0.21535    -0.21458
   48 40.3502    41.9533       .          .           .          .           .     
   49 43.7030    45.6560       .          .           .          .           .     
   50 43.7030    45.6560       .          .           .          .           .     
   51 43.7030    45.6560      8.6384     1.69567    10.4660     1.70380     1.69567
   52 43.7030    45.6560     11.3969     0.36504     1.1134     0.86728     0.86666
   53 40.3502    41.9533       .          .           .          .           .     
   54 40.3502    41.9533       .          .           .          .           .     
   55 40.3502    41.9533      0.7566     0.15609     8.6453     0.15664     0.15609
   56 40.3502    41.9533       .          .           .          .           .     
   57 40.3502    41.9533       .          .           .          .           .     
   58 40.3502    41.9533       .          .           .          .           .     
   59 40.3502    41.9533     -6.4951    -1.33988     7.1494    -1.34466    -1.33988
   60 40.3502    41.9533     -2.0738     0.25880     1.1911    -0.18065    -0.18054
                                                           The SAS System                          11:46 Friday, January 6, 2023   8

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   61  PT16     VIS1    PBO   Asian                                                                                               
   62  PT16     VIS2    PBO   Asian                                                                                               
   63  PT16     VIS3    PBO   Asian                                                                                               
   64  PT16     VIS4    PBO   Asian                                                                                               
   65  PT17     VIS1    PBO   White                                                                                               
   66  PT17     VIS2    PBO   White                                                                                               
   67  PT17     VIS3    PBO   White                                                                                               
   68  PT17     VIS4    PBO   White                                                                                               
   69  PT18     VIS1    TRT   Asian                                                                                               
   70  PT18     VIS2    TRT   Asian                                                                                               
   71  PT18     VIS3    TRT   Asian                                                                                               
   72  PT18     VIS4    TRT   Asian                                                                                               
   73  PT19     VIS1    TRT   Asian                                                                                               
   74  PT19     VIS2    TRT   Asian                                                                                               
   75  PT19     VIS3    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   61 Female    47.072849856               .    0.7332542388               1    2.4016177605    41.1517    0.40805    535     0.05
   62 Female    47.072849856    35.896120271    0.3069474535               2    -0.039240003    41.1517    0.40805    535     0.05
   63 Female    47.072849856               .    0.8887870654               3    0.6897393625    41.1517    0.40805    535     0.05
   64 Female    47.072849856    47.672635935    0.7054989949               4    0.0280021588    41.1517    0.40805    535     0.05
   65 Female    17.175155287    22.654403763    0.8838225977               1    -0.743273209    41.1517    0.40805    535     0.05
   66 Female    17.175155287               .    0.2751582714               2    0.1887922995    41.1517    0.40805    535     0.05
   67 Female    17.175155287               .    0.8589657465               3    -1.804958629    41.1517    0.40805    535     0.05
   68 Female    17.175155287    40.853755873    0.2195663569               4    1.4655548616    41.1517    0.40805    535     0.05
   69 Male      55.162419118    32.600479538    0.5802855765               1    0.1532533382    44.6795    0.49709    535     0.05
   70 Male      55.162419118    33.643287918    0.8571446015               2    2.1726116704    44.6795    0.49709    535     0.05
   71 Male      55.162419118               .    0.6506826855               3    0.4755095289    44.6795    0.49709    535     0.05
   72 Male      55.162419118    40.922778459    0.5044269785               4    -0.709946431    44.6795    0.49709    535     0.05
   73 Male      32.751436889    32.148306778    0.3983489959               1    0.6107263535    44.6795    0.49709    535     0.05
   74 Male      32.751436889    46.436038998    0.3686440308               2    -0.934097632    44.6795    0.49709    535     0.05
   75 Male      32.751436889    41.349734123     0.138601082               3      -1.2536334    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   61 40.3502    41.9533       .          .           .          .           .     
   62 40.3502    41.9533     -5.2556    -0.83021     5.6704    -0.83194    -0.83021
   63 40.3502    41.9533       .          .           .          .           .     
   64 40.3502    41.9533      6.5209     0.32762     6.2010     0.56804     0.56768
   65 40.3502    41.9533    -18.4973    -1.75785     2.1529    -1.75917    -1.75785
   66 40.3502    41.9533       .          .           .          .           .     
   67 40.3502    41.9533       .          .           .          .           .     
   68 40.3502    41.9533     -0.2980    -0.77018     4.7692    -0.02596    -0.02594
   69 43.7030    45.6560    -12.0790    -1.16899     3.1550    -1.17035    -1.16899
   70 43.7030    45.6560    -11.0362    -1.27781     4.2417    -1.73591    -1.73063
   71 43.7030    45.6560       .          .           .          .           .     
   72 43.7030    45.6560     -3.7567    -0.44772     3.5800    -0.28587    -0.28567
   73 43.7030    45.6560    -12.5312    -1.21275     3.1113    -1.21416    -1.21275
   74 43.7030    45.6560      1.7566     1.38936     6.9089     0.27629     0.27545
   75 43.7030    45.6560     -3.3297    -0.79379     7.0664    -0.65674    -0.65361
                                                           The SAS System                          11:46 Friday, January 6, 2023   9

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   76  PT19     VIS4    TRT   Asian                                                                                               
   77  PT20     VIS1    TRT   White                                                                                               
   78  PT20     VIS2    TRT   White                                                                                               
   79  PT20     VIS3    TRT   White                                                                                               
   80  PT20     VIS4    TRT   White                                                                                               
   81  PT21     VIS1    TRT   White                                                                                               
   82  PT21     VIS2    TRT   White                                                                                               
   83  PT21     VIS3    TRT   White                                                                                               
   84  PT21     VIS4    TRT   White                                                                                               
   85  PT22     VIS1    TRT   White                                                                                               
   86  PT22     VIS2    TRT   White                                                                                               
   87  PT22     VIS3    TRT   White                                                                                               
   88  PT22     VIS4    TRT   White                                                                                               
   89  PT23     VIS1    PBO   Black or African American                                                                           
   90  PT23     VIS2    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   76 Male      32.751436889    66.303816636    0.5951580312               4    0.2914462355    44.6795    0.49709    535     0.05
   77 Female    37.372227859               .    0.8691578334               1    -0.443291873    44.6795    0.49709    535     0.05
   78 Female    37.372227859    47.953584861    0.6239684077               2    0.0011053516    44.6795    0.49709    535     0.05
   79 Female    37.372227859    53.973639192    0.5082335932               3    0.0743413242    44.6795    0.49709    535     0.05
   80 Female    37.372227859               .    0.2200785685               4    -0.589520946    44.6795    0.49709    535     0.05
   81 Male      54.846752762               .    0.7963583043               1    -0.568668733    44.6795    0.49709    535     0.05
   82 Male      54.846752762    56.645435878    0.5115533423               2    -0.135178615    44.6795    0.49709    535     0.05
   83 Male      54.846752762    49.708716212    0.1069183309               3    1.1780869966    44.6795    0.49709    535     0.05
   84 Male      54.846752762    60.404967756    0.1153558124               4      -1.5235668    44.6795    0.49709    535     0.05
   85 Male      51.574745598    45.985250447    0.2156095212               1    0.5939461876    44.6795    0.49709    535     0.05
   86 Male      51.574745598    51.909105323    0.3440254038               2    0.3329503712    44.6795    0.49709    535     0.05
   87 Male      51.574745598    41.507874578    0.7605254902               3    1.0630998373    44.6795    0.49709    535     0.05
   88 Male      51.574745598    53.427273335    0.5018757138               4    -0.304183924    44.6795    0.49709    535     0.05
   89 Female    29.925606083    23.868591882    0.7428581007               1    0.3700188099    41.1517    0.40805    535     0.05
   90 Female    29.925606083    35.985632123    0.1485119857               2    0.2670987908    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   76 43.7030    45.6560     21.6243     1.34964     2.9093     1.64555     1.64438
   77 43.7030    45.6560       .          .           .          .           .     
   78 43.7030    45.6560      3.2741     0.51342     7.5198     0.51499     0.51342
   79 43.7030    45.6560      9.2942     1.76980     9.6336     1.83313     1.82438
   80 43.7030    45.6560       .          .           .          .           .     
   81 43.7030    45.6560       .          .           .          .           .     
   82 43.7030    45.6560     11.9660     1.87643     8.8828     1.88215     1.87643
   83 43.7030    45.6560      5.0292     0.73079     8.5946     0.99194     0.98721
   84 43.7030    45.6560     15.7255     1.13055     2.5032     1.19667     1.19581
   85 43.7030    45.6560      1.3058     0.12637     4.4504     0.12652     0.12637
   86 43.7030    45.6560      7.2296     1.37919     6.8987     1.13716     1.13370
   87 43.7030    45.6560     -3.1716    -0.83159     7.0286    -0.62555    -0.62257
   88 43.7030    45.6560      8.7478     0.76146     2.3212     0.66568     0.66521
   89 40.3502    41.9533    -17.2832    -1.64246     2.2683    -1.64370    -1.64246
   90 40.3502    41.9533     -5.1661     0.58864     5.9464    -0.81777    -0.81607
                                                           The SAS System                          11:46 Friday, January 6, 2023  10

 
  Obs USUBJID  AVISIT  ARMCD  RACE

   91  PT23     VIS3    PBO   Black or African American                                                                           
   92  PT23     VIS4    PBO   Black or African American                                                                           
   93  PT24     VIS1    TRT   White                                                                                               
   94  PT24     VIS2    TRT   White                                                                                               
   95  PT24     VIS3    TRT   White                                                                                               
   96  PT24     VIS4    TRT   White                                                                                               
   97  PT25     VIS1    TRT   White                                                                                               
   98  PT25     VIS2    TRT   White                                                                                               
   99  PT25     VIS3    TRT   White                                                                                               
  100  PT25     VIS4    TRT   White                                                                                               
  101  PT26     VIS1    TRT   White                                                                                               
  102  PT26     VIS2    TRT   White                                                                                               
  103  PT26     VIS3    TRT   White                                                                                               
  104  PT26     VIS4    TRT   White                                                                                               
  105  PT27     VIS1    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

   91 Female    29.925606083    43.606263938    0.8423641091               3    -0.542520031    41.1517    0.40805    535     0.05
   92 Female    29.925606083               .    0.7465428408               4     1.207867806    41.1517    0.40805    535     0.05
   93 Female    39.073571252    29.597732758    0.1630506719               1    1.1604026157    44.6795    0.49709    535     0.05
   94 Female    39.073571252    35.506880204    0.5807426253               2    0.7002136495    44.6795    0.49709    535     0.05
   95 Female    39.073571252     55.42944438    0.6718239045               3    1.5868334545    44.6795    0.49709    535     0.05
   96 Female    39.073571252    52.105298162    0.5110765226               4    0.5584864256    44.6795    0.49709    535     0.05
   97 Female    49.125423343    31.696436889    0.6760932039               1    -1.276592208    44.6795    0.49709    535     0.05
   98 Female    49.125423343     32.16159321    0.6999570159               2    -0.573265414    44.6795    0.49709    535     0.05
   99 Female    49.125423343    51.047349622    0.1765124191               3    -1.224612615    44.6795    0.49709    535     0.05
  100 Female    49.125423343    55.859865519    0.4182606921               4    -0.473400636    44.6795    0.49709    535     0.05
  101 Female    53.224143056    49.117058066    0.3355723225               1    -0.620366677    44.6795    0.49709    535     0.05
  102 Female    53.224143056    49.255437211    0.5938029325               2    0.0421158731    44.6795    0.49709    535     0.05
  103 Female    53.224143056    51.722113705    0.8794193018               3    -0.910921649    44.6795    0.49709    535     0.05
  104 Female    53.224143056    69.991277128    0.5945696304               4    0.1580287724    44.6795    0.49709    535     0.05
  105 Female    45.795904443    22.071687171    0.5170953548               1    -0.654584644    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

   91 40.3502    41.9533      2.4545     0.27288     9.2802     0.50815     0.50635
   92 40.3502    41.9533       .          .           .          .           .     
   93 43.7030    45.6560    -15.0817    -1.45959     2.8644    -1.46129    -1.45959
   94 43.7030    45.6560     -9.1726    -0.64829     4.8713    -1.44278    -1.43839
   95 43.7030    45.6560     10.7500     2.30288    10.1631     2.12026     2.11015
   96 43.7030    45.6560      7.4258    -0.55242     1.0073     0.56508     0.56468
   97 43.7030    45.6560    -12.9830    -1.25648     3.0675    -1.25794    -1.25648
   98 43.7030    45.6560    -12.5179    -1.50825     4.0113    -1.96897    -1.96298
   99 43.7030    45.6560      6.3679     1.54399     9.4042     1.25596     1.24997
  100 43.7030    45.6560     11.1804     0.33149     1.8912     0.85080     0.85019
  101 43.7030    45.6560      4.4376     0.42946     4.7535     0.42996     0.42946
  102 43.7030    45.6560      4.5760     0.57665     6.0962     0.71976     0.71757
  103 43.7030    45.6560      7.0426     1.29381     9.1540     1.38905     1.38242
  104 43.7030    45.6560     25.3118     1.80551     3.3652     1.92616     1.92478
  105 43.7030    45.6560    -22.6078    -2.18796     2.1361    -2.19049    -2.18796
                                                           The SAS System                          11:46 Friday, January 6, 2023  11

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  106  PT27     VIS2    TRT   Black or African American                                                                           
  107  PT27     VIS3    TRT   Black or African American                                                                           
  108  PT27     VIS4    TRT   Black or African American                                                                           
  109  PT28     VIS1    TRT   Black or African American                                                                           
  110  PT28     VIS2    TRT   Black or African American                                                                           
  111  PT28     VIS3    TRT   Black or African American                                                                           
  112  PT28     VIS4    TRT   Black or African American                                                                           
  113  PT29     VIS1    TRT   Black or African American                                                                           
  114  PT29     VIS2    TRT   Black or African American                                                                           
  115  PT29     VIS3    TRT   Black or African American                                                                           
  116  PT29     VIS4    TRT   Black or African American                                                                           
  117  PT30     VIS1    TRT   Asian                                                                                               
  118  PT30     VIS2    TRT   Asian                                                                                               
  119  PT30     VIS3    TRT   Asian                                                                                               
  120  PT30     VIS4    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  106 Female    45.795904443               .    0.8220030367               2    1.7672872694    44.6795    0.49709    535     0.05
  107 Female    45.795904443    46.083927828    0.6099635461               3     0.716707476    44.6795    0.49709    535     0.05
  108 Female    45.795904443    52.422880333    0.7914409064               4    0.9101742295    44.6795    0.49709    535     0.05
  109 Male      44.137340321    37.694659801    0.3008941928               1    0.3841853578    44.6795    0.49709    535     0.05
  110 Male      44.137340321    44.593999244    0.2720552646               2    1.6821760805    44.6795    0.49709    535     0.05
  111 Male      44.137340321    52.088974364    0.5875808358               3    -0.635736454    44.6795    0.49709    535     0.05
  112 Male      44.137340321    58.229606251    0.4067557083               4     -0.46164473    44.6795    0.49709    535     0.05
  113 Male      31.228939603    37.228241585    0.7042168356               1    1.4322822385    44.6795    0.49709    535     0.05
  114 Male      31.228939603     34.39862752    0.4037889943               2    -0.650696353    44.6795    0.49709    535     0.05
  115 Male      31.228939603               .    0.7359776508               3    -0.207380744    44.6795    0.49709    535     0.05
  116 Male      31.228939603    36.340121328    0.8245529087               4    -0.392807929    44.6795    0.49709    535     0.05
  117 Female    39.906338663    45.441815913    0.8872209387               1    -0.319992869    44.6795    0.49709    535     0.05
  118 Female    39.906338663    41.548470143    0.5703583788               2    -0.279113303    44.6795    0.49709    535     0.05
  119 Female    39.906338663    43.921722801    0.1075712413               3    0.4941883313    44.6795    0.49709    535     0.05
  120 Female    39.906338663    61.832428688    0.3566336554               4    -0.177330482    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  106 43.7030    45.6560       .          .           .          .           .     
  107 43.7030    45.6560      1.4044     0.39032     8.9467     0.27701     0.27568
  108 43.7030    45.6560      7.7434    -0.32174     2.0543     0.58925     0.58883
  109 43.7030    45.6560     -6.9848    -0.67598     3.6480    -0.67677    -0.67598
  110 43.7030    45.6560     -0.0855     0.55555     6.0751    -0.01345    -0.01340
  111 43.7030    45.6560      7.4095     1.42793     9.2882     1.46141     1.45443
  112 43.7030    45.6560     13.5501     0.29591     1.8556     1.03113     1.03039
  113 43.7030    45.6560     -7.4512    -0.72112     3.6029    -0.72196    -0.72112
  114 43.7030    45.6560    -10.2809    -1.50224     4.0173    -1.61710    -1.61218
  115 43.7030    45.6560       .          .           .          .           .     
  116 43.7030    45.6560     -8.3394    -0.60892     3.4188    -0.63460    -0.63415
  117 43.7030    45.6560      0.7623     0.07378     4.3978     0.07386     0.07378
  118 43.7030    45.6560     -3.1310    -0.70626     4.8133    -0.49248    -0.49099
  119 43.7030    45.6560     -0.7578    -0.05432     7.8059    -0.14946    -0.14874
  120 43.7030    45.6560     17.1529     1.72996     3.2897     1.30529     1.30436
                                                           The SAS System                          11:46 Friday, January 6, 2023  12

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  121  PT31     VIS1    PBO   Asian                                                                                               
  122  PT31     VIS2    PBO   Asian                                                                                               
  123  PT31     VIS3    PBO   Asian                                                                                               
  124  PT31     VIS4    PBO   Asian                                                                                               
  125  PT32     VIS1    TRT   Black or African American                                                                           
  126  PT32     VIS2    TRT   Black or African American                                                                           
  127  PT32     VIS3    TRT   Black or African American                                                                           
  128  PT32     VIS4    TRT   Black or African American                                                                           
  129  PT33     VIS1    TRT   Black or African American                                                                           
  130  PT33     VIS2    TRT   Black or African American                                                                           
  131  PT33     VIS3    TRT   Black or African American                                                                           
  132  PT33     VIS4    TRT   Black or African American                                                                           
  133  PT34     VIS1    PBO   Asian                                                                                               
  134  PT34     VIS2    PBO   Asian                                                                                               
  135  PT34     VIS3    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  121 Female     51.85189773    27.256556394    0.5475653866               1    -0.505957462    41.1517    0.40805    535     0.05
  122 Female     51.85189773               .    0.5119340481               2    1.3430388252    41.1517    0.40805    535     0.05
  123 Female     51.85189773     45.65133289    0.1717694897               3    -0.214579409    41.1517    0.40805    535     0.05
  124 Female     51.85189773               .     0.646600459               4     -0.17955653    41.1517    0.40805    535     0.05
  125 Male      38.091867548    33.193337655    0.6679776397               1    -0.100190741    44.6795    0.49709    535     0.05
  126 Male      38.091867548               .    0.7401852433               2    0.7126663071    44.6795    0.49709    535     0.05
  127 Male      38.091867548               .    0.8552627319               3    -0.073564404    44.6795    0.49709    535     0.05
  128 Male      38.091867548    41.668264343    0.2493169101               4    -0.037634171    44.6795    0.49709    535     0.05
  129 Male      20.183215828    27.127529337    0.3229138259               1    -0.681660479    44.6795    0.49709    535     0.05
  130 Male      20.183215828    31.748579276    0.7194106311               2    -0.324270272    44.6795    0.49709    535     0.05
  131 Male      20.183215828               .    0.1267580917               3    0.0601604404    44.6795    0.49709    535     0.05
  132 Male      20.183215828    41.600002284    0.6375345126               4    -0.588894486    44.6795    0.49709    535     0.05
  133 Female    49.270799769    39.452503413    0.7502136976               1    0.5314961926    41.1517    0.40805    535     0.05
  134 Female    49.270799769    32.618233958    0.6305289911               2    -1.518394082    41.1517    0.40805    535     0.05
  135 Female    49.270799769     34.62445244    0.8555797381               3    0.3065578608    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  121 40.3502    41.9533    -13.8952    -1.32049     2.5903    -1.32149    -1.32049
  122 40.3502    41.9533       .          .           .          .           .     
  123 40.3502    41.9533      4.4996     0.75465     9.8646     0.93153     0.92823
  124 40.3502    41.9533       .          .           .          .           .     
  125 43.7030    45.6560    -11.4861    -1.11162     3.2124    -1.11290    -1.11162
  126 43.7030    45.6560       .          .           .          .           .     
  127 43.7030    45.6560       .          .           .          .           .     
  128 43.7030    45.6560     -3.0112    -0.64681     4.5359    -0.22915    -0.22898
  129 43.7030    45.6560    -17.5520    -1.69866     2.6254    -1.70063    -1.69866
  130 43.7030    45.6560    -12.9309    -1.21827     4.3013    -2.03393    -2.02774
  131 43.7030    45.6560       .          .           .          .           .     
  132 43.7030    45.6560     -3.0795    -0.60278     3.4249    -0.23434    -0.23417
  133 40.3502    41.9533     -1.6992    -0.16148     3.7493    -0.16160    -0.16148
  134 40.3502    41.9533     -8.5335    -1.82239     3.5354    -1.35081    -1.34800
  135 40.3502    41.9533     -6.5273    -1.34637     7.6610    -1.35132    -1.34652
                                                           The SAS System                          11:46 Friday, January 6, 2023  13

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  136  PT34     VIS4    PBO   Asian                                                                                               
  137  PT35     VIS1    TRT   Black or African American                                                                           
  138  PT35     VIS2    TRT   Black or African American                                                                           
  139  PT35     VIS3    TRT   Black or African American                                                                           
  140  PT35     VIS4    TRT   Black or African American                                                                           
  141  PT36     VIS1    TRT   Asian                                                                                               
  142  PT36     VIS2    TRT   Asian                                                                                               
  143  PT36     VIS3    TRT   Asian                                                                                               
  144  PT36     VIS4    TRT   Asian                                                                                               
  145  PT37     VIS1    PBO   White                                                                                               
  146  PT37     VIS2    PBO   White                                                                                               
  147  PT37     VIS3    PBO   White                                                                                               
  148  PT37     VIS4    PBO   White                                                                                               
  149  PT38     VIS1    PBO   Asian                                                                                               
  150  PT38     VIS2    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  136 Female    49.270799769    45.905148261    0.7998752542               4    -1.536449824    41.1517    0.40805    535     0.05
  137 Female    55.987010244    36.177803217    0.6578969581               1    -0.300976127    44.6795    0.49709    535     0.05
  138 Female    55.987010244    39.797955816    0.2480327131               2    -0.528279904    44.6795    0.49709    535     0.05
  139 Female    55.987010244               .    0.1780354483               3    -0.652094781    44.6795    0.49709    535     0.05
  140 Female    55.987010244    50.082717241    0.7462079927               4    -0.056896778    44.6795    0.49709    535     0.05
  141 Female    22.720081408               .    0.5174221084               1    -1.914359426    44.6795    0.49709    535     0.05
  142 Female    22.720081408     44.64315775    0.6548325414               2     1.176583312    44.6795    0.49709    535     0.05
  143 Female    22.720081408               .    0.2730636714               3    -1.664972436    44.6795    0.49709    535     0.05
  144 Female    22.720081408    39.735287881    0.6039542973               4    -0.463530401    44.6795    0.49709    535     0.05
  145 Female    28.610500458    34.061642527     0.217606302               1    -1.115920105    41.1517    0.40805    535     0.05
  146 Female    28.610500458    40.185923507    0.8672563674               2    -0.750819001    41.1517    0.40805    535     0.05
  147 Female    28.610500458    41.175841555    0.8920883574               3    2.0871665456    41.1517    0.40805    535     0.05
  148 Female    28.610500458    57.766693925    0.4971514463               4    0.0173956197    41.1517    0.40805    535     0.05
  149 Female    59.302696135    38.184602643    0.8357181149               1     -1.28630053    41.1517    0.40805    535     0.05
  150 Female    59.302696135               .    0.3977041127               2    -1.640605534    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  136 40.3502    41.9533      4.7534     0.74280     3.9884     0.41407     0.41381
  137 43.7030    45.6560     -8.5017    -0.82278     3.5012    -0.82374    -0.82278
  138 43.7030    45.6560     -4.8815    -0.30600     5.2135    -0.76783    -0.76549
  139 43.7030    45.6560       .          .           .          .           .     
  140 43.7030    45.6560      5.4032     0.21423     4.2420     0.41117     0.41088
  141 43.7030    45.6560       .          .           .          .           .     
  142 43.7030    45.6560     -0.0363    -0.00570     7.0007    -0.00571    -0.00570
  143 43.7030    45.6560       .          .           .          .           .     
  144 43.7030    45.6560     -4.9442    -0.37690     3.4236    -0.37624    -0.37597
  145 40.3502    41.9533     -7.0901    -0.67379     3.2370    -0.67430    -0.67379
  146 40.3502    41.9533     -0.9658     0.51172     5.8695    -0.15288    -0.15257
  147 40.3502    41.9533      0.0241    -0.09803     8.9093     0.00499     0.00497
  148 40.3502    41.9533     16.6150     1.39253     4.6382     1.44733     1.44642
  149 40.3502    41.9533     -2.9671    -0.28197     3.6288    -0.28219    -0.28197
  150 40.3502    41.9533       .          .           .          .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  14

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  151  PT38     VIS3    PBO   Asian                                                                                               
  152  PT38     VIS4    PBO   Asian                                                                                               
  153  PT39     VIS1    PBO   Asian                                                                                               
  154  PT39     VIS2    PBO   Asian                                                                                               
  155  PT39     VIS3    PBO   Asian                                                                                               
  156  PT39     VIS4    PBO   Asian                                                                                               
  157  PT40     VIS1    PBO   Black or African American                                                                           
  158  PT40     VIS2    PBO   Black or African American                                                                           
  159  PT40     VIS3    PBO   Black or African American                                                                           
  160  PT40     VIS4    PBO   Black or African American                                                                           
  161  PT41     VIS1    PBO   Black or African American                                                                           
  162  PT41     VIS2    PBO   Black or African American                                                                           
  163  PT41     VIS3    PBO   Black or African American                                                                           
  164  PT41     VIS4    PBO   Black or African American                                                                           
  165  PT42     VIS1    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  151 Female    59.302696135    47.198925604    0.7616459567               3    0.4501871013    41.1517    0.40805    535     0.05
  152 Female    59.302696135               .    0.5472343583               4    -0.018559833    41.1517    0.40805    535     0.05
  153 Female    30.074932572    37.327851507    0.7365369637               1    -0.318068375    41.1517    0.40805    535     0.05
  154 Female    30.074932572               .    0.3816173961               2    -0.929362147    41.1517    0.40805    535     0.05
  155 Female    30.074932572    43.160483725    0.2668221382               3     -1.48746031    41.1517    0.40805    535     0.05
  156 Female    30.074932572    41.403488821    0.7278244995               4    -1.075192297    41.1517    0.40805    535     0.05
  157 Male      47.973963444    30.157325274    0.6464410005               1    1.0000288037    41.1517    0.40805    535     0.05
  158 Male      47.973963444    35.843527162    0.4456088113               2    -0.621266695    41.1517    0.40805    535     0.05
  159 Male      47.973963444    40.952495072    0.7771471895               3    -1.384426847    41.1517    0.40805    535     0.05
  160 Male      47.973963444               .    0.5815550713               4    1.8692906224    41.1517    0.40805    535     0.05
  161 Male      40.206803961               .    0.6925284123               1    0.4251003774    41.1517    0.40805    535     0.05
  162 Male      40.206803961    41.379278113    0.5759216009               2    -0.238647101    41.1517    0.40805    535     0.05
  163 Male      40.206803961    50.173155965    0.7812472718               3    1.0584830487    41.1517    0.40805    535     0.05
  164 Male      40.206803961    45.352257596     0.751120807               4    0.8864226514    41.1517    0.40805    535     0.05
  165 Male      31.498258171    39.064908638    0.4043386811               1    -0.619243048    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  151 40.3502    41.9533      6.0472     1.22038    10.3304     1.25192     1.24748
  152 40.3502    41.9533       .          .           .          .           .     
  153 40.3502    41.9533     -3.8239    -0.36339     3.5474    -0.36367    -0.36339
  154 40.3502    41.9533       .          .           .          .           .     
  155 40.3502    41.9533      2.0087     0.36813     9.4781     0.41586     0.41439
  156 40.3502    41.9533      0.2517    -0.24698     2.7806     0.02193     0.02192
  157 40.3502    41.9533    -10.9944    -1.04483     2.8659    -1.04561    -1.04483
  158 40.3502    41.9533     -5.3082    -0.09924     5.2585    -0.84027    -0.83852
  159 40.3502    41.9533     -0.1992    -0.18391     8.8234    -0.04125    -0.04110
  160 40.3502    41.9533       .          .           .          .           .     
  161 40.3502    41.9533       .          .           .          .           .     
  162 40.3502    41.9533      0.2275     0.03594     6.5365     0.03602     0.03594
  163 40.3502    41.9533      9.0214     1.87147    10.9683     1.86767     1.86104
  164 40.3502    41.9533      4.2005    -0.18714     3.0515     0.36591     0.36568
  165 40.3502    41.9533     -2.0868    -0.19832     3.7124    -0.19847    -0.19832
                                                           The SAS System                          11:46 Friday, January 6, 2023  15

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  166  PT42     VIS2    PBO   Black or African American                                                                           
  167  PT42     VIS3    PBO   Black or African American                                                                           
  168  PT42     VIS4    PBO   Black or African American                                                                           
  169  PT43     VIS1    TRT   Black or African American                                                                           
  170  PT43     VIS2    TRT   Black or African American                                                                           
  171  PT43     VIS3    TRT   Black or African American                                                                           
  172  PT43     VIS4    TRT   Black or African American                                                                           
  173  PT44     VIS1    TRT   Black or African American                                                                           
  174  PT44     VIS2    TRT   Black or African American                                                                           
  175  PT44     VIS3    TRT   Black or African American                                                                           
  176  PT44     VIS4    TRT   Black or African American                                                                           
  177  PT45     VIS1    PBO   Asian                                                                                               
  178  PT45     VIS2    PBO   Asian                                                                                               
  179  PT45     VIS3    PBO   Asian                                                                                               
  180  PT45     VIS4    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  166 Male      31.498258171               .    0.4938465619               2    2.2061024645    41.1517    0.40805    535     0.05
  167 Male      31.498258171               .    0.8947019717               3     -0.25502703    41.1517    0.40805    535     0.05
  168 Male      31.498258171    42.119598119    0.2392715601               4     -1.42449465    41.1517    0.40805    535     0.05
  169 Female    43.793881966    29.810419719    0.7674246397               1    -0.144399602    44.6795    0.49709    535     0.05
  170 Female    43.793881966     42.57054682    0.4166522989               2    0.2075383392    44.6795    0.49709    535     0.05
  171 Female    43.793881966    47.816515276    0.8752449073               3    2.3079783991    44.6795    0.49709    535     0.05
  172 Female    43.793881966    68.060238315    0.2505651735               4    0.1058023679    44.6795    0.49709    535     0.05
  173 Male      43.887601096    35.620712052    0.6993773358               1    0.4569988054    44.6795    0.49709    535     0.05
  174 Male      43.887601096               .     0.346775688               2    -0.077152935    44.6795    0.49709    535     0.05
  175 Male      43.887601096               .    0.4032471212               3    -0.334000842    44.6795    0.49709    535     0.05
  176 Male      43.887601096               .    0.7006126745               4    -0.034726028    44.6795    0.49709    535     0.05
  177 Female      30.0524415    33.891339091    0.6633613404               1    0.7876396056    41.1517    0.40805    535     0.05
  178 Female      30.0524415    36.428078825    0.8364744268               2    2.0752450087    41.1517    0.40805    535     0.05
  179 Female      30.0524415    37.575188622    0.7362218501               3    1.0273924388    41.1517    0.40805    535     0.05
  180 Female      30.0524415    58.468734346    0.7632615706               4    1.2079083984    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  166 40.3502    41.9533       .          .           .          .           .     
  167 40.3502    41.9533       .          .           .          .           .     
  168 40.3502    41.9533      0.9679     0.00774     5.5471     0.08431     0.08426
  169 43.7030    45.6560    -14.8691    -1.43901     2.8850    -1.44068    -1.43901
  170 43.7030    45.6560     -2.1089     0.78648     6.3060    -0.33172    -0.33071
  171 43.7030    45.6560      3.1370     0.58730     8.4475     0.61873     0.61578
  172 43.7030    45.6560     23.3808     1.09026     2.6500     1.77921     1.77794
  173 43.7030    45.6560     -9.0588    -0.87670     3.4473    -0.87771    -0.87670
  174 43.7030    45.6560       .          .           .          .           .     
  175 43.7030    45.6560       .          .           .          .           .     
  176 43.7030    45.6560       .          .           .          .           .     
  177 40.3502    41.9533     -7.2604    -0.68997     3.2208    -0.69049    -0.68997
  178 40.3502    41.9533     -4.7237    -0.35095     5.0068    -0.74773    -0.74618
  179 40.3502    41.9533     -3.5766    -0.83344     8.1739    -0.74044    -0.73781
  180 40.3502    41.9533     17.3170     1.64758     4.8932     1.50849     1.50753
                                                           The SAS System                          11:46 Friday, January 6, 2023  16

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  181  PT46     VIS1    PBO   Asian                                                                                               
  182  PT46     VIS2    PBO   Asian                                                                                               
  183  PT46     VIS3    PBO   Asian                                                                                               
  184  PT46     VIS4    PBO   Asian                                                                                               
  185  PT47     VIS1    TRT   Asian                                                                                               
  186  PT47     VIS2    TRT   Asian                                                                                               
  187  PT47     VIS3    TRT   Asian                                                                                               
  188  PT47     VIS4    TRT   Asian                                                                                               
  189  PT48     VIS1    PBO   Black or African American                                                                           
  190  PT48     VIS2    PBO   Black or African American                                                                           
  191  PT48     VIS3    PBO   Black or African American                                                                           
  192  PT48     VIS4    PBO   Black or African American                                                                           
  193  PT49     VIS1    PBO   White                                                                                               
  194  PT49     VIS2    PBO   White                                                                                               
  195  PT49     VIS3    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  181 Male      43.459024826    19.545158439      0.23403813               1    -1.231323422    41.1517    0.40805    535     0.05
  182 Male      43.459024826    31.135414577    0.4279678235               2    0.9838955701    41.1517    0.40805    535     0.05
  183 Male      43.459024826     40.89955126    0.2570021925               3    0.2199248037    41.1517    0.40805    535     0.05
  184 Male      43.459024826               .    0.3075204995               4    -1.467250029    41.1517    0.40805    535     0.05
  185 Male      31.832628377    22.188086021    0.8763330135               1    0.5210227426    44.6795    0.49709    535     0.05
  186 Male      31.832628377    41.058565358    0.7493145617               2    -0.158754605    44.6795    0.49709    535     0.05
  187 Male      31.832628377     37.32451604    0.3780766716               3     1.464587312    44.6795    0.49709    535     0.05
  188 Male      31.832628377               .    0.8506764222               4       -0.766082    44.6795    0.49709    535     0.05
  189 Male      46.596643994               .    0.2307095151               1    -0.430211754    41.1517    0.40805    535     0.05
  190 Male      46.596643994    43.124316646    0.2254473282               2    -0.926109497    41.1517    0.40805    535     0.05
  191 Male      46.596643994    41.993490944    0.7032506058               3    -0.177103961    41.1517    0.40805    535     0.05
  192 Male      46.596643994               .    0.8088403223               4    0.4020117795    41.1517    0.40805    535     0.05
  193 Female    50.272027416    44.030804534     0.345411309               1    -0.731748173    41.1517    0.40805    535     0.05
  194 Female    50.272027416    38.664171218    0.3488653988               2     0.830373168    41.1517    0.40805    535     0.05
  195 Female    50.272027416     53.45993169    0.8876201514               3    -1.208082786    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  181 40.3502    41.9533    -21.6066    -2.05333     1.8574    -2.05487    -2.05333
  182 40.3502    41.9533    -10.0163    -0.09767     5.2601    -1.58554    -1.58224
  183 40.3502    41.9533     -0.2522    -0.33428     8.6731    -0.05221    -0.05202
  184 40.3502    41.9533       .          .           .          .           .     
  185 43.7030    45.6560    -22.4914    -2.17669     2.1473    -2.17922    -2.17669
  186 43.7030    45.6560     -3.6209     1.10107     6.6206    -0.56954    -0.56781
  187 43.7030    45.6560     -7.3550    -1.50122     6.3590    -1.45065    -1.44373
  188 43.7030    45.6560       .          .           .          .           .     
  189 40.3502    41.9533       .          .           .          .           .     
  190 40.3502    41.9533      1.9726     0.31160     6.8122     0.31225     0.31160
  191 40.3502    41.9533      0.8417     0.20186     9.2987     0.17426     0.17365
  192 40.3502    41.9533       .          .           .          .           .     
  193 40.3502    41.9533      2.8791     0.27360     4.1844     0.27381     0.27360
  194 40.3502    41.9533     -2.4876    -0.88247     4.4753    -0.39377    -0.39295
  195 40.3502    41.9533     12.3082     2.61865    11.6260     2.54811     2.53907
                                                           The SAS System                          11:46 Friday, January 6, 2023  17

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  196  PT49     VIS4    PBO   White                                                                                               
  197  PT50     VIS1    TRT   Asian                                                                                               
  198  PT50     VIS2    TRT   Asian                                                                                               
  199  PT50     VIS3    TRT   Asian                                                                                               
  200  PT50     VIS4    TRT   Asian                                                                                               
  201  PT51     VIS1    TRT   Black or African American                                                                           
  202  PT51     VIS2    TRT   Black or African American                                                                           
  203  PT51     VIS3    TRT   Black or African American                                                                           
  204  PT51     VIS4    TRT   Black or African American                                                                           
  205  PT52     VIS1    TRT   Black or African American                                                                           
  206  PT52     VIS2    TRT   Black or African American                                                                           
  207  PT52     VIS3    TRT   Black or African American                                                                           
  208  PT52     VIS4    TRT   Black or African American                                                                           
  209  PT53     VIS1    PBO   White                                                                                               
  210  PT53     VIS2    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  196 Female    50.272027416               .    0.1055433841               4    -1.047984413    41.1517    0.40805    535     0.05
  197 Female    26.037342838     29.81948312    0.3194564622               1    1.4411577068    44.6795    0.49709    535     0.05
  198 Female    26.037342838    30.438587317    0.7384353718               2    -1.015847465    44.6795    0.49709    535     0.05
  199 Female    26.037342838    40.180949072    0.2949357742               3    0.4119747123    44.6795    0.49709    535     0.05
  200 Female    26.037342838               .    0.4666187696               4    -0.381076051    44.6795    0.49709    535     0.05
  201 Female    25.582965315    26.785779162     0.570873859               1    0.4094018397    44.6795    0.49709    535     0.05
  202 Female    25.582965315     34.55115461    0.8140734229               2    1.6888732862    44.6795    0.49709    535     0.05
  203 Female    25.582965315               .    0.1990359258               3    1.5865884334    44.6795    0.49709    535     0.05
  204 Female    25.582965315    40.064211927    0.5106472129               4    -0.330907801    44.6795    0.49709    535     0.05
  205 Female    52.970446576               .    0.6309121765               1    -2.285235535    44.6795    0.49709    535     0.05
  206 Female    52.970446576    43.093286904    0.7124336001               2    2.4976615898    44.6795    0.49709    535     0.05
  207 Female    52.970446576               .    0.1741009394               3    0.6670661668    44.6795    0.49709    535     0.05
  208 Female    52.970446576    45.715674129    0.1541156266               4     0.541327336    44.6795    0.49709    535     0.05
  209 Male      37.896001364    40.749922948    0.5448786659               1    -0.013399523    41.1517    0.40805    535     0.05
  210 Male      37.896001364    44.746345225    0.6210547257               2     0.510108423    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  196 40.3502    41.9533       .          .           .          .           .     
  197 43.7030    45.6560    -14.8600    -1.43813     2.8859    -1.43980    -1.43813
  198 43.7030    45.6560    -14.2409    -1.70847     3.8111    -2.23998    -2.23317
  199 43.7030    45.6560     -4.4985    -0.57529     7.2849    -0.88727    -0.88303
  200 43.7030    45.6560       .          .           .          .           .     
  201 43.7030    45.6560    -17.8937    -1.73173     2.5923    -1.73374    -1.73173
  202 43.7030    45.6560    -10.1283    -0.61404     4.9055    -1.59311    -1.58826
  203 43.7030    45.6560       .          .           .          .           .     
  204 43.7030    45.6560     -4.6153    -0.88457     3.1432    -0.35121    -0.35096
  205 43.7030    45.6560       .          .           .          .           .     
  206 43.7030    45.6560     -1.5862    -0.24874     6.7576    -0.24950    -0.24874
  207 43.7030    45.6560       .          .           .          .           .     
  208 43.7030    45.6560      1.0362     0.06481     3.8653     0.07885     0.07880
  209 40.3502    41.9533     -0.4018    -0.03819     3.8726    -0.03821    -0.03819
  210 40.3502    41.9533      3.5946     0.88398     6.2417     0.56901     0.56783
                                                           The SAS System                          11:46 Friday, January 6, 2023  18

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  211  PT53     VIS3    PBO   White                                                                                               
  212  PT53     VIS4    PBO   White                                                                                               
  213  PT54     VIS1    TRT   White                                                                                               
  214  PT54     VIS2    TRT   White                                                                                               
  215  PT54     VIS3    TRT   White                                                                                               
  216  PT54     VIS4    TRT   White                                                                                               
  217  PT55     VIS1    TRT   Asian                                                                                               
  218  PT55     VIS2    TRT   Asian                                                                                               
  219  PT55     VIS3    TRT   Asian                                                                                               
  220  PT55     VIS4    TRT   Asian                                                                                               
  221  PT56     VIS1    PBO   Black or African American                                                                           
  222  PT56     VIS2    PBO   Black or African American                                                                           
  223  PT56     VIS3    PBO   Black or African American                                                                           
  224  PT56     VIS4    PBO   Black or African American                                                                           
  225  PT57     VIS1    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  211 Male      37.896001364               .    0.3367701508               3    -0.164375832    41.1517    0.40805    535     0.05
  212 Male      37.896001364               .    0.6564039065               4    0.4206946433    41.1517    0.40805    535     0.05
  213 Female    41.543149552               .    0.4021359652               1    -0.400246744    44.6795    0.49709    535     0.05
  214 Female    41.543149552               .     0.308769553               2    -1.370207878    44.6795    0.49709    535     0.05
  215 Female    41.543149552               .    0.8521271899               3    0.9878382675    44.6795    0.49709    535     0.05
  216 Female    41.543149552               .    0.4447119582               4    1.5197450255    44.6795    0.49709    535     0.05
  217 Male      50.709326063    40.146740063    0.3616516676               1    -0.308740569    44.6795    0.49709    535     0.05
  218 Male      50.709326063    48.758590233    0.5279265106               2    -1.253289756    44.6795    0.49709    535     0.05
  219 Male      50.709326063    46.434617632    0.6007532934               3    0.6422413057    44.6795    0.49709    535     0.05
  220 Male      50.709326063               .    0.2363375895               4    -0.044709137    44.6795    0.49709    535     0.05
  221 Male      39.562896292    29.339898377    0.1874530435               1    -1.733218407    41.1517    0.40805    535     0.05
  222 Male      39.562896292               .    0.1858230261               2    0.0021318597    41.1517    0.40805    535     0.05
  223 Male      39.562896292               .    0.1741934184               3    -0.630300334    41.1517    0.40805    535     0.05
  224 Male      39.562896292     47.93164615    0.5276604237               4     -0.34096858    41.1517    0.40805    535     0.05
  225 Male      39.364331875               .    0.8171113716               1    -1.156572363    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  211 40.3502    41.9533       .          .           .          .           .     
  212 40.3502    41.9533       .          .           .          .           .     
  213 43.7030    45.6560       .          .           .          .           .     
  214 43.7030    45.6560       .          .           .          .           .     
  215 43.7030    45.6560       .          .           .          .           .     
  216 43.7030    45.6560       .          .           .          .           .     
  217 43.7030    45.6560     -4.5327    -0.43867     3.8854    -0.43918    -0.43867
  218 43.7030    45.6560      4.0791     1.21055     6.7301     0.64161     0.63966
  219 43.7030    45.6560      1.7551     0.20016     8.0604     0.34617     0.34452
  220 43.7030    45.6560       .          .           .          .           .     
  221 40.3502    41.9533    -11.8118    -1.12251     2.7882    -1.12335    -1.12251
  222 40.3502    41.9533       .          .           .          .           .     
  223 40.3502    41.9533       .          .           .          .           .     
  224 40.3502    41.9533      6.7799     0.16682     5.7062     0.59060     0.59023
  225 43.7030    45.6560       .          .           .          .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  19

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  226  PT57     VIS2    TRT   Black or African American                                                                           
  227  PT57     VIS3    TRT   Black or African American                                                                           
  228  PT57     VIS4    TRT   Black or African American                                                                           
  229  PT58     VIS1    TRT   White                                                                                               
  230  PT58     VIS2    TRT   White                                                                                               
  231  PT58     VIS3    TRT   White                                                                                               
  232  PT58     VIS4    TRT   White                                                                                               
  233  PT59     VIS1    TRT   White                                                                                               
  234  PT59     VIS2    TRT   White                                                                                               
  235  PT59     VIS3    TRT   White                                                                                               
  236  PT59     VIS4    TRT   White                                                                                               
  237  PT60     VIS1    TRT   Black or African American                                                                           
  238  PT60     VIS2    TRT   Black or African American                                                                           
  239  PT60     VIS3    TRT   Black or African American                                                                           
  240  PT60     VIS4    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  226 Male      39.364331875    41.116315332    0.6680208152               2    1.8031419079    44.6795    0.49709    535     0.05
  227 Male      39.364331875    47.058887596    0.8251633376               3    -0.331132036    44.6795    0.49709    535     0.05
  228 Male      39.364331875    52.245990919    0.4493508866               4    -1.605513412    44.6795    0.49709    535     0.05
  229 Female    56.770273206               .    0.4742551142               1    0.1971934387    44.6795    0.49709    535     0.05
  230 Female    56.770273206    54.142358224    0.5784956098               2    0.2631756464    44.6795    0.49709    535     0.05
  231 Female    56.770273206    50.446179579    0.3453983054               3      -0.9858267    44.6795    0.49709    535     0.05
  232 Female    56.770273206               .    0.5576006792               4    -2.888920672    44.6795    0.49709    535     0.05
  233 Female    47.800421972    37.536574647    0.4833625233               1    -0.640481703    44.6795    0.49709    535     0.05
  234 Female    47.800421972               .    0.6572935842               2    0.5705076359    44.6795    0.49709    535     0.05
  235 Female    47.800421972    49.458402751      0.68822388               3    -0.059723276    44.6795    0.49709    535     0.05
  236 Female    47.800421972     59.12866327    0.5132509131               4    -0.098178744    44.6795    0.49709    535     0.05
  237 Female    33.464257733    40.312676503    0.8882970853               1    0.5608207286    44.6795    0.49709    535     0.05
  238 Female    33.464257733    39.660494163    0.8343834065               2    -1.186458639    44.6795    0.49709    535     0.05
  239 Female    33.464257733    50.897259494    0.4779903404               3    1.0967770443    44.6795    0.49709    535     0.05
  240 Female    33.464257733     56.13116468    0.4045013223               4    -0.005344028    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  226 43.7030    45.6560     -3.5632    -0.55875     6.4476    -0.56046    -0.55875
  227 43.7030    45.6560      2.3794     0.55104     8.4148     0.46930     0.46706
  228 43.7030    45.6560      7.5665     0.38970     1.7624     0.57579     0.57538
  229 43.7030    45.6560       .          .           .          .           .     
  230 43.7030    45.6560      9.4629     1.48391     8.4903     1.48844     1.48391
  231 43.7030    45.6560      5.7667     0.93270     8.7965     1.13739     1.13196
  232 43.7030    45.6560       .          .           .          .           .     
  233 43.7030    45.6560     -7.1429    -0.69128     3.6327    -0.69208    -0.69128
  234 43.7030    45.6560       .          .           .          .           .     
  235 43.7030    45.6560      4.7789     0.97545     9.5319     0.94257     0.93807
  236 43.7030    45.6560     14.4492     0.61951     2.9956     1.09954     1.09876
  237 43.7030    45.6560     -4.3668    -0.42261     3.9014    -0.42310    -0.42261
  238 43.7030    45.6560     -5.0190    -0.67354     4.8460    -0.78945    -0.78705
  239 43.7030    45.6560      6.2178     1.35202     9.2123     1.22636     1.22051
  240 43.7030    45.6560     11.4517     0.54254     2.1022     0.87144     0.87082
                                                           The SAS System                          11:46 Friday, January 6, 2023  20

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  241  PT61     VIS1    TRT   Asian                                                                                               
  242  PT61     VIS2    TRT   Asian                                                                                               
  243  PT61     VIS3    TRT   Asian                                                                                               
  244  PT61     VIS4    TRT   Asian                                                                                               
  245  PT62     VIS1    PBO   Asian                                                                                               
  246  PT62     VIS2    PBO   Asian                                                                                               
  247  PT62     VIS3    PBO   Asian                                                                                               
  248  PT62     VIS4    PBO   Asian                                                                                               
  249  PT63     VIS1    PBO   White                                                                                               
  250  PT63     VIS2    PBO   White                                                                                               
  251  PT63     VIS3    PBO   White                                                                                               
  252  PT63     VIS4    PBO   White                                                                                               
  253  PT64     VIS1    PBO   Black or African American                                                                           
  254  PT64     VIS2    PBO   Black or African American                                                                           
  255  PT64     VIS3    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  241 Male      40.936610464    32.829811967    0.8510482939               1    0.7073106674    44.6795    0.49709    535     0.05
  242 Male      40.936610464    46.538372511    0.8555816347               2    1.0341077347    44.6795    0.49709    535     0.05
  243 Male      40.936610464               .    0.8254597241               3    0.2234804149    44.6795    0.49709    535     0.05
  244 Male      40.936610464    51.812645697    0.7275021588               4    -0.878707613    44.6795    0.49709    535     0.05
  245 Female    37.139052323               .    0.6010648532               1     1.162964556    41.1517    0.40805    535     0.05
  246 Female    37.139052323    29.919390341    0.6405149708               2    -2.000164945    41.1517    0.40805    535     0.05
  247 Female    37.139052323               .    0.8496878035               3     -0.54479074    41.1517    0.40805    535     0.05
  248 Female    37.139052323               .    0.5276217207               4    -0.255670709    41.1517    0.40805    535     0.05
  249 Female     42.97010526               .    0.3694320207               1    -0.166121037    41.1517    0.40805    535     0.05
  250 Female     42.97010526    51.056564567    0.7325366184               2    1.0204639088    41.1517    0.40805    535     0.05
  251 Female     42.97010526    50.500586325    0.1986116573               3    0.1362218931    41.1517    0.40805    535     0.05
  252 Female     42.97010526    64.113878971    0.8673026577               4    0.4071676034    41.1517    0.40805    535     0.05
  253 Female    31.091887032    32.218432885    0.1259935936               1    -0.069654813    41.1517    0.40805    535     0.05
  254 Female    31.091887032    29.647321565    0.3077513471               2    -0.247664342    41.1517    0.40805    535     0.05
  255 Female    31.091887032               .    0.8011442011               3    0.6955508066    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  241 43.7030    45.6560    -11.8497    -1.14680     3.1772    -1.14813    -1.14680
  242 43.7030    45.6560      1.8589     1.35447     6.8740     0.29239     0.29150
  243 43.7030    45.6560       .          .           .          .           .     
  244 43.7030    45.6560      7.1332    -0.15261     3.8751     0.54281     0.54243
  245 40.3502    41.9533       .          .           .          .           .     
  246 40.3502    41.9533    -11.2324    -1.77433     4.7262    -1.77803    -1.77433
  247 40.3502    41.9533       .          .           .          .           .     
  248 40.3502    41.9533       .          .           .          .           .     
  249 40.3502    41.9533       .          .           .          .           .     
  250 40.3502    41.9533      9.9048     1.56463     8.0652     1.56789     1.56463
  251 40.3502    41.9533      9.3488     2.07438    11.1712     1.93545     1.92858
  252 40.3502    41.9533     22.9621     2.07211     5.3107     2.00024     1.99897
  253 40.3502    41.9533     -8.9333    -0.84895     3.0618    -0.84959    -0.84895
  254 40.3502    41.9533    -11.5044    -1.76544     3.5923    -1.82110    -1.81731
  255 40.3502    41.9533       .          .           .          .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  21

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  256  PT64     VIS4    PBO   Black or African American                                                                           
  257  PT65     VIS1    TRT   Asian                                                                                               
  258  PT65     VIS2    TRT   Asian                                                                                               
  259  PT65     VIS3    TRT   Asian                                                                                               
  260  PT65     VIS4    TRT   Asian                                                                                               
  261  PT66     VIS1    TRT   Asian                                                                                               
  262  PT66     VIS2    TRT   Asian                                                                                               
  263  PT66     VIS3    TRT   Asian                                                                                               
  264  PT66     VIS4    TRT   Asian                                                                                               
  265  PT67     VIS1    TRT   White                                                                                               
  266  PT67     VIS2    TRT   White                                                                                               
  267  PT67     VIS3    TRT   White                                                                                               
  268  PT67     VIS4    TRT   White                                                                                               
  269  PT68     VIS1    TRT   White                                                                                               
  270  PT68     VIS2    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  256 Female    31.091887032    45.099187294    0.7764995754               4    1.1462283572    41.1517    0.40805    535     0.05
  257 Female    29.588498795    39.756591574    0.1134831225               1    -2.403096215    44.6795    0.49709    535     0.05
  258 Female    29.588498795    37.288937461    0.2469126964               2    0.5727395552    44.6795    0.49709    535     0.05
  259 Female    29.588498795    44.801446093    0.1926737046               3    0.3747244068    44.6795    0.49709    535     0.05
  260 Female    29.588498795    65.959197101    0.4827316964               4    -0.425267722    44.6795    0.49709    535     0.05
  261 Male       30.76419069    33.434393783    0.8597799066               1    0.9510128076    44.6795    0.49709    535     0.05
  262 Male       30.76419069    33.570422159    0.7605901524               2    -0.389237182    44.6795    0.49709    535     0.05
  263 Male       30.76419069    39.915432525     0.749246968               3    -0.284330662    44.6795    0.49709    535     0.05
  264 Male       30.76419069    49.570977059    0.8325895442               4    0.8574097781    44.6795    0.49709    535     0.05
  265 Female    25.601290344    38.916343315    0.6601322159               1    1.7196272991    44.6795    0.49709    535     0.05
  266 Female    25.601290344     36.69010922    0.1664308568               2    0.2700549009    44.6795    0.49709    535     0.05
  267 Female    25.601290344    45.666649734    0.1944609081               3     -0.42218401    44.6795    0.49709    535     0.05
  268 Female    25.601290344    52.074314233    0.7349197242               4    -1.189113295    44.6795    0.49709    535     0.05
  269 Female    21.938934396    42.214112374    0.8968350682               1    -0.331032979    44.6795    0.49709    535     0.05
  270 Female    21.938934396    45.029008433    0.6528285215               2    -0.939829327    44.6795    0.49709    535     0.05

                                         Scaled       Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid          Dep      Resid       Resid

  256 40.3502    41.9533      3.9474    -0.04559      5.6798     0.34386     0.34365
  257 43.7030    45.6560     -4.9229    -0.47643      3.8476    -0.47698    -0.47643
  258 43.7030    45.6560     -7.3905    -1.11548      4.4041    -1.16248    -1.15894
  259 43.7030    45.6560      0.1220     0.20729      8.0675     0.02406     0.02394
  260 43.7030    45.6560     21.2797     1.88751      3.4472     1.61933     1.61817
  261 43.7030    45.6560    -11.2451    -1.08829      3.2357    -1.08955    -1.08829
  262 43.7030    45.6560    -11.1091    -1.36121      4.1583    -1.74737    -1.74205
  263 43.7030    45.6560     -4.7640    -0.69562      7.1646    -0.93963    -0.93515
  264 43.7030    45.6560      4.8915     0.57774      2.1374     0.37223     0.37196
  265 43.7030    45.6560     -5.7631    -0.55775      3.7663    -0.55840    -0.55775
  266 43.7030    45.6560     -7.9894    -1.16965      4.3499    -1.25667    -1.25284
  267 43.7030    45.6560      0.9872     0.39101      8.2512     0.19470     0.19377
  268 43.7030    45.6560      7.3948     0.58602      2.1457     0.56273     0.56232
  269 43.7030    45.6560     -2.4654    -0.23860      4.0854    -0.23887    -0.23860
  270 43.7030    45.6560      0.3495     0.27415      5.7937     0.05498     0.05481
                                                           The SAS System                          11:46 Friday, January 6, 2023  22

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  271  PT68     VIS3    TRT   White                                                                                               
  272  PT68     VIS4    TRT   White                                                                                               
  273  PT69     VIS1    PBO   Black or African American                                                                           
  274  PT69     VIS2    PBO   Black or African American                                                                           
  275  PT69     VIS3    PBO   Black or African American                                                                           
  276  PT69     VIS4    PBO   Black or African American                                                                           
  277  PT70     VIS1    PBO   Black or African American                                                                           
  278  PT70     VIS2    PBO   Black or African American                                                                           
  279  PT70     VIS3    PBO   Black or African American                                                                           
  280  PT70     VIS4    PBO   Black or African American                                                                           
  281  PT71     VIS1    TRT   Asian                                                                                               
  282  PT71     VIS2    TRT   Asian                                                                                               
  283  PT71     VIS3    TRT   Asian                                                                                               
  284  PT71     VIS4    TRT   Asian                                                                                               
  285  PT72     VIS1    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  271 Female    21.938934396               .    0.2178713454               3    -0.258932583    44.6795    0.49709    535     0.05
  272 Female    21.938934396               .    0.3542782543               4    0.3943791682    44.6795    0.49709    535     0.05
  273 Male      51.741896784    30.983375056    0.2247831132               1    -0.851857092    41.1517    0.40805    535     0.05
  274 Male      51.741896784    44.729319186    0.8962028382               2    2.6491668811    41.1517    0.40805    535     0.05
  275 Male      51.741896784    40.687109013    0.6985818183               3    0.1560116757    41.1517    0.40805    535     0.05
  276 Male      51.741896784    34.715298508    0.4144314721               4    1.1302072675    41.1517    0.40805    535     0.05
  277 Male      43.348050968    27.307524806    0.5411130585               1     -2.28912398    41.1517    0.40805    535     0.05
  278 Male      43.348050968    37.315845238    0.1235280413               2    0.7410011572    41.1517    0.40805    535     0.05
  279 Male      43.348050968               .    0.3690416019               3     -1.31624516    41.1517    0.40805    535     0.05
  280 Male      43.348050968    44.829998571    0.7867033411               4    0.9198036776    41.1517    0.40805    535     0.05
  281 Male      41.143654822    32.930420054    0.2016705088               1    0.3981301555    44.6795    0.49709    535     0.05
  282 Male      41.143654822     44.91911419    0.7331955833               2    -0.407528579    44.6795    0.49709    535     0.05
  283 Male      41.143654822    45.686356781     0.178305514               3    1.3242586302    44.6795    0.49709    535     0.05
  284 Male      41.143654822    65.987998659     0.115322772               4    -0.701231669    44.6795    0.49709    535     0.05
  285 Female    37.102864171    46.601299546    0.3208179358               1    -0.580614304    44.6795    0.49709    535     0.05

                                         Scaled       Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid          Dep      Resid       Resid

  271 43.7030    45.6560       .          .            .          .           .     
  272 43.7030    45.6560       .          .            .          .           .     
  273 40.3502    41.9533    -10.1684    -0.96633      2.9444    -0.96705    -0.96633
  274 40.3502    41.9533      3.5776     1.89658      7.2543     0.56631     0.56514
  275 40.3502    41.9533     -0.4646    -0.26722      8.7401    -0.09619    -0.09585
  276 40.3502    41.9533     -6.4364    -0.91376      2.3319    -0.56068    -0.56033
  277 40.3502    41.9533    -13.8442    -1.31565      2.5951    -1.31664    -1.31565
  278 40.3502    41.9533     -3.8359     0.54233      5.9001    -0.60720    -0.60594
  279 40.3502    41.9533       .          .            .          .           .     
  280 40.3502    41.9533      3.6783    -0.18940      5.5360     0.32041     0.32021
  281 43.7030    45.6560    -11.7491    -1.13706      3.1870    -1.13838    -1.13706
  282 43.7030    45.6560      0.2396     1.01332      6.5329     0.03769     0.03758
  283 43.7030    45.6560      1.0069     0.11638      7.9766     0.19859     0.19764
  284 43.7030    45.6560     21.3085     1.13255      2.6922     1.62152     1.62036
  285 43.7030    45.6560      1.9218     0.18599      4.5100     0.18621     0.18599
                                                           The SAS System                          11:46 Friday, January 6, 2023  23

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  286  PT72     VIS2    TRT   Asian                                                                                               
  287  PT72     VIS3    TRT   Asian                                                                                               
  288  PT72     VIS4    TRT   Asian                                                                                               
  289  PT73     VIS1    PBO   White                                                                                               
  290  PT73     VIS2    PBO   White                                                                                               
  291  PT73     VIS3    PBO   White                                                                                               
  292  PT73     VIS4    PBO   White                                                                                               
  293  PT74     VIS1    PBO   White                                                                                               
  294  PT74     VIS2    PBO   White                                                                                               
  295  PT74     VIS3    PBO   White                                                                                               
  296  PT74     VIS4    PBO   White                                                                                               
  297  PT75     VIS1    PBO   White                                                                                               
  298  PT75     VIS2    PBO   White                                                                                               
  299  PT75     VIS3    PBO   White                                                                                               
  300  PT75     VIS4    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  286 Female    37.102864171    40.897859799    0.4289215248               2    -1.001072181    44.6795    0.49709    535     0.05
  287 Female    37.102864171    46.667083188    0.1533614621               3    -0.668178607    44.6795    0.49709    535     0.05
  288 Female    37.102864171               .    0.7372252515               4    0.9451849534    44.6795    0.49709    535     0.05
  289 Male      43.464318216               .    0.5050601944               1    0.4337021495    41.1517    0.40805    535     0.05
  290 Male      43.464318216               .    0.5148990551               2    1.0051592177    41.1517    0.40805    535     0.05
  291 Male      43.464318216    43.832698078    0.6643679611               3    -0.390118664    41.1517    0.40805    535     0.05
  292 Male      43.464318216     44.11603782    0.7652952664               4    0.3763702918    41.1517    0.40805    535     0.05
  293 Female     35.51143796    38.296117048    0.1487171441               1    0.2441649245    41.1517    0.40805    535     0.05
  294 Female     35.51143796               .    0.3694686206               2    -1.426257342    41.1517    0.40805    535     0.05
  295 Female     35.51143796    51.385702012    0.7417927701               3    1.7784292875    41.1517    0.40805    535     0.05
  296 Female     35.51143796    56.209792538    0.3268020285               4    0.1344476609    41.1517    0.40805    535     0.05
  297 Male      31.247727014               .    0.7519017152               1    0.7655989992    41.1517    0.40805    535     0.05
  298 Male      31.247727014    43.458191936    0.2720664909               2    0.9551366769    41.1517    0.40805    535     0.05
  299 Male      31.247727014    38.387411892    0.5441222714               3    -0.050565701    41.1517    0.40805    535     0.05
  300 Male      31.247727014    56.428178863    0.1124221612               4     -0.30581542    41.1517    0.40805    535     0.05

                                         Scaled       Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid          Dep      Resid       Resid

  286 43.7030    45.6560     -3.7816    -0.93515      4.5844    -0.59482    -0.59301
  287 43.7030    45.6560      1.9876     0.51719      8.3774     0.39202     0.39015
  288 43.7030    45.6560       .          .            .          .           .     
  289 40.3502    41.9533       .          .            .          .           .     
  290 40.3502    41.9533       .          .            .          .           .     
  291 40.3502    41.9533      2.6810     0.55306      9.0423     0.55503     0.55306
  292 40.3502    41.9533      2.9643     0.08676      1.0191     0.25822     0.25806
  293 40.3502    41.9533     -2.8556    -0.27138      3.6394    -0.27158    -0.27138
  294 40.3502    41.9533       .          .            .          .           .     
  295 40.3502    41.9533     10.2340     2.09373     11.2037     2.11869     2.11117
  296 40.3502    41.9533     15.0581     0.73263      3.7602     1.31171     1.31088
  297 40.3502    41.9533       .          .            .          .           .     
  298 40.3502    41.9533      2.3064     0.36434      6.8649     0.36510     0.36434
  299 40.3502    41.9533     -2.7643    -0.54028      8.5565    -0.57229    -0.57026
  300 40.3502    41.9533     15.2764     1.76713      5.0057     1.33073     1.32989
                                                           The SAS System                          11:46 Friday, January 6, 2023  24

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  301  PT76     VIS1    TRT   White                                                                                               
  302  PT76     VIS2    TRT   White                                                                                               
  303  PT76     VIS3    TRT   White                                                                                               
  304  PT76     VIS4    TRT   White                                                                                               
  305  PT77     VIS1    TRT   Asian                                                                                               
  306  PT77     VIS2    TRT   Asian                                                                                               
  307  PT77     VIS3    TRT   Asian                                                                                               
  308  PT77     VIS4    TRT   Asian                                                                                               
  309  PT78     VIS1    TRT   White                                                                                               
  310  PT78     VIS2    TRT   White                                                                                               
  311  PT78     VIS3    TRT   White                                                                                               
  312  PT78     VIS4    TRT   White                                                                                               
  313  PT79     VIS1    PBO   Asian                                                                                               
  314  PT79     VIS2    PBO   Asian                                                                                               
  315  PT79     VIS3    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  301 Male      35.618713533    39.050495386     0.142150653               1    0.8936737024    44.6795    0.49709    535     0.05
  302 Male      35.618713533               .    0.5789258255               2    -1.047298149    44.6795    0.49709    535     0.05
  303 Male      35.618713533               .    0.6666325172               3    1.9713373862    44.6795    0.49709    535     0.05
  304 Male      35.618713533    54.092000431    0.6227525279               4    -0.383632106    44.6795    0.49709    535     0.05
  305 Male      33.275382105     31.40520682    0.5619311748               1    1.6541453023    44.6795    0.49709    535     0.05
  306 Male      33.275382105    46.133296488    0.6426284265               2     1.512212694    44.6795    0.49709    535     0.05
  307 Male      33.275382105      45.2984459    0.2679823095               3    0.0829657336    44.6795    0.49709    535     0.05
  308 Male      33.275382105    28.069356213    0.2895840839               4    0.5672209149    44.6795    0.49709    535     0.05
  309 Female    37.024704112               .    0.4654002141               1     -1.02454848    44.6795    0.49709    535     0.05
  310 Female    37.024704112    42.502827117    0.3721210616               2     0.323006503    44.6795    0.49709    535     0.05
  311 Female    37.024704112    46.453678626    0.4207421489               3    1.0436124584    44.6795    0.49709    535     0.05
  312 Female    37.024704112    64.973663495     0.445353776               4    0.0990784869    44.6795    0.49709    535     0.05
  313 Female    41.272469434               .    0.8642984485               1    -0.454136909    41.1517    0.40805    535     0.05
  314 Female    41.272469434               .    0.2778232574               2    -0.655781852    41.1517    0.40805    535     0.05
  315 Female    41.272469434               .    0.3922486344               3    -0.035922423    41.1517    0.40805    535     0.05

                                         Scaled       Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid          Dep      Resid       Resid

  301 43.7030    45.6560     -5.6290    -0.54477      3.7793    -0.54540    -0.54477
  302 43.7030    45.6560       .          .            .          .           .     
  303 43.7030    45.6560       .          .            .          .           .     
  304 43.7030    45.6560      9.4125     0.56378      5.7465     0.71627     0.71576
  305 43.7030    45.6560    -13.2743    -1.28467      3.0394    -1.28616    -1.28467
  306 43.7030    45.6560      1.4538     1.38809      6.9076     0.22867     0.22798
  307 43.7030    45.6560      0.6190    -0.00591      7.8543     0.12208     0.12150
  308 43.7030    45.6560    -16.6101    -2.30788     -0.7482    -1.26399    -1.26308
  309 43.7030    45.6560       .          .            .          .           .     
  310 43.7030    45.6560     -2.1767    -0.34133      6.6650    -0.34237    -0.34133
  311 43.7030    45.6560      1.7742     0.40020      8.2640     0.34993     0.34826
  312 43.7030    45.6560     20.2942     1.47567      2.8483     1.54433     1.54323
  313 40.3502    41.9533       .          .            .          .           .     
  314 40.3502    41.9533       .          .            .          .           .     
  315 40.3502    41.9533       .          .            .          .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  25

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  316  PT79     VIS4    PBO   Asian                                                                                               
  317  PT80     VIS1    TRT   Asian                                                                                               
  318  PT80     VIS2    TRT   Asian                                                                                               
  319  PT80     VIS3    TRT   Asian                                                                                               
  320  PT80     VIS4    TRT   Asian                                                                                               
  321  PT81     VIS1    PBO   White                                                                                               
  322  PT81     VIS2    PBO   White                                                                                               
  323  PT81     VIS3    PBO   White                                                                                               
  324  PT81     VIS4    PBO   White                                                                                               
  325  PT82     VIS1    PBO   Black or African American                                                                           
  326  PT82     VIS2    PBO   Black or African American                                                                           
  327  PT82     VIS3    PBO   Black or African American                                                                           
  328  PT82     VIS4    PBO   Black or African American                                                                           
  329  PT83     VIS1    TRT   White                                                                                               
  330  PT83     VIS2    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  316 Female    41.272469434    43.978466825     0.805980291               4    1.0691614607    41.1517    0.40805    535     0.05
  317 Male      50.338269315    35.334664216     0.521613168               1     -0.48397493    44.6795    0.49709    535     0.05
  318 Male      50.338269315    39.343782448    0.5685701761               2    -0.121010111    44.6795    0.49709    535     0.05
  319 Male      50.338269315    41.276330727    0.3061297096               3    -1.294140004    44.6795    0.49709    535     0.05
  320 Male      50.338269315               .    0.7950951956               4     0.494312836    44.6795    0.49709    535     0.05
  321 Male      34.293489863               .    0.3503223652               1    1.3079015201    41.1517    0.40805    535     0.05
  322 Male      34.293489863     39.83058385    0.6382881265               2    1.4970410094    41.1517    0.40805    535     0.05
  323 Male      34.293489863    43.496732633    0.5952901594               3    0.8147027309    41.1517    0.40805    535     0.05
  324 Male      34.293489863    44.061139901    0.4228193168               4     -1.86978879    41.1517    0.40805    535     0.05
  325 Female    46.100432418    41.437421986    0.4235201139               1    0.4820295041    41.1517    0.40805    535     0.05
  326 Female    46.100432418               .    0.8698687866               2    0.4561356033    41.1517    0.40805    535     0.05
  327 Female    46.100432418    46.169542792    0.3519980954               3    -0.353400286    41.1517    0.40805    535     0.05
  328 Female    46.100432418    54.240243738    0.1126966383               4    0.1704894709    41.1517    0.40805    535     0.05
  329 Male      45.249850446    36.618313005    0.2285174802               1    -0.864035954    44.6795    0.49709    535     0.05
  330 Male      45.249850446    42.092722715    0.2834050415               2     0.679230774    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  316 40.3502    41.9533      2.8267     0.24608     3.8286     0.24624     0.24608
  317 43.7030    45.6560     -9.3448    -0.90438     3.4196    -0.90543    -0.90438
  318 43.7030    45.6560     -5.3357    -0.33019     5.1894    -0.83926    -0.83671
  319 43.7030    45.6560     -3.4032    -0.58114     7.2791    -0.67122    -0.66802
  320 43.7030    45.6560       .          .           .          .           .     
  321 40.3502    41.9533       .          .           .          .           .     
  322 40.3502    41.9533     -1.3212    -0.20870     6.2919    -0.20913    -0.20870
  323 40.3502    41.9533      2.3450     0.46719     9.5640     0.48547     0.48375
  324 40.3502    41.9533      2.9094     0.05806     3.2967     0.25344     0.25328
  325 40.3502    41.9533      0.2857     0.02715     3.9379     0.02717     0.02715
  326 40.3502    41.9533       .          .           .          .           .     
  327 40.3502    41.9533      5.0178     1.04870    10.1587     1.03881     1.03513
  328 40.3502    41.9533     13.0885     0.98650     4.0141     1.14014     1.13942
  329 43.7030    45.6560     -8.0612    -0.78015     3.5439    -0.78106    -0.78015
  330 43.7030    45.6560     -2.5868     0.12963     5.6492    -0.40688    -0.40564
                                                           The SAS System                          11:46 Friday, January 6, 2023  26

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  331  PT83     VIS3    TRT   White                                                                                               
  332  PT83     VIS4    TRT   White                                                                                               
  333  PT84     VIS1    PBO   Asian                                                                                               
  334  PT84     VIS2    PBO   Asian                                                                                               
  335  PT84     VIS3    PBO   Asian                                                                                               
  336  PT84     VIS4    PBO   Asian                                                                                               
  337  PT85     VIS1    PBO   Asian                                                                                               
  338  PT85     VIS2    PBO   Asian                                                                                               
  339  PT85     VIS3    PBO   Asian                                                                                               
  340  PT85     VIS4    PBO   Asian                                                                                               
  341  PT86     VIS1    TRT   Black or African American                                                                           
  342  PT86     VIS2    TRT   Black or African American                                                                           
  343  PT86     VIS3    TRT   Black or African American                                                                           
  344  PT86     VIS4    TRT   Black or African American                                                                           
  345  PT87     VIS1    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  331 Male      45.249850446    50.695561404    0.4115918091               3    -0.327101015    44.6795    0.49709    535     0.05
  332 Male      45.249850446    51.725633857    0.7792745316               4    -1.569082185    44.6795    0.49709    535     0.05
  333 Female    31.986982608               .    0.6893110707               1    -0.367450756    41.1517    0.40805    535     0.05
  334 Female    31.986982608               .    0.6398778101               2    1.3644349291    41.1517    0.40805    535     0.05
  335 Female    31.986982608               .    0.1860170372               3    -0.334281365    41.1517    0.40805    535     0.05
  336 Female    31.986982608    53.899474237    0.1475270119               4    0.7327500422    41.1517    0.40805    535     0.05
  337 Female     40.07873121               .    0.8689283516               1    0.9465856402    41.1517    0.40805    535     0.05
  338 Female     40.07873121               .     0.683759198               2    0.0043987043    41.1517    0.40805    535     0.05
  339 Female     40.07873121    39.944202407    0.4924431762               3    -0.352322306    41.1517    0.40805    535     0.05
  340 Female     40.07873121    56.424817938     0.804766986               4    -0.529695509    41.1517    0.40805    535     0.05
  341 Female    29.145562986     41.86385048    0.5633828919               1    0.7395892256    44.6795    0.49709    535     0.05
  342 Female    29.145562986    34.564195555    0.6554693775               2    -1.063457415    44.6795    0.49709    535     0.05
  343 Female    29.145562986    38.689267709    0.8288327355               3    0.2462108435    44.6795    0.49709    535     0.05
  344 Female    29.145562986    62.887430874      0.77028496               4    -0.289499367    44.6795    0.49709    535     0.05
  345 Male      39.322245197    28.853427926    0.5115104964               1    -2.264889356    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  331 43.7030    45.6560      6.0161     1.21711     9.0773     1.18658     1.18092
  332 43.7030    45.6560      7.0462    -0.13841     1.4213     0.53619     0.53581
  333 40.3502    41.9533       .          .           .          .           .     
  334 40.3502    41.9533       .          .           .          .           .     
  335 40.3502    41.9533       .          .           .          .           .     
  336 40.3502    41.9533     12.7477     1.10976     4.6922     1.11046     1.10976
  337 40.3502    41.9533       .          .           .          .           .     
  338 40.3502    41.9533       .          .           .          .           .     
  339 40.3502    41.9533     -1.2075    -0.24910     8.2401    -0.24999    -0.24910
  340 40.3502    41.9533     15.2731     1.48585     2.4182     1.33044     1.32960
  341 43.7030    45.6560     -2.8156    -0.27249     4.0515    -0.27281    -0.27249
  342 43.7030    45.6560    -10.1153    -1.84857     3.6710    -1.59106    -1.58622
  343 43.7030    45.6560     -5.9902    -0.91306     6.9472    -1.18148    -1.17584
  344 43.7030    45.6560     18.2080     2.26464     3.8243     1.38558     1.38459
  345 40.3502    41.9533    -12.2983    -1.16874     2.7420    -1.16962    -1.16874
                                                           The SAS System                          11:46 Friday, January 6, 2023  27

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  346  PT87     VIS2    PBO   White                                                                                               
  347  PT87     VIS3    PBO   White                                                                                               
  348  PT87     VIS4    PBO   White                                                                                               
  349  PT88     VIS1    PBO   Black or African American                                                                           
  350  PT88     VIS2    PBO   Black or African American                                                                           
  351  PT88     VIS3    PBO   Black or African American                                                                           
  352  PT88     VIS4    PBO   Black or African American                                                                           
  353  PT89     VIS1    PBO   Black or African American                                                                           
  354  PT89     VIS2    PBO   Black or African American                                                                           
  355  PT89     VIS3    PBO   Black or African American                                                                           
  356  PT89     VIS4    PBO   Black or African American                                                                           
  357  PT90     VIS1    PBO   Asian                                                                                               
  358  PT90     VIS2    PBO   Asian                                                                                               
  359  PT90     VIS3    PBO   Asian                                                                                               
  360  PT90     VIS4    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  346 Male      39.322245197               .    0.6012658233               2    -1.408850456    41.1517    0.40805    535     0.05
  347 Male      39.322245197    49.294954744    0.7361562224               3    0.9160193288    41.1517    0.40805    535     0.05
  348 Male      39.322245197               .    0.8550508689               4    -0.191278951    41.1517    0.40805    535     0.05
  349 Female    45.559909336    28.740293981    0.1354517993               1    0.8032832161    41.1517    0.40805    535     0.05
  350 Female    45.559909336               .     0.702786405               2    1.8874744633    41.1517    0.40805    535     0.05
  351 Female    45.559909336    43.599938722    0.6477792295               3    1.4738811811    41.1517    0.40805    535     0.05
  352 Female    45.559909336    57.386164796    0.5979018016               4    0.6772684923    41.1517    0.40805    535     0.05
  353 Male      32.132592138    35.368243291    0.8947968001               1    0.3799626866    41.1517    0.40805    535     0.05
  354 Male      32.132592138    43.061099952    0.6085221883               2    -0.192798426    41.1517    0.40805    535     0.05
  355 Male      32.132592138    31.275512104    0.6247394318               3    1.5778917949    41.1517    0.40805    535     0.05
  356 Male      32.132592138    54.132452405    0.6819577958               4    0.5962341093    41.1517    0.40805    535     0.05
  357 Male      36.371783478     25.97049929    0.5681483218               1    -1.173576941    41.1517    0.40805    535     0.05
  358 Male      36.371783478               .    0.5602181038               2    -0.155642535    41.1517    0.40805    535     0.05
  359 Male      36.371783478               .     0.127765804               3     -1.91890982    41.1517    0.40805    535     0.05
  360 Male      36.371783478               .    0.7296180442               4    -0.195258846    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  346 40.3502    41.9533       .          .           .          .           .     
  347 40.3502    41.9533      8.1432     1.53439    10.6444     1.68586     1.67987
  348 40.3502    41.9533       .          .           .          .           .     
  349 40.3502    41.9533    -12.4114    -1.17949     2.7313    -1.18038    -1.17949
  350 40.3502    41.9533       .          .           .          .           .     
  351 40.3502    41.9533      2.4482     0.34692     9.4569     0.50684     0.50504
  352 40.3502    41.9533     16.2344     0.97756     4.0051     1.41418     1.41329
  353 40.3502    41.9533     -5.7835    -0.54962     3.3611    -0.55003    -0.54962
  354 40.3502    41.9533      1.9094     1.04933     6.4071     0.30224     0.30161
  355 40.3502    41.9533     -9.8762    -2.15348     6.8539    -2.04463    -2.03738
  356 40.3502    41.9533     12.9807     1.73232     4.9779     1.13075     1.13004
  357 40.3502    41.9533    -15.1812    -1.44271     2.4680    -1.44380    -1.44271
  358 40.3502    41.9533       .          .           .          .           .     
  359 40.3502    41.9533       .          .           .          .           .     
  360 40.3502    41.9533       .          .           .          .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  28

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  361  PT91     VIS1    TRT   White                                                                                               
  362  PT91     VIS2    TRT   White                                                                                               
  363  PT91     VIS3    TRT   White                                                                                               
  364  PT91     VIS4    TRT   White                                                                                               
  365  PT92     VIS1    TRT   White                                                                                               
  366  PT92     VIS2    TRT   White                                                                                               
  367  PT92     VIS3    TRT   White                                                                                               
  368  PT92     VIS4    TRT   White                                                                                               
  369  PT93     VIS1    PBO   Black or African American                                                                           
  370  PT93     VIS2    PBO   Black or African American                                                                           
  371  PT93     VIS3    PBO   Black or African American                                                                           
  372  PT93     VIS4    PBO   Black or African American                                                                           
  373  PT94     VIS1    PBO   Asian                                                                                               
  374  PT94     VIS2    PBO   Asian                                                                                               
  375  PT94     VIS3    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  361 Female    41.351740137               .    0.2447623642               1     -2.59232767    44.6795    0.49709    535     0.05
  362 Female    41.351740137               .    0.2346616827               2    1.3140021672    44.6795    0.49709    535     0.05
  363 Female    41.351740137    51.174932756    0.4843534712               3    -0.635543001    44.6795    0.49709    535     0.05
  364 Female    41.351740137    48.440432784    0.2940355126               4    -0.429978839    44.6795    0.49709    535     0.05
  365 Female    25.673679634    43.331284857    0.3740770869               1    -0.169318332    44.6795    0.49709    535     0.05
  366 Female    25.673679634               .    0.6738519104               2     0.612218174    44.6795    0.49709    535     0.05
  367 Female    25.673679634    55.935463619    0.7966738462               3    0.6783401772    44.6795    0.49709    535     0.05
  368 Female    25.673679634    54.153120872    0.3032056639               4    0.5679519725    44.6795    0.49709    535     0.05
  369 Male      45.771560037               .    0.7340774624               1    -0.572542604    41.1517    0.40805    535     0.05
  370 Male      45.771560037    40.602519889    0.5571871808               2    -1.363291256    41.1517    0.40805    535     0.05
  371 Male      45.771560037     44.44714803    0.5243652239               3    -0.388722244    41.1517    0.40805    535     0.05
  372 Male      45.771560037    40.541610414    0.7276369119               4    0.2779141325    41.1517    0.40805    535     0.05
  373 Female    40.311140504    33.955631719    0.8415934522               1    -0.823081122    41.1517    0.40805    535     0.05
  374 Female    40.311140504               .    0.5973482806               2    -0.068840934    41.1517    0.40805    535     0.05
  375 Female    40.311140504    43.678023003    0.6166743089               3    -1.167662326    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  361 43.7030    45.6560       .          .           .          .           .     
  362 43.7030    45.6560       .          .           .          .           .     
  363 43.7030    45.6560      6.4955     1.27501    10.0453     1.28113     1.27501
  364 43.7030    45.6560      3.7610    -0.10963     0.6387     0.28620     0.28599
  365 43.7030    45.6560     -1.3482    -0.13048     4.1936    -0.13063    -0.13048
  366 43.7030    45.6560       .          .           .          .           .     
  367 43.7030    45.6560     11.2560     2.21930    10.7757     2.22007     2.20947
  368 43.7030    45.6560      9.4736    -0.04987     2.3262     0.72092     0.72040
  369 40.3502    41.9533       .          .           .          .           .     
  370 40.3502    41.9533     -0.5492    -0.08676     6.4138    -0.08694    -0.08676
  371 40.3502    41.9533      3.2954     0.67479     9.7716     0.68223     0.67981
  372 40.3502    41.9533     -0.6101    -0.30574     2.9329    -0.05315    -0.05312
  373 40.3502    41.9533     -7.1961    -0.68386     3.2269    -0.68438    -0.68386
  374 40.3502    41.9533       .          .           .          .           .     
  375 40.3502    41.9533      2.5263     0.43164     9.5416     0.52301     0.52115
                                                           The SAS System                          11:46 Friday, January 6, 2023  29

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  376  PT94     VIS4    PBO   Asian                                                                                               
  377  PT95     VIS1    PBO   Asian                                                                                               
  378  PT95     VIS2    PBO   Asian                                                                                               
  379  PT95     VIS3    PBO   Asian                                                                                               
  380  PT95     VIS4    PBO   Asian                                                                                               
  381  PT96     VIS1    PBO   Black or African American                                                                           
  382  PT96     VIS2    PBO   Black or African American                                                                           
  383  PT96     VIS3    PBO   Black or African American                                                                           
  384  PT96     VIS4    PBO   Black or African American                                                                           
  385  PT97     VIS1    TRT   White                                                                                               
  386  PT97     VIS2    TRT   White                                                                                               
  387  PT97     VIS3    TRT   White                                                                                               
  388  PT97     VIS4    TRT   White                                                                                               
  389  PT98     VIS1    PBO   Asian                                                                                               
  390  PT98     VIS2    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  376 Female    40.311140504    42.760231025    0.4475151697               4    -0.008309014    41.1517    0.40805    535     0.05
  377 Female    37.514556575               .    0.4457196789               1    0.1288554016    41.1517    0.40805    535     0.05
  378 Female    37.514556575    42.826783537     0.880089429               2    -0.145875628    41.1517    0.40805    535     0.05
  379 Female    37.514556575    39.592179866    0.3462071322               3    -0.163910957    41.1517    0.40805    535     0.05
  380 Female    37.514556575               .    0.4657343598               4    1.7635520028    41.1517    0.40805    535     0.05
  381 Female    40.292593413    33.492156579    0.6652918475               1    0.7625865124    41.1517    0.40805    535     0.05
  382 Female    40.292593413    35.392663722    0.7488246793               2    1.1114310807    41.1517    0.40805    535     0.05
  383 Female    40.292593413               .    0.3453712786               3    -0.923206953    41.1517    0.40805    535     0.05
  384 Female    40.292593413    42.362662552    0.6424444387               4    0.1643418384    41.1517    0.40805    535     0.05
  385 Male      37.236485427    48.543682645    0.7274394294               1    1.1548251871    44.6795    0.49709    535     0.05
  386 Male      37.236485427    43.943663442    0.7881291825               2    -0.056521425    44.6795    0.49709    535     0.05
  387 Male      37.236485427               .    0.5946187686               3    -2.129360648    44.6795    0.49709    535     0.05
  388 Male      37.236485427     47.91203977     0.250822502               4    0.3448457621    44.6795    0.49709    535     0.05
  389 Male       39.73143883    20.729276526    0.8239519622               1    -1.904955446    41.1517    0.40805    535     0.05
  390 Male       39.73143883     28.00599427     0.125677423               2    -0.811170153    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  376 40.3502    41.9533      1.6085    -0.27362    2.75394     0.14012     0.14003
  377 40.3502    41.9533       .          .          .           .           .     
  378 40.3502    41.9533      1.6750     0.26460    6.76518     0.26515     0.26460
  379 40.3502    41.9533     -1.5596    -0.29959    8.79723    -0.32287    -0.32172
  380 40.3502    41.9533       .          .          .           .           .     
  381 40.3502    41.9533     -7.6596    -0.72791    3.18284    -0.72846    -0.72791
  382 40.3502    41.9533     -5.7591    -0.55198    4.80578    -0.91163    -0.90974
  383 40.3502    41.9533       .          .          .           .           .     
  384 40.3502    41.9533      1.2109    -0.21179    5.51365     0.10548     0.10542
  385 43.7030    45.6560      3.8642     0.37397    4.69800     0.37441     0.37397
  386 43.7030    45.6560     -0.7358    -0.46835    5.05120    -0.11574    -0.11539
  387 43.7030    45.6560       .          .          .           .           .     
  388 43.7030    45.6560      3.2326     0.51790    4.54563     0.24599     0.24581
  389 40.3502    41.9533    -20.4225    -1.94080    1.96996    -1.94226    -1.94080
  390 40.3502    41.9533    -13.1457    -0.95409    4.40367    -2.08091    -2.07658
                                                           The SAS System                          11:46 Friday, January 6, 2023  30

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  391  PT98     VIS3    PBO   Asian                                                                                               
  392  PT98     VIS4    PBO   Asian                                                                                               
  393  PT99     VIS1    PBO   Black or African American                                                                           
  394  PT99     VIS2    PBO   Black or African American                                                                           
  395  PT99     VIS3    PBO   Black or African American                                                                           
  396  PT99     VIS4    PBO   Black or African American                                                                           
  397  PT100    VIS1    PBO   Black or African American                                                                           
  398  PT100    VIS2    PBO   Black or African American                                                                           
  399  PT100    VIS3    PBO   Black or African American                                                                           
  400  PT100    VIS4    PBO   Black or African American                                                                           
  401  PT101    VIS1    TRT   White                                                                                               
  402  PT101    VIS2    TRT   White                                                                                               
  403  PT101    VIS3    TRT   White                                                                                               
  404  PT101    VIS4    TRT   White                                                                                               
  405  PT102    VIS1    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  391 Male       39.73143883    40.192554077    0.7301524745               3    1.3240043213    41.1517    0.40805    535     0.05
  392 Male       39.73143883    37.793604182    0.7835199976               4    0.6156368493    41.1517    0.40805    535     0.05
  393 Male      47.692307897               .    0.7420612512               1    1.0916689555    41.1517    0.40805    535     0.05
  394 Male      47.692307897    36.751772198    0.2343967596               2    0.3066048615    41.1517    0.40805    535     0.05
  395 Male      47.692307897               .    0.3629419899               3    -0.110158762    41.1517    0.40805    535     0.05
  396 Male      47.692307897               .    0.2594918536               4    -0.924312773    41.1517    0.40805    535     0.05
  397 Female    51.841876524    34.598222892    0.3620150704               1    1.5929137537    41.1517    0.40805    535     0.05
  398 Female    51.841876524    39.320343052    0.4044874851               2    0.0450105981    41.1517    0.40805    535     0.05
  399 Female    51.841876524    40.657018747    0.5042462299               3    -0.715128401    41.1517    0.40805    535     0.05
  400 Female    51.841876524               .    0.2008041842               4    0.8652230997    41.1517    0.40805    535     0.05
  401 Male      38.980275498               .    0.1603843566               1    1.0744409583    44.6795    0.49709    535     0.05
  402 Male      38.980275498    43.032546813     0.479507393               2    1.8956547742    44.6795    0.49709    535     0.05
  403 Male      38.980275498    54.657154397    0.3116716364               3    -0.602997304    44.6795    0.49709    535     0.05
  404 Male      38.980275498               .    0.2845968585               4    -0.390867821    44.6795    0.49709    535     0.05
  405 Female    52.179964825    35.557415061    0.5769595092               1    -0.416222032    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  391 40.3502    41.9533     -0.9592    -0.44932    8.55802    -0.19858    -0.19787
  392 40.3502    41.9533     -3.3581    -1.08605    2.15957    -0.29253    -0.29234
  393 40.3502    41.9533       .          .          .           .           .     
  394 40.3502    41.9533     -4.4000    -0.69505    5.80553    -0.69649    -0.69505
  395 40.3502    41.9533       .          .          .           .           .     
  396 40.3502    41.9533       .          .          .           .           .     
  397 40.3502    41.9533     -6.5535    -0.62280    3.28796    -0.62327    -0.62280
  398 40.3502    41.9533     -1.8314     0.25308    5.61084    -0.28990    -0.28930
  399 40.3502    41.9533     -0.4947    -0.19401    8.81333    -0.10242    -0.10206
  400 40.3502    41.9533       .          .          .           .           .     
  401 43.7030    45.6560       .          .          .           .           .     
  402 43.7030    45.6560     -1.6469    -0.25826    6.74810    -0.25905    -0.25826
  403 43.7030    45.6560      9.9777     2.01483    9.87863     1.96794     1.95855
  404 43.7030    45.6560       .          .          .           .           .     
  405 40.3502    41.9533     -5.5943    -0.53164    3.37911    -0.53204    -0.53164
                                                           The SAS System                          11:46 Friday, January 6, 2023  31

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  406  PT102    VIS2    PBO   Asian                                                                                               
  407  PT102    VIS3    PBO   Asian                                                                                               
  408  PT102    VIS4    PBO   Asian                                                                                               
  409  PT103    VIS1    PBO   Asian                                                                                               
  410  PT103    VIS2    PBO   Asian                                                                                               
  411  PT103    VIS3    PBO   Asian                                                                                               
  412  PT103    VIS4    PBO   Asian                                                                                               
  413  PT104    VIS1    PBO   Black or African American                                                                           
  414  PT104    VIS2    PBO   Black or African American                                                                           
  415  PT104    VIS3    PBO   Black or African American                                                                           
  416  PT104    VIS4    PBO   Black or African American                                                                           
  417  PT105    VIS1    TRT   Black or African American                                                                           
  418  PT105    VIS2    TRT   Black or African American                                                                           
  419  PT105    VIS3    TRT   Black or African American                                                                           
  420  PT105    VIS4    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  406 Female    52.179964825    43.702152586    0.2271404631               2    -0.375657423    41.1517    0.40805    535     0.05
  407 Female    52.179964825    42.521568696    0.7840438703               3    -0.366630946    41.1517    0.40805    535     0.05
  408 Female    52.179964825    54.893365921    0.2899630366               4    -0.295677453    41.1517    0.40805    535     0.05
  409 Female    26.992628636    32.034600291    0.7376893589               1    1.4418204102    41.1517    0.40805    535     0.05
  410 Female    26.992628636    29.451072583    0.1627884734               2    -0.697538292    41.1517    0.40805    535     0.05
  411 Female    26.992628636    45.351381398     0.533516906               3    -0.388167506    41.1517    0.40805    535     0.05
  412 Female    26.992628636               .    0.6735556956               4    0.6525364522    41.1517    0.40805    535     0.05
  413 Female    27.043193829    38.737840062    0.1326234689               1    1.1247724465    41.1517    0.40805    535     0.05
  414 Female    27.043193829               .    0.1204803582               2    -0.772110803    41.1517    0.40805    535     0.05
  415 Female    27.043193829     41.42283465     0.692493145               3    -0.508086216    41.1517    0.40805    535     0.05
  416 Female    27.043193829    47.323847899    0.7161192531               4    0.5236205905    41.1517    0.40805    535     0.05
  417 Female    38.587493423               .    0.5309425518               1    1.0177542265    44.6795    0.49709    535     0.05
  418 Female    38.587493423    47.553095462    0.4105091531               2    -0.251164588    44.6795    0.49709    535     0.05
  419 Female    38.587493423    49.065089714    0.4755341625               3    -1.429993447    44.6795    0.49709    535     0.05
  420 Female    38.587493423               .    0.1979891878               4    1.7091210321    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  406 40.3502    41.9533      2.5504     1.17982    6.53759     0.40372     0.40288
  407 40.3502    41.9533      1.3698     0.18889    9.19623     0.28359     0.28258
  408 40.3502    41.9533     13.7416     1.10793    4.35356     1.19704     1.19628
  409 40.3502    41.9533     -9.1171    -0.86642    3.04433    -0.86708    -0.86642
  410 40.3502    41.9533    -11.7007    -1.79229    3.56548    -1.85216    -1.84831
  411 40.3502    41.9533      4.1996     0.78996    9.79730     0.86943     0.86635
  412 40.3502    41.9533       .          .          .           .           .     
  413 40.3502    41.9533     -2.4139    -0.22940    3.68135    -0.22957    -0.22940
  414 40.3502    41.9533       .          .          .           .           .     
  415 40.3502    41.9533      0.2711     0.02477    9.13475     0.05612     0.05592
  416 40.3502    41.9533      6.1721     0.50072    3.52828     0.53765     0.53731
  417 43.7030    45.6560       .          .          .           .           .     
  418 43.7030    45.6560      2.8736     0.45062    7.45698     0.45200     0.45062
  419 43.7030    45.6560      4.3856     0.80554    8.66934     0.86499     0.86087
  420 43.7030    45.6560       .          .          .           .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  32

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  421  PT106    VIS1    TRT   Asian                                                                                               
  422  PT106    VIS2    TRT   Asian                                                                                               
  423  PT106    VIS3    TRT   Asian                                                                                               
  424  PT106    VIS4    TRT   Asian                                                                                               
  425  PT107    VIS1    PBO   White                                                                                               
  426  PT107    VIS2    PBO   White                                                                                               
  427  PT107    VIS3    PBO   White                                                                                               
  428  PT107    VIS4    PBO   White                                                                                               
  429  PT108    VIS1    TRT   White                                                                                               
  430  PT108    VIS2    TRT   White                                                                                               
  431  PT108    VIS3    TRT   White                                                                                               
  432  PT108    VIS4    TRT   White                                                                                               
  433  PT109    VIS1    PBO   Black or African American                                                                           
  434  PT109    VIS2    PBO   Black or African American                                                                           
  435  PT109    VIS3    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  421 Female    44.310465081    29.225909995    0.7715113647               1    1.4350695723    44.6795    0.49709    535     0.05
  422 Female    44.310465081    40.081749147    0.3138964275               2    -0.710371146    44.6795    0.49709    535     0.05
  423 Female    44.310465081     45.68141624    0.2560808755               3    -0.065067574    44.6795    0.49709    535     0.05
  424 Female    44.310465081    41.474030249     0.301040126               4    -1.759468735    44.6795    0.49709    535     0.05
  425 Female    41.464612305               .    0.4113063261               1    0.5697229718    41.1517    0.40805    535     0.05
  426 Female    41.464612305               .    0.7748796843               2    1.6123467982    41.1517    0.40805    535     0.05
  427 Female    41.464612305    42.519702198     0.884477945               3    -1.637280647    41.1517    0.40805    535     0.05
  428 Female    41.464612305    69.360987138    0.3450557554               4    -0.779568513    41.1517    0.40805    535     0.05
  429 Male      50.997042806    42.397601226    0.3163334224               1    -0.641176934    44.6795    0.49709    535     0.05
  430 Male      50.997042806    43.723762652    0.5983500777               2    -0.681131394    44.6795    0.49709    535     0.05
  431 Male      50.997042806    49.476013002     0.599081441               3    -2.033285596    44.6795    0.49709    535     0.05
  432 Male      50.997042806    51.941884446     0.144632175               4    0.5009635592    44.6795    0.49709    535     0.05
  433 Female    42.262212224               .    0.6963737682               1     -1.53179814    41.1517    0.40805    535     0.05
  434 Female    42.262212224    40.591001862    0.3486706894               2    -0.024997639    41.1517    0.40805    535     0.05
  435 Female    42.262212224    39.978332399    0.1340131456               3     0.592984721    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  421 43.7030    45.6560    -15.4536    -1.49558     2.8285    -1.49731    -1.49558
  422 43.7030    45.6560     -4.5977     0.32277     5.8423    -0.72319    -0.72099
  423 43.7030    45.6560      1.0019     0.23208     8.0923     0.19762     0.19667
  424 43.7030    45.6560     -3.2055    -1.03061     0.5291    -0.24393    -0.24375
  425 40.3502    41.9533       .          .           .          .           .     
  426 40.3502    41.9533       .          .           .          .           .     
  427 40.3502    41.9533      1.3680     0.28220     8.7714     0.28320     0.28220
  428 40.3502    41.9533     28.2092     2.49549     3.4278     2.45731     2.45576
  429 43.7030    45.6560     -2.2819    -0.22084     4.1032    -0.22109    -0.22084
  430 43.7030    45.6560     -0.9557    -0.00925     5.5103    -0.15033    -0.14987
  431 43.7030    45.6560      4.7965     0.96517     8.8254     0.94604     0.94153
  432 43.7030    45.6560      7.2624     0.22192     1.7816     0.55265     0.55225
  433 40.3502    41.9533       .          .           .          .           .     
  434 40.3502    41.9533     -0.5607    -0.08858     6.4120    -0.08876    -0.08858
  435 40.3502    41.9533     -1.1734    -0.25084     8.8460    -0.24293    -0.24206
                                                           The SAS System                          11:46 Friday, January 6, 2023  33

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  436  PT109    VIS4    PBO   Black or African American                                                                           
  437  PT110    VIS1    TRT   Asian                                                                                               
  438  PT110    VIS2    TRT   Asian                                                                                               
  439  PT110    VIS3    TRT   Asian                                                                                               
  440  PT110    VIS4    TRT   Asian                                                                                               
  441  PT111    VIS1    PBO   White                                                                                               
  442  PT111    VIS2    PBO   White                                                                                               
  443  PT111    VIS3    PBO   White                                                                                               
  444  PT111    VIS4    PBO   White                                                                                               
  445  PT112    VIS1    PBO   Black or African American                                                                           
  446  PT112    VIS2    PBO   Black or African American                                                                           
  447  PT112    VIS3    PBO   Black or African American                                                                           
  448  PT112    VIS4    PBO   Black or African American                                                                           
  449  PT113    VIS1    PBO   Asian                                                                                               
  450  PT113    VIS2    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  436 Female    42.262212224    31.690491427    0.5538420347               4    -0.198195421    41.1517    0.40805    535     0.05
  437 Male      34.166269966               .    0.1131166263               1    0.8920083925    44.6795    0.49709    535     0.05
  438 Male      34.166269966    37.205173236    0.8006922355               2    -0.025715071    44.6795    0.49709    535     0.05
  439 Male      34.166269966    46.287395636    0.5219868351               3    -0.647660451    44.6795    0.49709    535     0.05
  440 Male      34.166269966               .    0.1875650849               4     0.646359415    44.6795    0.49709    535     0.05
  441 Female    37.007722535               .     0.745803226               1     -0.43383274    41.1517    0.40805    535     0.05
  442 Female    37.007722535               .     0.747261795               2     1.772611185    41.1517    0.40805    535     0.05
  443 Female    37.007722535               .     0.108807501               3    -0.018259711    41.1517    0.40805    535     0.05
  444 Female    37.007722535    41.587204769    0.6467258405               4    0.8528149936    41.1517    0.40805    535     0.05
  445 Female    40.256688303    32.173647252    0.4522457954               1    0.2051629032    41.1517    0.40805    535     0.05
  446 Female    40.256688303               .    0.8224680828               2    -3.008048599    41.1517    0.40805    535     0.05
  447 Female    40.256688303    40.693753874    0.4152390437               3    -1.366111931    41.1517    0.40805    535     0.05
  448 Female    40.256688303               .    0.1034034293               4     -0.42410226    41.1517    0.40805    535     0.05
  449 Male      41.880398355    32.287706643    0.8707039833               1    0.2368036637    41.1517    0.40805    535     0.05
  450 Male      41.880398355    41.762051891     0.873548194               2     -2.34272312    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  436 40.3502    41.9533     -9.4613    -0.85904     2.3796    -0.82417    -0.82365
  437 43.7030    45.6560       .          .           .          .           .     
  438 43.7030    45.6560     -7.4743    -1.17207     5.8343    -1.17565    -1.17207
  439 43.7030    45.6560      1.6079     0.48513     8.3489     0.31714     0.31562
  440 43.7030    45.6560       .          .           .          .           .     
  441 40.3502    41.9533       .          .           .          .           .     
  442 40.3502    41.9533       .          .           .          .           .     
  443 40.3502    41.9533       .          .           .          .           .     
  444 40.3502    41.9533      0.4355     0.03791     3.6204     0.03793     0.03791
  445 40.3502    41.9533     -8.9781    -0.85321     3.0575    -0.85385    -0.85321
  446 40.3502    41.9533       .          .           .          .           .     
  447 40.3502    41.9533     -0.4580    -0.21322     8.8968    -0.09482    -0.09448
  448 40.3502    41.9533       .          .           .          .           .     
  449 40.3502    41.9533     -8.8640    -0.84237     3.0684    -0.84301    -0.84237
  450 40.3502    41.9533      0.6103     1.06563     6.4234     0.09661     0.09641
                                                           The SAS System                          11:46 Friday, January 6, 2023  34

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  451  PT113    VIS3    PBO   Asian                                                                                               
  452  PT113    VIS4    PBO   Asian                                                                                               
  453  PT114    VIS1    PBO   Black or African American                                                                           
  454  PT114    VIS2    PBO   Black or African American                                                                           
  455  PT114    VIS3    PBO   Black or African American                                                                           
  456  PT114    VIS4    PBO   Black or African American                                                                           
  457  PT115    VIS1    PBO   Asian                                                                                               
  458  PT115    VIS2    PBO   Asian                                                                                               
  459  PT115    VIS3    PBO   Asian                                                                                               
  460  PT115    VIS4    PBO   Asian                                                                                               
  461  PT116    VIS1    TRT   Black or African American                                                                           
  462  PT116    VIS2    TRT   Black or African American                                                                           
  463  PT116    VIS3    TRT   Black or African American                                                                           
  464  PT116    VIS4    TRT   Black or African American                                                                           
  465  PT117    VIS1    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  451 Male      41.880398355    40.067675009    0.6994347693               3    0.9616966334    41.1517    0.40805    535     0.05
  452 Male      41.880398355               .    0.4200331116               4    -0.604425734    41.1517    0.40805    535     0.05
  453 Male      40.209544417    29.142127866    0.4336852638               1    -0.752877279    41.1517    0.40805    535     0.05
  454 Male      40.209544417    39.509887552    0.7580932161               2    -1.555611593    41.1517    0.40805    535     0.05
  455 Male      40.209544417    43.323491235    0.5038879933               3    -1.453893738    41.1517    0.40805    535     0.05
  456 Male      40.209544417    47.167558567    0.6570055664               4    0.0563318361    41.1517    0.40805    535     0.05
  457 Female    41.063220567    40.930200746    0.8499996375               1    0.5093694067    41.1517    0.40805    535     0.05
  458 Female    41.063220567    42.194059566    0.3047771621               2     -2.09788296    41.1517    0.40805    535     0.05
  459 Female    41.063220567    41.210574158     0.524643443               3    -1.004361979    41.1517    0.40805    535     0.05
  460 Female    41.063220567               .    0.1735217895               4    0.5357717223    41.1517    0.40805    535     0.05
  461 Male      29.829308889    38.543302397    0.5250079878               1    -0.453037085    44.6795    0.49709    535     0.05
  462 Male      29.829308889               .    0.8395318298               2    2.1653685018    44.6795    0.49709    535     0.05
  463 Male      29.829308889    43.963239237    0.2743303731               3    1.2457466727    44.6795    0.49709    535     0.05
  464 Male      29.829308889    42.676516472     0.788868906               4    0.5954980341    44.6795    0.49709    535     0.05
  465 Male      49.233903488    22.795835641    0.5529133879               1    0.0048844495    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  451 40.3502    41.9533     -1.0841    -0.36293     8.6444    -0.22443    -0.22363
  452 40.3502    41.9533       .          .           .          .           .     
  453 40.3502    41.9533    -12.0096    -1.14130     2.7694    -1.14216    -1.14130
  454 40.3502    41.9533     -1.6419     0.86540     6.2232    -0.25990    -0.25936
  455 40.3502    41.9533      2.1717     0.27783     9.2852     0.44961     0.44801
  456 40.3502    41.9533      6.0158     0.03706     3.2827     0.52404     0.52371
  457 40.3502    41.9533     -0.2215    -0.02105     3.8897    -0.02107    -0.02105
  458 40.3502    41.9533      1.0423     0.26726     5.6250     0.16499     0.16465
  459 40.3502    41.9533      0.0588     0.00414     9.0115     0.01218     0.01214
  460 40.3502    41.9533       .          .           .          .           .     
  461 43.7030    45.6560     -6.1362    -0.59385     3.7302    -0.59454    -0.59385
  462 43.7030    45.6560       .          .           .          .           .     
  463 43.7030    45.6560     -0.7162    -0.10977     8.4467    -0.14127    -0.14059
  464 43.7030    45.6560     -2.0030    -0.36178     2.0143    -0.15242    -0.15231
  465 40.3502    41.9533    -18.3559    -1.74441     2.1663    -1.74572    -1.74441
                                                           The SAS System                          11:46 Friday, January 6, 2023  35

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  466  PT117    VIS2    PBO   Black or African American                                                                           
  467  PT117    VIS3    PBO   Black or African American                                                                           
  468  PT117    VIS4    PBO   Black or African American                                                                           
  469  PT118    VIS1    PBO   Asian                                                                                               
  470  PT118    VIS2    PBO   Asian                                                                                               
  471  PT118    VIS3    PBO   Asian                                                                                               
  472  PT118    VIS4    PBO   Asian                                                                                               
  473  PT119    VIS1    TRT   White                                                                                               
  474  PT119    VIS2    TRT   White                                                                                               
  475  PT119    VIS3    TRT   White                                                                                               
  476  PT119    VIS4    TRT   White                                                                                               
  477  PT120    VIS1    PBO   Asian                                                                                               
  478  PT120    VIS2    PBO   Asian                                                                                               
  479  PT120    VIS3    PBO   Asian                                                                                               
  480  PT120    VIS4    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  466 Male      49.233903488               .     0.417984846               2    0.2793607821    41.1517    0.40805    535     0.05
  467 Male      49.233903488               .    0.5836962275               3    -0.705906125    41.1517    0.40805    535     0.05
  468 Male      49.233903488               .    0.4011023493               4     0.628017153    41.1517    0.40805    535     0.05
  469 Female    35.315541583    31.435589536    0.7507812683               1    1.4802139601    41.1517    0.40805    535     0.05
  470 Female    35.315541583    38.850636263    0.3338311851               2    1.0834299101    41.1517    0.40805    535     0.05
  471 Female    35.315541583    48.242880925    0.3559457714               3    -0.813244257    41.1517    0.40805    535     0.05
  472 Female    35.315541583               .    0.4335960688               4    -1.618876849    41.1517    0.40805    535     0.05
  473 Male      48.695792095    44.713024438    0.7207092866               1    -0.109655699    44.6795    0.49709    535     0.05
  474 Male      48.695792095    51.853703176     0.612409672               2    0.4408893709    44.6795    0.49709    535     0.05
  475 Male      48.695792095               .    0.3084177544               3    1.3509939798    44.6795    0.49709    535     0.05
  476 Male      48.695792095               .    0.3501463152               4    -1.318609485    44.6795    0.49709    535     0.05
  477 Female    53.248494323    30.567569062    0.6879124193               1    0.3643845926    41.1517    0.40805    535     0.05
  478 Female    53.248494323               .    0.7205283258               2    0.2334998351    41.1517    0.40805    535     0.05
  479 Female    53.248494323               .    0.5784484079               3    1.1939552613    41.1517    0.40805    535     0.05
  480 Female    53.248494323               .    0.1932855669               4    -0.027909972    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  466 40.3502    41.9533       .          .           .          .           .     
  467 40.3502    41.9533       .          .           .          .           .     
  468 40.3502    41.9533       .          .           .          .           .     
  469 40.3502    41.9533     -9.7162    -0.92335     2.9874    -0.92405    -0.92335
  470 40.3502    41.9533     -2.3011     0.47223     5.8300    -0.36425    -0.36350
  471 40.3502    41.9533      7.0911     1.34025    10.3476     1.46805     1.46284
  472 40.3502    41.9533       .          .           .          .           .     
  473 43.7030    45.6560      0.0335     0.00325     4.3273     0.00325     0.00325
  474 43.7030    45.6560      7.1742     1.47220     6.9917     1.12845     1.12502
  475 43.7030    45.6560       .          .           .          .           .     
  476 43.7030    45.6560       .          .           .          .           .     
  477 40.3502    41.9533    -10.5842    -1.00584     2.9049    -1.00660    -1.00584
  478 40.3502    41.9533       .          .           .          .           .     
  479 40.3502    41.9533       .          .           .          .           .     
  480 40.3502    41.9533       .          .           .          .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  36

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  481  PT121    VIS1    TRT   Black or African American                                                                           
  482  PT121    VIS2    TRT   Black or African American                                                                           
  483  PT121    VIS3    TRT   Black or African American                                                                           
  484  PT121    VIS4    TRT   Black or African American                                                                           
  485  PT122    VIS1    PBO   Asian                                                                                               
  486  PT122    VIS2    PBO   Asian                                                                                               
  487  PT122    VIS3    PBO   Asian                                                                                               
  488  PT122    VIS4    PBO   Asian                                                                                               
  489  PT123    VIS1    PBO   White                                                                                               
  490  PT123    VIS2    PBO   White                                                                                               
  491  PT123    VIS3    PBO   White                                                                                               
  492  PT123    VIS4    PBO   White                                                                                               
  493  PT124    VIS1    TRT   Asian                                                                                               
  494  PT124    VIS2    TRT   Asian                                                                                               
  495  PT124    VIS3    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  481 Male      30.335696305               .    0.2935519826               1    -0.357298855    44.6795    0.49709    535     0.05
  482 Male      30.335696305               .    0.3114775918               2    -1.146814136    44.6795    0.49709    535     0.05
  483 Male      30.335696305               .    0.3281765494               3    -0.517420484    44.6795    0.49709    535     0.05
  484 Male      30.335696305    59.904725735    0.5270576445               4    -0.362123773    44.6795    0.49709    535     0.05
  485 Female    39.726788231               .    0.4175154943               1    2.3505543258    41.1517    0.40805    535     0.05
  486 Female    39.726788231               .    0.6153126735               2    2.4465313757    41.1517    0.40805    535     0.05
  487 Female    39.726788231    49.761503667    0.2149523126               3    -0.166703279    41.1517    0.40805    535     0.05
  488 Female    39.726788231               .    0.7930123126               4    -1.043667439    41.1517    0.40805    535     0.05
  489 Female     38.45244607    47.219851148    0.4661159409               1    -1.972934934    41.1517    0.40805    535     0.05
  490 Female     38.45244607    40.345250047    0.8196187196               2    0.5146716334    41.1517    0.40805    535     0.05
  491 Female     38.45244607    48.297927833    0.7237418193               3    -1.090573584    41.1517    0.40805    535     0.05
  492 Female     38.45244607               .    0.7524373984               4    2.2846593255    41.1517    0.40805    535     0.05
  493 Female    60.239006639               .    0.8975972332               1    -0.885617573    44.6795    0.49709    535     0.05
  494 Female    60.239006639    44.396339557    0.5718397625               2    0.1111064297    44.6795    0.49709    535     0.05
  495 Female    60.239006639     41.71421115    0.4732433211               3    3.8102766807    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  481 43.7030    45.6560       .          .           .          .           .     
  482 43.7030    45.6560       .          .           .          .           .     
  483 43.7030    45.6560       .          .           .          .           .     
  484 43.7030    45.6560     15.2252     1.15777     4.5553     1.15860     1.15777
  485 40.3502    41.9533       .          .           .          .           .     
  486 40.3502    41.9533       .          .           .          .           .     
  487 40.3502    41.9533      8.6098     1.77612    10.2654     1.78244     1.77612
  488 40.3502    41.9533       .          .           .          .           .     
  489 40.3502    41.9533      6.0681     0.57667     4.4874     0.57710     0.57667
  490 40.3502    41.9533     -0.8065    -0.82057     4.5372    -0.12766    -0.12740
  491 40.3502    41.9533      7.1462     1.58412    10.5915     1.47944     1.47419
  492 40.3502    41.9533       .          .           .          .           .     
  493 43.7030    45.6560       .          .           .          .           .     
  494 43.7030    45.6560     -0.2831    -0.04440     6.9620    -0.04454    -0.04440
  495 43.7030    45.6560     -2.9653    -0.58159     7.2822    -0.58485    -0.58206
                                                           The SAS System                          11:46 Friday, January 6, 2023  37

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  496  PT124    VIS4    TRT   Asian                                                                                               
  497  PT125    VIS1    PBO   White                                                                                               
  498  PT125    VIS2    PBO   White                                                                                               
  499  PT125    VIS3    PBO   White                                                                                               
  500  PT125    VIS4    PBO   White                                                                                               
  501  PT126    VIS1    TRT   Asian                                                                                               
  502  PT126    VIS2    TRT   Asian                                                                                               
  503  PT126    VIS3    TRT   Asian                                                                                               
  504  PT126    VIS4    TRT   Asian                                                                                               
  505  PT127    VIS1    TRT   Black or African American                                                                           
  506  PT127    VIS2    TRT   Black or African American                                                                           
  507  PT127    VIS3    TRT   Black or African American                                                                           
  508  PT127    VIS4    TRT   Black or African American                                                                           
  509  PT128    VIS1    TRT   Asian                                                                                               
  510  PT128    VIS2    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  496 Female    60.239006639    47.375349609    0.3647900168               4    -1.108909998    44.6795    0.49709    535     0.05
  497 Male      42.331105096    42.037970091    0.6653043864               1    0.3075666244    41.1517    0.40805    535     0.05
  498 Male      42.331105096      37.5610027    0.7059032962               2    -1.106894472    41.1517    0.40805    535     0.05
  499 Male      42.331105096    45.117927565    0.7193866694               3    0.3476536488    41.1517    0.40805    535     0.05
  500 Male      42.331105096               .     0.797009776               4    -0.873264535    41.1517    0.40805    535     0.05
  501 Male      35.582185154    34.625295643    0.2674810445               1    0.0773031227    44.6795    0.49709    535     0.05
  502 Male      35.582185154    45.282062635     0.712990582               2    -0.296868642    44.6795    0.49709    535     0.05
  503 Male      35.582185154               .    0.7732924491               3     -1.18324224    44.6795    0.49709    535     0.05
  504 Male      35.582185154    63.577605472    0.8473010343               4    0.0112926884    44.6795    0.49709    535     0.05
  505 Female    43.567679828    35.808780258    0.6406591097               1    0.9916010361    44.6795    0.49709    535     0.05
  506 Female    43.567679828               .    0.7871668009               2    1.5939674539    44.6795    0.49709    535     0.05
  507 Female    43.567679828               .    0.1606003361               3    -1.372711271    44.6795    0.49709    535     0.05
  508 Female    43.567679828    52.673135042    0.6083979685               4    -0.249610933    44.6795    0.49709    535     0.05
  509 Female    46.259935036    35.887340129     0.416309863               1    1.1594245269    44.6795    0.49709    535     0.05
  510 Female    46.259935036    38.732221712    0.6981816463               2    -1.114222348    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  496 43.7030    45.6560      2.6959     0.40882     1.7815     0.20515     0.20500
  497 40.3502    41.9533      0.8862     0.08422     3.9950     0.08428     0.08422
  498 40.3502    41.9533     -3.5907    -0.93350     4.4243    -0.56840    -0.56722
  499 40.3502    41.9533      3.9662     0.85593     9.8633     0.82110     0.81819
  500 40.3502    41.9533       .          .           .          .           .     
  501 43.7030    45.6560    -10.0542    -0.97303     3.3510    -0.97416    -0.97303
  502 43.7030    45.6560      0.6026     0.94886     6.4684     0.09478     0.09449
  503 43.7030    45.6560       .          .           .          .           .     
  504 43.7030    45.6560     18.8981     0.98493     5.0127     1.43810     1.43707
  505 43.7030    45.6560     -8.8707    -0.85850     3.4655    -0.85949    -0.85850
  506 43.7030    45.6560       .          .           .          .           .     
  507 43.7030    45.6560       .          .           .          .           .     
  508 43.7030    45.6560      7.9937     0.33520     5.5179     0.60830     0.60786
  509 43.7030    45.6560     -8.7921    -0.85089     3.4731    -0.85188    -0.85089
  510 43.7030    45.6560     -5.9473    -0.50127     5.0183    -0.93546    -0.93261
                                                           The SAS System                          11:46 Friday, January 6, 2023  38

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  511  PT128    VIS3    TRT   Asian                                                                                               
  512  PT128    VIS4    TRT   Asian                                                                                               
  513  PT129    VIS1    TRT   White                                                                                               
  514  PT129    VIS2    TRT   White                                                                                               
  515  PT129    VIS3    TRT   White                                                                                               
  516  PT129    VIS4    TRT   White                                                                                               
  517  PT130    VIS1    PBO   White                                                                                               
  518  PT130    VIS2    PBO   White                                                                                               
  519  PT130    VIS3    PBO   White                                                                                               
  520  PT130    VIS4    PBO   White                                                                                               
  521  PT131    VIS1    PBO   Asian                                                                                               
  522  PT131    VIS2    PBO   Asian                                                                                               
  523  PT131    VIS3    PBO   Asian                                                                                               
  524  PT131    VIS4    PBO   Asian                                                                                               
  525  PT132    VIS1    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  511 Female    46.259935036    46.703612948     0.691590769               3    -2.528500689    44.6795    0.49709    535     0.05
  512 Female    46.259935036    53.653978531    0.3973725559               4    -0.935902559    44.6795    0.49709    535     0.05
  513 Male       29.29119059    36.715434003    0.3712506013               1    -0.967239458    44.6795    0.49709    535     0.05
  514 Male       29.29119059               .    0.6382426787               2    0.0474885923    44.6795    0.49709    535     0.05
  515 Male       29.29119059               .     0.358328329               3    -0.403736793    44.6795    0.49709    535     0.05
  516 Male       29.29119059               .    0.6472893724               4    0.2314961282    44.6795    0.49709    535     0.05
  517 Male      51.717294784               .    0.2712290714               1    -0.422372408    41.1517    0.40805    535     0.05
  518 Male      51.717294784    41.543170228    0.2971716022               2    0.3741183947    41.1517    0.40805    535     0.05
  519 Male      51.717294784    51.679090849    0.1986576321               3    -0.366005775    41.1517    0.40805    535     0.05
  520 Male      51.717294784               .    0.7283097483               4    1.1901014465    41.1517    0.40805    535     0.05
  521 Female    35.719789663    27.401304422    0.7091390382               1    -0.737327525    41.1517    0.40805    535     0.05
  522 Female    35.719789663    30.335168668    0.2569599641               2    0.2906666454    41.1517    0.40805    535     0.05
  523 Female    35.719789663    37.730920936    0.8180239145               3    -0.884849568    41.1517    0.40805    535     0.05
  524 Female    35.719789663    29.116682507    0.5763214841               4    0.2080064789    41.1517    0.40805    535     0.05
  525 Male      50.537229891               .    0.4544683563               1    -0.047730172    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  511 43.7030    45.6560      2.0241     0.51769     8.3779     0.39923     0.39732
  512 43.7030    45.6560      8.9745     0.39990     1.9596     0.68293     0.68245
  513 43.7030    45.6560     -7.9640    -0.77075     3.5533    -0.77164    -0.77075
  514 43.7030    45.6560       .          .           .          .           .     
  515 43.7030    45.6560       .          .           .          .           .     
  516 43.7030    45.6560       .          .           .          .           .     
  517 40.3502    41.9533       .          .           .          .           .     
  518 40.3502    41.9533      0.3914     0.06183     6.5624     0.06196     0.06183
  519 40.3502    41.9533     10.5273     2.18563    11.2825     2.17943     2.17170
  520 40.3502    41.9533       .          .           .          .           .     
  521 40.3502    41.9533    -13.7504    -1.30674     2.6040    -1.30772    -1.30674
  522 40.3502    41.9533    -10.8166    -1.10289     4.2549    -1.71221    -1.70865
  523 40.3502    41.9533     -3.4208    -0.87156     8.1358    -0.70820    -0.70568
  524 40.3502    41.9533    -12.0351    -1.54054     1.7051    -1.04838    -1.04771
  525 40.3502    41.9533       .          .           .          .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  39

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  526  PT132    VIS2    PBO   Asian                                                                                               
  527  PT132    VIS3    PBO   Asian                                                                                               
  528  PT132    VIS4    PBO   Asian                                                                                               
  529  PT133    VIS1    PBO   White                                                                                               
  530  PT133    VIS2    PBO   White                                                                                               
  531  PT133    VIS3    PBO   White                                                                                               
  532  PT133    VIS4    PBO   White                                                                                               
  533  PT134    VIS1    PBO   Black or African American                                                                           
  534  PT134    VIS2    PBO   Black or African American                                                                           
  535  PT134    VIS3    PBO   Black or African American                                                                           
  536  PT134    VIS4    PBO   Black or African American                                                                           
  537  PT135    VIS1    PBO   Black or African American                                                                           
  538  PT135    VIS2    PBO   Black or African American                                                                           
  539  PT135    VIS3    PBO   Black or African American                                                                           
  540  PT135    VIS4    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  526 Male      50.537229891    32.088295356    0.3391362362               2    -1.684520646    41.1517    0.40805    535     0.05
  527 Male      50.537229891    41.660670405     0.342613125               3    -0.144226557    41.1517    0.40805    535     0.05
  528 Male      50.537229891    53.908153331    0.5589785654               4    1.1802136655    41.1517    0.40805    535     0.05
  529 Male      44.399431431               .    0.8447586689               1    0.6813999232    41.1517    0.40805    535     0.05
  530 Male      44.399431431    35.069371205    0.7476395493               2    0.1432476309    41.1517    0.40805    535     0.05
  531 Male      44.399431431    47.176146957    0.4483368471               3    -1.192316444    41.1517    0.40805    535     0.05
  532 Male      44.399431431     56.49347176      0.38481462               4    1.1692286528    41.1517    0.40805    535     0.05
  533 Male       41.73307334               .    0.5133077858               1    0.0792017089    41.1517    0.40805    535     0.05
  534 Male       41.73307334    38.880060226    0.6218274815               2    -0.451773753    41.1517    0.40805    535     0.05
  535 Male       41.73307334    47.540701181    0.6483730331               3    1.6420282128    41.1517    0.40805    535     0.05
  536 Male       41.73307334     43.53704952    0.7585478347               4    -0.769592322    41.1517    0.40805    535     0.05
  537 Male      40.666683598     31.82054002    0.1951798543               1    0.3033609608    41.1517    0.40805    535     0.05
  538 Male      40.666683598    39.628156371    0.8322863601               2    1.2817374212    41.1517    0.40805    535     0.05
  539 Male      40.666683598    44.955431666    0.3027852708               3    0.6022227952    41.1517    0.40805    535     0.05
  540 Male      40.666683598    21.115430799    0.4248988645               4    -0.307022265    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  526 40.3502    41.9533     -9.0634    -1.43172     5.0689    -1.43470    -1.43172
  527 40.3502    41.9533      0.5089    -0.02113     9.0757     0.10536     0.10499
  528 40.3502    41.9533     12.7564     0.74572     3.9843     1.11121     1.11051
  529 40.3502    41.9533       .          .           .          .           .     
  530 40.3502    41.9533     -6.0824    -0.96081     5.5398    -0.96281    -0.96081
  531 40.3502    41.9533      6.0244     1.16271    10.2595     1.24721     1.24278
  532 40.3502    41.9533     15.3417     0.77308     4.0117     1.33642     1.33558
  533 40.3502    41.9533       .          .           .          .           .     
  534 40.3502    41.9533     -2.2717    -0.35885     6.1417    -0.35960    -0.35885
  535 40.3502    41.9533      6.3890     1.29141    10.3882     1.32268     1.31798
  536 40.3502    41.9533      2.3853    -0.30917     2.9294     0.20778     0.20765
  537 40.3502    41.9533     -9.3312    -0.88677     3.0240    -0.88744    -0.88677
  538 40.3502    41.9533     -1.5236     0.61432     5.9721    -0.24118    -0.24067
  539 40.3502    41.9533      3.8037     0.65780     9.6651     0.78746     0.78467
  540 40.3502    41.9533    -20.0363    -2.54958     0.6960    -1.74537    -1.74427
                                                           The SAS System                          11:46 Friday, January 6, 2023  40

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  541  PT136    VIS1    TRT   White                                                                                               
  542  PT136    VIS2    TRT   White                                                                                               
  543  PT136    VIS3    TRT   White                                                                                               
  544  PT136    VIS4    TRT   White                                                                                               
  545  PT137    VIS1    TRT   Asian                                                                                               
  546  PT137    VIS2    TRT   Asian                                                                                               
  547  PT137    VIS3    TRT   Asian                                                                                               
  548  PT137    VIS4    TRT   Asian                                                                                               
  549  PT138    VIS1    TRT   Asian                                                                                               
  550  PT138    VIS2    TRT   Asian                                                                                               
  551  PT138    VIS3    TRT   Asian                                                                                               
  552  PT138    VIS4    TRT   Asian                                                                                               
  553  PT139    VIS1    TRT   Asian                                                                                               
  554  PT139    VIS2    TRT   Asian                                                                                               
  555  PT139    VIS3    TRT   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  541 Female    39.064786002    34.746713872    0.3102627149               1    -0.418418103    44.6795    0.49709    535     0.05
  542 Female    39.064786002               .    0.3560140539               2      0.35513553    44.6795    0.49709    535     0.05
  543 Female    39.064786002               .    0.2930808876               3    0.5134811146    44.6795    0.49709    535     0.05
  544 Female    39.064786002     56.69248543    0.5299581571               4    0.0186074003    44.6795    0.49709    535     0.05
  545 Female    31.377644674    22.731261449    0.6743837861               1    1.3184489723    44.6795    0.49709    535     0.05
  546 Female    31.377644674     32.50075458    0.5303139884               2       -0.065832    44.6795    0.49709    535     0.05
  547 Female    31.377644674    42.372055198    0.1138375578               3    -0.700296078    44.6795    0.49709    535     0.05
  548 Female    31.377644674    42.898473522     0.598362161               4    0.5373261315    44.6795    0.49709    535     0.05
  549 Male       46.14103795     55.62581723    0.5823351327               1    -2.201782322    44.6795    0.49709    535     0.05
  550 Male       46.14103795    45.389983114     0.711383274               2    0.3919737438    44.6795    0.49709    535     0.05
  551 Male       46.14103795    52.667429601    0.7994683793               3    0.4969609524    44.6795    0.49709    535     0.05
  552 Male       46.14103795               .    0.4547656061               4    -0.224874715    44.6795    0.49709    535     0.05
  553 Female    40.203936196               .    0.5047212752               1    -1.117143165    44.6795    0.49709    535     0.05
  554 Female    40.203936196               .    0.8126725445               2    -0.394994603    44.6795    0.49709    535     0.05
  555 Female    40.203936196    34.189306444    0.4020954825               3    1.5498303422    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  541 43.7030    45.6560     -9.9328    -0.96128     3.3627    -0.96240    -0.96128
  542 43.7030    45.6560       .          .           .          .           .     
  543 43.7030    45.6560       .          .           .          .           .     
  544 43.7030    45.6560     12.0130     0.62305     5.8057     0.91416     0.91350
  545 43.7030    45.6560    -21.9482    -2.12412     2.1999    -2.12659    -2.12412
  546 43.7030    45.6560    -12.1787    -0.70290     4.8167    -1.91562    -1.90979
  547 43.7030    45.6560     -2.3074    -0.24651     7.6137    -0.45510    -0.45293
  548 43.7030    45.6560     -1.7810    -0.73416     0.8255    -0.13553    -0.13543
  549 43.7030    45.6560     10.9463     1.05937     5.3834     1.06060     1.05937
  550 43.7030    45.6560      0.7105    -0.75211     4.7674     0.11176     0.11142
  551 43.7030    45.6560      7.9879     1.63640     9.4966     1.57550     1.56798
  552 43.7030    45.6560       .          .           .          .           .     
  553 43.7030    45.6560       .          .           .          .           .     
  554 43.7030    45.6560       .          .           .          .           .     
  555 43.7030    45.6560    -10.4902    -2.05915     6.7111    -2.06902    -2.05915
                                                           The SAS System                          11:46 Friday, January 6, 2023  41

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  556  PT139    VIS4    TRT   Asian                                                                                               
  557  PT140    VIS1    PBO   Black or African American                                                                           
  558  PT140    VIS2    PBO   Black or African American                                                                           
  559  PT140    VIS3    PBO   Black or African American                                                                           
  560  PT140    VIS4    PBO   Black or African American                                                                           
  561  PT141    VIS1    TRT   White                                                                                               
  562  PT141    VIS2    TRT   White                                                                                               
  563  PT141    VIS3    TRT   White                                                                                               
  564  PT141    VIS4    TRT   White                                                                                               
  565  PT142    VIS1    TRT   Black or African American                                                                           
  566  PT142    VIS2    TRT   Black or African American                                                                           
  567  PT142    VIS3    TRT   Black or African American                                                                           
  568  PT142    VIS4    TRT   Black or African American                                                                           
  569  PT143    VIS1    TRT   Black or African American                                                                           
  570  PT143    VIS2    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  556 Female    40.203936196    45.597401628    0.3062421832               4     -0.74351448    44.6795    0.49709    535     0.05
  557 Female    37.649560312    28.891981993    0.2355892679               1    -2.331712118    41.1517    0.40805    535     0.05
  558 Female    37.649560312    38.461474229    0.1691324634               2    0.8122454422    41.1517    0.40805    535     0.05
  559 Female    37.649560312               .    0.6456327958               3    -0.501310657    41.1517    0.40805    535     0.05
  560 Female    37.649560312    49.903566961    0.3869567472               4    -0.510886566    41.1517    0.40805    535     0.05
  561 Male      29.861173465               .    0.1520241268               1    -1.215364041    44.6795    0.49709    535     0.05
  562 Male      29.861173465    44.141668419    0.1543199213               2    -0.022558628    44.6795    0.49709    535     0.05
  563 Male      29.861173465               .    0.5521960208               3    0.7012393004    44.6795    0.49709    535     0.05
  564 Male      29.861173465    55.242779968    0.6456647232               4    -0.587482026    44.6795    0.49709    535     0.05
  565 Male      50.859323663               .    0.2535311041               1    -0.606727941    44.6795    0.49709    535     0.05
  566 Male      50.859323663               .    0.3125065207               2     1.096640215    44.6795    0.49709    535     0.05
  567 Male      50.859323663               .    0.8555654401               3    -0.247509677    44.6795    0.49709    535     0.05
  568 Male      50.859323663               .    0.5157021796               4    -0.159901713    44.6795    0.49709    535     0.05
  569 Female    22.859362148    27.380009675    0.6928430172               1    -0.625778251    44.6795    0.49709    535     0.05
  570 Female    22.859362148    33.632505256    0.2772447322               2    0.9004346356    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  556 43.7030    45.6560      0.9179     0.73556     1.4839     0.06985     0.06980
  557 40.3502    41.9533    -12.2598    -1.16508     2.7457    -1.16595    -1.16508
  558 40.3502    41.9533     -2.6903     0.64581     6.0036    -0.42586    -0.42497
  559 40.3502    41.9533       .          .           .          .           .     
  560 40.3502    41.9533      8.7518     0.35742     6.0829     0.76237     0.76189
  561 43.7030    45.6560       .          .           .          .           .     
  562 43.7030    45.6560     -0.5378    -0.08434     6.9220    -0.08459    -0.08434
  563 43.7030    45.6560       .          .           .          .           .     
  564 43.7030    45.6560     10.5633     0.79977     4.6002     0.80384     0.80326
  565 43.7030    45.6560       .          .           .          .           .     
  566 43.7030    45.6560       .          .           .          .           .     
  567 43.7030    45.6560       .          .           .          .           .     
  568 43.7030    45.6560       .          .           .          .           .     
  569 43.7030    45.6560    -17.2995    -1.67422     2.6498    -1.67616    -1.67422
  570 43.7030    45.6560    -11.0470    -0.85167     4.6679    -1.73760    -1.73232
                                                           The SAS System                          11:46 Friday, January 6, 2023  42

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  571  PT143    VIS3    TRT   Black or African American                                                                           
  572  PT143    VIS4    TRT   Black or African American                                                                           
  573  PT144    VIS1    PBO   Asian                                                                                               
  574  PT144    VIS2    PBO   Asian                                                                                               
  575  PT144    VIS3    PBO   Asian                                                                                               
  576  PT144    VIS4    PBO   Asian                                                                                               
  577  PT145    VIS1    PBO   Black or African American                                                                           
  578  PT145    VIS2    PBO   Black or African American                                                                           
  579  PT145    VIS3    PBO   Black or African American                                                                           
  580  PT145    VIS4    PBO   Black or African American                                                                           
  581  PT146    VIS1    TRT   Asian                                                                                               
  582  PT146    VIS2    TRT   Asian                                                                                               
  583  PT146    VIS3    TRT   Asian                                                                                               
  584  PT146    VIS4    TRT   Asian                                                                                               
  585  PT147    VIS1    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  571 Female    22.859362148               .    0.6116739746               3    -0.994193629    44.6795    0.49709    535     0.05
  572 Female    22.859362148    39.344095119    0.6010438742               4    0.8492503859    44.6795    0.49709    535     0.05
  573 Female    43.960853015    26.985752843     0.532622125               1     0.805702289    41.1517    0.40805    535     0.05
  574 Female    43.960853015    24.041749967    0.2927148407               2    -0.467600936    41.1517    0.40805    535     0.05
  575 Female    43.960853015    42.166482121    0.2998025049               3    0.8484203137    41.1517    0.40805    535     0.05
  576 Female    43.960853015    44.753801826    0.4741948145               4    0.9867698636    41.1517    0.40805    535     0.05
  577 Male      56.023147312    31.554694982    0.7675967027               1    0.5756202885    41.1517    0.40805    535     0.05
  578 Male      56.023147312    44.426957648    0.2871362656               2    2.0248420454    41.1517    0.40805    535     0.05
  579 Male      56.023147312    44.103434093    0.7201091271               3    -1.962353191    41.1517    0.40805    535     0.05
  580 Male      56.023147312               .    0.5172903882               4    -1.164920931    41.1517    0.40805    535     0.05
  581 Female    39.594341681               .    0.3673772749               1    -1.376519214    44.6795    0.49709    535     0.05
  582 Female    39.594341681    37.874454282    0.7227710366               2    0.1676799345    44.6795    0.49709    535     0.05
  583 Female    39.594341681    48.318283028    0.2901094802               3    1.5846290792    44.6795    0.49709    535     0.05
  584 Female    39.594341681     50.21519948    0.3693820415               4     1.677888953    44.6795    0.49709    535     0.05
  585 Female    49.956502045    41.946151662    0.4396032711               1    0.4882966984    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  571 43.7030    45.6560       .          .           .          .           .     
  572 43.7030    45.6560     -5.3354    -0.86719     3.1605    -0.40601    -0.40572
  573 40.3502    41.9533    -14.1660    -1.34623     2.5645    -1.34724    -1.34623
  574 40.3502    41.9533    -17.1100    -2.53408     2.8237    -2.70843    -2.70280
  575 40.3502    41.9533      1.0147     0.07475     9.0821     0.21008     0.20933
  576 40.3502    41.9533      3.6021    -0.35145     2.8942     0.31378     0.31358
  577 40.3502    41.9533     -9.5970    -0.91203     2.9987    -0.91272    -0.91203
  578 40.3502    41.9533      3.2752     1.76627     7.1240     0.51845     0.51737
  579 40.3502    41.9533      2.9517     0.45441     9.4617     0.61108     0.60891
  580 40.3502    41.9533       .          .           .          .           .     
  581 43.7030    45.6560       .          .           .          .           .     
  582 43.7030    45.6560     -6.8050    -1.06712     5.9392    -1.07038    -1.06712
  583 43.7030    45.6560      3.6388     0.87288     8.7367     0.71770     0.71427
  584 43.7030    45.6560      5.5357     0.08829     1.4609     0.42125     0.42095
  585 40.3502    41.9533      0.7944     0.07549     3.9862     0.07555     0.07549
                                                           The SAS System                          11:46 Friday, January 6, 2023  43

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  586  PT147    VIS2    PBO   Asian                                                                                               
  587  PT147    VIS3    PBO   Asian                                                                                               
  588  PT147    VIS4    PBO   Asian                                                                                               
  589  PT148    VIS1    TRT   Black or African American                                                                           
  590  PT148    VIS2    TRT   Black or African American                                                                           
  591  PT148    VIS3    TRT   Black or African American                                                                           
  592  PT148    VIS4    TRT   Black or African American                                                                           
  593  PT149    VIS1    PBO   Asian                                                                                               
  594  PT149    VIS2    PBO   Asian                                                                                               
  595  PT149    VIS3    PBO   Asian                                                                                               
  596  PT149    VIS4    PBO   Asian                                                                                               
  597  PT150    VIS1    PBO   White                                                                                               
  598  PT150    VIS2    PBO   White                                                                                               
  599  PT150    VIS3    PBO   White                                                                                               
  600  PT150    VIS4    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  586 Female    49.956502045     39.62690071    0.6584950881               2    0.8786732626    41.1517    0.40805    535     0.05
  587 Female    49.956502045    46.697634075    0.6242975602               3    -0.144874874    41.1517    0.40805    535     0.05
  588 Female    49.956502045               .     0.677617274               4    0.4689717601    41.1517    0.40805    535     0.05
  589 Male       43.28537313               .    0.2312604148               1    0.3762354771    44.6795    0.49709    535     0.05
  590 Male       43.28537313    43.752547605    0.1405221678               2    -0.761040275    44.6795    0.49709    535     0.05
  591 Male       43.28537313     47.38873166    0.5583120586               3    -0.293294934    44.6795    0.49709    535     0.05
  592 Male       43.28537313               .    0.1913288863               4    -0.134841264    44.6795    0.49709    535     0.05
  593 Female    42.405682283    32.434119624    0.1126122644               1    1.3938458162    41.1517    0.40805    535     0.05
  594 Female    42.405682283    43.071625346     0.721795881               2     -1.03698869    41.1517    0.40805    535     0.05
  595 Female    42.405682283    42.995513212     0.313322608               3    -2.114335148    41.1517    0.40805    535     0.05
  596 Female    42.405682283    53.827587537    0.6441660281               4    0.7682782182    41.1517    0.40805    535     0.05
  597 Male      41.611736369               .    0.2776039908               1    -0.816160621    41.1517    0.40805    535     0.05
  598 Male      41.611736369               .    0.8793941246               2    -0.436106923    41.1517    0.40805    535     0.05
  599 Male      41.611736369    50.648022218     0.643029568               3    0.9047050313    41.1517    0.40805    535     0.05
  600 Male      41.611736369    63.440509706    0.7253027093               4    -0.763086265    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  586 40.3502    41.9533     -1.5248    -0.43993     4.9178    -0.24138    -0.24087
  587 40.3502    41.9533      5.5459     1.17415    10.1815     1.14814     1.14407
  588 40.3502    41.9533       .          .           .          .           .     
  589 43.7030    45.6560       .          .           .          .           .     
  590 43.7030    45.6560     -0.9269    -0.14536     6.8610    -0.14580    -0.14536
  591 43.7030    45.6560      2.7093     0.55777     8.4216     0.53436     0.53181
  592 43.7030    45.6560       .          .           .          .           .     
  593 40.3502    41.9533     -8.7176    -0.82846     3.0823    -0.82908    -0.82846
  594 40.3502    41.9533      1.9199     1.35720     6.7150     0.30391     0.30328
  595 40.3502    41.9533      1.8438     0.24315     9.2505     0.38171     0.38035
  596 40.3502    41.9533     12.6758     0.86140     4.1070     1.10420     1.10350
  597 40.3502    41.9533       .          .           .          .           .     
  598 40.3502    41.9533       .          .           .          .           .     
  599 40.3502    41.9533      9.4963     1.95900    10.4482     1.96597     1.95900
  600 40.3502    41.9533     22.2888     1.38972     2.3221     1.94158     1.94035
                                                           The SAS System                          11:46 Friday, January 6, 2023  44

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  601  PT151    VIS1    PBO   Asian                                                                                               
  602  PT151    VIS2    PBO   Asian                                                                                               
  603  PT151    VIS3    PBO   Asian                                                                                               
  604  PT151    VIS4    PBO   Asian                                                                                               
  605  PT152    VIS1    TRT   Asian                                                                                               
  606  PT152    VIS2    TRT   Asian                                                                                               
  607  PT152    VIS3    TRT   Asian                                                                                               
  608  PT152    VIS4    TRT   Asian                                                                                               
  609  PT153    VIS1    PBO   Black or African American                                                                           
  610  PT153    VIS2    PBO   Black or African American                                                                           
  611  PT153    VIS3    PBO   Black or African American                                                                           
  612  PT153    VIS4    PBO   Black or African American                                                                           
  613  PT154    VIS1    PBO   Black or African American                                                                           
  614  PT154    VIS2    PBO   Black or African American                                                                           
  615  PT154    VIS3    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  601 Female    50.605325775    34.489490276      0.65941045               1     -0.34106698    41.1517    0.40805    535     0.05
  602 Female    50.605325775    40.080562048     0.108325576               2    1.5024245342    41.1517    0.40805    535     0.05
  603 Female    50.605325775               .    0.5031256646               3    0.5283077123    41.1517    0.40805    535     0.05
  604 Female    50.605325775    47.465530183    0.6848473679               4    0.5421913555    41.1517    0.40805    535     0.05
  605 Female    41.799866574               .    0.3638224179               1    -0.136673356    44.6795    0.49709    535     0.05
  606 Female    41.799866574    37.116968426    0.7563993162               2    -1.136733853    44.6795    0.49709    535     0.05
  607 Female    41.799866574               .    0.8078649396               3    -1.496627154    44.6795    0.49709    535     0.05
  608 Female    41.799866574    36.251199442    0.7847775655               4    -0.223385644    44.6795    0.49709    535     0.05
  609 Male      37.316621041    29.201705264    0.4625955278               1    2.0017192278    41.1517    0.40805    535     0.05
  610 Male      37.316621041    31.537725138     0.476304342               2    0.2217038162    41.1517    0.40805    535     0.05
  611 Male      37.316621041    42.356827013    0.5121918378               3    0.1643729092    41.1517    0.40805    535     0.05
  612 Male      37.316621041    64.783524587    0.2310740603               4    0.3326236089    41.1517    0.40805    535     0.05
  613 Female    43.013754766    32.727572301    0.8071348075               1    -0.385207999    41.1517    0.40805    535     0.05
  614 Female    43.013754766    37.500220927    0.2605141932               2    -1.398754027    41.1517    0.40805    535     0.05
  615 Female    43.013754766               .    0.6076489605               3    2.6757407959    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  601 40.3502    41.9533     -6.6623    -0.63313     3.2776    -0.63361    -0.63313
  602 40.3502    41.9533     -1.0712     0.44250     5.8003    -0.16956    -0.16921
  603 40.3502    41.9533       .          .           .          .           .     
  604 40.3502    41.9533      6.3138     0.34465     6.0701     0.55000     0.54965
  605 43.7030    45.6560       .          .           .          .           .     
  606 43.7030    45.6560     -7.5625    -1.18591     5.8205    -1.18953    -1.18591
  607 43.7030    45.6560       .          .           .          .           .     
  608 43.7030    45.6560     -8.4283    -0.70921     3.0912    -0.64137    -0.64091
  609 40.3502    41.9533    -11.9500    -1.13564     2.7751    -1.13650    -1.13564
  610 40.3502    41.9533     -9.6140    -1.00855     4.3492    -1.52185    -1.51869
  611 40.3502    41.9533      1.2051     0.11377     9.1211     0.24948     0.24860
  612 40.3502    41.9533     23.6318     1.76344     5.0091     2.05857     2.05727
  613 40.3502    41.9533     -8.4242    -0.80057     3.1102    -0.80117    -0.80057
  614 40.3502    41.9533     -3.6515     0.02137     5.3791    -0.57802    -0.57682
  615 40.3502    41.9533       .          .           .          .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  45

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  616  PT154    VIS4    PBO   Black or African American                                                                           
  617  PT155    VIS1    TRT   Asian                                                                                               
  618  PT155    VIS2    TRT   Asian                                                                                               
  619  PT155    VIS3    TRT   Asian                                                                                               
  620  PT155    VIS4    TRT   Asian                                                                                               
  621  PT156    VIS1    PBO   White                                                                                               
  622  PT156    VIS2    PBO   White                                                                                               
  623  PT156    VIS3    PBO   White                                                                                               
  624  PT156    VIS4    PBO   White                                                                                               
  625  PT157    VIS1    TRT   Black or African American                                                                           
  626  PT157    VIS2    TRT   Black or African American                                                                           
  627  PT157    VIS3    TRT   Black or African American                                                                           
  628  PT157    VIS4    TRT   Black or African American                                                                           
  629  PT158    VIS1    TRT   Black or African American                                                                           
  630  PT158    VIS2    TRT   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  616 Female    43.013754766    57.038614852    0.1353991063               4    -0.423686089    41.1517    0.40805    535     0.05
  617 Male      45.220753959    36.324751219    0.3968402132               1    -0.298601512    44.6795    0.49709    535     0.05
  618 Male      45.220753959               .    0.5830664467               2    -1.792341727    44.6795    0.49709    535     0.05
  619 Male      45.220753959    41.467253135     0.862100105               3    -0.248008225    44.6795    0.49709    535     0.05
  620 Male      45.220753959    59.014108955    0.2718862941               4    -0.247303918    44.6795    0.49709    535     0.05
  621 Male      38.321849667    30.149703335    0.2434353588               1    -0.255510379    41.1517    0.40805    535     0.05
  622 Male      38.321849667    34.917399892    0.7935770174               2      -1.7869381    41.1517    0.40805    535     0.05
  623 Male      38.321849667    52.138999315    0.4720119247               3     1.784662816    41.1517    0.40805    535     0.05
  624 Male      38.321849667    58.738392884     0.281557945               4    1.7635863477    41.1517    0.40805    535     0.05
  625 Male       44.79605932    35.831845084    0.8253052091               1    0.6896002219    44.6795    0.49709    535     0.05
  626 Male       44.79605932               .    0.8776743021               2    -1.100740644    44.6795    0.49709    535     0.05
  627 Male       44.79605932               .    0.8666040316               3    0.7145093569    44.6795    0.49709    535     0.05
  628 Male       44.79605932    56.414090905    0.5381546557               4    -0.246470317    44.6795    0.49709    535     0.05
  629 Male        54.6073631               .    0.8877710968               1    -0.319786166    44.6795    0.49709    535     0.05
  630 Male        54.6073631    43.555932987    0.3788180798               2     1.362644293    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  616 40.3502    41.9533     15.8869     1.16467     6.8901     1.38391     1.38304
  617 43.7030    45.6560     -8.3547    -0.80856     3.5155    -0.80950    -0.80856
  618 43.7030    45.6560       .          .           .          .           .     
  619 43.7030    45.6560     -3.2122    -0.58917     7.9673    -0.63356    -0.63054
  620 43.7030    45.6560     14.3346     1.13955     3.5156     1.09083     1.09005
  621 40.3502    41.9533    -11.0020    -1.04555     2.8652    -1.04634    -1.04555
  622 40.3502    41.9533     -6.2343    -0.31542     5.0423    -0.98687    -0.98481
  623 40.3502    41.9533     10.9873     2.15023    11.1576     2.27465     2.26657
  624 40.3502    41.9533     17.5867     0.61138     3.8570     1.53198     1.53101
  625 43.7030    45.6560     -8.8476    -0.85626     3.4678    -0.85726    -0.85626
  626 43.7030    45.6560       .          .           .          .           .     
  627 43.7030    45.6560       .          .           .          .           .     
  628 43.7030    45.6560     11.7346     0.63862     5.8213     0.89297     0.89233
  629 43.7030    45.6560       .          .           .          .           .     
  630 43.7030    45.6560     -1.1235    -0.17619     6.8302    -0.17673    -0.17619
                                                           The SAS System                          11:46 Friday, January 6, 2023  46

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  631  PT158    VIS3    TRT   Black or African American                                                                           
  632  PT158    VIS4    TRT   Black or African American                                                                           
  633  PT159    VIS1    TRT   Asian                                                                                               
  634  PT159    VIS2    TRT   Asian                                                                                               
  635  PT159    VIS3    TRT   Asian                                                                                               
  636  PT159    VIS4    TRT   Asian                                                                                               
  637  PT160    VIS1    TRT   Asian                                                                                               
  638  PT160    VIS2    TRT   Asian                                                                                               
  639  PT160    VIS3    TRT   Asian                                                                                               
  640  PT160    VIS4    TRT   Asian                                                                                               
  641  PT161    VIS1    PBO   Black or African American                                                                           
  642  PT161    VIS2    PBO   Black or African American                                                                           
  643  PT161    VIS3    PBO   Black or African American                                                                           
  644  PT161    VIS4    PBO   Black or African American                                                                           
  645  PT162    VIS1    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  631 Male        54.6073631    44.263200721    0.4008822316               3     -1.22788259    44.6795    0.49709    535     0.05
  632 Male        54.6073631    59.255791204    0.4362320513               4    -0.511219233    44.6795    0.49709    535     0.05
  633 Female    46.641110281    28.473144181    0.3260905223               1    -0.731194999    44.6795    0.49709    535     0.05
  634 Female    46.641110281    47.475807851    0.1532159889               2    0.0197520069    44.6795    0.49709    535     0.05
  635 Female    46.641110281               .    0.1638473235               3    -1.572863915    44.6795    0.49709    535     0.05
  636 Female    46.641110281               .    0.4462351073               4     -0.70333327    44.6795    0.49709    535     0.05
  637 Male      44.732231797               .    0.8906649049               1    0.7159320889    44.6795    0.49709    535     0.05
  638 Male      44.732231797    46.474830978    0.1903943321               2    0.4652149064    44.6795    0.49709    535     0.05
  639 Male      44.732231797    51.226770331    0.2763174089               3    -0.973902306    44.6795    0.49709    535     0.05
  640 Male      44.732231797    45.827765924    0.2762516337               4    0.5592177305    44.6795    0.49709    535     0.05
  641 Female    24.037995496               .    0.6185155679               1    -2.432639745    41.1517    0.40805    535     0.05
  642 Female    24.037995496    39.067827202    0.5074244408               2    -0.340484927    41.1517    0.40805    535     0.05
  643 Female    24.037995496               .    0.6819647532               3    0.7130331949    41.1517    0.40805    535     0.05
  644 Female    24.037995496               .    0.3527575683               4    -0.659037386    41.1517    0.40805    535     0.05
  645 Male      47.695167544    29.995422255    0.7768467894               1    -0.036402623    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  631 43.7030    45.6560     -0.4163    -0.05753    7.80627    -0.08210    -0.08171
  632 43.7030    45.6560     14.5763     1.17964    2.55230     1.10922     1.10843
  633 43.7030    45.6560    -16.2063    -1.56843    2.75560    -1.57025    -1.56843
  634 43.7030    45.6560      2.7963     1.90468    7.42423     0.43984     0.43850
  635 43.7030    45.6560       .          .          .           .           .     
  636 43.7030    45.6560       .          .          .           .           .     
  637 43.7030    45.6560       .          .          .           .           .     
  638 43.7030    45.6560      1.7954     0.28154    7.28789     0.28239     0.28154
  639 43.7030    45.6560      6.5473     1.25811    9.12191     1.29135     1.28519
  640 43.7030    45.6560      1.1483    -0.31257    1.06008     0.08738     0.08732
  641 40.3502    41.9533       .          .          .           .           .     
  642 40.3502    41.9533     -2.0839    -0.32919    6.17139    -0.32987    -0.32919
  643 40.3502    41.9533       .          .          .           .           .     
  644 40.3502    41.9533       .          .          .           .           .     
  645 40.3502    41.9533    -11.1563    -1.06021    2.85054    -1.06101    -1.06021
                                                           The SAS System                          11:46 Friday, January 6, 2023  47

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  646  PT162    VIS2    PBO   Asian                                                                                               
  647  PT162    VIS3    PBO   Asian                                                                                               
  648  PT162    VIS4    PBO   Asian                                                                                               
  649  PT163    VIS1    PBO   White                                                                                               
  650  PT163    VIS2    PBO   White                                                                                               
  651  PT163    VIS3    PBO   White                                                                                               
  652  PT163    VIS4    PBO   White                                                                                               
  653  PT164    VIS1    PBO   Black or African American                                                                           
  654  PT164    VIS2    PBO   Black or African American                                                                           
  655  PT164    VIS3    PBO   Black or African American                                                                           
  656  PT164    VIS4    PBO   Black or African American                                                                           
  657  PT165    VIS1    TRT   White                                                                                               
  658  PT165    VIS2    TRT   White                                                                                               
  659  PT165    VIS3    TRT   White                                                                                               
  660  PT165    VIS4    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  646 Male      47.695167544               .    0.5049247766               2    -1.593286302    41.1517    0.40805    535     0.05
  647 Male      47.695167544               .     0.646068969               3    0.8477927972    41.1517    0.40805    535     0.05
  648 Male      47.695167544    54.177955868     0.855536741               4    -1.850388849    41.1517    0.40805    535     0.05
  649 Male      56.247513589               .    0.1115278088               1    -0.323650632    41.1517    0.40805    535     0.05
  650 Male      56.247513589    44.557432809    0.5168663993               2    -0.255248113    41.1517    0.40805    535     0.05
  651 Male      56.247513589               .    0.7597116996               3    0.0609212273    41.1517    0.40805    535     0.05
  652 Male      56.247513589    62.595793691    0.3624407209               4    -0.823491629    41.1517    0.40805    535     0.05
  653 Female    38.186502186               .    0.6462093361               1    1.8297304848    41.1517    0.40805    535     0.05
  654 Female    38.186502186    35.483960044     0.594192197               2    -1.429916216    41.1517    0.40805    535     0.05
  655 Female    38.186502186    44.077675008    0.6214686664               3     0.254137143    41.1517    0.40805    535     0.05
  656 Female    38.186502186    46.578370494    0.8649803828               4    -2.939773695    41.1517    0.40805    535     0.05
  657 Female    39.434505983    47.679791279    0.2868099846               1    0.0024158089    44.6795    0.49709    535     0.05
  658 Female    39.434505983               .    0.3637476992               2    0.5096655713    44.6795    0.49709    535     0.05
  659 Female    39.434505983               .    0.7704558508               3    -1.084720001    44.6795    0.49709    535     0.05
  660 Female    39.434505983               .    0.2160246981               4    0.7048329769    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  646 40.3502    41.9533       .          .          .           .           .     
  647 40.3502    41.9533       .          .          .           .           .     
  648 40.3502    41.9533     13.0262     0.78335    6.32273     1.13472     1.13400
  649 40.3502    41.9533       .          .          .           .           .     
  650 40.3502    41.9533      3.4057     0.53798    7.03856     0.53910     0.53798
  651 40.3502    41.9533       .          .          .           .           .     
  652 40.3502    41.9533     21.4441     2.13687    8.01027     1.86800     1.86682
  653 40.3502    41.9533       .          .          .           .           .     
  654 40.3502    41.9533     -5.6678    -0.89532    5.60526    -0.89718    -0.89532
  655 40.3502    41.9533      2.9259     0.52682    9.62365     0.60574     0.60359
  656 40.3502    41.9533      5.4266     0.04701    3.28561     0.47271     0.47242
  657 43.7030    45.6560      3.0003     0.29037    4.61440     0.29070     0.29037
  658 43.7030    45.6560       .          .          .           .           .     
  659 43.7030    45.6560       .          .          .           .           .     
  660 43.7030    45.6560       .          .          .           .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  48

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  661  PT166    VIS1    TRT   Asian                                                                                               
  662  PT166    VIS2    TRT   Asian                                                                                               
  663  PT166    VIS3    TRT   Asian                                                                                               
  664  PT166    VIS4    TRT   Asian                                                                                               
  665  PT167    VIS1    PBO   Black or African American                                                                           
  666  PT167    VIS2    PBO   Black or African American                                                                           
  667  PT167    VIS3    PBO   Black or African American                                                                           
  668  PT167    VIS4    PBO   Black or African American                                                                           
  669  PT168    VIS1    PBO   Black or African American                                                                           
  670  PT168    VIS2    PBO   Black or African American                                                                           
  671  PT168    VIS3    PBO   Black or African American                                                                           
  672  PT168    VIS4    PBO   Black or African American                                                                           
  673  PT169    VIS1    PBO   White                                                                                               
  674  PT169    VIS2    PBO   White                                                                                               
  675  PT169    VIS3    PBO   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  661 Male      38.420370308    22.154387355    0.8382195136               1      0.33097635    44.6795    0.49709    535     0.05
  662 Male      38.420370308               .    0.1695157314               2     0.976327473    44.6795    0.49709    535     0.05
  663 Male      38.420370308               .    0.6488529904               3     -0.84333988    44.6795    0.49709    535     0.05
  664 Male      38.420370308               .    0.8741210921               4    -0.970579905    44.6795    0.49709    535     0.05
  665 Male      51.713270467    34.277652797    0.6092352802               1    -1.771531349    41.1517    0.40805    535     0.05
  666 Male      51.713270467    36.900588497     0.436412215               2    -0.322470342    41.1517    0.40805    535     0.05
  667 Male      51.713270467               .    0.7441117814               3    -1.338800742    41.1517    0.40805    535     0.05
  668 Male      51.713270467    40.542854177    0.3083100043               4    0.6881560281    41.1517    0.40805    535     0.05
  669 Female    41.247113228    29.094939852    0.6256946541               1    0.0712806523    41.1517    0.40805    535     0.05
  670 Female    41.247113228      37.2176805    0.5660386879               2    2.1897523593    41.1517    0.40805    535     0.05
  671 Female    41.247113228    43.084912398    0.6145658007               3    -1.157707599    41.1517    0.40805    535     0.05
  672 Female    41.247113228               .    0.1201660458               4    1.1816880641    41.1517    0.40805    535     0.05
  673 Female    33.617744016    27.121739597     0.151484956               1    -0.527368362    41.1517    0.40805    535     0.05
  674 Female    33.617744016    34.119161664    0.8846772501               2    -1.456628011    41.1517    0.40805    535     0.05
  675 Female    33.617744016               .    0.8515245084               3    0.5729673705    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  661 43.7030    45.6560    -22.5251    -2.17995    2.14408    -2.18248    -2.17995
  662 43.7030    45.6560       .          .          .           .           .     
  663 43.7030    45.6560       .          .          .           .           .     
  664 43.7030    45.6560       .          .          .           .           .     
  665 40.3502    41.9533     -6.8741    -0.65326    3.25749    -0.65375    -0.65326
  666 40.3502    41.9533     -4.2512    -0.28046    5.07730    -0.67294    -0.67154
  667 40.3502    41.9533       .          .          .           .           .     
  668 40.3502    41.9533     -0.6089    -0.34306    5.38238    -0.05304    -0.05301
  669 40.3502    41.9533    -12.0568    -1.14579    2.76497    -1.14665    -1.14579
  670 40.3502    41.9533     -3.9341     0.33329    5.69105    -0.62274    -0.62145
  671 40.3502    41.9533      1.9332     0.23788    9.24522     0.40022     0.39880
  672 40.3502    41.9533       .          .          .           .           .     
  673 40.3502    41.9533    -14.0300    -1.33331    2.57745    -1.33431    -1.33331
  674 40.3502    41.9533     -7.0326    -0.18726    5.17051    -1.11322    -1.11091
  675 40.3502    41.9533       .          .          .           .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  49

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  676  PT169    VIS4    PBO   White                                                                                               
  677  PT170    VIS1    TRT   White                                                                                               
  678  PT170    VIS2    TRT   White                                                                                               
  679  PT170    VIS3    TRT   White                                                                                               
  680  PT170    VIS4    TRT   White                                                                                               
  681  PT171    VIS1    PBO   Asian                                                                                               
  682  PT171    VIS2    PBO   Asian                                                                                               
  683  PT171    VIS3    PBO   Asian                                                                                               
  684  PT171    VIS4    PBO   Asian                                                                                               
  685  PT172    VIS1    TRT   Asian                                                                                               
  686  PT172    VIS2    TRT   Asian                                                                                               
  687  PT172    VIS3    TRT   Asian                                                                                               
  688  PT172    VIS4    TRT   Asian                                                                                               
  689  PT173    VIS1    TRT   White                                                                                               
  690  PT173    VIS2    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  676 Female    33.617744016               .    0.2576674003               4    -1.433377705    41.1517    0.40805    535     0.05
  677 Female    37.149436684               .     0.653136472               1    -1.055185019    44.6795    0.49709    535     0.05
  678 Female    37.149436684    40.802298142    0.3638632571               2    -0.733111877    44.6795    0.49709    535     0.05
  679 Female    37.149436684    45.892688168    0.6420440694               3    0.2109072643    44.6795    0.49709    535     0.05
  680 Female    37.149436684    43.691525577    0.1581865866               4    -0.998920727    44.6795    0.49709    535     0.05
  681 Female    46.106061083               .    0.8848686654               1    1.0778503232    41.1517    0.40805    535     0.05
  682 Female    46.106061083    29.228689037    0.2008532796               2    -1.198974383    41.1517    0.40805    535     0.05
  683 Female    46.106061083               .    0.4033392947               3    0.2166370352    41.1517    0.40805    535     0.05
  684 Female    46.106061083     55.68361847     0.782635471               4    0.1430870298    41.1517    0.40805    535     0.05
  685 Female    47.137504476     31.90698384    0.7636364322               1    -1.065750091    44.6795    0.49709    535     0.05
  686 Female    47.137504476    37.310607623    0.6366974687               2    -0.428623411    44.6795    0.49709    535     0.05
  687 Female    47.137504476    40.755459096    0.6623279421               3    -0.656179477    44.6795    0.49709    535     0.05
  688 Female    47.137504476               .    0.8076594321               4    0.9593943269    44.6795    0.49709    535     0.05
  689 Female    36.429200449    42.194736599     0.469551916               1    1.5560526361    44.6795    0.49709    535     0.05
  690 Female    36.429200449    44.872277155    0.6602340568               2    -1.040796434    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  676 40.3502    41.9533       .          .          .           .           .     
  677 43.7030    45.6560       .          .          .           .           .     
  678 43.7030    45.6560     -3.8772    -0.60800    6.39836    -0.60985    -0.60800
  679 43.7030    45.6560      1.2132     0.32682    8.19062     0.23929     0.23814
  680 43.7030    45.6560     -0.9880    -0.22527    1.14739    -0.07518    -0.07513
  681 40.3502    41.9533       .          .          .           .           .     
  682 40.3502    41.9533    -11.9231    -1.88344    4.61714    -1.88736    -1.88344
  683 40.3502    41.9533       .          .          .           .           .     
  684 40.3502    41.9533     14.5319     0.71931    6.59271     1.26587     1.26508
  685 43.7030    45.6560    -12.7725    -1.23611    3.08792    -1.23754    -1.23611
  686 43.7030    45.6560     -7.3689    -0.46694    5.05261    -1.15907    -1.15554
  687 43.7030    45.6560     -3.9240    -0.64769    7.21254    -0.77395    -0.77026
  688 43.7030    45.6560       .          .          .           .           .     
  689 43.7030    45.6560     -2.4847    -0.24047    4.08356    -0.24075    -0.24047
  690 43.7030    45.6560      0.1928     0.24352    5.76307     0.03033     0.03023
                                                           The SAS System                          11:46 Friday, January 6, 2023  50

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  691  PT173    VIS3    TRT   White                                                                                               
  692  PT173    VIS4    TRT   White                                                                                               
  693  PT174    VIS1    TRT   Black or African American                                                                           
  694  PT174    VIS2    TRT   Black or African American                                                                           
  695  PT174    VIS3    TRT   Black or African American                                                                           
  696  PT174    VIS4    TRT   Black or African American                                                                           
  697  PT175    VIS1    PBO   Black or African American                                                                           
  698  PT175    VIS2    PBO   Black or African American                                                                           
  699  PT175    VIS3    PBO   Black or African American                                                                           
  700  PT175    VIS4    PBO   Black or African American                                                                           
  701  PT176    VIS1    TRT   Black or African American                                                                           
  702  PT176    VIS2    TRT   Black or African American                                                                           
  703  PT176    VIS3    TRT   Black or African American                                                                           
  704  PT176    VIS4    TRT   Black or African American                                                                           
  705  PT177    VIS1    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  691 Female    36.429200449     47.55198474    0.4548119729               3    0.9305724085    44.6795    0.49709    535     0.05
  692 Female    36.429200449               .    0.8281013902               4    -0.075445931    44.6795    0.49709    535     0.05
  693 Female    45.105409543    50.628943087    0.1947195886               1    -1.967195349    44.6795    0.49709    535     0.05
  694 Female    45.105409543    45.475511103    0.1446256643               2    -0.755903643    44.6795    0.49709    535     0.05
  695 Female    45.105409543    48.621679848    0.6657861808               3    0.4611491605    44.6795    0.49709    535     0.05
  696 Female    45.105409543               .    0.7947959404               4     0.145106631    44.6795    0.49709    535     0.05
  697 Female    24.259885343    29.664926185    0.1039308261               1    -2.442311321    41.1517    0.40805    535     0.05
  698 Female    24.259885343     34.57406021    0.7065688981               2    0.5803186855    41.1517    0.40805    535     0.05
  699 Female    24.259885343               .    0.7255845582               3    0.6550519985    41.1517    0.40805    535     0.05
  700 Female    24.259885343    38.116757394     0.495015345               4    -0.304508837    41.1517    0.40805    535     0.05
  701 Male      34.428275123    33.772041634    0.5921728868               1    -0.707568233    44.6795    0.49709    535     0.05
  702 Male      34.428275123    34.261479368    0.3848576339               2    1.9715720145    44.6795    0.49709    535     0.05
  703 Male      34.428275123               .     0.472361481               3    -0.089998681    44.6795    0.49709    535     0.05
  704 Male      34.428275123    58.810371486    0.3391542539               4    -0.014017252    44.6795    0.49709    535     0.05
  705 Male      33.608440326               .    0.1570201496               1    -1.123456937    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  691 43.7030    45.6560      2.8725     0.54846    8.40868     0.56656     0.56385
  692 43.7030    45.6560       .          .          .           .           .     
  693 43.7030    45.6560      5.9495     0.57578    4.89981     0.57645     0.57578
  694 43.7030    45.6560      0.7960    -0.32452    5.19503     0.12521     0.12483
  695 43.7030    45.6560      3.9422     0.79819    8.65842     0.77754     0.77383
  696 43.7030    45.6560       .          .          .           .           .     
  697 40.3502    41.9533    -11.4868    -1.09162    2.81913    -1.09244    -1.09162
  698 40.3502    41.9533     -6.5777    -0.34540    5.01236    -1.04122    -1.03905
  699 40.3502    41.9533       .          .          .           .           .     
  700 40.3502    41.9533     -3.0350    -0.75980    4.96563    -0.26438    -0.26421
  701 43.7030    45.6560    -10.9074    -1.05561    3.26842    -1.05683    -1.05561
  702 43.7030    45.6560    -10.4180    -1.24684    4.27270    -1.63867    -1.63369
  703 43.7030    45.6560       .          .          .           .           .     
  704 43.7030    45.6560     14.1309     1.07356    5.10128     1.07532     1.07455
  705 40.3502    41.9533       .          .          .           .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  51

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  706  PT177    VIS2    PBO   Black or African American                                                                           
  707  PT177    VIS3    PBO   Black or African American                                                                           
  708  PT177    VIS4    PBO   Black or African American                                                                           
  709  PT178    VIS1    PBO   Black or African American                                                                           
  710  PT178    VIS2    PBO   Black or African American                                                                           
  711  PT178    VIS3    PBO   Black or African American                                                                           
  712  PT178    VIS4    PBO   Black or African American                                                                           
  713  PT179    VIS1    TRT   White                                                                                               
  714  PT179    VIS2    TRT   White                                                                                               
  715  PT179    VIS3    TRT   White                                                                                               
  716  PT179    VIS4    TRT   White                                                                                               
  717  PT180    VIS1    PBO   Asian                                                                                               
  718  PT180    VIS2    PBO   Asian                                                                                               
  719  PT180    VIS3    PBO   Asian                                                                                               
  720  PT180    VIS4    PBO   Asian                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  706 Male      33.608440326               .    0.6779579315               2    -1.344130123    41.1517    0.40805    535     0.05
  707 Male      33.608440326    39.881193305    0.2114915131               3    -1.523155771    41.1517    0.40805    535     0.05
  708 Male      33.608440326               .    0.7238571499               4     -0.42196821    41.1517    0.40805    535     0.05
  709 Male      42.991675558    31.627076856    0.7839299222               1    1.3609244641    41.1517    0.40805    535     0.05
  710 Male      42.991675558               .     0.375554511               2    1.7537948453    41.1517    0.40805    535     0.05
  711 Male      42.991675558               .     0.387442893               3    1.5683647344    41.1517    0.40805    535     0.05
  712 Male      42.991675558    48.220491988    0.8508342981               4    1.2967555699    41.1517    0.40805    535     0.05
  713 Male      33.437948069    42.588288304     0.609642745               1    -0.237596251    44.6795    0.49709    535     0.05
  714 Male      33.437948069               .    0.3708735675               2    -1.224150136    44.6795    0.49709    535     0.05
  715 Male      33.437948069    49.332622184    0.5090173379               3     -0.32781268    44.6795    0.49709    535     0.05
  716 Male      33.437948069    53.743311488    0.4497337842               4    -2.412450276    44.6795    0.49709    535     0.05
  717 Male      31.509103384    29.718574136    0.6455284989               1    -0.313792873    41.1517    0.40805    535     0.05
  718 Male      31.509103384    30.456514813    0.8264439745               2    1.6598787046    41.1517    0.40805    535     0.05
  719 Male      31.509103384    38.298000505    0.2432058582               3    0.1309531006    41.1517    0.40805    535     0.05
  720 Male      31.509103384               .    0.3114751875               4    1.0958886827    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  706 40.3502    41.9533       .          .          .           .           .     
  707 40.3502    41.9533     -1.2705    -0.26210    8.22713    -0.26304    -0.26210
  708 40.3502    41.9533       .          .          .           .           .     
  709 40.3502    41.9533     -9.5247    -0.90515    3.00560    -0.90583    -0.90515
  710 40.3502    41.9533       .          .          .           .           .     
  711 40.3502    41.9533       .          .          .           .           .     
  712 40.3502    41.9533      7.0687     0.28587    5.82524     0.61576     0.61537
  713 43.7030    45.6560     -2.0912    -0.20238    4.12165    -0.20262    -0.20238
  714 43.7030    45.6560       .          .          .           .           .     
  715 43.7030    45.6560      4.6531     0.92519    9.48162     0.91776     0.91338
  716 43.7030    45.6560      9.0638     0.36280    2.73887     0.68973     0.68924
  717 40.3502    41.9533    -11.4332    -1.08652    2.82423    -1.08734    -1.08652
  718 40.3502    41.9533    -10.6952    -1.31566    4.04211    -1.69300    -1.68948
  719 40.3502    41.9533     -2.8537    -0.71887    8.28847    -0.59080    -0.58870
  720 40.3502    41.9533       .          .          .           .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  52

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  721  PT181    VIS1    PBO   Asian                                                                                               
  722  PT181    VIS2    PBO   Asian                                                                                               
  723  PT181    VIS3    PBO   Asian                                                                                               
  724  PT181    VIS4    PBO   Asian                                                                                               
  725  PT182    VIS1    TRT   Black or African American                                                                           
  726  PT182    VIS2    TRT   Black or African American                                                                           
  727  PT182    VIS3    TRT   Black or African American                                                                           
  728  PT182    VIS4    TRT   Black or African American                                                                           
  729  PT183    VIS1    TRT   Black or African American                                                                           
  730  PT183    VIS2    TRT   Black or African American                                                                           
  731  PT183    VIS3    TRT   Black or African American                                                                           
  732  PT183    VIS4    TRT   Black or African American                                                                           
  733  PT184    VIS1    TRT   White                                                                                               
  734  PT184    VIS2    TRT   White                                                                                               
  735  PT184    VIS3    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  721 Female    34.933346602    36.810396399     0.382819267               1    0.4893409569    41.1517    0.40805    535     0.05
  722 Female    34.933346602               .    0.1242745982               2    -0.778910295    41.1517    0.40805    535     0.05
  723 Female    34.933346602    42.350448494    0.1279429894               3    1.7435593529    41.1517    0.40805    535     0.05
  724 Female    34.933346602    39.398604824    0.1728286337               4    -0.078387285    41.1517    0.40805    535     0.05
  725 Female    48.424776669               .    0.5908450671               1    -0.975553793    44.6795    0.49709    535     0.05
  726 Female    48.424776669               .    0.1157625053               2    0.0706598247    44.6795    0.49709    535     0.05
  727 Female    48.424776669    49.736287916    0.4398419563               3    -1.518599529    44.6795    0.49709    535     0.05
  728 Female    48.424776669    41.580817213     0.164195691               4    0.8637790328    44.6795    0.49709    535     0.05
  729 Female     30.20877967    43.589010424    0.5056998502               1    0.5015683854    44.6795    0.49709    535     0.05
  730 Female     30.20877967    40.167615484    0.5280545501               2     -0.35478133    44.6795    0.49709    535     0.05
  731 Female     30.20877967               .    0.6938342603               3    -0.488428888    44.6795    0.49709    535     0.05
  732 Female     30.20877967               .    0.6117273418               4    0.9362939473    44.6795    0.49709    535     0.05
  733 Female    59.123126961               .    0.5974531716               1    -1.062408386    44.6795    0.49709    535     0.05
  734 Female    59.123126961    41.082056345    0.7869781205               2    -0.983820872    44.6795    0.49709    535     0.05
  735 Female    59.123126961               .    0.8619020602               3     0.424247877    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  721 40.3502    41.9533     -4.3413    -0.41257    3.49818    -0.41288    -0.41257
  722 40.3502    41.9533       .          .          .           .           .     
  723 40.3502    41.9533      1.1987     0.19265    9.30262     0.24816     0.24728
  724 40.3502    41.9533     -1.7531    -0.41345    2.61411    -0.15272    -0.15262
  725 43.7030    45.6560       .          .          .           .           .     
  726 43.7030    45.6560       .          .          .           .           .     
  727 43.7030    45.6560      5.0568     0.99262    9.76290     0.99738     0.99262
  728 43.7030    45.6560     -3.0987    -0.56675    0.18161    -0.23580    -0.23563
  729 43.7030    45.6560     -1.0905    -0.10553    4.21850    -0.10566    -0.10553
  730 43.7030    45.6560     -4.5119    -0.83812    4.68143    -0.70968    -0.70752
  731 43.7030    45.6560       .          .          .           .           .     
  732 43.7030    45.6560       .          .          .           .           .     
  733 43.7030    45.6560       .          .          .           .           .     
  734 43.7030    45.6560     -3.5974    -0.56413    6.44223    -0.56585    -0.56413
  735 43.7030    45.6560       .          .          .           .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  53

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  736  PT184    VIS4    TRT   White                                                                                               
  737  PT185    VIS1    PBO   Black or African American                                                                           
  738  PT185    VIS2    PBO   Black or African American                                                                           
  739  PT185    VIS3    PBO   Black or African American                                                                           
  740  PT185    VIS4    PBO   Black or African American                                                                           
  741  PT186    VIS1    PBO   White                                                                                               
  742  PT186    VIS2    PBO   White                                                                                               
  743  PT186    VIS3    PBO   White                                                                                               
  744  PT186    VIS4    PBO   White                                                                                               
  745  PT187    VIS1    PBO   Black or African American                                                                           
  746  PT187    VIS2    PBO   Black or African American                                                                           
  747  PT187    VIS3    PBO   Black or African American                                                                           
  748  PT187    VIS4    PBO   Black or African American                                                                           
  749  PT188    VIS1    PBO   Black or African American                                                                           
  750  PT188    VIS2    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  736 Female    59.123126961    69.374086153    0.5978893928               4    -0.451313481    44.6795    0.49709    535     0.05
  737 Female     49.86060304               .    0.6995229786               1    0.9250847967    41.1517    0.40805    535     0.05
  738 Female     49.86060304    41.276245306    0.1918663196               2     -0.19862081    41.1517    0.40805    535     0.05
  739 Female     49.86060304    44.761382808    0.4125529574               3    1.1948510169    41.1517    0.40805    535     0.05
  740 Female     49.86060304    39.698154918    0.8342022549               4    0.4955447052    41.1517    0.40805    535     0.05
  741 Male      50.025948006    38.442958786    0.4535602255               1    -2.245152574    41.1517    0.40805    535     0.05
  742 Male      50.025948006    48.205857775    0.1531047627               2     -1.33537136    41.1517    0.40805    535     0.05
  743 Male      50.025948006               .    0.8644552255               3    1.2827752062    41.1517    0.40805    535     0.05
  744 Male      50.025948006     35.50734863     0.854869622               4    0.6907959042    41.1517    0.40805    535     0.05
  745 Female    37.655450451     32.08152787    0.6450459264               1    -0.967062668    41.1517    0.40805    535     0.05
  746 Female    37.655450451               .    0.1440276315               2    -1.345793685    41.1517    0.40805    535     0.05
  747 Female    37.655450451               .    0.6756925162               3    1.0336653893    41.1517    0.40805    535     0.05
  748 Female    37.655450451               .    0.3623819601               4     -0.81177646    41.1517    0.40805    535     0.05
  749 Female       53.650774     44.69256059    0.6978408502               1    1.8017254786    41.1517    0.40805    535     0.05
  750 Female       53.650774               .      0.85261639               2    1.7715419604    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  736 43.7030    45.6560     24.6946     1.84887    5.64932     1.87919     1.87785
  737 40.3502    41.9533       .          .          .           .           .     
  738 40.3502    41.9533      0.1245     0.01967    6.52025     0.01971     0.01967
  739 40.3502    41.9533      3.6096     0.74928    9.84610     0.74729     0.74464
  740 40.3502    41.9533     -1.4536    -0.37460    2.86400    -0.12662    -0.12654
  741 40.3502    41.9533     -2.7088    -0.25742    3.65333    -0.25762    -0.25742
  742 40.3502    41.9533      7.0541     1.93462    7.29238     1.11663     1.11431
  743 40.3502    41.9533       .          .          .           .           .     
  744 40.3502    41.9533     -5.6444    -0.57637    5.14906    -0.49168    -0.49137
  745 40.3502    41.9533     -9.0702    -0.86197    3.04879    -0.86261    -0.86197
  746 40.3502    41.9533       .          .          .           .           .     
  747 40.3502    41.9533       .          .          .           .           .     
  748 40.3502    41.9533       .          .          .           .           .     
  749 40.3502    41.9533      3.5408     0.33649    4.24725     0.33675     0.33649
  750 40.3502    41.9533       .          .          .           .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  54

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  751  PT188    VIS3    PBO   Black or African American                                                                           
  752  PT188    VIS4    PBO   Black or African American                                                                           
  753  PT189    VIS1    TRT   Asian                                                                                               
  754  PT189    VIS2    TRT   Asian                                                                                               
  755  PT189    VIS3    TRT   Asian                                                                                               
  756  PT189    VIS4    TRT   Asian                                                                                               
  757  PT190    VIS1    TRT   Black or African American                                                                           
  758  PT190    VIS2    TRT   Black or African American                                                                           
  759  PT190    VIS3    TRT   Black or African American                                                                           
  760  PT190    VIS4    TRT   Black or African American                                                                           
  761  PT191    VIS1    TRT   White                                                                                               
  762  PT191    VIS2    TRT   White                                                                                               
  763  PT191    VIS3    TRT   White                                                                                               
  764  PT191    VIS4    TRT   White                                                                                               
  765  PT192    VIS1    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  751 Female       53.650774    42.186893965    0.2744149249               3     -1.45469137    41.1517    0.40805    535     0.05
  752 Female       53.650774               .    0.6938024225               4    -0.845654313    41.1517    0.40805    535     0.05
  753 Female    48.000041599    37.017405812    0.8021209063               1    -1.250479659    44.6795    0.49709    535     0.05
  754 Female    48.000041599    38.269197329    0.4642523983               2    0.6672880679    44.6795    0.49709    535     0.05
  755 Female    48.000041599     49.28805689    0.1197868071               3    -1.290769688    44.6795    0.49709    535     0.05
  756 Female    48.000041599               .     0.315147469               4    -2.035003538    44.6795    0.49709    535     0.05
  757 Female    45.597075649    40.459533114    0.7232831979               1    2.0213469945    44.6795    0.49709    535     0.05
  758 Female    45.597075649    45.103365199    0.6709012946               2    1.0059734876    44.6795    0.49709    535     0.05
  759 Female    45.597075649    45.582497323    0.8904658424               3    0.8171236012    44.6795    0.49709    535     0.05
  760 Female    45.597075649    62.969894641    0.1136214962               4    -0.663988284    44.6795    0.49709    535     0.05
  761 Male      18.792378606    30.782524511    0.3532672957               1    -0.011281231    44.6795    0.49709    535     0.05
  762 Male      18.792378606               .    0.3032777878               2    0.6196772562    44.6795    0.49709    535     0.05
  763 Male      18.792378606               .    0.4673183646               3    -1.281238742    44.6795    0.49709    535     0.05
  764 Male      18.792378606    44.696667272    0.5270021191               4    -0.124261326    44.6795    0.49709    535     0.05
  765 Female    37.433381846    32.724907349    0.6150583168               1    0.1757416545    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  751 40.3502    41.9533      1.0352     0.26205    9.37202     0.21430     0.21354
  752 40.3502    41.9533       .          .          .           .           .     
  753 43.7030    45.6560     -7.6621    -0.74153    3.58250    -0.74239    -0.74153
  754 43.7030    45.6560     -6.4103    -0.68919    4.83036    -1.00829    -1.00522
  755 43.7030    45.6560      4.6086     1.05160    8.91183     0.90897     0.90463
  756 43.7030    45.6560       .          .          .           .           .     
  757 43.7030    45.6560     -4.2199    -0.40840    3.91563    -0.40888    -0.40840
  758 43.7030    45.6560      0.4239     0.43341    5.95296     0.06667     0.06647
  759 43.7030    45.6560      0.9030     0.13944    7.99967     0.17811     0.17726
  760 43.7030    45.6560     18.2904     1.29050    2.85020     1.39185     1.39086
  761 43.7030    45.6560    -13.8970    -1.34493    2.97910    -1.34649    -1.34493
  762 43.7030    45.6560       .          .          .           .           .     
  763 43.7030    45.6560       .          .          .           .           .     
  764 43.7030    45.6560      0.0172    -0.48647    4.69622     0.00131     0.00131
  765 43.7030    45.6560    -11.9546    -1.15695    3.16708    -1.15829    -1.15695
                                                           The SAS System                          11:46 Friday, January 6, 2023  55

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  766  PT192    VIS2    TRT   White                                                                                               
  767  PT192    VIS3    TRT   White                                                                                               
  768  PT192    VIS4    TRT   White                                                                                               
  769  PT193    VIS1    PBO   Asian                                                                                               
  770  PT193    VIS2    PBO   Asian                                                                                               
  771  PT193    VIS3    PBO   Asian                                                                                               
  772  PT193    VIS4    PBO   Asian                                                                                               
  773  PT194    VIS1    PBO   Black or African American                                                                           
  774  PT194    VIS2    PBO   Black or African American                                                                           
  775  PT194    VIS3    PBO   Black or African American                                                                           
  776  PT194    VIS4    PBO   Black or African American                                                                           
  777  PT195    VIS1    TRT   White                                                                                               
  778  PT195    VIS2    TRT   White                                                                                               
  779  PT195    VIS3    TRT   White                                                                                               
  780  PT195    VIS4    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  766 Female    37.433381846    45.787023997     0.838085144               2    1.6927737945    44.6795    0.49709    535     0.05
  767 Female    37.433381846     48.74885768    0.3369401917               3    0.6421327172    44.6795    0.49709    535     0.05
  768 Female    37.433381846    84.084487078     0.749780922               4    1.2822330323    44.6795    0.49709    535     0.05
  769 Male      21.971170914               .    0.6550263461               1    0.1405469735    41.1517    0.40805    535     0.05
  770 Male      21.971170914    30.194945315    0.2527406447               2    -1.112502683    41.1517    0.40805    535     0.05
  771 Male      21.971170914    36.785734378    0.4521300426               3    -0.339676972    41.1517    0.40805    535     0.05
  772 Male      21.971170914    61.035875425    0.7878315348               4    -1.664764639    41.1517    0.40805    535     0.05
  773 Male      34.462375838    20.367493986     0.753653493               1    0.9288517617    41.1517    0.40805    535     0.05
  774 Male      34.462375838    35.224795499    0.3500484597               2    1.4168268347    41.1517    0.40805    535     0.05
  775 Male      34.462375838    37.428470912    0.8900163852               3    -0.062720778    41.1517    0.40805    535     0.05
  776 Male      34.462375838    30.205007008    0.4135350725               4    -0.980902336    41.1517    0.40805    535     0.05
  777 Female    35.881101046               .    0.1928156102               1    1.0871502512    44.6795    0.49709    535     0.05
  778 Female    35.881101046    49.128616211    0.1140906462               2    0.1393270266    44.6795    0.49709    535     0.05
  779 Female    35.881101046    47.312339949    0.3702260323               3    -0.386272098    44.6795    0.49709    535     0.05
  780 Female    35.881101046               .    0.7603676483               4    1.1235854232    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  766 43.7030    45.6560      1.1075     1.20861    6.72816     0.17421     0.17368
  767 43.7030    45.6560      4.0694     0.69774    8.55797     0.80262     0.79879
  768 43.7030    45.6560     39.4050     2.46644    4.02614     2.99861     2.99647
  769 40.3502    41.9533       .          .          .           .           .     
  770 40.3502    41.9533    -10.9568    -1.73080    4.76978    -1.73441    -1.73080
  771 40.3502    41.9533     -4.3660    -1.05714    8.03968    -0.90388    -0.90067
  772 40.3502    41.9533     19.8841     1.66316    4.90177     1.73211     1.73102
  773 40.3502    41.9533    -20.7842    -1.97518    1.93557    -1.97667    -1.97518
  774 40.3502    41.9533     -5.9269     0.77481    6.13258    -0.93821    -0.93626
  775 40.3502    41.9533     -3.7233    -1.06347    7.94387    -0.77081    -0.76808
  776 40.3502    41.9533    -10.9467    -1.60276    1.64287    -0.95357    -0.95297
  777 43.7030    45.6560       .          .          .           .           .     
  778 43.7030    45.6560      4.4491     0.69769    7.70404     0.69982     0.69769
  779 43.7030    45.6560      2.6329     0.42297    8.28677     0.51929     0.51681
  780 43.7030    45.6560       .          .          .           .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  56

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  781  PT196    VIS1    PBO   Asian                                                                                               
  782  PT196    VIS2    PBO   Asian                                                                                               
  783  PT196    VIS3    PBO   Asian                                                                                               
  784  PT196    VIS4    PBO   Asian                                                                                               
  785  PT197    VIS1    PBO   Black or African American                                                                           
  786  PT197    VIS2    PBO   Black or African American                                                                           
  787  PT197    VIS3    PBO   Black or African American                                                                           
  788  PT197    VIS4    PBO   Black or African American                                                                           
  789  PT198    VIS1    TRT   Black or African American                                                                           
  790  PT198    VIS2    TRT   Black or African American                                                                           
  791  PT198    VIS3    TRT   Black or African American                                                                           
  792  PT198    VIS4    TRT   Black or African American                                                                           
  793  PT199    VIS1    TRT   White                                                                                               
  794  PT199    VIS2    TRT   White                                                                                               
  795  PT199    VIS3    TRT   White                                                                                               

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  781 Male      29.393058415     19.28388473     0.730110155               1    -0.759845657    41.1517    0.40805    535     0.05
  782 Male      29.393058415    30.006815822     0.400501891               2    1.1489591032    41.1517    0.40805    535     0.05
  783 Male      29.393058415               .    0.6526549218               3    -0.842476259    41.1517    0.40805    535     0.05
  784 Male      29.393058415    49.217682043    0.5862825496               4    0.3914133404    41.1517    0.40805    535     0.05
  785 Male       35.69673346               .    0.5380673863               1    0.8913772423    41.1517    0.40805    535     0.05
  786 Male       35.69673346               .    0.7863398317               2    -1.335258713    41.1517    0.40805    535     0.05
  787 Male       35.69673346               .     0.385387123               3    0.3981234778    41.1517    0.40805    535     0.05
  788 Male       35.69673346    40.133533747    0.3443687845               4    -0.111586803    41.1517    0.40805    535     0.05
  789 Male      29.474841317    42.345344243    0.5827735232               1    0.6757439166    44.6795    0.49709    535     0.05
  790 Male      29.474841317    52.325750041    0.3612457639               2    -0.788597935    44.6795    0.49709    535     0.05
  791 Male      29.474841317               .    0.5828885486               3    -0.086986334    44.6795    0.49709    535     0.05
  792 Male      29.474841317      69.2625362    0.2989890486               4    1.3822840078    44.6795    0.49709    535     0.05
  793 Male      41.054005919               .    0.6913230626               1    0.1684901638    44.6795    0.49709    535     0.05
  794 Male      41.054005919               .     0.112059233               2    0.8231909483    44.6795    0.49709    535     0.05
  795 Male      41.054005919               .    0.5964899974               3    -0.220894598    44.6795    0.49709    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  781 40.3502    41.9533    -21.8679    -2.07816    1.83260    -2.07972    -2.07816
  782 40.3502    41.9533    -11.1449    -0.33489    5.02288    -1.76419    -1.76052
  783 40.3502    41.9533       .          .          .           .           .     
  784 40.3502    41.9533      8.0659    -0.12655    5.59889     0.70263     0.70218
  785 40.3502    41.9533       .          .          .           .           .     
  786 40.3502    41.9533       .          .          .           .           .     
  787 40.3502    41.9533       .          .          .           .           .     
  788 40.3502    41.9533     -1.0182    -0.08864    3.49383    -0.08870    -0.08864
  789 43.7030    45.6560     -2.3341    -0.22590    4.09813    -0.22616    -0.22590
  790 43.7030    45.6560      7.6463     1.76352    7.28307     1.20270     1.19904
  791 43.7030    45.6560       .          .          .           .           .     
  792 43.7030    45.6560     24.5831     1.54442    5.57214     1.87070     1.86937
  793 43.7030    45.6560       .          .          .           .           .     
  794 43.7030    45.6560       .          .          .           .           .     
  795 43.7030    45.6560       .          .          .           .           .     
                                                           The SAS System                          11:46 Friday, January 6, 2023  57

 
  Obs USUBJID  AVISIT  ARMCD  RACE

  796  PT199    VIS4    TRT   White                                                                                               
  797  PT200    VIS1    PBO   Black or African American                                                                           
  798  PT200    VIS2    PBO   Black or African American                                                                           
  799  PT200    VIS3    PBO   Black or African American                                                                           
  800  PT200    VIS4    PBO   Black or African American                                                                           

                                                                                                            StdErr
  Obs SEX            FEV1_BL            FEV1          WEIGHT          VISITN         VISITN2      Pred       Pred      DF    Alpha

  796 Male      41.054005919               .    0.7897474121               4    -1.029391655    44.6795    0.49709    535     0.05
  797 Male      51.191006818    35.703411791    0.4894285582               1    -0.010925691    41.1517    0.40805    535     0.05
  798 Male      51.191006818    41.644542707    0.4903211238               2    -1.224991155    41.1517    0.40805    535     0.05
  799 Male      51.191006818               .    0.1676835185               3    -2.596111388    41.1517    0.40805    535     0.05
  800 Male      51.191006818    54.250812574    0.4189190561               4     1.169122592    41.1517    0.40805    535     0.05

                                         Scaled      Scaled     Student     Pearson
  Obs  Lower      Upper        Resid      Resid       Dep        Resid       Resid

  796 43.7030    45.6560       .          .          .           .           .     
  797 40.3502    41.9533     -5.4483    -0.51777    3.39298    -0.51816    -0.51777
  798 40.3502    41.9533      0.4928     0.68256    6.04033     0.07801     0.07785
  799 40.3502    41.9533       .          .          .           .           .     
  800 40.3502    41.9533     13.0991     1.04310    6.76854     1.14106     1.14034
